<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation M230L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 45
Isolates 46
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1147UK1147AY901330AZT, 3TC, DDI, D4T, ABCDLVM41L, L74V, M184V, T215YM230LV35T, E36A, T39D, V60I, V90I, K173T, Q174K, I178L, E203D, Q207EC
 UK1995UK1995AY901376AZT, 3TCEFVM184VK103N, M230LV35T, T39E, T69N, K122E, D123S, K173A, N175H, D177E, I178V, T200E, K201T, E204K, Q207EC
 SA83_DR28SA83_DR28AY901716AZT, 3TCEFVM184V, T215YA98G, K103N, M230LV35T, T39E, S48T, K122E, I159V, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, I293V, P294QC
Novitsky (2007)16241624_7985EF026217AZT, DDINNRTIL74V, T215YV106M, Y188H, M230LV35T, E36A, T39E, K122E, D123S, I142T, K173A, D177E, I178M, V179VI, T200A, E204K, Q207D, R211K, P243T, V245Q, A272P, K275R, Q278Y, E291D, V292I, I293VC
Marconi (2008)ICH30ICH030EU308020D4T, 3TCEFVM184VV106M, V179D, M230LS48T, V60I, V118I, K122E, D123N, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 SW008sw008EU308026D4T, DDI, AZT, 3TCEFVM184V, T215YV106M, M230LS48T, E79EG, K103R, K122E, T139M, S162C, K173A, D177E, T200A, I202V, Q207E, R211K, V245QC
 SW081SW081EU308091D4T, DDI, AZT, 3TCEFV, NVPM41L, D67N, T69D, K70R, M184V, T215F, K219QK103N, V106M, Y188F, M230LK122E, D123N, I142V, M164L, K173A, Q174K, D177E, Q197T, T200A, Q207E, R211K, F214L, L228H, V245QC
Pillay (2008)DR41DR41AY589896D4T, DDI, AZT, 3TCNVPM41L, L74V, M184V, L210W, T215Y, K219KNA98G, Y181C, M230LT39D, E44D, S48T, K122E, D123S, S162C, I167V, K173A, D177DE, T200A, Q207E, L228H, Q242H, V245Q, P247A, K249Q, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, Q334XC
 DR52DR52AY5899053TC, D4TEFVM184VV106M, F227FL, M230LE6K, K32KR, V35T, T39R, S48T, K122E, K173A, D177G, T200A, Q207E, R211K, P225S, V245Q, E248D, D250E, S251N, A272P, E291ED, V292I, I293V, S322AC
 DR2802ZA.DR28AY589885D4T, DDI, AZT, 3TCEFVM184V, T215YA98G, K103N, M230LV35T, T39E, S48T, K122E, I159V, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, I293V, P294QC
Deshpande (2009)Pat19936RTFJ530742AZT, 3TCNVPK70KR, M184V, T215F, K219KQA98AG, K103N, V108VI, M230LV35T, T39N, V60I, T69TN, V118C, D121Y, K122E, K173A, Q174K, D177E, T200A, Q207E, R211RK, L228H, V245QC
 Pat17882RTFJ530763D4T, 3TC, AZTNVPM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44D, S48T, V60I, K102Q, V118I, D121Y, K122E, S162SDGN, K166R, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HR, V245QC
 Pat152162RTFJ530789NRTINNRTIM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44G, G45W, S48ST, V60I, K102Q, V118I, D121Y, K122E, S162DN, K166R, E169A, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HRC
 Pat127206RTFJ530814NRTINNRTIM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44D, V60I, K102Q, V118I, D121Y, K122E, S162D, K166R, E169A, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HRC
Hawkins (2009)R347ZZR347FJ931374AZT, 3TCNVPM184V, T215FK101H, G190A, M230LT7A, V35T, T39E, S48T, V60I, D121H, K122E, I135R, S162C, K173T, Q174KR, D177E, V179VI, T200A, Q207E, R211K, V245Q, A272P, K275Q, K277KR, L283I, E291D, V292I, I293V, Q334NC
Hosseinipour (2009)94549454GQ228369D4T, 3TCNVPM184V, T215FV106M, V179D, M230LT39E, S48T, K103R, L109I, K122E, D123N, K173A, Q174R, T200A, I202IV, Q207R, R211EC
Kassaye (2009)TCDD-08TC08_2004FJ445726D4T, 3TCEFVM184V, T215FV179D, M230LV8I, K20R, V35K, T39E, S48T, V60I, K103R, K173T, D177E, T200A, Q207EC
Orrell (2009)GT269GT2692005 D4T, 3TCEFVM184V, K219QK103N, M230LT39E, E40D, S48T, V60I, K122E, D123N, K173T, T200A, Q207K, V245QC
 MD100816MD1008162005 D4T, 3TCEFVM184VK103N, P225H, M230LT39E, S48T, V60I, S68G, T69K, K122E, D123N, K173A, D177E, I178L, T200A, Q207D, R211K, V245QC
Wallis (2009)GT00496439GT00496439 AZT, 3TCEFVM184V, T215YK103N, V108I, M230LV8I, K20R, V35T, T39K, S48T, V60I, K122E, K166R, K173I, Q174K, D177E, T200A, Q207E, R211K, L228R, V245E, A272P, K277R, T286A, E291D, V292I, E297QC
 23674142367414 AZT, 3TCEFVM41L, D67N, T69D, L74V, M184V, L210W, T215YK103N, V179E, M230LS3C, V35T, T39E, E44D, S48T, E53D, V60I, V90I, K102KQ, V111VIM, P119PL, K122E, D123S, E138R, A158S, S162A, R172K, I178L, T200A, E203K, Q207D, R211K, V245C, A272P, Q278H, T286A, E291D, V292I, I293V, D324EC
 TJC2394973TJC2394973 D4T, 3TCEFVM184VV106M, V179D, M230LE6K, K11N, K32R, V35T, T39E, S48T, W88S, K103R, K122E, D123N, E138A, K173T, Q174K, T200A, I202V, E204Q, Q207E, R211K, F214L, V245Q, E248D, D250A, A272P, K275R, Q278H, K281R, T286A, A288T, E291D, V292I, I293V, I329L, Q334EC
 TJC2377938TJC2377938 D4T, 3TCEFVM184V, T215YK103N, V106M, M230LE6K, V35T, T39E, S48T, K102N, K122E, S162C, K173AT, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, V317A, S322AC
 TJC2382138TJC2382138 D4T, 3TCEFVL74V, M184V, T215FV106M, V179D, M230LP4S, V35T, E36A, T39E, S48T, K104R, K122E, D123N, S162C, K173A, Q174K, D177G, T200A, Q207E, R211K, V245Q, E248D, A272P, Q278H, E291D, V292I, I293V, I329VC
 GT00131322GT00131322 D4T, 3TCEFVM41L, A62V, V75T, M184V, T215FK103N, M230LK20KR, V35T, T39E, S48T, S68SG, K101KR, K102Q, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, H221L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, I309V, L310F, I329LC
 GT00256420GT00256420 AZT, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
 GT00238555GT00238555 D4T, 3TCEFVM184V, T215YK103N, V108VI, M230LP4S, V35R, T39E, S48T, K122E, D123S, S162C, K173A, Q174K, T200A, Q207E, L228LH, V245Q, K277KR, T286A, E291D, V292I, I293VC
 TJC2473907TJC2473907 D4T, 3TCEFVM41L, L74V, M184V, L210W, T215YK103N, V106M, M230LP4S, K20KR, V35T, T39E, E44D, S48ST, V60I, S68SG, L109LIM, V111VI, V118I, K122E, I135V, S162C, K173A, Q174K, D177E, I178L, T200A, E203D, Q207E, H208HY, R211K, H221Y, F227I, L228LI, V245Q, A272P, E291D, I293V, V317AC
 23567552356755 AZT, 3TCEFVM41L, D67N, T69D, L74V, M184V, L210W, T215YK103N, V179E, M230LS3SC, V35T, T39E, E44D, S48T, E53D, V60I, V90I, K102KQ, V111VIM, K122E, D123S, E138R, A158S, S162A, R172K, I178L, T200A, E203K, Q207D, R211K, V245C, A272P, Q278H, T286A, E291D, V292I, I293V, L310LQ, D324EC
El-Khatib (2010)Pat00410ZA_SAVE1032HQ012282D4T, 3TCEFVM184VK103N, M230LK11Q, V35T, T39E, D121Y, K122E, D123G, I135T, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 Pat01810ZA_SAVE1252HQ012296D4T, 3TCEFVM184VK101E, V108VI, G190A, M230LV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207A, R211K, H221HY, P243T, V245Q, D250EC
 Pat04610ZA_SAVE2237HQ012324D4T, 3TCEFVM184V, T215FK101H, V106M, P225H, M230LV35T, T39E, K122E, T139A, K173A, Q174K, D177E, E203D, Q207E, R211K, V245K, D250EC
 Pat04810ZA_SAVE2248HQ012326ABC, 3TCEFVM41L, L74V, M184V, L210W, T215YK103N, V108I, M230LV35T, E36A, T39E, S48T, K122E, D123N, S162A, K173T, Q174K, T200A, Q207E, R211K, P243T, V245QC
 Pat05810ZA_SAVE2342HQ012336D4T, 3TCEFVM184V, T215YK103N, M230L, L234IV35T, T39E, K122E, D123G, K173T, T200A, Q207E, R211K, H221HY, V245QC
 Pat09811ZA_SAVE2040JF960548NRTI, AZT, DDINNRTIM184IK103N, P225H, M230LV35T, E36A, T39D, S48T, K122E, E138A, I142V, S162A, K173T, T200A, Q207K, R211Q, F214L, D250E, A272P, K277RC
Green (2011)707PKE15F707PKE15FHM623505D4T, 3TCEFVM41L, D67N, L74V, M184V, T215Y, K219NK103S, V106M, M230LP4H, V35T, E36A, T39E, K43KQ, E44ED, S48T, V60I, A98AS, K102KR, V118I, K122E, D123S, K173A, Q174K, D177EG, I178IM, T200A, Q207A, R211K, K223E, V245Q, K277R, T286A, E291D, V292I, I293VC
Sigaloff (2011)GT00256420GT00256420JN381584D4T, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
van Zyl (2011)A117A117JN638075D4T, 3TCEFVD67DG, M184V, T215FV106M, V179D, M230LV35M, T39E, S48T, K102Q, K103KR, K122E, D123G, E138ED, S162C, K173A, T200A, Q207E, V245Q, E248DC
 A183A183JN638108D4T, 3TCNVPM184VE138K, G190A, M230LP4S, K11Q, V35T, T39E, S48T, V60I, S68G, L80LV, D121Y, K122E, K166R, K173A, T200A, E204K, Q207D, R211K, V245QC
 A223A223JN638132AZT, 3TCEFVM184VV179D, G190A, M230LV35T, T39E, S48T, K122E, D123S, E169G, D177E, T200A, Q207E, L228R, V245QC
 A248A248JN638145D4T, 3TCEFVA62V, M184VK103N, M230LV35T, E36A, T39E, E53D, V60I, K102Q, K122E, D123N, I135V, E138S, T139A, K173L, Q174K, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250EC
 A304A304JN638186D4T, 3TCEFVM184VK103N, M230LE6K, V35T, T39K, S48T, V60I, K104R, K122E, D123S, K173T, Q174R, D177E, T200A, Q207D, R211K, V245Q, D250NC
 A348A348JN638202D4T, 3TCEFVM184VK103N, V106M, M230LV21I, V35T, T39E, S48T, V60I, T69N, K122E, I135V, K173A, Q174K, D177E, T200A, Q207E, V245QC
Brehm (2012)36ZA36ZA.120JN601971D4T, 3TCEFVM184VK103N, M230L, L234IV35T, T39E, S48T, D121H, K122E, D123S, I135V, E138EA, S162C, K173IR, Q174K, D177E, I178L, T200A, Q207E, H221Y, L228Q, V245Q, E248D, A272P, K275R, Q278H, L279M, T286A, E291D, V292I, I293V, P294T, Q334N, G335D, R356K, G359S, V365I, A371V, T377LM, K390R, A400T, V435P, A446S, L452V, R461RK, V467VI, S468T, D471E, T477AS, H483Q, L491S, E516D, S519N, K527N, K530R, V531I, A534S, A554NC
 42ZA42ZA.36JN601984D4T, 3TCNVPM184VV106M, M230LV35T, E36A, T39E, S48T, K122E, D123N, Q174N, T200A, Q207N, R211K, F214L, V245M, A272P, K275Q, K277R, Q278H, E291D, V292I, I293V, P294T, I329L, Q334D, K347R, R356K, G359T, A376T, T377L, K390R, A400T, E404D, W410C, V435A, E449D, L452M, R461K, V466I, S468T, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554SC
 59ZA59ZA.72JN602020D4T, 3TCEFVM184VK103N, M230LK20R, K22R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, S163T, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, I274V, Q278H, K281R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, A400I, E404D, V435A, A437V, N447S, L452M, K454R, T470S, D471E, Q480H, H483Q, L491S, K530R, A534S, A554SC

Database

Resources

Team