<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation N348I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 4
Patients 15
Isolates 15
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)48-71017101-30723DQ878954NRTINNRTIM41L, D67N, K70R, L210W, T215Y, K219Q, N348IK103NV35I, T39E, E44ED, V60I, V118I, K122E, D123G, I135T, K173T, Q174K, T200A, E203ED, Q207E, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359A, T377M, A400SC
Sen (2007)T107NPT107-PLEF186962D4T, 3TCNVPM41L, D67G, K70R, L74V, M184V, L210W, T215F, K219W, N348IY181C, G190AV35T, T39D, V60I, S68G, D121Y, K122E, K173A, Q174K, D177E, T200A, H208Y, R211K, L228H, E233D, V245Q, A272P, E291D, V292I, I293V, E297A, I326V, G335DC
 T111NPT111-PLEF186965D4T, 3TC, DDINVP, EFVM41L, D67N, M184V, T215Y, N348IY188LK20KR, V35T, T39D, E44D, S48T, V60I, V106VL, V118I, D121Y, K122E, I135T, S162A, K166R, K173T, D177E, T200A, Q207E, L210S, D218E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377I, K390R, A400TC
 T113NPT113-PLEF186967AZT, D4T, 3TCNVPM184V, N348IY181VV35T, E36A, T39E, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, T200A, Q207E, F214L, V245Q, D256E, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, G359T, A376T, T377R, K390R, E396D, A400T, E404DC
 T094NPT94-PLEF186973AZT, D4T, 3TCNVPD67DN, K70R, M184V, K219KQ, N348IG190AV35T, E36EA, T39D, S48ST, V60I, K102L, K103R, D121Y, K122E, T139R, S162A, K173A, D177E, Q197K, T200A, Q207G, R211RK, V245Q, A272P, T286A, V292I, I293V, E297KR, V317A, G335D, R356K, G359T, E370EG, T377M, K390R, A400AT, E404D, V435A, L452IM, V466I, D471E, H483YC
 T099NPT99-PLEF186975AZT, 3TCNVPM184V, N348IK103KN, G190AT27S, V35T, E36A, T39D, S48T, V60I, K122E, I135L, S162A, E169EA, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377LR, K385R, K390R, A400T, E404D, E432D, V435A, A437VC
 T102NPT102-PLEF186981D4T, 3TCNVPM184V, N348IV108VI, Y181CV35T, T39E, S48T, K49KR, V60I, D121Y, K122E, D123E, I135R, E169Q, K173E, Q174R, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, G335D, R356K, G359T, T377MR, K390R, A400TC
 T095NPT95-PLEF186988AZT, D4T, 3TCNVPM41L, D67N, V75M, M184V, T215F, K219W, N348IV108I, Y181CT7A, V8I, L34I, V35T, T39D, E44D, V60I, V90I, I94L, D121H, K122E, T139TK, I142V, S162H, E169A, K173A, D177E, T200A, E203ED, Q207E, H208HY, R211K, V245Q, A272P, K277KR, E291D, V292I, I293V, E297A, G335GD, R356K, G359AC
Sigaloff (2011)GT00366729GT00366729_2JN381608D4T, 3TCEFVM184V, N348IK103N, K238TE28A, V35T, T39E, S48T, K122E, K173A, D177E, T200A, I202V, Q207K, R211K, L228R, P243T, V245Q, A272P, K275R, K277R, Q278S, T286A, E291D, V292I, I293V, E297KQ, E308K, L310C, E312K, V314G, Q334H, G335DC
Brehm (2012)04ZA04ZA.96JN601899D4T, 3TCEFVM184V, N348IK103NV35T, T39E, S48T, K122E, D123DG, I135T, S162SC, K173A, D177E, T200A, E203EK, Q207E, R211K, D250E, S251D, A272P, T286A, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, A360T, E370EG, T377Q, S379C, K390R, A400T, E404DN, V435L, K451R, L452V, V467I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554SC
 11ZA11ZA.144JN601915D4T, 3TCNVPM184V, N348IY181CV35T, T39K, S48T, K122E, I135IT, K166R, K173A, Q174K, D177E, T200A, I202V, E204D, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, S322T, I329L, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404DN, V435A, A437V, E449D, V466I, V467I, L469I, D471E, H483Q, L491P, S519N, Q524E, K530R, A534S, A554SC
 24ZA24ZA.48JN601944D4T, 3TCNVPM184V, N348IK103NV35T, E36A, T39D, S48T, K122E, D123G, I135T, E138A, S162A, K173T, T200A, Q207D, R211K, D250E, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, P294S, Q334H, G335D, R356K, G359T, K366R, T369A, T377L, K390R, E399G, A400T, E404D, N447I, L452I, V467I, T470S, D471E, T477A, H483Q, L491S, L517X, S519N, K527N, K530R, V531I, A534S, A554SC
 28ZA28ZA.84JN601954D4T, 3TCNVPM184V, N348IK103N, Y181CK20KR, V35T, E36A, T39DE, K122E, D123G, I135IV, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P313Q, Q334H, G335D, R356K, G359T, T377LR, K390R, A400T, E404DN, V435A, L452M, S468P, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554SC
 38ZA38ZA.24JN601976D4T, 3TCNVPM184V, N348IK103N, K238NV35T, E36A, T39E, S48T, K49KR, K122E, D123G, I135IM, S162A, K166I, D177E, T200A, Q207E, R211K, V245Q, A272P, K275R, K277R, Q278N, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, L452Q, V466S, V467I, S468C, T470N, D471E, H483Q, L491S, Q509H, S519N, K530R, A534S, A554SC
 50ZA50ZA.132JN602001D4T, 3TCEFVM184V, N348IK103N, V108IT27S, V35T, E36A, T39E, S48T, K122E, D123N, I135T, T139TK, S162C, K173A, D177E, T200A, Q207K, R211K, F214L, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V, D324DE, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, L452M, V466I, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554SC