<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation A98S
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 35
Isolates 39
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Cuevas (2002)CU81CU81AF425462AZT, DDINoneD67N, K70R V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207EC
 CU39CU39AF425420AZTNoneD67N V35T, T39E, S48T, A98S, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, F214LC
Gibb (2002)DMG8080_w32 AZT, 3TCNone  V35T, T39E, A98S, K122E, D123DG, I135R, K173T, D177E, I178IL, T200A, I202V, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, Q334HN, G335D, A355AT, R356K, G359T, K366R, K390RC
Weber (2003)85H610185H-0AY140820NRTINoneM41L, L210W, T215Y V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
  610185H-12AY140821NRTI, AZT, 3TCNoneM41L, D67N, L210W, T215Y V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
  610185H-48AY140823NRTI, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293VC
Gulick (2004)RG258RG258w130 ABC, AZT, 3TC, TDFNoneM184V T39E, S48T, A98S, K122E, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214FL, V245QC
Richard (2004)RNJCR12RNJCR12AY556757D4T, DDINone  V21I, V35T, E36M, T39E, K43N, I50V, A98S, K122E, D123S, A158S, K173T, Q174K, T200AC
Non-B Workgroup (2005)IL81IL81AY901354AZT, 3TC, ABC, DDINoneM41L, D67DN, M184V, L210W, T215Y T39DE, K43KQ, E44D, A98S, V118VI, K122E, K173T, D177E, G196E, T200A, Q207E, R211K, V245QC
 IL208IL208 AZTNone  T39E, S48T, V60VI, A98S, K122E, D123N, K173A, D177E, T200A, I202V, Q207E, V245QC
 IL86IL86AY901741AZT, D4TNone  E44D, K49KR, A98S, K122E, D123S, I135T, A158S, K173A, D177EG, T200TA, Q207E, R211K, V245QC
 IL92IL92AY901744AZT, 3TCNone  T39E, E40D, K43KE, I47N, S48FL, A98S, K101Q, K122E, D123G, K166R, K173A, D177EG, T200A, Q207E, V245QC
 IL217IL217AY901757AZT, 3TCNoneM184V, T215NY T39E, S48ST, A98S, K122E, D123G, A129AE, A158S, K173A, Q174K, D177E, G196E, T200A, E203EK, Q207E, V245QC
 IL248IL248AY901759AZT, 3TCNone  I37FL, T39E, S48T, A98S, K122E, D123S, E169D, K173T, D177E, T200A, Q207E, R211K, F227FS, V245QC
 IL293IL293AY901766AZT, 3TC, DDINoneK70R, M184V T39E, K64R, T69N, A98S, K122E, D123S, A158S, K173A, D177E, T200A, Q207EG, H208HY, R211K, H235HY, V245QC
 IL297IL297AY901767AZT, 3TCNone  T39E, N57NY, A98S, K122E, D123S, I135V, A158S, K173AT, P176PT, T200A, Q207E, K220KR, V245QC
 IL310IL310bAY901768AZT, 3TCNone  T39E, A98S, T107S, K122E, D123N, N137NI, A158S, K173A, D177E, T200A, Q207E, R211K, V245QC
 IL370IL370AY901772AZT, 3TCNoneM184V T39D, A98S, K122E, D123S, I135L, K173A, Q174K, D177E, T200A, Q207E, V245QC
 IL401IL401AY901777AZT, 3TCNone  T39EG, K49KR, A98S, K122E, D123S, N137NI, A158S, K173A, D177E, T200A, I202IV, L205LF, Q207G, R211RK, V245QC
 IL665IL665AY901783AZT, D4T, DDINone  T39E, A98S, K122E, D123S, A158S, K173T, Q174K, D177E, T200A, Q207EC
 TK4017TK4017 AZT, 3TC, ABCNoneM41L, M184V, L210W, T215NE138KV35T, T39G, K43R, A98S, K122E, D123S, A158S, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292IC
Pillay (2008)DR59DR59AY589911D4T, DDINoneA62V, K65R, V75I, F77L, F116Y, Q151M T39E, S68G, A98S, K122A, S162X, S163ST, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, Q278H, I293V, S322A, Q334XC
Sylla (2008)B7173B7173_C1EF5256613TC, DDINoneD67N, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404DC
  B7173_C2EF5256623TC, DDINoneD67N, L74V, M184I V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VIC
Van Zyl (2013)1182872KC424328D4T, 3TCNoneM184V K20KR, V35T, E36A, T39E, S48T, A98S, K122E, K173T, Q174K, G196E, T200A, Q207D, R211K, V245E, D250EC
Grossman (2014)16281628KF134991AZT, 3TCNone  I37L, T39E, K43KQ, A98S, K102Q, K122E, D123DG, K173I, Q174K, D177E, I178L, T200A, V245QC
 20782078KF135019AZT, 3TCNone  I37L, T39E, A98S, K122E, D123S, R143RK, A158S, K173A, Q174QK, T200TI, Q207E, R211RK, V245QC
 512512KF1350923TC, DDINone  T39E, E44D, A98S, K122E, D123S, R125RS, I135M, K173A, D177E, Q207E, R211K, V245QC
 968968KF135168ABC, AZT, 3TCNone  T39E, A98S, K122E, D123GS, I135T, K173AT, Q174QK, D177E, I178IM, T200A, Q207E, R211RK, V245QC
 11201120KF134953ABC, AZT, 3TCNone  T39E, K49R, A98S, K102KE, K122KE, D123S, A158S, K173A, Q174QK, D177E, I178M, D192DN, T200A, Q207E, R211RK, V245QRC
 10891089KF134939AZT, 3TCNone  T39E, A98S, S117SP, K122E, D123S, A158S, K166R, K173A, D177E, T200E, I202IV, Q207E, R211RK, V245QC
 819819KF135150AZT, 3TCNone  T39G, A98S, K122E, D123ST, K173A, D177E, I195L, T200A, Q207E, R211K, V245KC
 18871887KF135009AZT, 3TCNone  T39A, A98S, K122E, D123S, Y144F, K173A, D177E, T200A, Q207A, V245QC
 20312031KF135015AZT, 3TCNone  T39E, A98S, K122E, D123S, I159V, K173A, D177DE, I178L, G196E, T200A, Q207E, V241I, V245QC
 976976KF135172AZT, 3TCNone  T39E, K49R, K82KR, A98S, K122E, D123S, A158S, K173T, D177E, T200A, Q207E, V245QC
 21662166KF135023AZT, 3TCNone  T39K, K43E, A98S, K122E, D123N, K173A, D177E, I178IV, G196E, T200A, E204K, Q207E, V245QC
 16251625KF134990TDF, FTCNone  T39E, S48T, A98S, K101R, K122E, D123G, K173A, Q174K, D177E, I202IK, Q207A, R211K, G213GE, H221HQ, H235HQ, D237DE, V245QC
 15331533KF134985TDF, FTCNone  T39K, K49R, A98S, K122E, D123S, I142IV, A158S, T165I, K173T, D177E, I178L, T200A, Q207E, V245QC
  1533KF134986TDF, FTCNone  T39E, K49KR, K65KE, A98S, K122E, D123S, I142IV, A158S, T165I, K173T, D177E, I178L, T200A, Q207E, V245QC