<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation F227L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 20
Patients 111
Isolates 120
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK3015TK3015c AZT, 3TC, DDC, ABC, TDFEFV, NVPM41L, D67N, L210W, T215Y, K219RV106M, V179D, F227LE6K, V35M, T39D, E44D, K102KR, V118I, K122E, I135L, K173A, Q174KR, N175NY, D177E, V189VI, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281KR, T286A, E291D, V292I, I293V, H315FC
Baxter (2006)12-10071007-30519DQ879146NRTINNRTIM41L, D67N, M184V, L210W, T215YF227LT39S, E44D, V111I, V118I, K122E, D123N, K173A, Q174K, D177E, I178L, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
 48-14071407-30410DQ877803NRTINNRTIM41L, D67N, V75VL, L210W, T215Y, K219RV106M, V179D, F227LE6K, V35M, T39D, E44D, V118I, K122E, I135L, K173AT, Q174KR, N175Y, D177DE, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281R, T286A, E291D, V292I, I293V, H315F, Q334H, G335D, R356K, G359T, A371V, T377M, T386I, K390RC
Sen (2007)T101NPT101-PLEF186969D4T, 3TCNVPM41ML, D67DN, K70KQ, M184V, T215FV106A, F227LT27TS, V35IT, T39N, V60I, D121Y, K122E, I142V, K173A, Q174R, D177E, I178L, T200A, E203A, Q207E, H208Y, R211K, K223KE, V245N, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297EK, L310I, E312Q, Q334H, G335D, R356K, M357MR, G359AT, V365VI, A371AV, T377Q, A400T, E404DC
Marconi (2008)SW043sw043EU308056D4T, DDI, AZT, 3TCEFVM41L, A62V, M184VV106M, V179D, F227LS48T, V60I, K103R, K122E, D123S, I135V, K173V, Q174K, D177E, T200A, I202V, Q207E, F214FL, L228R, V245QC
 SW068SW068EU308079NoneEFV, NVPM184VV106A, F227LS48T, V60I, K122E, D123S, K173A, Q174R, D177E, T200A, Q207E, R211K, V245EC
Riddler (2008)57737151285BbHM056578AZT, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, D121H, K122E, I135M, K173A, D177E, T200A, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, F416Y, N447S, L452M, V466I, D471E, T477A, V493A, S519N, A554SC
Deshpande (2009)Pat24716artFJ530694NRTINNRTIM184VV106A, F227LV35T, T39N, S48T, V60I, V90I, K122E, D123E, I135V, R143RI, S162A, K173A, D177E, T200A, Q207EG, R211K, V245QC
 Pat150164RTFJ530791NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215Y, K219KRK101E, K103KN, V106A, G190GA, F227LK20R, V35T, T39D, E44A, S48T, V60I, K82KR, A98AS, K122E, I135L, E138A, I142IV, K166R, K173A, I178L, V179I, T200A, Q207D, H208Y, R211KC
 Pat123211RTFJ530818D4T, 3TCNVPM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219WV106M, Y181V, F227LV35T, T39D, V60I, L109I, D121Y, K122E, I135T, S162A, K173I, Q174K, D177E, T200A, I202V, Q207E, H208Y, R211KC
 Pat075292RTFJ530866D4T, 3TCNVPD67N, K70R, M184I, K219HY181C, G190A, F227LK11R, V35T, T39E, K46M, S48T, V60I, V118I, D121Y, K122E, K173A, Q174K, D177E, T200A, E203K, Q207E, R211E, D218EC
Hoffmann (2009)pat051MD38414 AZT, 3TCEFVA62V, M184VK103N, V106M, F227LV35T, E36A, T39E, K102R, K122E, D123G, I135T, K173T, D177E, T200A, R211K, V245Q, A272PC
 pat014MD92135 AZT, 3TCEFVM184VV106M, F227LV35T, T39N, S48T, K122E, D123S, I135IM, T139A, K173A, Q174K, D177E, G196V, T200A, Q207E, V245K, A272PC
Hosseinipour (2009)94309430GQ228366D4T, 3TCNVPM184VK101KHNQ, K103KNRS, V106M, F227LT39E, S48T, K122E, D123S, K173T, D177E, I178L, T200A, Q207R, R211K, V245QC
Orrell (2009)GT01007GT010072006 D4T, 3TCEFVM184VV106M, F227LT39E, S48T, V60I, K122E, D123G, I135T, K173A, D177E, T200A, E203EK, Q207E, E224D, V245QC
Rajesh (2009)F9TRCFRT9FJ5953573TC, DDIEFVL74I, M184VK101E, V106M, G190A, F227LV35T, T39E, E40EG, D121Y, K122E, I159V, S162A, K173A, D177K, T200A, Q207G, R211T, I244IV, V245QC
Wallis (2009)GT00373095GT00373095 D4T, 3TCEFVM184VV106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165L, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, I257V, A272P, T286A, E291D, V292I, I293V, E328KC
 GT002457273GT002457273 D4T, 3TCEFVM184VV106M, F227LK11Q, V35M, E36A, T39E, S48T, D121Y, K122E, D123G, I135T, A158AT, K173A, Q174K, D177E, T200A, Q207E, R211RK, V245Q, A272P, T286A, E291D, V292IC
 TJC2402512TJC2402512 D4T, 3TCEFVM184VV106M, V179D, F227LP4H, K20R, V35T, E36A, T39E, K122E, D123S, A158S, K173A, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K277T, K281R, T286A, E291D, V292I, I293VC
 TJC2384408TJC2384408 AZT, 3TCEFVM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219KQK101H, V106M, G190A, F227LV35I, E36A, T39E, S48T, T69N, K122E, D123N, I135T, K173T, T200A, Q207E, R211K, F214FL, A272P, K275Q, K277R, T286A, A288T, E291D, V292I, I293VC
 TJC2395299TJC2395299 D4T, 3TCEFVV75VI, M184VK103KN, V106M, F227LT27S, V35T, T39K, V60I, D121Y, K122E, I132IL, I135T, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, V245Q, A272P, Q278H, L279M, K281R, T286A, E291D, I293V, Q334NC
 23464402346440 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 TJC2414872TJC2414872 D4T, 3TCEFVD67N, K70E, M184VV106M, F227LV35T, E36A, T39E, E40K, S48T, K122E, D123N, I135M, S162D, K173T, I178M, V179VI, T200A, E204K, Q207E, R211K, F214L, H221Y, V245L, A272P, K275Q, V276I, K281R, L283I, T286A, E291D, V292I, I293V, P294Q, L310I, Q334HC
 TJC2370066TJC2370066 D4T, 3TCEFVK70R, M184VV106M, G190A, F227LV35T, E36A, T39E, S48T, V60I, K122E, D123G, K173T, D177E, I178L, T200A, Q207E, R211K, H221HY, L228F, V245E, A272P, K277R, E291D, V292I, I293V, D324EC
 TJC2379522TJC2379522 D4T, 3TCEFVM184VK101E, V106M, F227LV35T, T39E, S48T, V60I, S105A, I135V, K173T, Q174K, D177E, T200A, Q207E, R211K, V245E, A272P, K277R, E291D, V292I, I293VC
 GT00387892GT00387892 D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 23628782362878 AZT, 3TCEFVD67N, K70R, M184V, T215F, K219QA98G, K101E, V106M, F227LK20R, V35I, T39D, E40D, S48T, T69TN, D86DE, W88S, K103R, L109I, V118VI, D121H, K122E, E138A, I142V, K173A, D177E, I178L, T200A, I202V, E204K, Q207E, R211K, F214L, V245Q, E248N, D250DN, A272P, T286A, E291D, V292I, I293VC
 23499842349984 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 TJC2429706TJC2429706 D4T, 3TCEFVM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219EV106M, V179D, F227LV35T, E36A, T39E, V60I, K122E, D123G, I132V, K173T, D177E, I178L, T200A, E203EK, Q207D, R211K, H221Y, V245Q, K281R, L283I, T286A, E291D, V292I, I293VC
 TJC2420050TJC2420050 D4T, 3TCEFVM184VK101KE, V106M, F227LK20R, V35M, T39E, S48T, K122E, D123G, I135IT, G141X, K173A, Q174K, D177E, T200A, Q207D, V245Q, A272P, K277R, T286A, V292I, I293V, P294T, V317A, I329VC
 GT00150239GT00150239 D4T, 3TCNVPV75I, M184VV106M, F227LK32R, V35T, E36A, T39E, S48T, V60I, K122E, I132L, T139A, K173A, D177E, E203EK, Q207E, R211K, K223KE, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293VC
El-Khatib (2010)Pat00310ZA_SAVE1026HQ012281D4T, 3TCNVPA62V, M184VV106M, F227LV35T, T39E, S48T, K122E, D123S, K166KR, K173A, D177E, I178L, T200A, E204K, Q207D, R211K, V245QC
 Pat04110ZA_SAVE2169HQ012319D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39D, S48T, K122E, D123N, A129AT, A158S, K173A, D177E, T200A, Q207E, V245QC
Green (2011)707PKE04F707PKE04FHM623496D4T, 3TC, AZTEFVM41ML, D67DN, V75M, M184V, T215YV106M, V179VD, G190GA, F227LI31L, V35T, E36EA, T39E, V60I, A98AS, L109LI, K122E, D123S, S163SC, T165TI, K173T, Q174N, D177E, T200A, Q207A, R211K, V245T, A272P, E291D, V292I, I293V, E298EK, D324E, I326IVC
 707PKE11F707PKE11FHM623502D4T, 3TCEFVK65R, T69~, K219RK103N, V106M, F227LK20R, T27S, V35T, T39E, S48T, V60I, S68N, K122E, D123S, T165I, K173A, Q174K, D177E, I195IL, G196E, T200A, Q207E, R211K, F214L, K223Q, L228R, V245Q, L283LI, E291D, V292I, I293V, S322TC
 707PKE27F707PKE27FHM623516AZT, 3TCEFVM41L, D67N, K70R, V75M, F77L, M184V, T215Y, K219EV106M, G190A, F227LV35T, E36A, T39E, S48T, V60I, T69TN, A98S, L109I, K122E, D123S, I135T, S163T, K173A, Q174K, D177E, T200A, Q207E, R211K, D218E, L228H, P243T, V245Q, A272P, T286A, E291D, V292I, I329IVC
 707PKE29F707PKE29FHM623518D4T, 3TCEFVD67DN, M184V, K219RV106M, V179D, F227LK20R, V35T, T39E, V60VI, K102N, K122KE, I135V, S162SN, E169KR, K173E, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, I326VC
 707PKE39F707PKE39FHM623526D4T, 3TCEFVD67G, K70R, V75I, M184V, K219QV106M, Y181C, F227LK20KR, V35T, T39E, S48T, V60I, K101KI, K122E, D123N, I132L, I135V, K173A, Q174K, D177E, T200E, E203K, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293VC
Sigaloff (2011)GP25335969GP25335969_1JN381559AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EV106M, V108I, F227LK20R, V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, K223T, L228R, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
  GP25335969_2JN381560AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EV106M, V108I, F227LK20R, V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, K223T, L228R, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 GT00150239GT00150239JN381571D4T, 3TCNVPV75I, M184VV106M, F227LK32R, V35T, E36A, T39E, S48T, V60I, K122E, I132L, T139A, K173A, D177E, E203EK, Q207E, R211K, K223KE, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293VC
 GT00373095GT00373095_2JN381610D4T, 3TCEFVM184VV106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165L, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, I257V, A272P, T286A, E291D, V292I, I293V, E328KC
 GT00387892GT00387892_1JN381612D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
  GT00387892_2JN381613D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
van Zyl (2011)A114A114JN638072AZT, 3TCNVPD67N, M184VV106A, F227LV35T, T39E, S48T, K122E, K173A, Q174N, D177E, T200A, Q207E, R211K, V245QC
 A163A163JN638094D4T, 3TCNVPM184VV106M, F227LV35T, E36A, T39D, S48T, V60I, K122E, D123N, T139R, S162C, K173A, Q174K, T200A, Q207A, R211K, V245QC
 A164A164JN638095D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39DE, S48T, K49KR, V60I, K122A, D123N, I135IT, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245QC
 A247A247JN638144AZT, 3TCEFVA62V, M184VK103KN, V106M, F227LV35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, V179I, G196E, T200A, E203D, E204K, Q207E, R211K, H221Y, L228R, V245QC
 A48A48JN638213D4T, 3TCNVPM184VV106M, F227LT27S, V35T, E36A, T39D, S48T, K122E, D123S, I135T, E138G, S162C, K173A, T200A, Q207A, R211K, V245QC
 A80A80JN638225AZT, 3TCNVPK70T, M184VV106M, F227LP9S, V35T, T39K, S48T, S68G, K122E, D123N, E138A, K173T, Q174K, D177N, T200A, I202V, Q207V, R211K, F214L, V245Q, E248DC
Aghokeng (2013)HJ3025HJ3025JX982979NRTINNRTID67N, K70R, M184V, T215CY, K219QV106M, F227LK20R, V35T, T39E, K102KR, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA, D324E, G335D, R356K, G359T, T377L, K390R, I393IM, A400T, E404DC
Hoffmann (2013)449813_2449813_2KJ081327TDF, 3TCEFVA62V, M184VV106M, V179D, F227LM16I, V35T, E36A, T39D, S48T, K82R, K122E, K173A, D177E, T200A, E203T, Q207E, R211K, F214L, V245QC
Sunpath (2013)CAS074CAS074 TDF, 3TCEFVM184VV106M, G190A, F227LP4S, V8I, V35T, T39D, S48T, V60I, I142V, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, K311RC
 CAS092CAS092 TDF, 3TCEFVK65RK101E, V106M, F227LV35T, T39E, S48T, V60I, K122E, I135K, K173A, Q174K, D177E, I178L, G196E, T200A, E204K, Q207E, R211K, V245E, D250E, A272P, T286A, E291D, V292I, I293VC
 CAS071CAS071 TDF, 3TCEFVK65RV106M, Y181C, F227LK20R, V35T, T39E, S48T, V60I, K122E, D123S, T165V, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, E291D, V292I, I293V, D324DEC
 CAS061CAS061 D4T, 3TCEFV V106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, E138A, K173A, Q174K, D177E, I178L, G196E, T200A, K201R, E204K, Q207D, R211K, F214L, V245K, A272P, K275R, Q278E, T286A, E291D, V292I, I293V, E328D, I329VC
Van Zyl (2013)1162541KC424128D4T, 3TCEFVM184VV106M, F227L, M230LV35T, T39E, K122E, D123G, K173A, Q174K, D177E, G196R, T200A, Q207E, R211K, V245QC
 7571551KC423223D4T, 3TCEFVM184VK101E, V106M, F227LV35T, T39E, S48T, K122E, K173T, D177E, T200A, Q207E, V245QC
 1712664KC424213AZT, D4T, 3TC, DDINVP, EFVM41L, M184V, L210W, T215FV106M, G190A, F227LP4S, V21VI, V35T, T39E, E44D, S48T, K49KT, K122E, D123N, K173T, Q174K, I178IL, T200TA, E203K, Q207E, H208HY, R211K, K223E, L228R, V245Q, D250XC
 12621107KC422882D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, K122E, D123S, I135M, S162C, K173T, D177E, T200A, Q207E, V245QC
 16961380KC423107D4T, 3TCNVPM184V, T215FK103N, F227L, M230LV35T, T39A, S48T, S68G, T69TA, K102Q, K122E, D123S, K173A, Q174K, D177E, T200A, Q207D, R211K, H221Y, V245Q, E248TC
 13601870KC423472TDF, 3TCEFVA62V, K65R, M184VV106M, V108I, Y181C, F227LV35T, T39E, S48T, K101KI, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, T200A, Q207A, R211AE, H221Y, V245QC
 11081767KC423390D4T, 3TCEFVV75M, M184VV106M, F227LT7TI, V35L, E36A, T39E, S48T, K122E, D123G, I135V, S162C, K173A, Q174K, D177E, T200A, Q207D, R211K, V241MT, V245QC
 12501210KC422963D4T, 3TCEFVM184VK101H, V106M, V179D, F227LV35T, T39G, D123S, S162SC, K173A, T200A, Q207E, R211RK, V245QC
  2691KC423789D4T, 3TCEFVK70KR, M184VK101H, V106M, V179D, F227LV35T, T39G, K122E, D123S, R125RK, S162C, K173A, T200A, Q207E, F214FL, V245QC
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  3001KC423926D4T, 3TC, ABCEFVL74V, M184VV106M, V179D, G190A, F227LV35T, T39E, S48T, K122E, D123N, K173I, Q174K, D177E, T200A, Q207E, R211K, V245N, E248N, D250EC
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Grossman (2014)609609 ABC, DDINVPM41L, D67N, L74V, M184V, L210W, T215Y, K219NA98G, V106M, Y181C, F227LT39E, K43Q, E44D, V118I, K122E, D123S, I142V, K173A, Q174K, D177E, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
  609 ABC, DDI, AZT, 3TCNVPM41L, D67N, L74LI, M184V, L210SW, T215Y, K219NA98G, V106M, G190A, F227LT39K, K43R, E44D, K64KR, V118VI, K122E, D123S, I142V, K173A, Q174K, D177E, T200A, I202IV, E203K, Q207E, H208Y, R211K, K223E, V245QC