<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K238T
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 42
Isolates 48
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK3035TK3035 AZT, 3TC, D4T, DDI, ABCNVP, EFVM41L, D67N, K70R, L74I, L210W, T215Y, K219EK101E, G190A, K238TV35T, E36A, T39E, V60I, K122E, D123S, I135T, E138A, R172RK, K173T, Q174K, T200A, E203K, Q207E, R211K, D218DE, V245Q, E248D, A272P, K275R, Q278H, E291D, V292I, I293V, G316E, V317VG, Y319XC
 TK5010TK5010 AZT, 3TCNVPK70R, M184V, K219QK103N, K238TK30KI, V35T, E36A, T39E, E40D, K43R, T69N, A98S, K102R, K122E, D123S, I135T, A158S, K173AT, D177E, E194D, T200A, Q207N, F214L, L228R, V245Q, K249Q, A272P, T286TA, E291D, V292I, I293VC
Weber (2005)M60223M60223AY677540D4T, 3TCNVPM184VK103N, K238TV35T, E36A, T39D, K122E, D123S, T139R, S162C, K173A, Q174R, D177E, T200A, Q207E, R211RK, V245Q, D250E, S251H, A272P, K277R, T286A, E291D, V292IC
Martinson (2007)CHB374MCHB374MEU152431NoneNVP K238TV35T, E36A, T39E, S48T, K122E, D123G, S162C, K173A, Q174K, D177E, T200A, E203G, Q207E, R211K, V245Q, D250E, K277R, T286A, E291D, V292I, I293V, I326V, Q334EC
Marconi (2008)ICH17ICH17EU308008D4T, 3TCEFVM41L, D67G, K70R, M184I, T215F, K219EA98G, K103N, Y181C, G190A, K238TT69N, R83RK, D121Y, K122E, D123G, Y144YF, P157PS, S162C, K173A, D177E, T200A, E203EK, Q207E, R211K, K223E, L228H, Q242X, V245QC
 SW039sw039EU308052AZT, 3TC, DDIEFV V106M, V179D, K238TE40D, S48T, V60I, D121H, K122E, E138A, I142ST, K173A, Q174K, D177E, T200A, Q207E, F214L, V245QC
 SW044sw044EU308057DDI, D4T, 3TCEFVM41L, D67N, M184V, T215YK103N, V108I, K238TS48T, V60I, K122E, D123G, I135V, K173A, Q174K, D177E, V189I, T200A, Q207E, R211K, V245QC
Deshpande (2009)Pat23930artFJ530702AZT, 3TCNVPM41L, D67DN, K70KR, M184V, T215YK103N, K238TV21VG, L34LF, V35T, T39E, S48T, V60VI, K122E, D123S, I135L, E138A, S162C, K173A, T200A, Q207E, R211RK, V245QC
 Pat2223RTFJ530719AZT, 3TCNVPM41L, D67N, M184V, L210W, T215Y, K219NA98G, Y181C, K238TL12F, K13KE, V35T, T39D, E44D, V60I, K122E, D123S, T139R, K166R, K173T, D177E, T200A, I202V, Q207E, R211K, V245Q, E248DC
 Pat114231RTFJ530827D4T, 3TCEFVD67N, L74V, M184MV, K219RK103N, P225H, L234I, K238TK20R, V35T, T39D, S48T, N54NI, D121Y, K122E, K173A, Q174K, D177E, I178L, E194AP, T200A, Q207E, R211K, V245QC
 Pat050343aRTFJ530891D4T, 3TCEFVM41L, D67N, K70R, L74I, M184V, T215FY, K219WK103S, G190A, K238TV35T, T39E, V60I, I94IL, D121Y, K122E, I135T, K173E, Q174R, D177E, T200A, Q207E, H208Y, R211K, L228H, V245QC
 Pat048347aRTFJ530893AZT, 3TCNVPM41L, D67N, K70R, L74I, M184V, T215F, K219WK103S, G190A, K238TI5N, V35T, T39E, V60I, I94L, D121Y, K122E, I135T, K173E, Q174R, D177E, T200A, Q207E, H208Y, R211K, L228H, V245QC
 Pat029366RTFJ530912D4T, 3TCNVPD67N, T69D, K70R, M184V, T215I, K219EK103N, K238TV35T, T39D, V60I, D121Y, K122E, I135T, S162A, K173T, D177E, I178L, T200A, Q207T, R211RK, V245QC
Hoffmann (2009)pat060MD06596 AZT, 3TCEFVM184VK103N, K238TV35T, T39E, S48T, V60I, A98S, D121H, K122E, I135T, K173T, Q174K, D177E, T200A, Q207E, L228LR, V245Q, A272PC
  MD40394 AZT, 3TCEFVM184VK103N, K238TV35T, T39E, S48T, V60I, A98S, V111VA, D121HY, K122E, I135T, K173T, Q174K, D177E, T200A, Q207E, L228LR, V245Q, A272PC
Hosseinipour (2009)72417241GQ228299D4T, 3TCNVPM41L, D67DN, T69D, L74LV, M184V, L210W, T215Y, K219RK103N, K238TT39E, E44ED, V60I, V118I, K122E, D123N, I135LM, E138A, E169EA, F171Y, K173A, I195IT, T200A, I202V, Q207D, R211K, L228H, P243T, V245QC
Wallis (2009)GT00366729GT00366729 D4T, 3TCEFVM184VK103N, K238TE28A, V35T, T39E, S48T, K122KE, K173A, D177E, T200A, I202V, Q207K, R211K, L228R, P243T, V245Q, A272P, K275R, K277R, Q278S, T286A, E291D, V292I, I293V, E297EKC
Deshpande (2010)38IND43938IND439GU108165AZT, 3TCNVPM41L, D67N, V75M, M184V, L210L*W, T215YK103N, K238TV35T, T39N, V60I, V90I, I94L, D121Y, K122E, I135T, S162A, K173T, D177E, T200A, Q207E, F214FL, V245Q, D256EC
 39IND4439IND44GU108166D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215YK103N, K238TL34LS, V35T, T39N, V60I, V90I, I94L, D121Y, K122E, I135T, S162A, K173T, D177E, T200A, Q207E, W239WC, V245QC
 68IND45168IND451GU108177AZT, 3TCNVPM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K103N, K238TV35T, T39D, S48ST, V60I, K122E, D123N, I135L, E138A, I142V, S162SN, L168LV, Q174K, N175Y, T200E, Q207A, R211K, L228LH, V245QC
El-Khatib (2010)Pat01310ZA_SAVE1174HQ012291AZT, 3TCEFVM184VK103N, V108I, K238TK20R, V35T, E36A, T39D, S48T, K122E, D123G, I135T, S162A, K173T, Q174K, T200A, Q207E, H221Y, E224D, V245K, D250E, I257ILC
 Pat04310ZA_SAVE2200HQ012321D4T, 3TCEFVM184VK103N, V108VI, K238TV35T, E36A, T39E, S48T, V60I, K101KQ, K122E, D123G, I135IT, K173A, T200A, Q207E, R211K, V245KC
Green (2011)707PKE41F707PKE41FHM623528D4T, DDIEFVM41L, D67N, L210W, T215YA98G, G190S, K238TE6K, K20R, V35T, T39DE, V60I, V118I, K122E, D123G, K173A, D177E, V179I, T200A, Q207E, R211RK, V245K, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, D324E, I329LC
Sigaloff (2011)GT00366729GT00366729_1JN381607D4T, 3TCEFVM184VK103N, K238TE28A, V35T, T39E, S48T, K122KE, K173A, D177E, T200A, I202V, Q207K, R211K, L228R, P243T, V245Q, A272P, K275R, K277R, Q278S, T286A, E291D, V292I, I293V, E297EKC
  GT00366729_2JN381608D4T, 3TCEFVM184V, N348IK103N, K238TE28A, V35T, T39E, S48T, K122E, K173A, D177E, T200A, I202V, Q207K, R211K, L228R, P243T, V245Q, A272P, K275R, K277R, Q278S, T286A, E291D, V292I, I293V, E297KQ, E308K, L310C, E312K, V314G, Q334H, G335DC
van Zyl (2011)A118A118JN638076D4T, 3TCEFVM184VK103N, K238TV8I, V35T, T39E, S48T, K122E, D123S, I135KR, K166R, K173A, Q174R, D177E, T200A, Q207D, R211K, V245Q, E248T, D250EC
 A362A362JN638207D4T, 3TCEFVD67N, M184VK103N, K238TV35T, E36A, T39E, S48T, K122E, D123G, I135T, S162C, K173A, Q174K, Q207E, R211K, V245E, E248DC
Van Zyl (2013)4701286KC423029D4T, 3TCEFVM184VK103N, K238TV35T, E36V, T39E, S48T, K82R, A98S, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, V245QC
 10771228KC422978D4T, 3TCEFVM184VK103S, G190A, K238TK20KR, V35T, T39E, S48T, K49R, V60I, K122E, D123S, S162D, T165L, E169K, K173A, D177E, T200A, Q207E, P243A, V245QC
 266226KC423687AZT, D4T, 3TC, DDINVP, EFVD67DN, V75M, M184V, K219KQK103N, P225H, K238TV35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245QC
  235KC423690AZT, D4T, 3TC, DDINVP, EFVD67N, V75VM, M184V, K219QK103N, P225H, K238TV35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245QC
 13421243KC422993D4T, 3TCEFVM184VK103N, P225H, K238TP4S, V35T, E36A, T39E, S48T, V90I, K122E, A158S, S162A, K173T, Q174R, D177E, T200A, Q207E, R211K, V245QC
 14071550KC423222AZT, D4T, 3TC, TDFNVP, EFVM41L, D67N, M184V, L210W, T215YK103N, V179E, K238TE6K, K20R, V35T, T39E, E44D, S48T, V60I, V118I, K122E, D123N, I135T, E138A, K173T, Q174K, D177N, I178L, T200A, E203K, Q207E, H208Y, R211K, K223E, P243Q, V245Q, E248D, D250EC
 16711358KC423089AZT, D4T, 3TC, DDINVP, EFV K103N, K238TV35T, T39E, V60I, D121H, K122E, K173A, Q174K, D177E, I178IL, T200A, Q207E, R211K, V245KC
 4111885KC423485D4T, 3TCEFVM184VK103N, P225H, K238TV35T, T39K, S48T, V60VI, K122E, D123S, K173A, Q174K, D177E, G196M, T200A, Q207E, R211K, V245KC
 1560792KC424281AZT, 3TCEFVD67N, K70R, M184V, T215Y, K219QK103N, P225H, K238TK32R, V35T, T39E, E40D, S48T, V60I, K122E, I135M, S163T, K173A, Q174K, D177E, T200E, Q207E, R211K, V245MC
 6682113KC423626ABC, 3TCEFVK65R, M184VK103N, P225H, K238TV35T, T39E, S48T, V60I, K101R, K122E, D123N, L168LS, K173T, Q174K, T200A, Q207E, V245QC
 7503077KC423960TDF, 3TCEFVA62V, K70E, V75S, Q151M, M184V, K219RK103N, V108I, P225H, K238TK20R, K22R, V35T, E36A, T39E, S68SG, K122E, D123N, I135R, K173E, D177EG, I178IM, T200A, Q207A, F214L, L228I, V241VM, V245QC
 15621774KC423396AZT, D4T, 3TC, DDI, ABCNVP, EFVM41L, D67N, L74V, M184V, T215YA98G, K103N, K238TK20R, V35T, T39E, E44Y, S117A, K122E, D123S, I135L, E138A, S162CY, K173A, Q174K, Q207E, H208Y, R211K, W212R, V245K, D250EC
 6791533KC423209D4T, 3TCEFVM184VK103N, P225H, K238TK20R, V35T, T39E, K43KR, S48T, V60I, K101Q, K122E, D123S, E138A, S162T, K166R, K173T, I178L, T200A, Q207D, R211K, V245KC
 17823072KC423955D4T, 3TCEFVM184V, T215Y, K219RK103N, P225H, K238TK20R, V35T, T39D, S48T, D76DN, K122E, D123S, E138A, S162A, K173A, Q174R, T200A, Q207D, V245Q, D250EC
 4271882KC423482D4T, 3TCEFVD67N, K70R, M184V, T215TI, K219EK103N, P225H, K238TV35T, E36A, T39E, V60I, T69N, A98S, D121H, K122E, D123S, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, P243T, V245QC
 16881797KC423415D4T, 3TCEFVM184VK103N, V108I, P225H, K238TP25PT, E29K, V35T, E36A, T39E, G45E, K122A, D123E, I135V, S162C, K173T, Q174K, G196GR, T200A, Q207E, R211K, V245Q, E248NC
 15951889KC423489AZT, D4T, 3TC, ABCNVP, EFVM184V, T215FA98G, K238TK20R, V35T, T39E, S48T, K49R, S68SG, K122E, D123G, A158S, S162A, T165L, K173A, Q174QK, D177E, I178M, T200A, Q207E, V245QC
 6441536KC423211AZT, D4T, 3TC, TDFNVP, EFV K103N, K238TE28R, V35T, T39N, S48T, K101A, K122E, D123G, Q145I, K173A, Q174K, D177E, I178L, V179A, V189I, G196S, T200A, I202V, Q207D, V245Q, D250EC
  1168KC422931AZT, D4T, 3TC, TDFNVP, EFV K103KN, K238TE28K, K32KE, V35T, T39N, S48T, K101A, K122E, D123G, Q145I, K173A, Q174K, D177E, I178L, V179A, V189I, G196S, T200A, I202V, Q207D, V245Q, D250EC
  1729KC423359AZT, D4T, 3TC, TDFNVP, EFV Y188YFHL, K238TE28K, K32E, V35T, T39N, S48T, K101A, K122E, D123G, Q145I, K173A, Q174K, D177EG, I178L, V179VA, V189I, G196S, T200A, I202V, Q207D, F214FL, V245Q, D250EC
 11192048KC423584D4T, 3TCEFVM184VK103N, K238TP4S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173A, T200A, Q207E, R211K, V245KC