<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 17
Patients 68
Isolates 72
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1447UK1447AY901338AZT, 3TC, ABC, DDIEFVM41ML, M184V, T215Y, K219RK103N, P225HV35T, T39E, S48T, K122E, D123S, I135L, K173T, Q174K, T200A, Q207E, R211RK, L228RC
 UK1447bUK1447b AZT, 3TC, ABC, DDIEFVM41L, M184V, T215Y, K219RK103NS, P225HV35T, T39E, S48T, V118VI, K122E, D123S, I135L, K173T, Q174K, T200A, Q207E, R211K, L228HRC
 UK4758UK4758AY901816D4T, 3TC, AZTEFVM184VK103N, P225HE6EK, K20KR, V21I, V35T, E36A, T39E, E40D, S48T, E53ED, W88C, V90VI, D121Y, K122E, S162Y, K173A, D177E, I195L, T200A, Q207D, R211KC
Doualla-Bell (2006)Pt13FDB_Pt13EF434893D4T, DDI, AZT, 3TCEFVK65R, K70R, V75A, F77L, Y115F, F116Y, Q151M, K219EK103N, V106M, P225HV35T, E36A, T39E, T58N, S68G, K122E, D123S, R172K, K173T, D177E, I178M, T200A, Q207K, R211K, V245Q, E248D, A272P, K277R, E291D, V292IC
Marconi (2008)SW015sw015EU308032D4T, DDI, AZT, 3TCNVP, EFVM184VA98G, K103N, P225HS48T, V60I, K122E, D123G, I135L, K173A, Q174K, T200A, Q207A, R211K, V245QC
 SW025sw025EU308038D4T, AZT, 3TCNVPM184VK103N, P225HS48T, V60I, D121Y, K122E, I135R, S162A, K173A, D177E, T200A, Q207D, R211K, V245QC
 SW027sw027EU308040D4T, 3TCEFVM184VK101KDEN, K103N, P225HS48T, V60VI, K122E, I135K, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 SW030sw030EU308043D4T, 3TCEFVD67DN, K70KR, L74I, V75IT, M184V, K219EA98AG, L100I, K103N, P225HS48T, V60I, K122E, D123N, I135IMT, K173A, D177E, G196K, T200A, Q207E, R211K, V245QC
 SW054sw054EU308065D4T, 3TCEFVM41ML, M184V, T215YA98G, K103N, P225HS48T, K49KI, V60VI, S68SG, K101KQ, I135L, K173A, D177E, I178M, T200A, E203ED, Q207A, H208HY, R211K, H221HY, V245QC
 SW058sw058EU308069D4T, 3TCEFVM184VA98AG, K103N, P225HS48T, V60I, K122E, D123G, I135L, K173A, T200A, Q207E, R211K, V245QC
 SW092SW092EU308101D4T, 3TCEFVV75T, M184VA98G, K103N, P225HS48T, V60I, K122E, D123S, I135L, E138A, K173A, D177E, T200A, R211K, Q242QHR, V245QC
Pillay (2008)DR8003ZA.DR80AY589924AZT, D4T, 3TC, DDIEFV, NVP K103N, P225HV35T, T39E, S48T, K122E, D123G, K173A, Q174R, D177E, T200A, Q207A, L210F, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 DR9403ZA.DR94AY589933AZT, 3TCEFVM184VK103N, P225HI31L, V35T, E36A, T39D, S48T, K122E, I135L, E138D, I142V, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K275Q, K277R, Q278N, T286A, E291D, V292I, I293V, E297AC
Deshpande (2009)Pat17199RTFJ530770AZT, 3TC, D4TEFVM184VK103N, P225HV35T, E36A, T39D, S48T, V60I, D121Y, K122E, D123E, K173A, Q174R, D177E, T200A, Q207G, R211K, V245Q, K249NC
 Pat130200RTFJ530811NRTINNRTIM184VK103N, P225HK20R, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, I135T, S162A, K173A, D177G, T200A, Q207E, V245QC
 Pat114231RTFJ530827D4T, 3TCEFVD67N, L74V, M184MV, K219RK103N, P225H, L234I, K238TK20R, V35T, T39D, S48T, N54NI, D121Y, K122E, K173A, Q174K, D177E, I178L, E194AP, T200A, Q207E, R211K, V245QC
 Pat037344FJ530904AZT, 3TCNVPV75I, M184VK103N, P225HV35T, T39N, V60I, K101R, K122E, D123S, I132L, K173A, Q174K, D177G, T200E, Q207E, R211K, L228LIPT, V245EC
 Pat027372rtFJ530914AZT, D4TEFVD67DN, K70R, M184V, T215TN, K219EK103N, P225HV35T, E36A, T39D, S48T, V60I, D121Y, K122E, S162A, K173T, D177E, T200A, Q207A, R211K, V245QC
 Pat016420rtFJ530925AZT, D4TNVPM41L, M184V, T215TNSYK103N, P225HK20R, V35T, E36A, T39E, S48T, V60I, K101KR, D121Y, K122E, K166R, K173A, D177E, T200A, Q207E, R211K, V245QC
 Pat008439RTFJ530933AZT, 3TCEFVM184VY188L, P225HV35T, E36EA, T39D, V60I, D121H, K122E, K166R, K173A, D177E, I195IL, T200A, Q207E, R211K, F214FL, V245QC
 Pat003VR011RTFJ530938AZT, 3TCEFVD67N, K70R, M184V, T215V, K219QK103N, G190A, P225HK20R, V35T, E36A, T39DN, K46Q, S48T, V60I, T69N, K102KN, K122E, D123S, K173T, Q174K, D177E, I178M, T200E, L228H, V245QC
Hoffmann (2009)pat058MD63316 AZT, 3TCEFV K103N, P225HV35T, E36A, T39E, S48T, K122E, D123N, A158S, K173A, D177E, T200A, Q207E, R211K, V245L, A272PC
 pat036MD124917 AZT, 3TCEFVM41L, M184V, T215YA98G, K103N, P225HV35T, T39E, S48T, V60I, K122E, D123S, I135L, K173T, T200A, Q207A, R211K, V245Q, A272PC
  MD24460 AZT, 3TCEFVM184V, T215TNSYK103N, P225HV35T, T39E, S48T, V60I, K122E, D123S, I135ILM, K173T, T200A, Q207A, R211K, V245Q, A272PC
  MD84512 AZT, 3TCEFVM41L, M184V, T215YK103N, P225HV35T, T39E, S48T, V60I, K122E, D123S, I135L, K173T, T200A, Q207A, R211K, V245Q, A272PC
 pat002MD12728 AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, V60I, A98AS, K122E, D123G, I135T, K173KE, D177E, E194Q, G196E, T200A, Q207E, R211K, V245Q, D250DE, N255NH, A272PC
 pat035MD39129 AZT, 3TCEFV K103N, V108I, P225HV35T, E36A, T39E, E40D, V60I, K122E, D123G, S162N, M164T, K173A, Q174N, D177E, T200A, Q207E, H221Y, V245Q, A272PC
 pat070MD63317 AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, A98S, K122E, D123G, K173A, D177E, T200A, Q207K, V245Q, Y271F, A272PC
 pat050MD59449 AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, E40D, S48T, K122E, D123G, I135L, K173T, Q174K, T200A, Q207A, R211K, V245QC
 pat056MD73022 AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, A98S, K122E, D123G, I135L, T165I, K173A, D177E, I178IL, T200A, Q207E, V245Q, A272PC
Hosseinipour (2009)93699369GQ228358D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K101E, G190A, P225HT39E, S48T, I94IL, K103R, K122E, D123N, K173T, Q174K, D177E, I195IM, T200A, Q207D, R211K, F214L, V245QC
Jones (2009)176988176988FJ659847NRTINNRTIM184VK103N, P225HV35T, E36A, T39E, S48T, T69TP, K122E, D123N, I135M, K173T, D177E, T200A, Q207A, R211K, V245Q, T253TA, A272P, K277R, E291D, V292I, I293V, G335D, R356K, G359T, K366R, T377Q, G384GEC
Orrell (2009)MD100816MD1008162005 D4T, 3TCEFVM184VK103N, P225H, M230LT39E, S48T, V60I, S68G, T69K, K122E, D123N, K173A, D177E, I178L, T200A, Q207D, R211K, V245QC
Wallis (2009)TJC2455335TJC2455335 D4T, 3TCEFVK65R, V75A, F77L, F116Y, Q151MG190E, P225HK20R, V35T, T39E, S48T, S68G, T69TI, K73M, W88S, K101R, K122E, E138A, P157A, R172K, K173A, V179G, T200A, Q207E, F214L, V245Q, A272P, T286A, V292I, I293VC
 ReA2GT02 D4T, 3TCEFVF116Y, Q151M, M184VK103N, P225HV35T, E36A, T39E, A158S, K173A, Q174K, D177E, I178L, V245Q, D250E, A272P, K277R, T286A, V292I, I293V, I329LC
 GT00153387GT00153387 AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, K122E, D123S, I135T, S162C, K173A, D177E, G196E, Q197K, T200A, Q207E, R211K, F214FL, V245K, A272P, K277R, Q278QH, E291D, V292I, I293V, I309IV, Q330QL, Q332QPC
 TJC2371553TJC2371553 D4T, 3TCEFVF116Y, Q151M, M184VK103N, P225HV8I, V35T, E36A, T39E, S48T, V60I, S68G, K122E, D123G, K173A, Q174K, D177E, I178IM, G196E, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, D324EC
 23617932361793 D4T, 3TCEFVL74V, M184VK103N, P225HV35K, T39E, S48T, K102R, D121Y, K122E, I135M, S162C, K173A, Q174R, D177E, T200A, Q207AE, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, E308K, I309FC
 TJC2475972TJC2475972 D4T, 3TCEFVL74LIK103N, V108I, P225HK22R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, D177E, I178L, Q197E, T200A, Q207D, R211K, V245Q, A272P, K281R, T286A, E291D, V292IC
 TJC2413549TJC2413549 D4T, 3TCEFVM184VK101E, V179DE, G190A, P225HE28EGKR, V35M, E36A, T39E, E40D, S48T, K103R, K122E, D123S, E138N, S162C, K173T, T200A, Q207D, R211K, V245Q, D250DE, A272P, Q278CNSY, K281R, E291D, V292I, I293V, L310CF, Q334NC
 GP00004082GP00004082 D4T, 3TCNVPM184VA98AG, K103N, P225HV8I, K20KR, V35T, E36EA, T39E, S48T, D121H, K122E, D123DN, I135L, K173A, D177E, T200A, Q207D, R211K, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, P294TC
 22816742281674 D4T, 3TCEFVM184VK103N, P225HK20R, V35T, T39D, S48T, V60I, K122E, D123N, A158S, S162A, K173A, Q174K, D177E, T200A, Q207T, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, Q334EC
 TJC2387448TJC2387448 D4T, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, K104KR, K122E, S162C, E169D, K173A, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K275KQ, E291D, V292IC
 TJC2387636TJC2387636 D4T, 3TCEFVM184VK103N, V108VI, P225HV35T, T39DN, S48T, K122E, D123NS, I135V, T139TS, K173V, T200A, E203ED, Q207K, R211K, V245Q, A272P, E291D, V292I, I293V, S322T, D324E, I329LC
El-Khatib (2010)Pat01510ZA_SAVE1193HQ012293AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EK103N, P225HK22R, V35T, E36A, T39E, S48T, E53D, V118VI, K122E, D123S, I135T, K173T, Q174K, G196E, T200A, Q207E, R211K, F214L, V245Q, E248VC
 Pat02910ZA_SAVE1434HQ012307D4T, 3TCEFVM184I, T215I, K219RK103N, Y181YC, P225HK20R, K22R, V35T, E36A, T39E, W88C, V90I, K122E, D123G, I135T, S162Y, K173A, Q174K, N175Y, D177E, T200A, Q207E, R211K, F214L, V245Q, D250EC
 Pat04010ZA_SAVE2160HQ012318D4T, 3TCEFVM184VK103N, P225HV35T, E36A, T39D, S48T, K102K*RW, K122E, D123G, I135IT, K173A, T200A, Q207E, V245Q, I257LC
 Pat04610ZA_SAVE2237HQ012324D4T, 3TCEFVM184V, T215FK101H, V106M, P225H, M230LV35T, T39E, K122E, T139A, K173A, Q174K, D177E, E203D, Q207E, R211K, V245K, D250EC
 Pat06210ZA_SAVE2377HQ012340AZT, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, V60I, K122E, D123S, I135M, K173A, D177E, G196E, T200A, Q207E, V245E, S251DC
 Pat07110ZA_SAVE2452HQ012349D4T, 3TCEFVM184VK103N, P225HK20R, E28EQ, V35T, T39E, S48T, K122E, I135L, E138A, K173A, T200A, E204K, Q207E, R211K, F214L, V245Q, E248DC
 Pat09611ZA_SAVE2019JF960546NRTI, AZT, DDINNRTI K103N, P225HP4S, K11KT, K20KR, V35T, T39E, S48T, V60VI, K122E, D123S, E138G, T139TS, A158S, K173A, Q174QK, D177E, G196GE, T200A, Q207E, R211RK, V245Q, A272PC
 Pat09811ZA_SAVE2040JF960548NRTI, AZT, DDINNRTIM184IK103N, P225H, M230LV35T, E36A, T39D, S48T, K122E, E138A, I142V, S162A, K173T, T200A, Q207K, R211Q, F214L, D250E, A272P, K277RC
 Pat11611ZA_SAVE2358JF960566NRTI, AZT, DDINNRTIM184MVK103N, P225HV35T, T39E, S48T, V60I, K122E, D123G, E138A, K173A, Q174K, T200A, Q207E, R211K, V245Q, A272PC
Rodrigues (2010)346_07BR07SC346GQ401328AZT, 3TCEFVM184VK103N, P225HV35K, E36A, T39D, K43R, S48E, V90I, K101Q, K104R, S162A, D177E, T200A, Q207E, R211KC
Green (2011)707PKE23F707PKE23FHM623512D4T, 3TCEFVM184VK103N, P225HV8I, V35T, T39N, S48T, V60I, K101Q, K122E, I135T, E138A, K173A, Q174K, G196E, T200A, I202IV, Q207E, R211K, F214L, L228LI, V245Q, E248ED, A272P, E291D, V292I, I293V, K311RC
 707PKE37F707PKE37FHM623524D4T, 3TCEFVM41L, V75I, M184V, L210W, T215YK103N, P225HK20R, V35T, E36EA, T39E, V60I, W88C, I132L, K173A, D177E, G196T, T200A, Q207E, R211K, T240TK, V245Q, D250E, K277R, T286A, E291D, V292I, I293V, D324EC
Sigaloff (2011)GP00022848GP00022848_1JN381557D4T, 3TCEFVM184VK103N, P225HV35T, T39E, S48T, V60I, K122E, D123S, I135L, E138Q, K173A, Q174K, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293VC
  GP00022848_2JN381558D4T, 3TCEFVM184VK103N, P225HP14PT, M16MK, D17DY, G18GA, V35T, T39E, S48T, V60I, K122E, D123S, I135L, E138Q, K173A, Q174K, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293VC
 GP25416072GP25416072_2JN381562D4T, 3TCEFVL74LI, M184VK103N, P225HV35T, T39E, K102Q, K122E, D123S, I135R, S162C, K173T, D177E, T200A, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
van Zyl (2011)A106A106JN638069D4T, 3TCEFVM184VK103N, V108I, P225HK20KR, V35T, E36A, T39D, S48T, E53D, V60I, K102Q, K122E, D123G, K173A, Q174K, D177E, V189I, Q197E, T200A, Q207E, V245QC
 A173A173JN638102D4T, 3TCEFVM184IK103N, P225HK20R, V35T, T39E, S48T, V90VI, K122E, D123S, I135T, T165I, K173A, D177E, Q197P, T200A, Q207E, R211K, V245LC
 A175A175JN638103D4T, 3TCEFVM184VK103N, P225HK20R, V35T, T39E, S48T, V60VI, D121H, K122E, I135T, S162C, K173A, Q174K, D177E, I178L, T200A, E204D, Q207D, R211K, V241M, V245QC
 A190A190JN638111D4T, 3TCEFVM184VK103N, P225HK32R, V35T, T39E, S48T, V60I, K122E, D123N, I135T, K173A, Q174K, D177E, T200E, Q207E, R211K, V245QC
 A21A21JN638125D4T, 3TCEFVM184VK103N, V108I, P225HK20R, V35T, T39EK, S48T, K122E, D123N, I135LV, K173A, D177E, I178M, T200A, Q207D, R211K, V245Q, E248TC
 A222A222JN638131D4T, 3TCEFVM184VK101KE, K103N, P225HE28EK, V35T, E36A, T39E, A98S, K122E, D123S, K173A, D177EG, T200A, Q207E, R211K, V245QC
 A321A321JN638193D4T, 3TCEFV K103N, P225HV35K, T39E, S48T, K122E, S162C, K173A, D177E, T200A, Q207G, R211K, V245QC
 A52A52JN638215D4T, 3TCEFVM184VK103N, P225HV35M, T39D, S48T, K122E, D123N, I132L, K166R, K173T, D177E, T200A, Q207E, R211K, K259XC
Brehm (2012)07ZA07ZA.48JN601906D4T, 3TCEFVM184VK103N, P225HV35T, T39A, S48T, K64R, K122E, S162C, K173A, N175H, D177E, T200A, K201T, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E344D, R356K, G359T, A376G, T377L, K390R, A400I, E404N, V435A, A437V, L452I, V466I, S468H, D471E, H483Q, L491S, S519N, Q520E, E529D, A534S, A554NC
 33ZA33ZA.96JN601965D4T, 3TCEFVM184VK101E, K103N, V108VI, P225HK20R, V35T, T39A, E40D, K122E, D123S, I135R, S162C, K173A, T200A, Q207A, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, E432D, V435A, A445G, E449D, V466I, V467I, T470P, D471EK, T477A, Q480H, H483Q, L491S, Q509QL, S519N, K527N, K530R, V531I, A534S, A554KC
 49ZA49ZA.108JN601999D4T, 3TCEFVM184VK103N, P225HI31L, V35T, E36A, T39E, S48T, K102KR, K122E, S162Y, K173A, Q174R, D177E, G196E, T200A, Q207E, R211K, L228R, V245Q, A272S, K281R, T286A, E291D, V292I, I293V, D324E, Q334D, G335D, Y342F, A355T, R356K, M357R, G359A, T377M, I382T, K390R, A400T, E404D, V435A, A437V, K454R, S468P, D471E, T477A, H483Q, V493A, A508AV, S519N, K527N, K530R, A534S, A554SC
 58ZA58ZA.39JN602018D4T, 3TCEFVM184VK103N, P225HV35K, E36A, T39E, S48T, V60I, I135M, S162C, T165L, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, G335D, R356K, M357K, R358K, G359S, A360AT, E370D, T377M, K390R, E399D, A400T, T403S, E404D, E432D, A437AV, R461K, H483K, L491A, K512N, S519N, K530R, A534S, A554SC
Jones (2012)176988176988JN670420NRTINNRTIM184VK103N, P225HV35T, E36A, T39E, S48T, T69TP, K122E, D123N, I135M, K173T, D177E, T200A, Q207A, R211K, V245Q, T253TA, A272P, K277R, E291D, V292I, I293V, G335D, R356K, G359T, K366R, T377Q, G384GE, K390R, E399EKC

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