<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation N348I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 5
Patients 26
Isolates 26
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)48-71017101-30723DQ878954NRTINNRTIM41L, D67N, K70R, L210W, T215Y, K219Q, N348IK103NV35I, T39E, E44ED, V60I, V118I, K122E, D123G, I135T, K173T, Q174K, T200A, E203ED, Q207E, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359A, T377M, A400SC
Sen (2007)T107NPT107-PLEF186962D4T, 3TCNVPM41L, D67G, K70R, L74V, M184V, L210W, T215F, K219W, N348IY181C, G190AV35T, T39D, V60I, S68G, D121Y, K122E, K173A, Q174K, D177E, T200A, H208Y, R211K, L228H, E233D, V245Q, A272P, E291D, V292I, I293V, E297A, I326V, G335DC
 T111NPT111-PLEF186965D4T, 3TC, DDINVP, EFVM41L, D67N, M184V, T215Y, N348IY188LK20KR, V35T, T39D, E44D, S48T, V60I, V106VL, V118I, D121Y, K122E, I135T, S162A, K166R, K173T, D177E, T200A, Q207E, L210S, D218E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377I, K390R, A400TC
 T113NPT113-PLEF186967AZT, D4T, 3TCNVPM184V, N348IY181VV35T, E36A, T39E, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, T200A, Q207E, F214L, V245Q, D256E, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, G359T, A376T, T377R, K390R, E396D, A400T, E404DC
 T094NPT94-PLEF186973AZT, D4T, 3TCNVPD67DN, K70R, M184V, K219KQ, N348IG190AV35T, E36EA, T39D, S48ST, V60I, K102L, K103R, D121Y, K122E, T139R, S162A, K173A, D177E, Q197K, T200A, Q207G, R211RK, V245Q, A272P, T286A, V292I, I293V, E297KR, V317A, G335D, R356K, G359T, E370EG, T377M, K390R, A400AT, E404D, V435A, L452IM, V466I, D471E, H483YC
 T099NPT99-PLEF186975AZT, 3TCNVPM184V, N348IK103KN, G190AT27S, V35T, E36A, T39D, S48T, V60I, K122E, I135L, S162A, E169EA, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377LR, K385R, K390R, A400T, E404D, E432D, V435A, A437VC
 T102NPT102-PLEF186981D4T, 3TCNVPM184V, N348IV108VI, Y181CV35T, T39E, S48T, K49KR, V60I, D121Y, K122E, D123E, I135R, E169Q, K173E, Q174R, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, G335D, R356K, G359T, T377MR, K390R, A400TC
 T095NPT95-PLEF186988AZT, D4T, 3TCNVPM41L, D67N, V75M, M184V, T215F, K219W, N348IV108I, Y181CT7A, V8I, L34I, V35T, T39D, E44D, V60I, V90I, I94L, D121H, K122E, T139TK, I142V, S162H, E169A, K173A, D177E, T200A, E203ED, Q207E, H208HY, R211K, V245Q, A272P, K277KR, E291D, V292I, I293V, E297A, G335GD, R356K, G359AC
Sigaloff (2011)GT00366729GT00366729_2JN381608D4T, 3TCEFVM184V, N348IK103N, K238TE28A, V35T, T39E, S48T, K122E, K173A, D177E, T200A, I202V, Q207K, R211K, L228R, P243T, V245Q, A272P, K275R, K277R, Q278S, T286A, E291D, V292I, I293V, E297KQ, E308K, L310C, E312K, V314G, Q334H, G335DC
Brehm (2012)04ZA04ZA.96JN601899D4T, 3TCEFVM184V, N348IK103NV35T, T39E, S48T, K122E, D123DG, I135T, S162SC, K173A, D177E, T200A, E203EK, Q207E, R211K, D250E, S251D, A272P, T286A, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, A360T, E370EG, T377Q, S379C, K390R, A400T, E404DN, V435L, K451R, L452V, V467I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554SC
 11ZA11ZA.144JN601915D4T, 3TCNVPM184V, N348IY181CV35T, T39K, S48T, K122E, I135IT, K166R, K173A, Q174K, D177E, T200A, I202V, E204D, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, S322T, I329L, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404DN, V435A, A437V, E449D, V466I, V467I, L469I, D471E, H483Q, L491P, S519N, Q524E, K530R, A534S, A554SC
 24ZA24ZA.48JN601944D4T, 3TCNVPM184V, N348IK103NV35T, E36A, T39D, S48T, K122E, D123G, I135T, E138A, S162A, K173T, T200A, Q207D, R211K, D250E, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, P294S, Q334H, G335D, R356K, G359T, K366R, T369A, T377L, K390R, E399G, A400T, E404D, N447I, L452I, V467I, T470S, D471E, T477A, H483Q, L491S, L517X, S519N, K527N, K530R, V531I, A534S, A554SC
 28ZA28ZA.84JN601954D4T, 3TCNVPM184V, N348IK103N, Y181CK20KR, V35T, E36A, T39DE, K122E, D123G, I135IV, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P313Q, Q334H, G335D, R356K, G359T, T377LR, K390R, A400T, E404DN, V435A, L452M, S468P, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554SC
 38ZA38ZA.24JN601976D4T, 3TCNVPM184V, N348IK103N, K238NV35T, E36A, T39E, S48T, K49KR, K122E, D123G, I135IM, S162A, K166I, D177E, T200A, Q207E, R211K, V245Q, A272P, K275R, K277R, Q278N, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, L452Q, V466S, V467I, S468C, T470N, D471E, H483Q, L491S, Q509H, S519N, K530R, A534S, A554SC
 50ZA50ZA.132JN602001D4T, 3TCEFVM184V, N348IK103N, V108IT27S, V35T, E36A, T39E, S48T, K122E, D123N, I135T, T139TK, S162C, K173A, D177E, T200A, Q207K, R211K, F214L, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V, D324DE, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, L452M, V466I, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554SC
Steegen (2014)12ZAKS19812ZAKS198KJ176478D4T, 3TCEFVM184I, N348IK103NT27S, I31L, V35T, E36A, T39E, S48T, K122E, D123G, E138A, S162C, K173A, Q174R, G196E, T200A, Q207E, R211K, D237N, V245Q, T286A, V292I, I293V, V317A, D324E, Q334N, G335D, R356K, G359T, T377I, K390R, A400T, E404N, K431TC
 12ZAKS29412ZAKS294KJ176573D4T, 3TCEFVM184V, N348IK103NI31L, V35T, T39E, A98S, K102HQ, K122E, D123N, S162C, D177E, I178L, T200A, E204K, Q207E, R211K, L228R, P243A, V245E, A272S, T286A, V292I, I293IV, Q334H, G335D, P345PQ, R356K, M357K, G359T, K366R, A376S, T377Q, T386I, K390R, A400T, E404D, E432DC
 11ZAKS12711ZAKS127KJ176409D4T, 3TCEFVD67N, K70R, M184V, K219Q, N348IK103N, K238T, Y318FV35T, T39E, T69N, K122E, D123S, E138Q, S162C, K173A, Q174K, N175Y, I178L, E194D, G196V, T200A, K201KI, E203K, Q207E, L228H, E233ED, Q242QE, V245Q, P247A, E248D, D250E, A272P, E291D, V292I, I293V, K311R, D324E, Q334H, G335DC
 12ZAKS35812ZAKS358KJ176637D4T, 3TCEFVM184V, T215F, N348IL100I, K103NK32KR, V35T, T39E, S48T, V60I, K122E, D123S, I135V, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324DE, Q334H, G335D, R356K, R358K, G359S, T377R, K390R, A400T, E404DC
 12ZAKS31212ZAKS312KJ176591D4T, 3TCEFVM184V, K219R, N348IK103N, V108IK20KR, K22KR, V35T, T39A, K102Q, K122E, D123S, K173Q, D177DE, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, V245Q, A272P, E291D, V292I, I293V, D324E, I329L, G335D, P345Q, R356K, M357MT, G359T, K366R, A376S, T377L, S379C, K390R, A400TC
 12ZAKS32412ZAKS324KJ176603D4T, 3TCEFVM184V, N348IK103N, V108IV35T, E36A, T39E, S48T, V60I, K64R, V90I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245K, A272P, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, E370EG, T377M, K390R, A400T, E404NC
 12ZAKS24912ZAKS249KJ176528D4T, 3TCEFVM184V, N348IK103N, K238TK32R, V35K, E36A, T39E, K43R, S48T, V60VI, K122E, D123G, K173T, D177E, T200E, Q207E, V245K, D250T, K277R, T286A, E291D, V292I, I293V, Q334Y, G335D, R356K, M357R, G359T, T377M, S379C, K390R, A400T, E404H, P421S, K431T, V435AC
 12ZAKS32112ZAKS321KJ176600D4T, 3TCEFVM184V, N348IK101P, K103NE28EAKT, V35T, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, R358K, G359S, T377Q, K390R, A400T, T403S, E404DC
 12ZAKS27712ZAKS277KJ176556D4T, 3TCEFVM184V, N348IV106M, Y188LP4PS, V35R, T39E, S48T, K122E, D123S, S162C, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, A272P, R284K, T286TA, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, E432DC
 11ZAKS10411ZAKS104KJ176386D4T, 3TC, AZTEFV, NVPA62V, M184V, N348IK103N, V108I, Y181CE6K, T7A, K20R, V35T, T39K, S48T, K122E, D123S, I135V, T139A, K173A, D177E, T200A, Q207E, R211K, L228R, V245E, E248T, D250E, A272S, K277R, K281R, E291D, V292I, I293V, V314VA, I329L, Q334H, G335D, R356K, G359T, T369V, Q373N, T377M, T386I, K390RC
 12ZAKS36512ZAKS365KJ176644D4T, 3TCNVPM41L, D67N, T69D, K70KR, V75M, M184V, T215F, K219W, N348IV108I, Y181CV8L, V21VI, V35IKLQ, E36EA, T39EK, K43Q, S48T, K49R, E53D, V60I, V90I, K101R, V118I, K122E, D123N, S162H, K173T, Q174K, D177E, T200A, E203D, Q207E, R211RK, K223Q, L228H, V245Q, R284RK, T286A, T290S, E291D, V292I, I293V, D324DE, Q334DN, G335D, R356K, M357R, G359S, A360T, T377R, K390KR, A400AITV, E404DC