<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation L100I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 9
Patients 17
Isolates 18
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hsu (2005)BAA157676BAA157676AY870181AZT, DDI, D4T, 3TCEFVM41L, L74V, M184V, L210W, T215YL100I, K103NE6D, K20R, V35T, T39K, K43E, E44A, K49R, K122E, D123S, I135M, K173T, Q174K, D177E, I178M, V179I, T200A, Q207D, R211K, L228R, K238R, V245E, T286A, A288T, E291D, I293V, K311R, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390RCRF01_AE
Non-B Workgroup (2005)TH_162TH_162AY605576ABC, DDIEFVM41L, K70R, L74V, M184VL100I, K103NV35T, T39K, K43E, T69N, K122E, D123N, K173I, Q174K, D177E, I178M, V179I, T200A, E204Q, Q207A, R211K, V245A, I257R, Q258P, K259QCRF01_AE
 TH_653TH_653AY901916AZT, DDIEFVM41L, D67G, L210W, T215FL100I, K103NV35T, T39K, K43E, V60I, K122E, D123N, I135T, K173L, Q174K, D177E, I178M, V179T, Q197E, Q207A, R211S, V245E, K249QCRF01_AE
Baxter (2006)48-30333033-30227DQ877944NRTINNRTIM41L, T215FL100I, K103NV21I, V35T, T39K, K43A, V60I, K173L, Q174K, D177E, T200A, Q207A, R211K, V245Q, L283I, E291D, I293V, E312N, I329V, G335D, F346Y, R356K, M357R, R358G, G359S, T369V, A371V, K390R, E396DCRF01_AE
Tee (2006)MYKL135603MYKL1356AY960876D4T, DDIEFVM41L, D67G, L74V, T215FL100I, K103NV35K, T39K, K43E, I47F, Y56S, T58I, V60I, S68G, T84I, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, V179I, T200E, Q207A, R211S, K223Q, K238R, V245ECRF01_AE
  03MYKL1356.1AY960916D4T, DDIEFVM41L, D67G, L74V, L210W, T215FL100I, K103NV35T, T39K, K43E, V60I, S68G, V118I, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, V179I, T200E, Q207A, R211S, K238R, V245ECRF01_AE
 MYKL165204MYKL1652AY960898AZT, 3TCEFVM41L, M184VL100I, K103NL34I, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, T200A, Q207A, R211S, H221Y, L228R, K238R, V245ECRF01_AE
 MYKL195804MYKL1958AY960909NRTI, AZT, 3TCEFVL74VL100I, K103N, P225HV35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
Manosuthi (2010)250745250745 D4T, 3TCNVPD67N, K70R, M184V, T215F, K219EL100I, K103NT39K, K43A, V60I, T69N, V111VIM, K122E, D123S, I135T, K166R, K173IT, Q174K, D177E, T200A, I202V, Q207A, R211S, G213A, L228H, W239WR, V245ECRF01_AE
Bunupuradah (2011)079-008-001079-008-001 D4T, 3TCNVP, EFVM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QA98G, L100I, K101E, V108IV35T, E36D, T39K, K43E, V60I, K122E, D123S, K173R, Q174K, D177E, V179I, T200A, Q207A, R211N, H221Y, L228H, K238R, V245KCRF01_AE
Ngo-Giang-Huong (2011)PHPT1699PHPT1699RTHQ996494AZT, 3TCEFVD67N, K70R, M184V, T215I, K219EL100I, K103NV35T, T39K, K43E, K122E, D123N, I135IT, I142T, K173A, Q174K, D177E, I178IL, Q207A, R211SCRF01_AE
Nouhin (2013)R0220214R0220214KF292451NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215YL100I, K103N, Y181IV35T, T39A, E44D, V111I, V118I, K122E, D123S, I135T, I159L, T165V, K173I, Q174K, D177E, I178M, V179I, T200A, E203D, Q207K, H208Y, R211D, K223KQ, K238RCRF01_AE
 R0321184R0321184KF292459NRTINNRTID67G, K70R, M184V, T215I, K219EL100I, K103NV35T, T39E, V60I, S68G, K122E, D123S, I135R, K173L, Q174K, D177E, T200A, Q207A, R211S, K238RCRF01_AE
 T0624301T0624301KF292652NRTINNRTID67G, K70R, L74I, M184V, T215F, K219EL100I, K103NV35T, T39N, S68G, K122E, D123N, K173I, Q174K, D177E, I202V, Q207A, R211S, L228H, K238RCRF01_AE
 S0421065S0421065KF292526NRTINNRTIM41L, D67N, K70R, M184V, L210W, T215F, K219EL100I, G190AV35T, T39K, K43E, E44A, V118I, K122E, D123S, I142V, S162T, K173I, Q174K, D177E, I178M, V179I, T200I, Q207A, R211N, L228HCRF01_AE
 T0804081T0804081KF292683NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215YA98G, L100I, K103NV35T, T39K, K43E, E44D, K49R, V60I, V111I, K122E, D123S, I135T, K173IM, Q174K, N175Y, D177E, K201I, Q207A, R211N, K238RCRF01_AE
Theys (2013)4056340563KC221201NRTI, TDFNNRTIK65RL100I, K103NK43A, V60I, K122E, D123S, K173I, Q174K, D177E, T200TA, Q207A, R211S, K238RCRF01_AE
 4378643786KC221290NRTI, TDFNNRTIM41L, D67N, L74V, M184V, L210W, T215F, K219EL100I, K103NV60I, K66R, K122E, D123S, K173A, D177E, I178M, V179I, T200A, E204Q, Q207A, R211K, D218E, L228HRCRF01_AE