Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	C
Gene	RT
Mutation	A98S
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	8
Patients	21
Isolates	24

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Cuevas (2002)	CU81	CU81	AF425462	AZT, DDI	None	D67N, K70R		V35T, T39E, K64R, T69N, A98S, D121H, K122E, D123S, K173A, D177E, I178L, I195M, Q197P, T200A, Q207E	C
	CU39	CU39	AF425420	AZT	None	D67N		V35T, T39E, S48T, A98S, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, F214L	C
Gibb (2002)	DMG80	80_w32		AZT, 3TC	None			V35T, T39E, A98S, K122E, D123DG, I135R, K173T, D177E, I178IL, T200A, I202V, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, Q334HN, G335D, A355AT, R356K, G359T, K366R, K390R	C
Weber (2003)	85H	610185H-0	AY140820	NRTI	None	M41L, L210W, T215Y		V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
		610185H-12	AY140821	NRTI, AZT, 3TC	None	M41L, D67N, L210W, T215Y		V35T, T39E, S48T, A98S, K122E, D123N, I135T, K173T, Q174K, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
		610185H-48	AY140823	NRTI, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y		V35T, T39E, S48T, A98S, V118I, K122E, D123N, I135T, K173T, Q174K, N175Y, G196E, T200A, Q207N, R211K, V245Q, A272Q, E291D, V292I, I293V	C
Gulick (2004)	RG258	RG258w130		ABC, AZT, 3TC, TDF	None	M184V		T39E, S48T, A98S, K122E, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214FL, V245Q	C
Richard (2004)	RNJCR12	RNJCR12	AY556757	D4T, DDI	None			V21I, V35T, E36M, T39E, K43N, I50V, A98S, K122E, D123S, A158S, K173T, Q174K, T200A	C
Non-B Workgroup (2005)	IL81	IL81	AY901354	AZT, 3TC, ABC, DDI	None	M41L, D67DN, M184V, L210W, T215Y		T39DE, K43KQ, E44D, A98S, V118VI, K122E, K173T, D177E, G196E, T200A, Q207E, R211K, V245Q	C
	IL208	IL208		AZT	None			T39E, S48T, V60VI, A98S, K122E, D123N, K173A, D177E, T200A, I202V, Q207E, V245Q	C
	IL86	IL86	AY901741	AZT, D4T	None			E44D, K49KR, A98S, K122E, D123S, I135T, A158S, K173A, D177EG, T200TA, Q207E, R211K, V245Q	C
	IL92	IL92	AY901744	AZT, 3TC	None			T39E, E40D, K43KE, I47N, S48FL, A98S, K101Q, K122E, D123G, K166R, K173A, D177EG, T200A, Q207E, V245Q	C
	IL217	IL217	AY901757	AZT, 3TC	None	M184V, T215NY		T39E, S48ST, A98S, K122E, D123G, A129AE, A158S, K173A, Q174K, D177E, G196E, T200A, E203EK, Q207E, V245Q	C
	IL248	IL248	AY901759	AZT, 3TC	None			I37FL, T39E, S48T, A98S, K122E, D123S, E169D, K173T, D177E, T200A, Q207E, R211K, F227FS, V245Q	C
	IL293	IL293	AY901766	AZT, 3TC, DDI	None	K70R, M184V		T39E, K64R, T69N, A98S, K122E, D123S, A158S, K173A, D177E, T200A, Q207EG, H208HY, R211K, H235HY, V245Q	C
	IL297	IL297	AY901767	AZT, 3TC	None			T39E, N57NY, A98S, K122E, D123S, I135V, A158S, K173AT, P176PT, T200A, Q207E, K220KR, V245Q	C
	IL310	IL310b	AY901768	AZT, 3TC	None			T39E, A98S, T107S, K122E, D123N, N137NI, A158S, K173A, D177E, T200A, Q207E, R211K, V245Q	C
	IL370	IL370	AY901772	AZT, 3TC	None	M184V		T39D, A98S, K122E, D123S, I135L, K173A, Q174K, D177E, T200A, Q207E, V245Q	C
	IL401	IL401	AY901777	AZT, 3TC	None			T39EG, K49KR, A98S, K122E, D123S, N137NI, A158S, K173A, D177E, T200A, I202IV, L205LF, Q207G, R211RK, V245Q	C
	IL665	IL665	AY901783	AZT, D4T, DDI	None			T39E, A98S, K122E, D123S, A158S, K173T, Q174K, D177E, T200A, Q207E	C
	TK4017	TK4017		AZT, 3TC, ABC	None	M41L, M184V, L210W, T215N	E138K	V35T, T39G, K43R, A98S, K122E, D123S, A158S, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I	C
Pillay (2008)	DR59	DR59	AY589911	D4T, DDI	None	A62V, K65R, V75I, F77L, F116Y, Q151M		T39E, S68G, A98S, K122A, S162X, S163ST, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, Q278H, I293V, S322A, Q334X	C
Sylla (2008)	B7173	B7173_C1	EF525661	3TC, DDI	None	D67N, M184I		V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D	C
		B7173_C2	EF525662	3TC, DDI	None	D67N, L74V, M184I		V35T, T39E, S48T, V60I, A98S, D121H, K122E, I135V, K173A, Q174K, P176T, I178L, T200A, Q207E, R211K, V245M, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435VI	C

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