<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y318F
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 31
Isolates 31
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Doualla-Bell (2006)Pt7FDB_Pt7EF434895D4T, DDINVPK65RK103KN, Y181C, G190GA, Y318FK22KN, V35T, T39K, S48E, T69N, D123DE, I135IM, K173IT, T200A, Q207E, R211K, V245Q, K277KR, K281KR, T286A, E291D, V292I, I293V, E312F, V314P, Y319CC
Waleria-Aleixo (2008)08PR05028708PR050287FJ591315NRTINNRTIM184VK103N, Y318FV35T, E36A, T39E, S48T, I135M, K173T, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294T, G335DC
 08PR06056008PR060560FJ591475NRTINNRTIM41L, M184V, T215FA98G, K103N, V108I, Y318FV35T, E36A, T39D, S48T, K122E, I135T, K173A, Q174K, V189I, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294T, K311R, G335DC
Hawkins (2009)R115ZZR115FJ931311D4T, 3TCNVPQ151M, M184VA98G, Y181C, Y318FV35T, T39E, S48T, S68G, K122E, D123N, K173A, D177EG, V179VI, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292I, I293V, S322AC
Green (2011)707PKE05F707PKE05FHM623497AZT, 3TCNVP, EFVD67N, K70R, M184V, K219QA98G, K103N, Y318FK20KR, V35T, T39E, S48T, V60I, T69TN, K122E, D123S, I135T, S162A, K173A, D177E, T200A, Q207E, R211K, D218E, V245K, A272P, L283I, R284K, V292I, I293V, D324EC
Sigaloff (2011)GT00011000GT00011000_2JN381564D4T, 3TCEFVD67N, M184V, K219QK103N, Y318FV35T, T39E, S48T, V60I, K122E, D123S, I135L, E138A, K173A, I178L, T200A, Q207T, R211K, V245Q, I257IL, A272P, T286A, E291D, I293V, L295I, E308D, I309~C
Sigaloff (2011)HIV101474HIV101474JN132265D4T, 3TCEFVA62V, M184VK103N, Y318FV35T, E36A, T39D, D123E, I135T, K166R, K173A, D177E, I178L, T200A, Q207E, R211RK, L228LHQ, V245Q, V276VI, K277R, L283LI, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS096CAS096 TDF, 3TCEFVK65R, M184VL100I, K103S, Y318FK20R, V35R, T39D, S48T, K122E, D123S, I135T, K173T, T200A, Q207E, F214L, V245K, A272P, T286A, E291D, V292IC
Theys (2013)BM42108BM42108 AZT, 3TCNVPM184VK103N, Y318FV35T, E36EA, T39E, S48T, K101KR, K122E, D123N, K173R, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, E297TC
Steegen (2014)11ZAKS14711ZAKS147KJ176429D4T, 3TCEFVD67N, K70R, V75M, F77L, F116FY, Q151M, M184V, K219QK103N, V106M, Y318FK20R, T27S, V35T, T39A, S48T, V60I, K122E, D123S, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, D218E, V245Q, T286A, E291D, V292I, I293VC
 12ZAKS21112ZAKS211KJ176491ABC, 3TCEFVA62V, D67N, T69D, Y115F, F116Y, Q151M, M184VK101E, G190S, Y318FE28K, K32E, V35T, E36A, T39D, K122E, D123S, E169Q, P170PH, R172K, K173A, D177G, T200A, Q207A, R211K, V245Q, E291D, V292I, I293V, S322A, Q334N, G335DC
 11ZAKS12711ZAKS127KJ176409D4T, 3TCEFVD67N, K70R, M184V, K219Q, N348IK103N, K238T, Y318FV35T, T39E, T69N, K122E, D123S, E138Q, S162C, K173A, Q174K, N175Y, I178L, E194D, G196V, T200A, K201KI, E203K, Q207E, L228H, E233ED, Q242QE, V245Q, P247A, E248D, D250E, A272P, E291D, V292I, I293V, K311R, D324E, Q334H, G335DC
 12ZAKS23412ZAKS234KJ176513D4T, 3TCEFVM184VA98AG, K103N, V108I, Y318FK20R, T27S, V35T, T39E, S48T, V60I, K102KQ, K122E, D123S, K173R, D177E, I178L, T200A, E204K, Q207E, R211K, F214L, V245L, D250E, A272P, T286A, E291D, V292I, I293V, P294PT, E297A, D324E, I329LC
Skhosana (2015)11ZALS08311ZALS083KM115747D4T, 3TCNVPD67N, K70R, M184V, K219QK103N, Y318FV35T, T39E, S48T, V60VI, K101Q, K102Q, K122E, D123DN, T139R, S162CY, K173A, Q174KNRS, D177E, I178L, G196E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K281KR, E291D, V292I, I293V, Q334N, G335DC
 12ZALS11612ZALS116KM115725TDF, 3TCEFVM41L, L74V, M184V, T215FK103N, M230L, L234I, Y318FK22R, E28T, K32E, V35K, E36A, T39E, S48T, K122E, D123S, K173A, Q174K, D177E, I178IM, G196E, T200A, Q207A, R211RK, H221Y, V245T, E248D, A272P, I274V, Q278H, T286A, E291D, V292I, I293V, V317VA, G333D, Q334LC
 11ZALS05111ZALS051KM115853D4T, 3TCNVPM184VK103N, Y318FV35T, T39Q, S48T, K49KR, V60I, K122E, D123S, T165L, E169A, K173A, Q174K, D177E, I178L, G196E, T200A, Q207N, R211K, F214L, D250E, A272P, T286TA, E291D, V292I, I293V, Q334D, G335DC
Lam (2016)1601104216011042KR868061D4T, 3TCNVPM184VK103N, Y318FE28K, K32E, V35T, E36A, T39E, S48T, V60I, D121Y, K122E, I135T, S162A, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, D237N, V245Q, A272P, K277R, E291D, V292I, I293V, E308EQ, Q332QP, G335DC
 1601101816011018KR868124TDF, 3TCEFVK70E, M184VK103N, V108VI, P225PH, M230ML, Y318FK20R, V35T, T39A, S48T, V60I, D121Y, K122E, I135T, S162H, K173E, G196K, T200A, Q207A, R211K, I244IL, V245Q, A272P, V276I, T286A, E291D, V292I, I293V, E297A, L310I, S322AC
 1601203616012036KR868126AZT, 3TCNVPM41L, D67DN, M184V, T215FA98AG, K103N, Y318FE28A, V35T, T39D, E53D, V90I, D121H, K122E, I135T, S162H, K173A, Q174K, D177E, Q197K, T200A, Q207E, R211K, L228V, V245Q, A272P, K277R, T286A, V292I, I293V, E297A, D324E, I329V, Q334E, G335DC
Steegen (2016)GFKZB415GFKZB415KU128358TDF, FTCEFVK65R, M184VL100I, K103N, Y318FM16L, V35T, T39E, S48T, S68SG, V118I, K122E, D123S, I135T, E138Q, K173A, Q174K, D177G, Q197K, T200A, Q207N, R211K, F214L, V245Q, E248T, I257L, A272P, E291D, I293V, Q334H, G335EC
 GFKZB100GFKZB100KU127972AZT, 3TCNVPD67N, K70R, M184V, K219QA98AG, K103N, Y318FV35T, T39E, S48T, V60VI, K122E, I135T, K173T, T200A, Q207E, R211K, D218E, K238KQ, V245Q, D250E, S251DH, A272P, E291D, V292I, I293V, Q334P, G335D, R356K, M357R, G359T, K366R, A371V, I375V, A376T, T377M, T386A, K390R, A400T, E404DC
 GFMPB015GFMPB015KU127885TDF, 3TCEFVK65R, L74I, Y115F, M184VK103N, V106M, Y318FK20R, V35T, E36A, T39E, S48T, S68G, K102R, K122E, K173S, Q174N, D177E, T200A, I202IV, R211K, F214L, V245Q, A272P, L279I, T286A, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, M357K, R358RK, G359S, K366KR, T377L, K390R, A400T, E404D, V435VAC
 GFKZB095GFKZB095KU127967TDF, 3TCNVPA62V, K65R, M184VA98G, K101E, Y181C, G190A, Y318FK20R, V21I, V35T, E36A, T39E, K46Q, S68N, K122E, D123N, I135T, K173T, Q174K, V179VI, T200A, Q207A, R211RK, L228LQ, V245N, A272S, Q278N, T286TA, E291D, V292I, I293V, S322SA, Q334D, G335N, R356K, G359SC
 GFECB009GFECB009KU127696D4T, 3TCEFVD67G, K70R, M184V, K219EK103N, Y318FK11Q, T27S, E28K, K32E, V35T, T39E, V60I, S68G, K101Q, D121H, K122E, I135T, S162C, K173A, Q174K, D177E, I178L, T200A, I202IV, Q207A, R211K, V245Q, I257IV, A272P, L283LI, T286V, E291D, V292I, I293V, P294T, Q334N, G335D, R356RK, R358K, G359S, T369A, A371V, I375V, A376T, T377Y, T386A, K390RC
 GFKZB099GFKZB099KU127974D4T, 3TC, TDF, FTCNVP, EFVM41L, L74LI, M184V, T215YA98G, K103N, V108VI, Y318FV35IMT, E36EQ, T39DE, S48T, V60I, V118VI, K122E, D123S, E138Q, K173A, Q174QK, N175NY, D177E, T200AE, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334D, G335D, R356K, M357R, G359AT, T369V, T377M, K388KR, K390R, A400T, E404DC
 GFGPB064GFGPB064KU127680D4T, 3TC, TDFNVPK65R, M184V, K219KQK101E, G190A, Y318FK20R, V35T, T39E, S48T, S68SDGN, T69TI, K122E, D123E, E138A, K173T, Q174K, V179I, T200A, Q207E, F214L, V245K, D250DE, S251SI, A272P, K275R, Q278H, K281R, E291D, V292I, I293V, E297EK, Q334H, G335D, R356K, R358K, G359S, A371V, I375V, A376S, T377I, S379C, K390R, A400T, E404DC
 GFGPB119GFGPB119KU127889TDF, 3TCEFVM41L, K65R, L74I, M184VA98G, V106M, G190A, Y318FK20R, V35T, T39E, V60I, S68N, K122E, I135L, T139A, K173A, T200A, Q207E, R211K, F214L, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, E297K, A304E, I329V, Q334D, G335D, R356K, M357R, G359TC
 GFKZB373GFKZB373KU128282TDF, 3TC, FTCNVP, EFVK65R, M184VA98G, V179D, Y181C, G190A, Y318FK20KR, V35T, T39D, S48T, E53D, V60VI, S68SN, K103R, K122E, D123S, K173A, Q174K, T200A, E203Q, Q207E, K223Q, I244V, V245K, D250E, A272P, K275Q, V276T, Q278H, T286A, V292I, I293V, D324E, G335D, R356K, M357R, G359T, K366R, T369A, T377Q, K390R, A400V, E404DC
Steegen (2016)ZA14GFKZC101ZA14GFKZC101KU253113NRTINNRTIM184VK103N, Y318FP4S, V35T, T39E, S48T, K122E, D123S, T139K, S162A, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, F214L, V245Q, A272P, E291D, V292I, I293V, Q334N, G335D, R356K, M357Q, G359T, A371V, T377L, I382V, T386I, K390R, A400I, E404DC
 ZA14GFKZC156ZA14GFKZC156KU253152NRTINNRTIM184VK103N, Y318FE28A, V35T, T39E, S48T, V60I, K122E, D123S, I135T, I142V, T165L, K173A, Q174K, G196E, T200A, Q207D, R211K, F214L, V245Q, E248D, I257L, A272P, K281R, E291D, V292I, I293V, Q334D, E344D, R356K, G359T, K366R, A371V, T377L, K390RC
 ZA14GFKZC165ZA14GFKZC165KU253173NRTINNRTI K103N, Y318FK22KR, V35T, T39E, S48T, V60I, K122E, D123S, E138Q, I142V, T200A, Q207E, R211K, D237DE, V245Q, A272P, R284K, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357R, R358K, G359S, T369TA, T377M, K390R, A400IC