<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation V90I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 23
Patients 68
Isolates 75
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lee EJ (2005)Zim47_8wZim47_8wAY901732NoneNVP  V35T, E36A, T39E, S48T, N57NK, K64KR, V90I, K122E, K173AT, D177E, I178M, T200A, Q207E, R211K, V245QC
Non-B Workgroup (2005)UK1147UK1147AY901330AZT, 3TC, DDI, D4T, ABCDLVM41L, L74V, M184V, T215YM230LV35T, E36A, T39D, V60I, V90I, K173T, Q174K, I178L, E203D, Q207EC
 UK4903UK4903AY901808AZT, 3TCNVPM184VK103NV21VI, V35K, T39D, S48ST, V60VI, W88S, V90I, D121Y, K122E, I135IM, S162HY, K173A, D177E, T200A, Q207E, F214FLC
 TK2006TK2006a AZT, DDI, 3TC, D4TEFVM184VK103KN, V179FL, Y188LV35T, T39D, S48T, V90I, K101R, K122E, D123G, S162Y, K166KR, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, I293V, E297K, V317VAC
 TK3022TK3022 DDC, AZT, 3TC, D4TEFVD67N, K70R, M184V, K219EG190SK22KR, V35M, T39E, S48T, V90I, K101KQ, K122E, D123S, A158S, K173T, Q174K, D177E, I178L, V179VI, I195L, T200A, V245Q, S251I, A272P, K275R, L283I, E291D, V292I, I293VC
Weber (2005)M85804M85804AY677525AZT, 3TCNVPD67N, M184VK103NE28A, V35T, T39E, S48T, V90I, K122E, D123S, I135T, S162Y, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
Baxter (2006)12-31023102-30610DQ880328NRTINNRTID67N, T69D, K70R, T215I, K219QK103NST39E, S48T, V60I, V90I, K122E, D123S, I135T, K173T, D177E, I178L, V179VI, T200A, E204K, Q207D, R211K, L228H, V245QC
Doualla-Bell (2006)Pt17FDB_Pt17EF434890AZT, 3TC, D4T, DDIEFVM41L, L74LV, V75M, M184MV, T215YK101H, K103N, G190AP4S, V35T, E36A, T39E, S48T, V60VI, V90I, K122E, I135V, S162A, K173A, D177E, Q197K, Q207E, R211K, V245Q, A272P, T286A, E291D, I293V, E297DC
Novitsky (2007)14471447_2037EF026204AZT, DDINNRTIT215YK103NP4S, V8I, V35T, E36A, T39E, S48T, V90I, K122E, D123G, I135M, S162C, D177E, V189I, T200A, R211K, V245Q, A272S, K277R, T286V, E291D, V292I, I293V, V317AC
 17081708_5064EF026223AZT, DDINNRTIT215YK103N, G190AV35T, E36A, T39E, S48T, V90I, K122E, D123S, K173T, T200A, Q207E, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, P294TC
Sen (2007)T095NPT95-PLEF186988AZT, D4T, 3TCNVPM41L, D67N, V75M, M184V, T215F, K219W, N348IV108I, Y181CT7A, V8I, L34I, V35T, T39D, E44D, V60I, V90I, I94L, D121H, K122E, T139TK, I142V, S162H, E169A, K173A, D177E, T200A, E203ED, Q207E, H208HY, R211K, V245Q, A272P, K277KR, E291D, V292I, I293V, E297A, G335GD, R356K, G359AC
Seoighe (2007)CHB106_C1EF381747NoneNVP  V35T, E36A, T39E, S48T, V90I, A98S, K122E, D123G, K173A, D177G, T200A, Q207E, V245Q, A272S, K277R, T286A, V292I, I293VC
 PL4606_PL46V2EF382232NoneNVP  V35T, E36A, T39E, S48T, V60I, V90I, K122E, D123G, K166R, K173ILST, Q174QK, D177E, V179I, T200A, I202V, Q207E, R211K, V245Q, A272P, E291D, V292I, I293VC
Church (2008)402788Z402788ZEU380753NoneNVP V106MV35T, E36A, T39E, S48T, V90I, K122E, D123S, A158S, K173A, D177E, T200A, Q207E, V241I, V245Q, A272Q, L283I, V292I, I329LC
Marconi (2008)SW034sw034EU308047D4T, 3TCNVPM184VY181VS48T, V90I, K122E, D123G, I135IM, I142T, S162Y, K166R, K173I, Q174R, D177E, V179I, T200A, E204EK, L205L*, Q207E, L210L*, R211K, E224EA, V245QC
 SW074SW074EU308085D4T, 3TCEFVM184VK103N, V108VIS48T, V60I, S68G, V90I, K101G, D121Y, K122E, I135T, S162Y, K173S, Q174K, D177E, I178L, V179I, G196E, T200A, Q207E, R211K, V245QC
 SW102SW0102EU308110D4T, 3TCEFVK70R, M184VV106M, V179DS48T, S68G, V90I, K103R, D121Y, K122E, D123G, S162C, K173A, D177E, T200A, E203EK, Q207E, R211KC
Nyombi (2008)TMS031TMS031EU251804NoneNVP  V35A, E36A, T39E, E40D, K49R, V90I, K122E, D123G, P140T, K173T, D177E, T200A, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, G335DC
Deshpande (2009)Pat24716artFJ530694NRTINNRTIM184VV106A, F227LV35T, T39N, S48T, V60I, V90I, K122E, D123E, I135V, R143RI, S162A, K173A, D177E, T200A, Q207EG, R211K, V245QC
 Pat19643RTFJ530745AZT, 3TCNVPM184V, T215YK103NI5T, E6D, V35T, E36A, T39D, S48T, K49R, V60I, V90I, K122E, D123G, I135T, S162H, E169K, K173E, D177E, T200A, Q207E, R211K, V245QC
 Pat19155RTFJ530750NRTINNRTIM41L, D67N, K70KR, M184I, T215Y, K219WK101E, Y181C, G190AE28A, V35T, T39D, E44ED, V60I, V90I, D121H, K122E, D123E, I135T, K173A, Q174R, D177E, V179A, T200A, Q207E, H208HY, R211K, D218E, V245QC
 Pat17494RTFJ530767D4T, 3TCNVPA62AV, K65R, F116Y, Q151M, M184IY181VV35T, T39N, S48T, S68G, T69TI, V90I, D121H, K122E, I135T, S162A, T165I, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 Pat159146RTFJ530782NRTINNRTIM41L, M184V, T215FA98G, K103NL34I, V35T, T39E, V60I, V90I, D121Y, K122E, I135K, S162Y, K173A, D177E, T200A, Q207E, R211K, V245QC
 Pat153155RTFJ530788D4T, 3TCNVPM184VK103N, Y181CK32E, V35T, E36A, T39D, S48T, V60I, V90I, D121Y, K122E, I135R, R143E, S162A, K173T, Q174K, D177E, I178L, T200A, Q207E, H221Y, V245QC
 Pat148167RTFJ530793NRTINNRTIM184VK103NV21G, V35T, E36A, T39D, K49R, V60I, V90I, D121Y, K122E, I135T, T139R, S162A, K173T, Q174K, T200A, Q207G, R211KC
 Pat145174RTFJ530796NRTINNRTIF116FY, Q151M, M184IV108I, Y181CV35T, T39D, S48T, V60I, V90I, D121Y, K122E, R143RW, S162C, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, H221Y, Q222QL, V245Q, K249MC
 Pat140182RTFJ530801NRTINNRTIM41L, D67DN, K70KR, V75VI, M184V, T215F, K219EK103N, Y181YCV35T, T39D, I50IM, V60I, V90I, D121Y, K122E, D123DE, I135RT, T139TK, S162A, K173A, Q174R, T200A, I202IV, Q207E, R211K, L228H, V245Q, K249NC
 Pat073294RTFJ530868D4T, 3TCNVPM41L, A62V, D67N, V75I, F77L, Q151M, M184V, T215YY181CK20KR, V35T, T39D, E44D, V60VI, T69TN, V90I, D121Y, K122E, I135R, I142V, S162Y, K173A, Q174K, N175H, D177E, V179I, T200A, K201T, E203D, Q207E, R211K, F214L, H221Y, V245QC
 Pat026373rtFJ530915AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FY181IV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
 Pat022391rtFJ530919AZT, D4TNVPM184I, T215YK101E, Y181CI31L, V35T, E36A, T39D, S48T, V60I, T69N, V90I, D121Y, K122E, S162A, K173T, D177E, T200A, Q207E, R211K, V245QC
 Pat005445RTFJ530936AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FK101EQ, V106M, Y181I, G190A, F227FLV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
 Pat002VR012RTFJ530939D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK32R, A33AV, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
Hoffmann (2009)pat061MD13967 AZT, 3TCEFVM184VK103NV35T, T39E, S48T, E53D, V90I, D121C, K122E, D123E, I135L, T139A, S162Y, K173A, D177E, T200A, I202V, Q207E, R211K, V245Q, A272PC
 pat080MD38416 AZT, 3TCEFVV75IK103NV35T, I37IM, T39E, V90I, I132L, K173A, D177E, I178M, G196K, T200A, Q207E, R211K, L228LH, V245Q, A272PC
Hosseinipour (2009)94469446GQ228294D4T, 3TCNVPM184MVK103NT39E, S48T, V90I, K122E, D123DG, I135IMT, S162H, K173IT, Q174K, D177E, I178IM, T200AE, E203ED, Q207E, R211KT, V245QC
 88958895GQ228313D4T, 3TCNVPA62V, K65R, V75I, F77L, F116Y, Q151MY181C, G190AT39E, S48ST, S68G, T69I, V90I, V118I, K122E, D123N, R172K, K173T, D177DE, I178IL, T200A, E204K, Q207E, R211RK, F214L, K223Q, L228R, V245QC
Rajesh (2009)F3TRCFRT3FJ5953513TC, DDINVPL74LV, M184IV, K219KNY181CK11Q, K32E, V35T, E36A, T39D, S48T, V60I, R72RG, V90I, K101KR, D121Y, K122E, I135R, S162Y, K173A, I178IM, T200A, E203EK, Q207E, R211RK, H221HY, Y232H, V245QC
 F12TRCFRT12FJ5953603TC, DDINVPL74LV, M184V, K219KEK103N, Y181CK30E, I31P, V35T, T39N, S48T, V60I, V90I, D121H, K122E, I142IV, S162A, E169K, K173E, I178L, T200A, Q207E, R211K, V245EC
Wallis (2009)GT00367353GT00367353 AZT, 3TCEFVM184VK103NV8I, V35A, T39EK, S48E, D86X, V90I, K122E, D123S, T139TK, K173A, D177E, I178L, T200A, Q207K, R211K, V245Q, E248D, A272P, A288T, E291D, V292I, I293V, L301FC
 23674142367414 AZT, 3TCEFVM41L, D67N, T69D, L74V, M184V, L210W, T215YK103N, V179E, M230LS3C, V35T, T39E, E44D, S48T, E53D, V60I, V90I, K102KQ, V111VIM, P119PL, K122E, D123S, E138R, A158S, S162A, R172K, I178L, T200A, E203K, Q207D, R211K, V245C, A272P, Q278H, T286A, E291D, V292I, I293V, D324EC
 23592452359245 AZT, 3TCEFVA62AV, M184V, T215TSV106M, G190AV35T, E36A, T39D, S48T, S68SG, V90I, K122E, D123N, S162C, K173T, Q174K, P176S, D177EK, I178L, T200A, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I329VC
 23450232345023 D4T, 3TCEFVM184VY188LK30KE, V35T, T39K, S48T, V90I, K101Q, K122E, D123S, I135IT, K173A, I178L, V179I, T200A, Q207N, R211K, V245Q, E248EK, A272S, K277R, L283LF, T286TA, E291D, V292I, I293V, L303LWC
 GT00130674GT00130674 D4T, 3TCEFVA62V, D67G, M184IV106M, Y188CV35T, T39E, S48T, V90I, K122E, I135M, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 GT00057847GT00057847 AZT, 3TCEFVA62V, M184VK101E, G190VV35T, E36A, T39E, S48T, T58S, V90I, K122E, D123S, I135IT, N147NK, K173A, Q174K, D177E, T200A, E203G, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, E297KC
 GT00240772GT00240772 AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293VC
 TJC2382305TJC2382305 D4T, 3TCNVPM184VK101H, G190AK32N, V35K, E36A, T39E, S48T, V90I, K122E, D123S, I135T, S162F, K173A, Q174K, N175Y, D177E, V179VI, T200A, Q207E, R211K, V245Q, A272P, K277R, T286V, V292I, I293VC
 TJC2417303TJC2417303 D4T, 3TCNVPM184VK101E, Y181CV35T, E36A, T39E, S48T, K64R, V90I, K122E, D123N, K173A, Q174R, D177E, I178M, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, V317AC
 23649712364971 AZT, 3TCEFVD67N, M184I, T215FK103NT27S, I31L, V35T, T39E, S48T, V60I, V90I, A98S, K122E, D123G, S162Y, K173A, Q174R, D177E, I178L, I195L, T200A, Q207K, R211K, V245Q, A272P, I293V, S322T, D324EC
 GT00327585GT00327585 D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
 TJC2499250TJC2499250 AZT, 3TCEFVM41L, D67N, K70R, M184V, T215FY, K219EQY188LK20R, V35T, T39E, V90I, A98S, K102X, K103R, K104Q, K122E, D123G, S162Y, K173A, D177E, V179I, T200A, E203K, Q207E, F214FL, L228LH, V245Q, D250DE, A272P, K277R, L283I, T286A, A288T, V292I, I293V, S322A, D324EC
 23567552356755 AZT, 3TCEFVM41L, D67N, T69D, L74V, M184V, L210W, T215YK103N, V179E, M230LS3SC, V35T, T39E, E44D, S48T, E53D, V60I, V90I, K102KQ, V111VIM, K122E, D123S, E138R, A158S, S162A, R172K, I178L, T200A, E203K, Q207D, R211K, V245C, A272P, Q278H, T286A, E291D, V292I, I293V, L310LQ, D324EC
Deshpande (2010)12IND42512IND425GU108151D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK20R, K32G, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
 16IND42816IND428GU108154D4T, 3TCNVPD67N, K70R, M184V, T215F, K219EY181CV35T, T39D, S48T, V60I, V90I, D121Y, K122E, D123G, I135R, S162A, T165L, K173T, Q174K, D177E, I178L, T200A, I202V, Q207E, R211K, V245QC
 36IND43736IND437GU108163AZT, 3TCEFV, NVPM41L, D67N, K70R, M184V, T215F, K219QK101E, V106M, G190AE28K, K32E, V35T, E36A, T39D, S48T, V60I, V90I, I94L, D121Y, K122E, S162A, K173AT, D177E, V179VI, T200E, Q207R, R211DE, V245QC
 38IND43938IND439GU108165AZT, 3TCNVPM41L, D67N, V75M, M184V, L210L*W, T215YK103N, K238TV35T, T39N, V60I, V90I, I94L, D121Y, K122E, I135T, S162A, K173T, D177E, T200A, Q207E, F214FL, V245Q, D256EC
 39IND4439IND44GU108166D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215YK103N, K238TL34LS, V35T, T39N, V60I, V90I, I94L, D121Y, K122E, I135T, S162A, K173T, D177E, T200A, Q207E, W239WC, V245QC
 55IND44555IND445GU108171D4T, 3TCNVPM184VY181CV35T, T39D, S48T, V90I, K102Q, K122E, I135M, S162Y, K166R, K173A, D177E, I178L, V179I, L187LW, T200A, Q207E, L228R, V245QC
 65IND44865IND448GU108174D4T, 3TCNVPM41L, V75M, M184V, T215F, K219WK103N, V108I, Y181CV8I, T27S, V35T, T39D, S48T, V60I, V90I, K122E, I135R, S162F, K173A, Q174K, D177E, T200A, Q207E, D218E, L228R, V245QC
El-Khatib (2010)Pat00810ZA_SAVE1078HQ012286D4T, 3TCEFV K103NV35T, E36A, T39E, S48T, V90I, K122E, D123S, K173M, Q174KR, T200A, Q207V, R211K, V245QC
 Pat02910ZA_SAVE1434HQ012307D4T, 3TCEFVM184I, T215I, K219RK103N, Y181YC, P225HK20R, K22R, V35T, E36A, T39E, W88C, V90I, K122E, D123G, I135T, S162Y, K173A, Q174K, N175Y, D177E, T200A, Q207E, R211K, F214L, V245Q, D250EC
Rodrigues (2010)320_07BR07SC320GQ401304AZT, 3TCNVPA62V, M184VG190AT7I, V35T, E36A, T39D, K43R, S48T, V90I, K173V, Q174R, D177E, Q207E, R211KC
 346_07BR07SC346GQ401328AZT, 3TCEFVM184VK103N, P225HV35K, E36A, T39D, K43R, S48E, V90I, K101Q, K104R, S162A, D177E, T200A, Q207E, R211KC
Green (2011)707PKE22F707PKE22FHM623511D4T, 3TCEFVK65R, T69~, K70R, Q151MK103N, V106ML34V, V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123G, T139E, A158S, K173A, D177E, I178M, T200A, Q207A, R211K, V245E, A272P, E291D, V292I, I293V, D324EC
Sigaloff (2011)GT00057847GT00057847_1JN381565AZT, 3TCEFVA62V, M184VK101E, G190VV35T, E36A, T39E, S48T, T58S, V90I, K122E, D123S, I135IT, N147NK, K173A, Q174K, D177E, T200A, E203G, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, E297KC
  GT00057847_2JN381566AZT, 3TCEFVA62V, M184VK101E, G190VV35T, E36A, T39E, S48T, T58S, V90I, K122E, D123S, N147K, K173A, Q174K, D177E, T200A, E203G, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, E297KC
 GT00240772GT00240772_1JN381581AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293V, V317XC
  GT00240772_2JN381582AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293VC
 GT00327585GT00327585_1JN381602D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
  GT00327585_2JN381603D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
van Zyl (2011)A178A178JN638105D4T, 3TCNVPM184VY188LRK32KR, V35T, E36A, T39E, S48T, V90I, K122E, D123G, Q145C, F160FV, S162A, K173T, D177E, T200TA, Q207E, R211RK, F214L, I244IT, V245QC
 A281A281JN638172D4T, 3TCNVP Y181CK11KQ, V35T, T39E, S48T, V90I, K103R, D121Y, K122E, I135T, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 A284A284JN638175D4T, 3TCNVPM184VV179D, Y181CT27I, V35T, E36A, T39E, S48T, V90I, K103R, K122E, D123S, T139A, S162C, T200A, Q207E, R211K, F214L, V245QC
 A72A72JN638221D4T, 3TCEFVM184VL100I, K103NI5V, V35T, T39A, S48T, V60I, V90I, K122E, D123G, I135T, S162Y, K173A, D177E, G196K, T200A, Q207E, R211K, F214L, V245QC
Brehm (2012)09ZA09ZA.24JN601910D4T, 3TCEFVM184VK103NI31L, V35T, T39E, S48T, V60I, V90I, K122E, D123N, K173A, Q174K, D177E, T200A, I202V, Q207T, R211K, V245Q, A272P, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377Q, S379C, K390R, A400I, E404D, V435A, L452M, V466I, L469Q, T470S, D471E, H483L, L484I, L491S, S519N, K530R, A534S, A554SC
  09ZA.36JN601911D4T, 3TCEFVM184V, N348NIK101KE, K103NE28EK, V35T, T39EG, S48T, V60I, V90I, K122E, D123N, I135IL, K173A, Q174K, D177E, T200A, I202V, Q207T, R211K, V245Q, A272P, E291D, V292I, I293V, P294PS, Q334D, G335D, R356K, M357R, G359T, T377Q, S379C, K390R, A400I, E404D, V435A, L452M, V466I, L469Q, T470S, D471E, H483L, L484I, L491S, S519N, K530R, A534S, A554SC

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