<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation G190S
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 43
Isolates 44
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK4700UK4700AY9018253TC, DDIEFVM184VK101KE, V106M, G190SV35T, T39E, V60VI, W88C, K122E, D123N, I135T, E138A, K173AT, Q174QK, T200A, E204EK, Q207QK, R211K, F214L, H221HYC
 TK3022TK3022 DDC, AZT, 3TC, D4TEFVD67N, K70R, M184V, K219EG190SK22KR, V35M, T39E, S48T, V90I, K101KQ, K122E, D123S, A158S, K173T, Q174K, D177E, I178L, V179VI, I195L, T200A, V245Q, S251I, A272P, K275R, L283I, E291D, V292I, I293VC
Weber (2005)M72003M72003AY677513AZT, 3TC, D4T, DDINVPD67N, K70R, K219EG190SW24WL, L26X, T27X, E28EA, K30X, V35T, E36A, T39E, S48T, K101KQ, K122E, I135V, K166R, K173T, D177E, T200A, E203K, Q207E, V245Q, D250E, A272P, V292I, I293V, E297EA, D324EC
 F26249F26249AY677547AZT, D4T, 3TC, ABCEFV K101E, Y181C, G190SV35T, T69N, K102Q, K122E, D123G, R172RI, K173T, Q174K, D177E, T200A, Q207E, D218DY, V245Q, E248ED, D250E, A272P, K277R, E291D, V292I, I293VC
Marconi (2008)SW097SW097EU308105D4T, 3TCEFVM184VK101N, G190SS48T, K122E, K173A, Q174K, I178L, G196T, Q197K, T200A, I202V, Q207E, V245QC
Deshpande (2009)Pat17786RTFJ530764D4T, 3TCNVPM184V, T215FA98G, K101E, G190SE28K, V35T, T39E, S48T, V60I, D121Y, K122E, I135L, Q151QH, K173T, D177E, T200A, Q207E, R211KC
Wallis (2009)TJC2436148TJC2436148 AZT, 3TCEFVM184V, T215TNSYG190S, M230MLV35T, T39EK, S48T, K122E, D123N, K173T, T200A, Q207E, R211K, L228LQ, V245K, E248D, D250E, A272P, K277R, Q278N, T286A, V292I, I293VC
 GT00470140GT00470140 D4T, 3TCEFVD67N, M184V, T215F, K219QK101E, G190SV35T, T39E, K122E, D123N, I135L, E138A, K173A, D177E, T200A, Q207D, R211K, V245Q, E248D, A272P, R284K, E291D, V292I, I293VC
 GP00005761GP00005761 AZT, 3TCEFVM41L, D67G, K70R, L74V, M184V, K219QK101P, G190SK20KR, V35T, T39E, S48T, V60I, S68G, K122E, D123GS, I135M, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, L228LH, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E308EK, I309IV, D324EC
 GT09066112GT09066112 D4T, 3TCEFVD67N, K70KR, M184V, T215Y, K219EG190SV35T, E36A, T39E, S48T, K101A, K122E, D123G, I135T, S162C, K173T, T200A, E203D, Q207N, R211K, V245Q, A272P, K277R, Q278C, T286A, E291D, V292I, I293V, Q334HC
 TJC2389178TJC2389178 AZT, 3TCEFVM184VK101H, G190SV8VA, G18X, V35T, E36A, T39E, S48T, K122E, D123G, E169EA, K173A, Q174K, D177E, V179VAIT, T200A, Q207E, R211K, V245Q, A272P, L279M, E291D, I293VC
Green (2011)707PKE35F707PKE35FHM623522D4T, 3TCEFVT69TADN, M184V, T215TIK101E, Y181C, G190SV8VA, E28K, V35T, T39E, W88WC, V118I, K122E, D123N, T165I, K166KR, K173A, Q174K, D177E, T200A, Q207E, L210LS, F214L, H221Y, V245Q, A272P, K275KQ, K281R, T286A, E291D, V292I, E297EK, Q334DC
 707PKE41F707PKE41FHM623528D4T, DDIEFVM41L, D67N, L210W, T215YA98G, G190S, K238TE6K, K20R, V35T, T39DE, V60I, V118I, K122E, D123G, K173A, D177E, V179I, T200A, Q207E, R211RK, V245K, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, D324E, I329LC
Brehm (2012)48ZA48ZA.36JN601997D4T, 3TCEFVM184VK103KN, V106VM, G190SV35T, T39K, S48T, V60I, K122E, D123S, I135T, T165I, K173A, Q174K, T200E, E203EK, Q207A, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357MR, G359S, T386V, K390R, A400T, E404D, V435A, E449ED, V466VI, D471E, Q480H, H483H*QY, L491S, L517LI, S519SN, Q520K, K527EGQR, K530R, A534S, A554NSC
Kouri (2012)CU1913-09CU1913-09JQ585321NRTINNRTID67N, K70R, M184V, T215F, K219EK101H, Y181C, G190SV35T, E36A, T39D, V60I, K122E, D123G, Q174K, D177E, T200A, E203D, Q207KR, R211Q, L228H, V245Q, A272P, K277R, K281R, E291D, V292IC
Manasa (2013)RES453RES453KC951845TDF, 3TCEFVA62V, K65R, L74I, M184VK103N, G190SK20R, V35K, T39E, K122E, D123S, T139A, S162A, T200A, Q207E, F214L, V245L, T286A, E291D, V292I, I293V, P294T, E297KC
 RES454RES454KC951846D4T, 3TCNVPM184V, T215FK101E, E138K, G190SP4S, K20R, V35T, E36A, T39D, S48T, V60I, K122E, D123S, I135T, K173A, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, A272P, E291D, V292I, I293V, P294T, E297KC
 RES063RES063KC951675D4T, 3TC, TDFEFVD67N, K70R, M184V, K219QA98G, K101E, G190SV35I, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, V179I, T200A, Q207E, R211K, V245K, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS054CAS054 TDF, 3TCEFVK65R, Y115FK103N, Y181C, G190SV35I, T39E, S48T, K122E, D123N, K173A, D177E, G196K, T200E, I202V, E204K, Q207D, R211K, H221Y, V245Q, E248D, D250E, A272P, R284K, E291D, I329LC
Van Zyl (2013)822465KC424075D4T, 3TCEFVM184VK101E, G190SV35T, T39E, S48T, K122E, D123N, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, P243T, V245QC
 3941409KC423131D4T, 3TCEFVM184VK101H, G190ST27S, V35R, T39E, S48T, K122E, D123G, S162C, K173I, Q174K, T200A, Q207E, R211K, K238R, V245QC
 1110655KC424206D4T, 3TCEFVA62V, M184VK101H, G190SE6K, V35T, T39E, K122E, I142V, K173T, Q174R, D177E, I178L, T200A, Q207E, V245EC
 7172117KC423629TDF, 3TCEFVK65RK101E, V106M, Y181C, G190SV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, G196E, T200A, Q207E, V245EC
 15991817KC423433ABC, 3TCEFVD67N, F116Y, Q151M, M184VK101E, G190SE28K, K32E, V35T, T39E, I94L, K122E, D123E, K173T, D177E, T200A, Q207E, R211K, V245QC
 870955KC424392AZT, D4T, 3TCNVP, EFVL74LV, M184VK101E, G190SV35T, T39K, K122E, D123S, I142V, K173A, D177E, V179VI, T200A, R211K, V245Q, D250EC
  1527KC423205AZT, D4T, 3TC, TDFNVP, EFVD67N, K70R, M184V, T215F, K219EQK101E, G190SE28K, V35T, T39E, K122E, D123S, I142V, K173A, D177E, V179VI, T200A, R211K, V245Q, D250EC
 1081406KC424043D4T, 3TCEFV G190SV35T, E36A, T39E, E40EG, S48T, V90I, K122E, D123S, K173I, Q174K, T200A, Q207E, R211RK, V245QC
 14111311KC423049D4T, 3TCEFVL74V, M184VK101DE, G190SV35T, T39E, K103R, K122E, D123S, E138A, K166R, K173I, Q174K, T200A, Q207E, R211K, F214L, V245QC
 276432KC424057AZT, 3TCEFVM184VK101E, G190SK20R, V21I, V35T, E36A, T39E, S48T, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, K249QC
 4211769KC423391TDF, 3TCEFVA62V, K65R, M184VK101E, Y181C, G190SE28K, V35T, T39D, S48T, K122E, D123N, K166R, K173A, Q174K, D177E, I178L, T200A, I202V, Q207E, R211K, V245QC
 6902991KC423921TDF, 3TCEFVK65R, V75I, Y115FV179D, Y181C, G190SV35T, E36A, T39E, K46Q, S48T, K122E, D123G, K173A, T200A, Q207N, R211K, V245QC
 652469KC424077ABC, 3TCEFVK65R, D67G, Y115FV106M, Y181C, G190SV35T, E36A, T39E, V60I, W88C, K122E, D123N, S134SN, R143RK, Q145Q*, E169EK, K173T, Q174K, D177EK, I178M, E194EK, I195L, R199RK, T200A, E203EK, Q207A, R211K, V245EK, E248EKC
 10192144KC423648AZT, D4T, 3TC, ABCNVP, EFVM184VK101E, Y181YC, G190SP4PS, E28K, K32KE, V35T, E36A, T39E, S48T, K122E, D123DGNS, T139A, K173T, D177E, G196GR, T200A, I202V, Q207E, R211K, V245QC
 17592694KC423790TDF, 3TCEFVK65RK101E, Y181C, G190SE28R, K32E, V35T, E36A, T39E, S48T, K122E, D123S, S162A, K173T, Q174R, T200A, Q207E, R211K, V245QC
Steegen (2014)12ZAKS33312ZAKS333KJ176612ABC, 3TC, D4TEFVM41L, D67N, T69D, M184V, L210W, T215YK101E, G190SE28K, V35T, T39E, E44D, V118I, K122E, D123DN, K173A, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, H221Y, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, D324E, G335D, A355S, R356K, G359T, T369V, E370G, I375V, A376AG, T377L, S379C, K390R, A400M, E404DC
 11ZAKS07811ZAKS078KJ176360ABC, 3TC, D4TEFVL74V, Y115F, M184VK101E, G190SV8I, K22KR, E28K, K32E, V35T, E36A, T39E, S48T, D121H, K122E, K173T, D177E, G196K, T200A, R206RK, Q207E, R211K, V245Q, A272P, T286A, V292I, I293VC
 12ZAKS21112ZAKS211KJ176491ABC, 3TCEFVA62V, D67N, T69D, Y115F, F116Y, Q151M, M184VK101E, G190S, Y318FE28K, K32E, V35T, E36A, T39D, K122E, D123S, E169Q, P170PH, R172K, K173A, D177G, T200A, Q207A, R211K, V245Q, E291D, V292I, I293V, S322A, Q334N, G335DC
 11ZAKS11911ZAKS119KJ176401D4T, 3TCEFVM184VY188YH, G190SE6K, V35T, T39D, S48T, K101A, S117Q, V118F, K122E, S162A, K173T, T200A, Q207E, R211K, D250E, A272P, K275Q, V276T, K277R, E291D, V292I, I293V, Q334HC
 12ZAKS32712ZAKS327KJ176606D4T, 3TCEFVM184VK101H, G190SP4PT, E6KR, V35T, E36A, T39E, W88S, K122E, I135V, K173KT, T200A, Q207E, F214FL, K277KR, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359T, T369V, E370EG, T377M, K390R, A400T, E404D, E413GC
Wallis (2014)4143541435KM458531NRTINNRTID67N, T69D, M184V, T215YA98AG, K101E, G190SE28K, K32E, V35T, T39D, E44D, S48T, V60I, V118I, D121Y, K122E, S162A, K173A, T200A, E203D, Q207E, L210S, R211K, H221HYC
 4123441234KM458482NRTINNRTIM184V, L210LWA98AG, K101E, G190SD17DY, K20R, E28K, V35T, T39A, S48T, K122E, K173A, V179I, T200A, E203EK, Q207N, R211KC
 4112741127KM458540NRTINNRTID67N, K70R, M184V, K219EK101E, G190SE6K, V35T, T39E, S48T, V60I, K122E, K173I, Q174K, T200A, Q207E, R211KC
Seu (2015)ZM.HIVDRM.34ZM.HIVDRM.34KP995644TDF, FTCEFVK65R, Y115F, M184VK101N, Y181C, G190SE6K, V8I, E28EAKT, V35T, T39E, S48T, K122E, K173T, D177E, I178M, T200A, E204K, Q207E, R211Q, V245QC
Brooks (2016)2130A2130A TDF, 3TCEFVA62V, K65R, M184VV106M, Y181C, G190SP4S, V35T, E36A, T39E, S48T, K101Q, K122E, D123N, T165I, K173T, Q174K, D177E, I178M, T200A, I202IV, Q207EC