<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K238R
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 28
Isolates 29
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Johnston (2003)TC-57TC-57 3TC, D4TNVP  V35T, E36A, T39E, S48T, K122E, S163T, T165I, K173T, Q174QK, D177E, T200A, I202V, Q207E, R211K, K238R, V245QC
Eshleman (2005)ESH3124ESH3124AY756846NoneNVP K103KN, V106VMV35T, E36A, T39E, S48T, K122E, D123N, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, K238R, V245Q, D250E, A272P, K277T, Q278R, E291DC
Seoighe (2007)PL12006_PL120V2EF382066NoneNVP  K20R, E28ED, V35T, E36A, T39E, S48T, K122E, D123G, A129AG, P150PS, K173T, D177E, I178M, T200A, Q207N, R211K, K238R, V245H, D250E, A272Q, T286A, E291D, V292I, I293VC
 PL16306_PL163V2EF382100NoneNVP  E6A, I31R, V35I, E36A, T39E, K122E, A158S, K173A, D177E, G196GR, T200A, Q207A, R211K, K238R, V245Q, A272P, K277R, E291D, I293V, E297KC
Hosseinipour (2009)93149314GQ228320D4T, 3TCNVPM41L, M184V, T215YK103NT39E, S48T, V60I, K122V, D123N, I135M, I178M, T200A, K238R, V245MC
 93009300GQ228345D4T, 3TCNVPM184V, T215YY181C, G190AT39E, S48T, K49KR, K122E, D123S, A158S, K173T, V179VI, G196K, T200A, Q207E, R211K, K238R, V245QC
Rey (2009)88w4 TDF, 3TCNVP V179DT39E, S48T, K122E, D123S, K173T, Q174K, T200A, Q207E, F214L, K238R, V245QC
  8w12 TDF, 3TCNVPK65RV179D, G190AT39E, S48T, K122E, D123G, K173T, Q174K, T200A, Q207E, F214L, L228Q, K238R, V245QC
El-Khatib (2010)Pat07410ZA_SAVE2481HQ012352ABC, 3TCEFVM184VY188LV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173T, D177E, I178IM, T200A, Q207E, R211K, K238R, T240K, V245T, S251NC
 Pat11111ZA_SAVE2266JF960561NRTI, AZT, DDINNRTI V106M, V179DP4S, V35T, E36A, T39E, E40D, S48T, K103R, K122E, D123S, I159V, E169D, K173A, Q174K, D177E, G196M, T200A, I202V, Q207E, F214L, K238R, V245Q, E248D, A272P, K275RC
van Zyl (2011)A250A250JN638146D4T, 3TCNVPM184VK103N, Y181YCV35T, T39E, S48T, V60I, K173A, Q174K, D177E, I178L, Q207A, R211K, K238R, V245QC
 A340A340JN638200D4T, 3TCEFVM184VV179D, Y188LV35T, T39E, S48T, K122E, D123N, I135T, K173A, Q174E, D177E, T200A, Q207E, K238R, V245QC
Brehm (2012)25ZA25ZA.48JN601947D4T, 3TCEFV V106ME28A, V35T, E36EA, T39E, S48T, K122E, D123G, I135T, S162C, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, K238R, V245Q, D250E, A272AP, K277R, T286A, E291D, V292I, I293V, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, E432D, L452K, V466I, S468P, D471E, T477A, H483L, G490E, L491V, E492K, S519N, K527N, K530R, V531I, L533M, A534S, A554N, K558RC
Manasa (2013)RES081RES081KC951691D4T, 3TC, TDFNVPM41L, D67N, K70Q, V75M, M184V, T215FV106A, F227LK20R, V35T, E36A, T39E, S48T, V60I, K102Q, K122E, I135T, K166R, K173A, D177E, I178L, T200A, Q207E, R211K, D218E, K238R, V245E, A272P, K277R, T286A, E291D, V292I, I293VC
Van Zyl (2013)858428KC424055D4T, 3TCNVPM184VK101KPQT, K103N, P225HE6EK, K20R, E28K, K32E, V35T, E36A, T39EK, S48T, K122E, S162C, K173T, D177E, T200A, Q207E, R211K, L228LH, K238R, V245QC
 372212KC423632AZT, 3TCEFVM184VY188LV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173T, D177E, I178M, T200A, Q207E, R211K, K238R, T240K, V245TC
 3941409KC423131D4T, 3TCEFVM184VK101H, G190ST27S, V35R, T39E, S48T, K122E, D123G, S162C, K173I, Q174K, T200A, Q207E, R211K, K238R, V245QC
 6691752KC423377TDF, 3TCEFV K103KN, V108VI, Y188YFHLK32N, V35K, E36A, T39E, S48T, K122E, D123S, K173A, Q174K, D177E, T200A, Q207DE, R211K, K238R, V245Q, E248TC
 13961406KC423128D4T, 3TCEFVM184VK103N, Y188LE28K, V35T, E36A, T39E, S48T, K104R, K122E, I135V, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, K238R, V245QC
 450809KC424287AZT, D4T, 3TCNVP, EFVM184VV106M, Y188LV8I, M16V, E28K, V35T, T39K, S48T, K102E, K122E, D123S, R143K, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, K238R, V245QC
 18202449KC423716TDF, 3TCEFVM41L, K65R, V75I, F116Y, Q151M, M184V, T215YV108VI, G190A, F227LV35T, T39E, V60I, S68G, K103KR, K122E, D123S, I132L, K173A, Q174K, N175Y, D177E, T200E, Q207E, R211RK, F214L, H221Y, K238R, V245QC
 4281573KC423242TDF, 3TCEFV  V35T, E36EA, T39E, S48T, V60I, K122E, D123DGNS, S162C, K173A, Q174H, D177E, I178L, G196E, T200A, Q207D, R211K, K238R, V245TC
 137652KC424203D4T, 3TCEFVM41L, M184V, T215YA98G, Y188LL34I, V35T, E36A, T39E, V106I, K122E, D123S, I135V, S162Y, K173A, D177Q, V179VI, T200A, Q207D, R211K, D237DE, K238R, V245Q, E248TC
 13161272KC423021D4T, 3TCEFVM184VV106M, Y188LE6EK, V35T, E36A, T39E, S48T, E53D, K122E, K173A, Q174K, D177E, I178L, V179VI, T200A, Q207E, R211K, F214L, K238R, V245QC
Steegen (2014)12ZAKS20712ZAKS207KJ176487D4T, 3TCEFVM184VK103N, V108IK20R, V35T, T39E, K122E, K173A, Q174K, D177E, T200A, Q207E, K238R, V245Q, A272P, K277T, T286A, E291D, V292I, I329L, Q334D, G335DC
 12ZAKS29712ZAKS297KJ176576D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, V60I, K122E, I132V, K173A, Q174K, D177E, T200A, Q207E, H221Y, K238R, V245E, A272S, T286A, E291D, V292I, E297K, K311R, V314A, D324E, Q334D, G335D, R356K, M357R, G359T, A371V, T377L, K390R, A400I, E404DC
 12ZAKS30812ZAKS308KJ176587D4T, 3TCEFVM184VA98G, K103N, Y188LK20R, V35T, E36A, T39E, S48T, V60I, S105T, K122E, D123GS, I135L, E138A, S162A, K173T, T200A, Q207E, R211K, K238R, D250E, A272S, E291D, V292I, I293V, P294PL, P313Q, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E413DC
Seu (2015)ZM.HIVDRM.64ZM.HIVDRM.64KP995674AZT, 3TCNVPD67N, K70R, M184V, K219QA98G, K101E, G190A, P225HE28K, K32E, V35T, E36A, T39E, E40D, V60I, K103R, K122E, D123S, I135T, K173A, T200A, Q207E, R211K, F214L, K238RC
Skhosana (2015)11ZALS03211ZALS032KM115730D4T, 3TCEFVD67N, K70R, M184V, K219QK101E, V106M, G190AE28K, V35T, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200EK, I202V, Q207V, R211K, F214FL, K238R, V245Q, A272P, K277R, T286A, E291D, Q334D, G335D, K350KR, R356K, M357MK, G359T, T377R, T386TI, K390R, E399D, A400M, E404D, V435AC