<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation F227L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 22
Patients 140
Isolates 149
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK3015TK3015c AZT, 3TC, DDC, ABC, TDFEFV, NVPM41L, D67N, L210W, T215Y, K219RV106M, V179D, F227LE6K, V35M, T39D, E44D, K102KR, V118I, K122E, I135L, K173A, Q174KR, N175NY, D177E, V189VI, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281KR, T286A, E291D, V292I, I293V, H315FC
Baxter (2006)12-10071007-30519DQ879146NRTINNRTIM41L, D67N, M184V, L210W, T215YF227LT39S, E44D, V111I, V118I, K122E, D123N, K173A, Q174K, D177E, I178L, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
 48-14071407-30410DQ877803NRTINNRTIM41L, D67N, V75VL, L210W, T215Y, K219RV106M, V179D, F227LE6K, V35M, T39D, E44D, V118I, K122E, I135L, K173AT, Q174KR, N175Y, D177DE, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281R, T286A, E291D, V292I, I293V, H315F, Q334H, G335D, R356K, G359T, A371V, T377M, T386I, K390RC
Sen (2007)T101NPT101-PLEF186969D4T, 3TCNVPM41ML, D67DN, K70KQ, M184V, T215FV106A, F227LT27TS, V35IT, T39N, V60I, D121Y, K122E, I142V, K173A, Q174R, D177E, I178L, T200A, E203A, Q207E, H208Y, R211K, K223KE, V245N, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297EK, L310I, E312Q, Q334H, G335D, R356K, M357MR, G359AT, V365VI, A371AV, T377Q, A400T, E404DC
Marconi (2008)SW043sw043EU308056D4T, DDI, AZT, 3TCEFVM41L, A62V, M184VV106M, V179D, F227LS48T, V60I, K103R, K122E, D123S, I135V, K173V, Q174K, D177E, T200A, I202V, Q207E, F214FL, L228R, V245QC
 SW068SW068EU308079NoneEFV, NVPM184VV106A, F227LS48T, V60I, K122E, D123S, K173A, Q174R, D177E, T200A, Q207E, R211K, V245EC
Riddler (2008)57737151285BbHM056578AZT, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, D121H, K122E, I135M, K173A, D177E, T200A, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, F416Y, N447S, L452M, V466I, D471E, T477A, V493A, S519N, A554SC
Deshpande (2009)Pat24716artFJ530694NRTINNRTIM184VV106A, F227LV35T, T39N, S48T, V60I, V90I, K122E, D123E, I135V, R143RI, S162A, K173A, D177E, T200A, Q207EG, R211K, V245QC
 Pat150164RTFJ530791NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215Y, K219KRK101E, K103KN, V106A, G190GA, F227LK20R, V35T, T39D, E44A, S48T, V60I, K82KR, A98AS, K122E, I135L, E138A, I142IV, K166R, K173A, I178L, V179I, T200A, Q207D, H208Y, R211KC
 Pat123211RTFJ530818D4T, 3TCNVPM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219WV106M, Y181V, F227LV35T, T39D, V60I, L109I, D121Y, K122E, I135T, S162A, K173I, Q174K, D177E, T200A, I202V, Q207E, H208Y, R211KC
 Pat075292RTFJ530866D4T, 3TCNVPD67N, K70R, M184I, K219HY181C, G190A, F227LK11R, V35T, T39E, K46M, S48T, V60I, V118I, D121Y, K122E, K173A, Q174K, D177E, T200A, E203K, Q207E, R211E, D218EC
Hoffmann (2009)pat051MD38414 AZT, 3TCEFVA62V, M184VK103N, V106M, F227LV35T, E36A, T39E, K102R, K122E, D123G, I135T, K173T, D177E, T200A, R211K, V245Q, A272PC
 pat014MD92135 AZT, 3TCEFVM184VV106M, F227LV35T, T39N, S48T, K122E, D123S, I135IM, T139A, K173A, Q174K, D177E, G196V, T200A, Q207E, V245K, A272PC
Hosseinipour (2009)94309430GQ228366D4T, 3TCNVPM184VK101KHNQ, K103KNRS, V106M, F227LT39E, S48T, K122E, D123S, K173T, D177E, I178L, T200A, Q207R, R211K, V245QC
Orrell (2009)GT01007GT010072006 D4T, 3TCEFVM184VV106M, F227LT39E, S48T, V60I, K122E, D123G, I135T, K173A, D177E, T200A, E203EK, Q207E, E224D, V245QC
Rajesh (2009)F9TRCFRT9FJ5953573TC, DDIEFVL74I, M184VK101E, V106M, G190A, F227LV35T, T39E, E40EG, D121Y, K122E, I159V, S162A, K173A, D177K, T200A, Q207G, R211T, I244IV, V245QC
Wallis (2009)GT00373095GT00373095 D4T, 3TCEFVM184VV106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165L, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, I257V, A272P, T286A, E291D, V292I, I293V, E328KC
 GT002457273GT002457273 D4T, 3TCEFVM184VV106M, F227LK11Q, V35M, E36A, T39E, S48T, D121Y, K122E, D123G, I135T, A158AT, K173A, Q174K, D177E, T200A, Q207E, R211RK, V245Q, A272P, T286A, E291D, V292IC
 TJC2402512TJC2402512 D4T, 3TCEFVM184VV106M, V179D, F227LP4H, K20R, V35T, E36A, T39E, K122E, D123S, A158S, K173A, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K277T, K281R, T286A, E291D, V292I, I293VC
 TJC2384408TJC2384408 AZT, 3TCEFVM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219KQK101H, V106M, G190A, F227LV35I, E36A, T39E, S48T, T69N, K122E, D123N, I135T, K173T, T200A, Q207E, R211K, F214FL, A272P, K275Q, K277R, T286A, A288T, E291D, V292I, I293VC
 TJC2395299TJC2395299 D4T, 3TCEFVV75VI, M184VK103KN, V106M, F227LT27S, V35T, T39K, V60I, D121Y, K122E, I132IL, I135T, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, V245Q, A272P, Q278H, L279M, K281R, T286A, E291D, I293V, Q334NC
 23464402346440 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 TJC2414872TJC2414872 D4T, 3TCEFVD67N, K70E, M184VV106M, F227LV35T, E36A, T39E, E40K, S48T, K122E, D123N, I135M, S162D, K173T, I178M, V179VI, T200A, E204K, Q207E, R211K, F214L, H221Y, V245L, A272P, K275Q, V276I, K281R, L283I, T286A, E291D, V292I, I293V, P294Q, L310I, Q334HC
 TJC2370066TJC2370066 D4T, 3TCEFVK70R, M184VV106M, G190A, F227LV35T, E36A, T39E, S48T, V60I, K122E, D123G, K173T, D177E, I178L, T200A, Q207E, R211K, H221HY, L228F, V245E, A272P, K277R, E291D, V292I, I293V, D324EC
 TJC2379522TJC2379522 D4T, 3TCEFVM184VK101E, V106M, F227LV35T, T39E, S48T, V60I, S105A, I135V, K173T, Q174K, D177E, T200A, Q207E, R211K, V245E, A272P, K277R, E291D, V292I, I293VC
 GT00387892GT00387892 D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 23628782362878 AZT, 3TCEFVD67N, K70R, M184V, T215F, K219QA98G, K101E, V106M, F227LK20R, V35I, T39D, E40D, S48T, T69TN, D86DE, W88S, K103R, L109I, V118VI, D121H, K122E, E138A, I142V, K173A, D177E, I178L, T200A, I202V, E204K, Q207E, R211K, F214L, V245Q, E248N, D250DN, A272P, T286A, E291D, V292I, I293VC
 23499842349984 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 TJC2429706TJC2429706 D4T, 3TCEFVM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219EV106M, V179D, F227LV35T, E36A, T39E, V60I, K122E, D123G, I132V, K173T, D177E, I178L, T200A, E203EK, Q207D, R211K, H221Y, V245Q, K281R, L283I, T286A, E291D, V292I, I293VC
 TJC2420050TJC2420050 D4T, 3TCEFVM184VK101KE, V106M, F227LK20R, V35M, T39E, S48T, K122E, D123G, I135IT, G141X, K173A, Q174K, D177E, T200A, Q207D, V245Q, A272P, K277R, T286A, V292I, I293V, P294T, V317A, I329VC
 GT00150239GT00150239 D4T, 3TCNVPV75I, M184VV106M, F227LK32R, V35T, E36A, T39E, S48T, V60I, K122E, I132L, T139A, K173A, D177E, E203EK, Q207E, R211K, K223KE, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293VC
El-Khatib (2010)Pat00310ZA_SAVE1026HQ012281D4T, 3TCNVPA62V, M184VV106M, F227LV35T, T39E, S48T, K122E, D123S, K166KR, K173A, D177E, I178L, T200A, E204K, Q207D, R211K, V245QC
 Pat04110ZA_SAVE2169HQ012319D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39D, S48T, K122E, D123N, A129AT, A158S, K173A, D177E, T200A, Q207E, V245QC
Green (2011)707PKE04F707PKE04FHM623496D4T, 3TC, AZTEFVM41ML, D67DN, V75M, M184V, T215YV106M, V179VD, G190GA, F227LI31L, V35T, E36EA, T39E, V60I, A98AS, L109LI, K122E, D123S, S163SC, T165TI, K173T, Q174N, D177E, T200A, Q207A, R211K, V245T, A272P, E291D, V292I, I293V, E298EK, D324E, I326IVC
 707PKE11F707PKE11FHM623502D4T, 3TCEFVK65R, T69~, K219RK103N, V106M, F227LK20R, T27S, V35T, T39E, S48T, V60I, S68N, K122E, D123S, T165I, K173A, Q174K, D177E, I195IL, G196E, T200A, Q207E, R211K, F214L, K223Q, L228R, V245Q, L283LI, E291D, V292I, I293V, S322TC
 707PKE27F707PKE27FHM623516AZT, 3TCEFVM41L, D67N, K70R, V75M, F77L, M184V, T215Y, K219EV106M, G190A, F227LV35T, E36A, T39E, S48T, V60I, T69TN, A98S, L109I, K122E, D123S, I135T, S163T, K173A, Q174K, D177E, T200A, Q207E, R211K, D218E, L228H, P243T, V245Q, A272P, T286A, E291D, V292I, I329IVC
 707PKE29F707PKE29FHM623518D4T, 3TCEFVD67DN, M184V, K219RV106M, V179D, F227LK20R, V35T, T39E, V60VI, K102N, K122KE, I135V, S162SN, E169KR, K173E, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, I326VC
 707PKE39F707PKE39FHM623526D4T, 3TCEFVD67G, K70R, V75I, M184V, K219QV106M, Y181C, F227LK20KR, V35T, T39E, S48T, V60I, K101KI, K122E, D123N, I132L, I135V, K173A, Q174K, D177E, T200E, E203K, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293VC
Sigaloff (2011)GP25335969GP25335969_1JN381559AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EV106M, V108I, F227LK20R, V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, K223T, L228R, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
  GP25335969_2JN381560AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EV106M, V108I, F227LK20R, V35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, K223T, L228R, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 GT00150239GT00150239JN381571D4T, 3TCNVPV75I, M184VV106M, F227LK32R, V35T, E36A, T39E, S48T, V60I, K122E, I132L, T139A, K173A, D177E, E203EK, Q207E, R211K, K223KE, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293VC
 GT00373095GT00373095_2JN381610D4T, 3TCEFVM184VV106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165L, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, I257V, A272P, T286A, E291D, V292I, I293V, E328KC
 GT00387892GT00387892_1JN381612D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
  GT00387892_2JN381613D4T, 3TCEFVD67N, M184VK101E, V106M, F227LK20R, V35T, T39E, S48T, T69S, K122E, K173A, Q174K, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
van Zyl (2011)A114A114JN638072AZT, 3TCNVPD67N, M184VV106A, F227LV35T, T39E, S48T, K122E, K173A, Q174N, D177E, T200A, Q207E, R211K, V245QC
 A163A163JN638094D4T, 3TCNVPM184VV106M, F227LV35T, E36A, T39D, S48T, V60I, K122E, D123N, T139R, S162C, K173A, Q174K, T200A, Q207A, R211K, V245QC
 A164A164JN638095D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39DE, S48T, K49KR, V60I, K122A, D123N, I135IT, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245QC
 A247A247JN638144AZT, 3TCEFVA62V, M184VK103KN, V106M, F227LV35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, V179I, G196E, T200A, E203D, E204K, Q207E, R211K, H221Y, L228R, V245QC
 A48A48JN638213D4T, 3TCNVPM184VV106M, F227LT27S, V35T, E36A, T39D, S48T, K122E, D123S, I135T, E138G, S162C, K173A, T200A, Q207A, R211K, V245QC
 A80A80JN638225AZT, 3TCNVPK70T, M184VV106M, F227LP9S, V35T, T39K, S48T, S68G, K122E, D123N, E138A, K173T, Q174K, D177N, T200A, I202V, Q207V, R211K, F214L, V245Q, E248DC
Aghokeng (2013)HJ3025HJ3025JX982979NRTINNRTID67N, K70R, M184V, T215CY, K219QV106M, F227LK20R, V35T, T39E, K102KR, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA, D324E, G335D, R356K, G359T, T377L, K390R, I393IM, A400T, E404DC
Hoffmann (2013)449813_2449813_2KJ081327TDF, 3TCEFVA62V, M184VV106M, V179D, F227LM16I, V35T, E36A, T39D, S48T, K82R, K122E, K173A, D177E, T200A, E203T, Q207E, R211K, F214L, V245QC
Sunpath (2013)CAS074CAS074 TDF, 3TCEFVM184VV106M, G190A, F227LP4S, V8I, V35T, T39D, S48T, V60I, I142V, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, K311RC
 CAS092CAS092 TDF, 3TCEFVK65RK101E, V106M, F227LV35T, T39E, S48T, V60I, K122E, I135K, K173A, Q174K, D177E, I178L, G196E, T200A, E204K, Q207E, R211K, V245E, D250E, A272P, T286A, E291D, V292I, I293VC
 CAS071CAS071 TDF, 3TCEFVK65RV106M, Y181C, F227LK20R, V35T, T39E, S48T, V60I, K122E, D123S, T165V, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, E291D, V292I, I293V, D324DEC
 CAS061CAS061 D4T, 3TCEFV V106M, F227LK20R, V35T, E36A, T39E, S48T, V60I, K122E, E138A, K173A, Q174K, D177E, I178L, G196E, T200A, K201R, E204K, Q207D, R211K, F214L, V245K, A272P, K275R, Q278E, T286A, E291D, V292I, I293V, E328D, I329VC
Theys (2013)8138081380KC219013NRTI, TDFNNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219EV106M, Y181YC, G190A, F227LT39R, K43E, V60I, S68SG, S105SA, K122E, D123G, T139A, K173T, Q174K, D177E, V179I, T200A, Q207E, D218E, K223KT, L228H, V245HC
Van Zyl (2013)1162541KC424128D4T, 3TCEFVM184VV106M, F227L, M230LV35T, T39E, K122E, D123G, K173A, Q174K, D177E, G196R, T200A, Q207E, R211K, V245QC
 7571551KC423223D4T, 3TCEFVM184VK101E, V106M, F227LV35T, T39E, S48T, K122E, K173T, D177E, T200A, Q207E, V245QC
 1712664KC424213AZT, D4T, 3TC, DDINVP, EFVM41L, M184V, L210W, T215FV106M, G190A, F227LP4S, V21VI, V35T, T39E, E44D, S48T, K49KT, K122E, D123N, K173T, Q174K, I178IL, T200TA, E203K, Q207E, H208HY, R211K, K223E, L228R, V245Q, D250XC
 12621107KC422882D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, K122E, D123S, I135M, S162C, K173T, D177E, T200A, Q207E, V245QC
 16961380KC423107D4T, 3TCNVPM184V, T215FK103N, F227L, M230LV35T, T39A, S48T, S68G, T69TA, K102Q, K122E, D123S, K173A, Q174K, D177E, T200A, Q207D, R211K, H221Y, V245Q, E248TC
 13601870KC423472TDF, 3TCEFVA62V, K65R, M184VV106M, V108I, Y181C, F227LV35T, T39E, S48T, K101KI, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, T200A, Q207A, R211AE, H221Y, V245QC
 11081767KC423390D4T, 3TCEFVV75M, M184VV106M, F227LT7TI, V35L, E36A, T39E, S48T, K122E, D123G, I135V, S162C, K173A, Q174K, D177E, T200A, Q207D, R211K, V241MT, V245QC
 12501210KC422963D4T, 3TCEFVM184VK101H, V106M, V179D, F227LV35T, T39G, D123S, S162SC, K173A, T200A, Q207E, R211RK, V245QC
  2691KC423789D4T, 3TCEFVK70KR, M184VK101H, V106M, V179D, F227LV35T, T39G, K122E, D123S, R125RK, S162C, K173A, T200A, Q207E, F214FL, V245QC
 9661262KC423011D4T, 3TCEFVD67N, Q151QKLM, M184VV106M, Y181C, F227LI5IV, V35T, T39E, K122E, D123S, I135R, T139A, K173A, D177E, T200A, I202V, E203EA, Q207E, R211K, F214LC
 342492KC423729AZT, D4T, 3TC, TDFNVP, EFVA62AV, K65R, M184VK101E, V106M, V108VI, F227LK22R, E28K, V35T, E36A, T39E, E40D, S68N, W88C, A98S, L109LI, K122E, D123N, K173A, D177G, T200A, Q207EK, R211K, F214FL, D218E, V245EC
 8432123KC423635TDF, 3TCEFVD67G, M184VK103N, V106M, F227LI31L, V35T, T39E, S48T, E53D, V60I, T69N, K122E, D123DN, K173A, Q174K, D177E, I178M, G196GE, T200A, Q207A, R211K, V245Q, D250EC
 17192507KC423733D4T, 3TCEFVM184VV106M, G190A, F227LK20R, V35T, E36A, T39E, S48T, K102R, K122E, D123G, K173A, D177E, I178IM, T200A, Q207E, R211K, F214FL, V241VI, V245QC
 5681110KC422886D4T, 3TCEFVM184VV106M, G190GA, F227LV35T, E36A, T39D, S48T, V60I, K101Q, K122E, K173A, Q174K, D177E, T200A, R211A, V245QC
 2861605KC423267D4T, 3TCNVPM184VV106M, Y181C, F227LV35T, T39E, S48T, K122E, D123S, I135R, K173A, Q174K, D177E, G196R, T200A, I202V, Q207E, R211K, V245Q, D250EC
 14451169KC422932D4T, 3TCEFVD67N, K70R, M184V, K219HV106M, V108I, F227LK11Q, K20R, V35T, T39E, K43R, K46Q, S48T, V60I, V118I, K122E, D123N, I135T, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, R211K, D218E, V245Q, D250EC
 10321666KC423311AZT, 3TCNVPM184VV106M, F227LV35T, S48T, V60I, V90I, K102KR, V118I, K122E, D123S, I135IM, E138EA, K173T, T200A, R211K, F214L, V245QC
 15832685KC423785D4T, 3TCEFVM184VV106M, F227LV35T, T39K, S48T, V60VI, K122E, I135M, K173T, Q174K, D177E, I178M, T200E, Q207A, R211K, V245QC
 1622077KC423601D4T, 3TCEFVM184VK103N, V106M, F227LV35T, T39N, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, R211K, V245QC
 484243KC423706AZT, D4T, 3TCNVP, EFVA62V, M184VK101E, V106M, F227LP4H, V35T, E36A, T39D, S48T, K122E, D123G, S162A, K173T, Q174K, T200A, Q207E, R211G, F214L, D250EC
 17151807KC423423D4T, 3TCEFVM184VK101E, V106M, F227LE28A, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166KR, K173T, D177E, T200A, Q207T, R211K, V245Q, D250EC
 13241332KC423066D4T, 3TCEFVM184VV106M, G190A, F227LV35T, E36A, T39E, S48T, K102Q, K103R, K122E, D123G, P133H, I135V, S162C, K173A, Q174K, D177E, D192N, T200A, E203EQ, Q207E, R211KC
 6861023KC422814D4T, 3TCEFVM184VV106M, F227L, M230LV35T, T39A, S48T, K104R, K122E, D123N, E138A, K173L, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248NC
 10891237KC422987D4T, 3TCEFVM184VV106M, G190A, F227LV35T, E36A, T39D, S48T, V90I, K122E, D123S, S134N, S162A, K173T, Q174K, T200A, Q207E, R211KC
 352954KC424391D4T, 3TCEFVM184V, T215FV106M, G190A, F227L, M230LV21I, T27S, V35T, T39E, S48T, V60I, K122E, D123G, I135T, K173A, Q174QK, T200A, Q207E, R211K, K220KN, V245QC
 1321765KC424272D4T, 3TCNVPD67N, M184VV106A, F227LK20R, V35T, T39D, S48T, V60I, W88C, K122E, D123S, E138A, T165L, K173A, Q174R, I178L, T200A, R211K, F214L, V245QC
 846645KC424198D4T, 3TCEFVM184VV106M, V179D, F227L, M230LP4T, V35T, T39E, S48T, K166R, K173A, Q174K, D177E, T200A, Q207K, R211K, L228R, V245QC
 1202873KC424329AZT, D4T, 3TC, ABCNVP, EFVM184VK103S, V106M, F227LV35T, E36A, T39E, S48T, V60I, K102Q, K122E, D123S, I135V, I142V, T165I, K173A, G196R, T200E, Q207A, R211K, V245QC
 3451455KC423156AZT, 3TCEFVD67N, K70R, M184V, T215TFIS, K219QV106M, Y181C, F227LK20R, V35T, T39E, E40D, V60I, T69N, K122E, D123N, I135R, F171Y, K173R, Q174K, V179I, T200A, I202V, Q207E, R211K, F214LC
 1997KC424233D4T, 3TCEFVM184V, T215FV106M, F227L, M230LV35T, T39E, S48T, E53D, K102R, K122E, D123S, I135T, S162C, K173A, D177E, G196K, T200A, Q207E, R211K, E224D, L228R, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, G335D, Q343KC
 552161KC423268D4T, 3TCEFVM184VV106M, F227LV35T, T39E, S48T, T58S, W88C, K122E, K173I, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248DC
 268389KC424032D4T, 3TCEFVK70KR, M184VK101KE, V106M, F227LT27S, V35T, E36A, T39E, S48T, K122E, I135T, S162SC, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, D250EC
 9671259KC423007D4T, 3TCEFVM184VK101E, V106M, G190A, F227LV35T, E36A, T39E, S48T, V60I, K64R, S105AV, K122E, D123N, K173A, Q174K, D177E, T200A, K201R, Q207E, R211K, V245QC
 13681205KC422959AZT, D4T, 3TCNVP, EFVD67N, K70R, M184V, K219EK101KDEN, V106M, Y181C, F227LV35T, E36A, T39E, S48T, K49R, K122E, D123G, T139A, K173N, T200A, I202V, Q207E, R211K, L228H, I244V, V245QC
  1836KC423449AZT, D4T, 3TC, TDFNVP, EFVD67N, K70R, M184V, K219EK101N, V106M, Y181C, F227LV35T, E36A, T39E, S48T, K49R, K122E, D123G, T139A, K173N, T200A, I202V, Q207E, R211K, F214FL, L228H, I244V, V245QC
 4541641KC423291AZT, D4T, 3TC, ABCNVP, EFVL74I, M184VV106M, G190A, F227LV35T, T39E, S48T, D121H, K122E, I135T, S162C, K173T, Q174K, D177E, I178L, T200A, E204D, Q207A, R211K, V245QC
 1711345KC423077D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, K122E, I135T, K173T, D177E, T200A, Q207E, R211K, F214L, V245QC
 6671893KC423492TDF, 3TCEFVK65R, V75M, M184VV106M, V179D, F227LK20R, V35T, T39E, S68N, K122E, D123N, A158S, K173T, G196K, T200A, Q207K, R211Q, V245QC
 16102714KC423796D4T, 3TCEFVM41L, K70R, M184VV106M, V179D, F227LV35T, T39K, K43E, V60I, K64R, I135T, K173A, D177E, T200A, Q207K, R211Q, V245QC
 7921558KC423230D4T, 3TCEFVM184V, K219RV106M, F227LV35T, T39E, S48T, K122E, D123N, I135M, K173T, Q174K, D177E, T200A, I202V, Q207A, R211K, L228R, V245Q, E248XC
 15723063KC423950TDF, 3TCEFVM184VV106M, V179D, F227LE6EK, V35T, T39E, S48T, E53D, V60I, W88C, K102R, K103R, V118I, K122E, E138A, T139A, M164L, K173A, Q174K, D177E, T200A, I202V, Q207E, H208L, R211Q, F214L, V245QC
 18202449KC423716TDF, 3TCEFVM41L, K65R, V75I, F116Y, Q151M, M184V, T215YV108VI, G190A, F227LV35T, T39E, V60I, S68G, K103KR, K122E, D123S, I132L, K173A, Q174K, N175Y, D177E, T200E, Q207E, R211RK, F214L, H221Y, K238R, V245QC
 7841212KC422964D4T, 3TCEFVM184VA98G, V106M, Y181C, F227LV35T, T39V, K122E, D123G, K166R, K173T, Q174K, D177E, T200A, I202V, Q207E, R211RK, F214L, V245HC
 10401378KC423105ABC, 3TCEFVL74V, Y115F, M184VK101E, V106M, G190A, F227LK20R, V35T, E36A, T39E, S48T, L109I, K122E, T165I, K173A, Q174K, D177E, G196K, T200E, I202V, Q207AV, R211E, V245Q, K259RC
 1041230KC422980D4T, 3TCEFVK70KN, M184V, K219RV106M, V179D, F227LI2IV, P4H, V35T, E36EA, T39E, E40D, S48T, K103R, V118I, K122E, D123N, T200A, Q207E, F214L, V245Q, E248D, D250DEC
 18103042KC423941TDF, 3TCEFVK70KQ, M184V, K219RV106M, G190A, F227LV35R, T39D, S48T, W88C, K122E, D123N, I135T, I142IL, K173A, Q174K, V179I, V189I, Q197E, T200A, I202V, Q207A, R211K, F214L, V245QC
 16861793KC423413D4T, 3TCEFVM184V, T215FV106M, F227LK32R, V35M, T39E, K122E, D123S, I132L, S162C, K173A, Q174K, D177E, T200A, Q207D, R211K, K223KQ, L228R, V245QC
 5001171KC422934D4T, 3TCEFVM184VV106M, F227LK20R, V35T, E36A, T39D, S48T, V60I, V90I, K122E, D123S, T139TK, S162A, K173A, Q174K, D177E, T200A, Q207E, V245QC
 1825372KC424017AZT, 3TCEFVM184V, T215YV106M, F227L, M230LV35T, T39E, S48T, K102KR, K122E, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, L228H, V245QC
 5252132KC423642D4T, 3TCEFVD67N, K70R, M184V, K219EK101E, V106M, G190A, F227LK20KR, E28K, K32E, V35K, E36A, T39E, S48T, V60I, W88C, K122E, D123G, K173T, Q174K, I195L, T200A, Q207E, R211K, V245KC
 684734KC424253D4T, 3TCNVPD67N, M184VK101E, V106M, F227LK20R, V35T, T39EG, S48ST, V60I, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245QC
 15662041KC423582AZT, 3TCNVPM184VK103N, F227L, M230LV35T, E36A, T39E, S48T, V60I, K173A, Q174K, D177E, G196E, T200A, Q207D, R211K, H221Y, V245QC
 321456KC424069D4T, 3TCEFVM184VK101E, V106M, F227LP4S, V35T, E36A, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, Q207R, R211A, V245QC
 13501515KC423199TDF, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, S162A, K166R, K173A, Q174K, D177E, T200A, I202V, Q207E, L210LF, R211K, V245Q, D250EC
 4181496KC423186AZT, D4T, 3TC, TDFNVP, EFVK65R, K70KE, Y115F, M184MIK101E, V106M, Y181C, F227LV35T, E36A, T39E, S48T, V90VI, K122E, D123S, T165I, Q174K, Q197P, T200A, Q207E, R211K, H221HY, V245QC
 1751265KC423013TDF, 3TCEFVA62V, M184VV106M, V179E, F227LT27S, I31R, V35I, K122E, K173A, D177E, I178L, I180L, T200A, Q207D, R211K, V245QC
 13971365KC423095D4T, 3TCEFVD67DN, M184V, K219KEV106M, V179D, F227LP4S, V21VI, V35T, E36A, T39E, S48T, W88C, K103R, K122E, K173T, Q174K, D177E, T200E, I202V, Q207R, R211K, V245K, D250EC
 961868KC424324D4T, 3TCEFVD67N, M184VV106M, V179D, F227LK20R, T27TS, K32R, V35T, T39K, K43E, S48T, V60I, K102Q, K122E, D123N, K173A, T200A, Q207S, R211K, K223KQ, V245KC
 1085246KC423724D4T, 3TCEFVA62AV, M184VV106M, Y181C, F227LV35T, E36A, T39D, S48T, T58S, D121DN, K122E, D123N, I135M, S162A, E169K, K173T, T200A, Q207E, R211K, H221HY, L228R, D250XC
 1149975KC424408D4T, 3TCEFVM184VV106M, G190A, F227LM16MT, V35T, T39E, S48T, K122KE, D123N, K173I, Q174K, D177E, T200A, Q207E, R211K, V245N, E248D, D250EC
  3001KC423926D4T, 3TC, ABCEFVL74V, M184VV106M, V179D, G190A, F227LV35T, T39E, S48T, K122E, D123N, K173I, Q174K, D177E, T200A, Q207E, R211K, V245N, E248N, D250EC
 4021000KC422794D4T, 3TCEFVM41MLV106M, G190A, F227LK20KR, V35T, T39E, S48T, V60I, S68SG, K101Q, S105V, K122E, D123N, I135K, K173T, Q174K, D177E, I178L, V179I, T200A, Q207E, H221Y, P243S, V245E, D250EC
Grossman (2014)609609 ABC, DDINVPM41L, D67N, L74V, M184V, L210W, T215Y, K219NA98G, V106M, Y181C, F227LT39E, K43Q, E44D, V118I, K122E, D123S, I142V, K173A, Q174K, D177E, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
  609 ABC, DDI, AZT, 3TCNVPM41L, D67N, L74LI, M184V, L210SW, T215Y, K219NA98G, V106M, G190A, F227LT39K, K43R, E44D, K64KR, V118VI, K122E, D123S, I142V, K173A, Q174K, D177E, T200A, I202IV, E203K, Q207E, H208Y, R211K, K223E, V245QC
Steegen (2014)11ZAKS16311ZAKS163KJ176445D4T, 3TCEFV, NVPM184V, T215FV106M, Y181C, F227LV21I, K32R, V35T, T39E, S48T, K101I, K122E, T165L, K173A, D177E, T200A, I202V, E204K, Q207E, V245Q, A272P, K277T, T286A, E291D, V292I, I293V, D324E, Q334N, G335DC
 12ZAKS29712ZAKS297KJ176576D4T, 3TCEFVM184VV106M, F227LV35T, E36A, T39E, S48T, V60I, K122E, I132V, K173A, Q174K, D177E, T200A, Q207E, H221Y, K238R, V245E, A272S, T286A, E291D, V292I, E297K, K311R, V314A, D324E, Q334D, G335D, R356K, M357R, G359T, A371V, T377L, K390R, A400I, E404DC
 11ZAKS09511ZAKS095KJ176377D4T, 3TCNVPM41L, A62V, V75I, F116Y, Q151M, M184VV106M, G190A, F227LV35T, T39E, S68G, T69I, K102E, K122E, K173T, D177E, I178L, V179I, T200A, I202V, Q207DE, R211RK, F214L, V245K, A272P, R284K, T286A, E291D, V292I, I293V, E297K, Q334D, G335D, R356K, M357R, G359T, V365I, K366R, T377M, K385KR, K390R, A400T, E404D, I434M, V435TC
 11ZAKS09811ZAKS098KJ176380ABC, 3TC, D4TEFVK65KR, L74LV, V75VIM, M184VV106M, F227LT7TA, M16MV, V35T, E36A, T39E, K64R, K102Q, A158S, S162C, K173A, Q174K, D177E, I178L, T200A, K201KR, E203K, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, N348H, R356K, G359CST, E370A, T386V, K390R, A400T, E404D, V435AC
 10ZAKS04710ZAKS047KJ176329D4T, 3TCEFVM41L, D67N, M184V, T215FV106M, V179E, G190GA, F227LK20KR, V35T, T39E, S48T, V60I, L109I, K122E, T139K, I142V, K173E, Q174R, D177G, T200E, E203EK, Q207E, H208Y, R211K, K223KHNQ, V245Q, A272P, E291D, V292I, I293VC
 09ZAKS01009ZAKS010KJ176294D4T, 3TCEFVM41ML, L74LV, M184V, K219KEK103KN, V106M, V179VD, F227LK20R, V35T, E36EA, T39AE, S48T, V60I, D123E, I135IV, I142V, K173A, Q174K, D177E, T200A, Q207A, R211K, F214FL, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, L301F, I329L, Q334D, G335DC
 11ZAKS18211ZAKS182KJ176463D4T, 3TCEFVM184V, T215FV106M, V108VI, F227L, M230LV35T, T39E, S48T, E53ED, V60I, A98AS, D121Y, K122E, K173A, D177E, T200A, Q207E, R211K, L228R, V245Q, T286A, E291D, V292I, I293V, P321S, D324E, G335DC
 10ZAKS03510ZAKS035KJ176317D4T, 3TCEFVM184VV106M, Y188F, F227L, M230LV8I, T27S, V35T, T39E, K122E, D123G, I135IV, S162CG, K173T, Q174K, D177E, T200A, Q207E, R211K, D218DE, L228LR, V245Q, A272G, T286A, E291D, V292I, I293VC
 12ZAKS21212ZAKS212KJ176492D4T, 3TCEFVM184VV106M, G190A, F227LV35T, E36A, T39E, S48T, K122E, D123N, S162C, K173T, Q174R, D177E, T200A, Q207D, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, A288S, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359T, T369A, E370A, T377R, S379C, K390R, T397A, A400T, E404D, V435IC
 10ZAKS05110ZAKS051KJ176333ABC, 3TC, D4TEFVL74V, M184V, T215F, K219QV106M, G190A, F227L, M230LV35T, E36A, T39E, K122E, D123DN, I135T, S162C, K173T, D177E, T200A, R211K, L228LHQ, V245E, E248D, A272P, T286V, E291D, V292I, I293VC
 12ZAKS25912ZAKS259KJ176538D4T, 3TCEFVA62V, M184VV106M, G190A, F227LP4T, E6A, V35T, T39E, K122E, I135T, S162C, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K275Q, K277R, E291D, V292I, I293V, D324E, Q334N, G335DC
 11ZAKS18711ZAKS187KJ176468ABC, 3TCEFVA62V, K65R, M184VV106M, Y181C, F227LP4S, K32E, V35K, E36A, T39E, S48T, W88S, K102R, K122E, D123S, I135R, A158S, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, V292I, I293V, Q334H, G335DC
 09ZAKS02009ZAKS020KJ176302D4T, 3TCEFVK70R, M184V, K219QV106M, V179D, F227L, M230LV35T, E36A, T39E, S48T, V60I, T69N, K122E, D123G, K173A, D177G, T200A, Q207E, F214L, L228R, V245K, A272P, K277R, T286A, E291D, V292I, I293VC
 12ZAKS22812ZAKS228KJ176508D4T, 3TCEFVD67DN, K70R, M184V, K219QV106M, V179D, F227LP4S, V35T, T39E, S48T, V60VI, K122E, D123N, I135IT, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, E291D, Q334N, G335DC
 12ZAKS34412ZAKS344KJ176623D4T, 3TCEFVM184VV106M, E138K, F227LV35T, T39E, S48T, D121H, K122E, K173A, D177E, I178L, Q197K, T200A, Q207D, R211K, V245T, E248D, A272P, V292I, I293V, P294T, E297K, E308K, K323RC
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