<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 91
Isolates 94
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK4463UK4463AY901829AZT, 3TCNVPM184V, T215FY181CV8I, I31IL, K32R, L34LI, V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173T, T200A, Q207E, R211K, H221YC
 TK4011TK4011 DDC, AZT, D4T, 3TC, ABC, DDIEFVM41L, A62V, D67N, K70R, L74I, M184V, T215Y, K219EV106M, G190AP4S, T7P, V35T, E36A, T39D, E44D, K122E, D123E, S162Y, K173T, Q174K, N175Y, D177E, V179I, T200A, E203D, Q207E, H208Y, R211K, W212R, H221Y, L228H, V245Q, D250E, A272P, E291D, V292I, E297KC
Weber (2005)00M387800M3878AY677526D4T, 3TC, AZTNVPM184VK103N, Y181CE28K, K32E, V35T, E36A, T39E, K122E, D123N, K173T, Q174K, D177E, V179I, T200A, Q207D, R211K, H221Y, V245Q, D250E, A272P, K275R, Q278G, L283I, V292I, I293VC
 F61874F61874AY677536AZT, 3TC, ABC, DDINVPM41L, M184V, T215FY181CV35T, T39D, S48T, K49R, V60I, V118I, K122E, T139R, K173T, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, D250E, A272P, K277R, Q278N, T286A, E291D, V292I, I293VC
 30088793008879AY677610D4T, DDINVPD67N, T69D, K70R, K219QY181CT27S, V35T, T39E, S48T, V60I, D121H, K122E, I135IR, T139TP, K166R, K173T, D177E, T200A, I202V, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 33050743305074AY677616ABC, AZT, 3TCNVP Y181CV35M, E36A, T39E, S48T, Y56YS, I63IL, D110DE, D121DE, K122E, D123G, S162C, K173A, D177E, T200A, Q207E, R211K, H221Y, V245Q, K249R, A272P, K277R, T286A, E291D, V292I, I293V, K331KNC
Baxter (2006)48-41344134-30317DQ878365NRTINNRTIM41L, D67N, T69D, L210W, T215Y, K219RK101N, V108I, Y181C, G190AP4S, V35T, T39E, E44D, V118I, K122E, D123S, K173A, T200A, E203K, Q207E, H208Y, R211K, D218E, H221Y, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, A376S, T377M, T386I, K390RC
Doualla-Bell (2006)Pt1FDB_Pt1EF434884AZT, 3TC, D4T, DDINVP Y188LV35T, T39E, S48T, V60I, K122E, D123N, I135L, K173A, D177E, I178M, E194G, T200A, Q207D, R211K, H221Y, L228R, P243T, V245Q, E248T, A272P, E291D, V292I, I293VC
 Pt23FDB_Pt23EF434886AZT, 3TC, D4T, DDINVPM41L, D67N, T69D, V75T, T215YV108I, V179D, Y181CK20R, V35T, T39D, E44D, D121C, K122E, I135T, E138A, K173T, D177E, I178L, V189I, T200A, E203D, E204K, Q207D, R211K, H221Y, P243S, V245Q, A272P, E291D, V292I, I293VC
 Pt10FDB_Pt10EF434894D4T, DDINVPK65R, D67DGY181CT39E, E40K, E79ED, D86DG, K102KQ, K122E, T139TP, K173A, D177GR, T200A, Q207E, R211K, H221Y, L228LR, V245E, D250E, A272P, K277R, E291D, V292I, I293VC
 Pt21FDB_Pt21EF434900AZT, 3TC, D4T, DDINVPD67N, K70R, M184V, K219QA98G, Y181CV35T, T39AE, S48E, D123E, I135T, K173A, D177E, I178L, T200A, E203EK, Q207E, F214FL, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, N306NDC
Sen (2007)T102NPT102-PLEF186981D4T, 3TCNVPM184V, N348IV108VI, Y181CV35T, T39E, S48T, K49KR, V60I, D121Y, K122E, D123E, I135R, E169Q, K173E, Q174R, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, G335D, R356K, G359T, T377MR, K390R, A400TC
 T069NPT69-PLEF186987D4T, 3TCNVPL74I, M184VY181CV35T, E36A, T39E, S48T, V60I, K102Q, D121Y, K122E, I159V, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E432D, N447S, L452I, V466I, D471E, H483YC
Marconi (2008)SW012sw012EU308030AZT, 3TCEFVM184VK103N, V108IS48T, V60I, K122E, I135M, T165V, K173A, Q174D, D177E, T200I, Q207A, R211K, F214L, H221Y, V245QC
 SW024sw024EU308037AZT, 3TCNVPM184VA98G, Y181CS48T, K49R, V60I, K122E, D123S, I142R, K173A, Q174K, D177E, I178L, T200A, I202V, Q207E, R211S, F214L, H221Y, L228R, V245QC
 SW046sw046EU308059D4T, 3TCEFVM184VK103N, G190AE40D, S48T, V60I, K122E, D123G, T165I, K166R, K173A, Q174K, D177E, T200A, I202V, Q207A, R211K, F214L, K219T, H221Y, V245QC
Pillay (2008)DR2902ZA.DR29AY589886D4T, DDI, AZT, 3TCNVPD67N, K70R, K219QK103N, G190AV35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317AC
Deshpande (2009)Pat25701artFJ530684AZT, 3TCNVPM41L, D67N, Q151QL, M184V, T215YA98AG, K101KE, Y181C, G190AV35T, T39E, E44D, T69TN, S117SA, V118VI, K122E, D123S, S162AD, E169EA, K173A, D177E, T200A, E203D, Q207D, H208Y, R211K, W212MR, H221Y, V245Q, E248KC
 Pat22550artFJ530716AZT, 3TCNVPM41L, D67N, M184V, T215YA98AG, K101E, Y181C, G190AV35T, T39E, E44DY, S117SA, V118VI, K122E, D123S, Q145QL, S162AD, E169EA, K173A, D177E, T200A, E203D, Q207D, H208Y, R211K, W212R, H221Y, Y232YH, V245Q, E248KC
 Pat20331RTFJ530738AZT, 3TC, D4TNVPM41L, D67N, T69D, M184V, T215YA98G, K101E, Y181C, G190AV35T, T39E, E44Y, S117A, K122E, D123S, I132IT, S162A, P170PS, K173A, D177E, T200A, E203D, Q207D, H208Y, R211K, W212MR, H221Y, V245QC
 Pat17882RTFJ530763D4T, 3TC, AZTNVPM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44D, S48T, V60I, K102Q, V118I, D121Y, K122E, S162SDGN, K166R, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HR, V245QC
 Pat153155RTFJ530788D4T, 3TCNVPM184VK103N, Y181CK32E, V35T, E36A, T39D, S48T, V60I, V90I, D121Y, K122E, I135R, R143E, S162A, K173T, Q174K, D177E, I178L, T200A, Q207E, H221Y, V245QC
 Pat152162RTFJ530789NRTINNRTIM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44G, G45W, S48ST, V60I, K102Q, V118I, D121Y, K122E, S162DN, K166R, E169A, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HRC
 Pat145174RTFJ530796NRTINNRTIF116FY, Q151M, M184IV108I, Y181CV35T, T39D, S48T, V60I, V90I, D121Y, K122E, R143RW, S162C, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, H221Y, Q222QL, V245Q, K249MC
 Pat134195RTFJ530807NRTINNRTIM184MVK101E, Y181YC, G190GAV35T, T39N, V60I, V90VI, D121H, K122E, I135R, S162N, D177E, T200A, Q207A, R211K, H221Y, V245QC
 Pat133196RTFJ530808NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215YY181C, G190AK20R, V35T, T39D, E44D, V60I, D121Y, K122E, K173AT, D177E, I178L, G196E, T200A, E203KN, L205F, Q207E, H208Y, R211K, W212M, H221Y, T240D, V245QC
 Pat127206RTFJ530814NRTINNRTIM41L, T69D, M184V, T215YV108I, Y181C, M230LV35T, T39E, E44D, V60I, K102Q, V118I, D121Y, K122E, S162D, K166R, E169A, K173A, D177E, I178M, T200A, E203D, E204Q, L210S, R211Q, D218E, H221Y, L228HRC
 Pat117227RTFJ530824NRTINNRTIM41L, D67N, M184V, T215Y, K219NA98G, Y188LV35T, T39D, E44D, S48T, V60I, K102R, D121H, K122E, I142V, F160C, K173T, D177E, I178L, V179I, T200A, I202V, E203A, L205S, Q207E, H208Y, L210S, R211K, H221Y, V245Q, K249HC
 Pat115230RTFJ530826D4T, 3TCNVPM184VY181CV35K, T39D, S48T, D121H, K122E, I135T, K166R, K173T, D177E, I178M, V179I, T200A, Q207A, R211K, F214L, H221Y, V245E, K249NC
 Pat076289RTFJ530865D4T, 3TCNVPK65R, V75A, F77L, Q151M, M184VV108I, Y181CK20KR, E28EG, V35T, T39EG, S68G, K73M, D121H, K122E, K173T, Q174K, D177E, I178L, T200A, I202V, Q207E, R211K, H221Y, V245QC
 Pat073294RTFJ530868D4T, 3TCNVPM41L, A62V, D67N, V75I, F77L, Q151M, M184V, T215YY181CK20KR, V35T, T39D, E44D, V60VI, T69TN, V90I, D121Y, K122E, I135R, I142V, S162Y, K173A, Q174K, N175H, D177E, V179I, T200A, K201T, E203D, Q207E, R211K, F214L, H221Y, V245QC
 Pat071298RTFJ530870AZT, 3TCNVPM184VK103NK20R, L34I, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, I142K, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245QC
 Pat061325RTFJ530880NRTINNRTIM41L, D67N, L74LI, M184V, T215YK103N, V108IK20R, V35T, T39D, E44D, V60I, K102HQ, V118I, D121Y, K122E, T139R, S162A, K173A, D177E, I178F, T200A, E203D, Q207G, H208Y, L210S, R211K, H221Y, V245QC
 Pat031361RTFJ530910AZT, 3TCNVPM184VV108I, Y181CV35T, T39D, S48T, V60I, D121Y, K122E, D123E, I135R, S162A, K173T, D177E, T200A, E204ED, Q207E, R211K, F214L, H221Y, V245QC
 Pat017418rtFJ530924D4T, 3TCNVPM41L, D67N, M184V, T215YA98G, K101E, Y181V, G190AK32KQ, V35T, T39DN, S48T, V60I, D121Y, K122E, I135K, S162A, T165I, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, H221Y, V245QC
 Pat012426RTFJ530929NRTINNRTIM41L, D67N, K70KIM, M184V, T215FA98G, Y181C, G190AK20KR, V35T, T39DE, V60I, K102R, D121Y, K122E, K166R, K173T, D177E, T200A, E203D, Q207E, H208Y, R211K, H221Y, V245QC
 Pat002VR012RTFJ530939D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK32R, A33AV, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
Hawkins (2009)R115ZZR115FJ931311D4T, 3TCNVPQ151M, M184VA98G, Y181C, Y318FV35T, T39E, S48T, S68G, K122E, D123N, K173A, D177EG, V179VI, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292I, I293V, S322AC
Hoffmann (2009)pat033MD05508 AZT, 3TCEFVM184VK103NV35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, I135L, S162F, K173A, Q174E, D177E, T200A, Q207E, H221Y, V245K, A272PC
  MD11734 AZT, 3TCEFVM184VK103NV35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, I135L, S162F, K173A, Q174E, D177E, T200A, Q207E, H221Y, V245K, A272PC
  MD41024 AZT, 3TCEFVM184VK103NV35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, I135L, S162F, K173A, Q174E, D177E, T200A, Q207E, H221Y, V245K, A272PC
  MD12554 AZT, 3TCEFVM184VK103NV35T, E36A, T39E, S48T, E53D, V60I, K122E, D123G, I135L, S162F, K173A, Q174E, D177E, T200A, Q207E, H221Y, V245K, A272PC
 pat035MD39129 AZT, 3TCEFV K103N, V108I, P225HV35T, E36A, T39E, E40D, V60I, K122E, D123G, S162N, M164T, K173A, Q174N, D177E, T200A, Q207E, H221Y, V245Q, A272PC
Hosseinipour (2009)70547054GQ228295D4T, 3TCNVPM184VK103N, Y181CT39E, S48T, K122E, D123G, I142V, E169EA, K173A, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245QC
 73367336GQ228301D4T, 3TCNVPM41L, D67N, T69D, M184V, L210W, T215YA98G, V108VI, Y181CT39E, E44D, V118VI, K122E, D123N, S162C, K173T, Q174K, T200A, E203K, Q207E, R211K, H221Y, L228LH, V245MC
 89838983GQ228316D4T, 3TCNVPM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IT39E, E44D, S48T, S68SG, V118I, K122E, D123S, I135L, E138EG, I142T, K173AE, Q174R, D177E, I178M, G196D, T200A, E203K, Q207E, R211K, H221Y, V245QC
 93889388GQ228332D4T, 3TCNVPM41L, A62V, V75T, M184V, T215YV108I, Y181CT39E, L109LI, K122E, I135R, S163T, T165I, K173A, Q174K, D177E, G196GE, T200A, Q207E, R211K, H221Y, V245QC
 94349434GQ228340D4T, 3TCNVPD67N, M184V, T215YV108I, Y181CT39E, S48T, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207E, H221Y, V245QC
 94389438GQ228341D4T, 3TCNVPK65R, T69~, K70KN, K219RV108I, Y181CT39E, E40D, S48T, S68G, V90VI, K122E, D123N, K173A, Q174K, D177E, I178L, V179IT, T200A, K201KR, Q207E, R211K, H221Y, P243T, V245QC
 94579457GQ228343D4T, 3TCNVPD67N, M184V, L210W, T215YA98G, K101E, V108I, Y181CT39E, E44ED, S48T, K49R, V118VI, K122E, D123S, I135R, K173A, D177E, V179VI, T200A, E203K, Q207D, H208Y, R211K, H221Y, V245QC
 94589458GQ228344D4T, 3TCNVPD67S, T69G, K70E, V75M, M184V, T215YV108I, Y181CT39E, S48T, V118I, K122E, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, H221Y, V241M, V245QC
 93069306GQ228347D4T, 3TCNVPA62V, D67N, K70E, V75T, Q151M, M184VY181C, G190AT39E, E40K, S48T, K122E, I135M, A158S, T165I, K173A, D177E, Q182H, G196T, T200A, Q207E, R211K, F214L, H221Y, V245QC
 93479347GQ228353D4T, 3TCNVPM41ML, L74LV, M184V, T215YK103N, Y181CT39E, S48T, K122E, D123N, I135IT, K173AT, D177E, T200A, Q207E, R211K, H221Y, P243ST, V245KTC
 93559355GQ228354D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YV108I, Y181IE44D, S48T, V118I, K122E, D123S, I135L, S162D, K173A, D177E, V179I, G196E, T200AE, E203K, Q207E, H208Y, R211K, H221Y, V245QC
 93599359GQ228355D4T, 3TCNVPK65R, T69~, V75M, K219RV106M, Y181CT39E, S48T, E53D, K122E, D123G, P157A, K173A, D177E, T200A, Q207E, R211K, F214L, H221Y, V245QC
 94249424GQ228365D4T, 3TCNVPK65R, K70KR, V75I, F77FL, F116Y, Q151M, M184IY181CT39E, S48T, V60I, S68G, K122E, D123S, I132L, I135T, K173A, Q174K, D177E, I178M, T200A, E204D, R211K, H221Y, V245QC
 79347934GQ228375D4T, 3TCNVPM41L, D67N, M184V, T215Y, K219NY181C, G190AT39E, E44D, S48T, V118I, K122E, D123N, S162D, K173AT, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, H221Y, V245QC
 85038503GQ228377D4T, 3TCNVPK65R, T69~, K219RK101E, Y181C, G190AT39E, S48T, V60I, S68G, K122E, D123S, E138A, P157A, K173A, D177E, T200A, I202V, E204K, Q207A, L210S, R211K, F214L, H221Y, V245QC
 80808080GQ228383D4T, 3TCNVPM184V, T215FK103N, Y181CT39E, S48T, K122E, I135IT, K173A, D177E, T200A, I202V, Q207E, R211K, H221Y, V245KC
 82618261GQ228385D4T, 3TCNVPA62V, K65R, K70R, V75I, F116Y, Q151M, K219EV106M, Y188CT39E, S48T, S68G, A98S, K122E, T139TA, A158S, K173A, Q174K, D177E, I178M, G196T, T200A, I202V, Q207K, H208HY, H221Y, E224D, P243PT, V245QC
Kassaye (2009)TCDD-28TC28_2004FJ445727AZT, 3TC, D4T, TDFNVPD67N, K70R, T215F, K219QK101E, Y181C, G190AV35T, T39E, S48T, V60I, T69N, K122E, D123G, I135T, E138A, I167V, K173A, Q174K, N175Y, T200A, I202V, Q207A, H221YC
Rajesh (2009)F10TRCFRT10FJ5953583TC, DDINVPL74LV, M184VV108I, Y181CV35T, E36EA, T39E, S48T, V60I, T69TI, K102KQ, D121Y, K122E, I135IM, K173A, N175K, P176S, T200A, Q207E, R211K, H221Y, V245QC
 F11TRCFRT11FJ5953593TC, DDINVPL74LV, M184VV108I, Y181CK20R, K30KE, I31ILPT, V35T, E36EA, T39E, V60I, D121H, K122E, D123E, K173A, Q174R, D177E, I178L, T200A, Q207DE, R211K, F214L, H221Y, P243H, V245Q, E248A, D250EC
 F13TRCFRT13FJ5953613TC, DDINVPL74V, M184VV108I, Y181CV8I, V35Q, E36A, T39D, S48T, V60I, D121H, K122E, K166R, K173A, D177E, T200V, Q207A, R211K, H221Y, V245E, S251NC
Wallis (2009)GT00476328GT00476328 D4T, 3TCNVPA62V, D67N, K70E, V75T, M184VY181CV35T, E36A, T39E, E40K, S48T, K122E, D123N, I135R, K173A, Q174K, D177E, I178M, V179VI, G196K, T200A, E204D, Q207D, R211K, F214L, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 TJC2399847TJC2399847 AZT, 3TCNVPV75I, M184V, T215YY181CV35T, T39E, S48T, E53D, K122E, D123S, I132L, K173T, T200E, E204Q, Q207E, R211K, H221Y, V245Q, A272P, K277R, Q278H, T286A, E291D, V292I, I293V, I309IVC
 TJC2414872TJC2414872 D4T, 3TCEFVD67N, K70E, M184VV106M, F227LV35T, E36A, T39E, E40K, S48T, K122E, D123N, I135M, S162D, K173T, I178M, V179VI, T200A, E204K, Q207E, R211K, F214L, H221Y, V245L, A272P, K275Q, V276I, K281R, L283I, T286A, E291D, V292I, I293V, P294Q, L310I, Q334HC
 TJC2473907TJC2473907 D4T, 3TCEFVM41L, L74V, M184V, L210W, T215YK103N, V106M, M230LP4S, K20KR, V35T, T39E, E44D, S48ST, V60I, S68SG, L109LIM, V111VI, V118I, K122E, I135V, S162C, K173A, Q174K, D177E, I178L, T200A, E203D, Q207E, H208HY, R211K, H221Y, F227I, L228LI, V245Q, A272P, E291D, I293V, V317AC
 TJC2429706TJC2429706 D4T, 3TCEFVM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219EV106M, V179D, F227LV35T, E36A, T39E, V60I, K122E, D123G, I132V, K173T, D177E, I178L, T200A, E203EK, Q207D, R211K, H221Y, V245Q, K281R, L283I, T286A, E291D, V292I, I293VC
 22852092285209 D4T, 3TCEFVM184VK103N, Y181CP4S, V8I, V35T, T39E, S48T, V60I, K104R, D121Y, K122E, I132V, I135V, K173T, Q174K, T200A, Q207E, R211K, F214L, H221Y, V245Q, K281R, E291D, V292I, I293VC
 GT00011279GT00011279 D4T, 3TCEFVM184V, T215YA98G, K101E, Y181C, G190AI31L, V35R, E36A, T39DE, K122E, D123G, K173T, D177EG, I195L, T200A, Q207E, R211K, H221Y, V245E, A272P, K275R, K277R, Q278H, R284K, T286A, E291D, V292I, I293VC
Deshpande (2010)12IND42512IND425GU108151D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK20R, K32G, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
 22IND42922IND429GU108155D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YA98AG, K101E, V106VAMT, V108I, Y181IS, G190AK20R, V35T, T39D, E44D, K49R, V60I, I94L, V118I, K122E, D123S, I135T, S162A, T165L, K173A, D177E, V179I, V189VI, T200A, E203D, Q207E, R211K, H221Y, V245QC
 41IND44241IND442GU108168D4T, 3TCNVPM41L, L74V, M184V, T215YK103N, V108I, Y181VK20R, W24WG, V35T, T39N, S48T, V60I, L109I, K122E, D123N, I135T, K173T, D177E, T200A, I202V, Q207E, R211K, H221Y, V245KC
El-Khatib (2010)Pat01110ZA_SAVE1154HQ012289AZT, 3TCEFVM41L, D67DN, K70KR, M184V, T215YV106M, Y188LV35T, T39E, S48T, K122E, D123S, I135V, S162C, K173A, Q174K, T200A, Q207E, R211K, H221Y, Y232H, V245QC
 Pat01310ZA_SAVE1174HQ012291AZT, 3TCEFVM184VK103N, V108I, K238TK20R, V35T, E36A, T39D, S48T, K122E, D123G, I135T, S162A, K173T, Q174K, T200A, Q207E, H221Y, E224D, V245K, D250E, I257ILC
 Pat02210ZA_SAVE1362HQ012300AZT, 3TCEFVM184VK103N, V108IE6D, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I132V, T165V, K173A, Q174K, T200A, Q207E, R211K, F214FL, H221Y, V245QC
Towler (2010)6478326-PHM037895D4T, 3TCNVPA62V, M184VY181CP14L, K32E, V35T, E36A, T39K, K102R, I135R, K173T, D177E, T200A, I202V, Q207D, R211K, H221Y, V245E, D250E, A272P, I274V, Q278H, L282C, L283I, A288AT, I293V, K311RC
Green (2011)707PKE06F707PKE06FHM623498D4T, 3TCEFVD67N, T69TADN, K70R, M184V, K219QL100I, K103N, P225PHV35T, T39E, S48ST, V60I, K122E, I135IT, K173T, Q174K, D177E, T200A, Q207A, H221Y, V245Q, A272P, K277KR, T286A, A288AT, E291D, V292I, I293V, D324DEC
 707PKE35F707PKE35FHM623522D4T, 3TCEFVT69TADN, M184V, T215TIK101E, Y181C, G190SV8VA, E28K, V35T, T39E, W88WC, V118I, K122E, D123N, T165I, K166KR, K173A, Q174K, D177E, T200A, Q207E, L210LS, F214L, H221Y, V245Q, A272P, K275KQ, K281R, T286A, E291D, V292I, E297EK, Q334DC
van Zyl (2011)A159A159JN638092AZT, 3TCNVPM184VV108I, Y181CV35T, E36A, T39E, E40D, S48T, K122E, D123S, K166R, K173N, Q174K, D177N, G196E, T200A, Q207E, H221Y, V245QC
 A194A194JN638115D4T, 3TCEFV  V35T, E36A, T39E, S48T, V60I, K122E, D123S, E138A, A158S, K166R, K173A, Q174E, T200A, Q207E, R211K, F214L, H221Y, V245QC
 A195A195JN638116D4T, 3TCEFVM184VK103N, V108IV35T, E36A, T39E, S48T, V60I, K122E, D123G, S162C, K173T, D177E, I178L, Q197R, T200A, R211K, H221Y, V245QC
 A198A198JN638118D4T, 3TCNVPD67N, K70R, M184V, K219HQY181IV35T, E36A, T39E, S48T, V60I, K122E, D123G, I132V, I135IV, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, F214L, H221Y, V245QC
 A247A247JN638144AZT, 3TCEFVA62V, M184VK103KN, V106M, F227LV35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, V179I, G196E, T200A, E203D, E204K, Q207E, R211K, H221Y, L228R, V245QC
 A248A248JN638145D4T, 3TCEFVA62V, M184VK103N, M230LV35T, E36A, T39E, E53D, V60I, K102Q, K122E, D123N, I135V, E138S, T139A, K173L, Q174K, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250EC
 A275A275JN638166D4T, 3TCNVPM41L, M184V, T215YA98G, Y181CV35T, E36A, T39E, S48T, S68SG, K122E, D123N, I135T, K173A, Q174E, D177E, I195L, T200A, I202IV, Q207E, R211K, H221Y, V245QC
 A278A278JN638169AZT, 3TCNVP Y181CV35T, T39E, S48T, K64KR, K104KR, K122E, D123N, I135V, A158AS, S162T, K173T, D177E, G196A, T200A, Q207E, R211K, H221Y, L228LR, V245QC
 A286A286JN638176D4T, 3TCNVPM184VY181CL34I, V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, H221Y, V245QC
 A298A298JN638183D4T, 3TCNVPA62AV, M184IV108I, Y181CV35T, T39E, S162C, K173A, V179VI, T200A, Q207E, R211K, H221Y, L228R, V245Q, P247AC
Brehm (2012)31ZA31ZA.96JN601961D4T, 3TCNVPM184VV108I, Y181CV35T, E36A, T39E, S48T, K122E, D123G, K173A, D177E, T200V, Q207E, R211K, H221Y, V241VI, V245Q, K277R, T286A, I293V, Q334C, G335D, R356K, G359NT, V365VI, T377L, K390R, A400R, E404D, V435A, G436E, V466I, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, A534S, A554SC
 36ZA36ZA.120JN601971D4T, 3TCEFVM184VK103N, M230L, L234IV35T, T39E, S48T, D121H, K122E, D123S, I135V, E138EA, S162C, K173IR, Q174K, D177E, I178L, T200A, Q207E, H221Y, L228Q, V245Q, E248D, A272P, K275R, Q278H, L279M, T286A, E291D, V292I, I293V, P294T, Q334N, G335D, R356K, G359S, V365I, A371V, T377LM, K390R, A400T, V435P, A446S, L452V, R461RK, V467VI, S468T, D471E, T477AS, H483Q, L491S, E516D, S519N, K527N, K530R, V531I, A534S, A554NC
Luebbert (2012)LEU 010070101825 D4T, 3TCNVPM184VV108VI, Y181CK20KR, V35T, E36A, T39E, S48T, K122E, D123G, S134SN, I135V, T139A, I142IV, K173T, Q174K, N175NY, V179I, T200A, Q207E, R211K, H221Y, V245Q, T286A, E291D, V292I, E297A, A304EC
 LEU 010370101829 D4T, 3TCNVPM184VK103N, Y181CK20KR, V35T, T39E, K49KR, K122E, D123S, I142IV, Q145H, K173A, Q174K, V179I, T200A, Q207E, F214FL, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC

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