<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation G190E
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 52
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)18911891_0851EF026224AZT, DDINNRTID67DN, K70KR, T215TNSYE138K, V179DG, G190EV35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, D250E, T286A, E291D, V292I, I293VC
von Wyl (2007)1485055699EF449802NRTINNRTIM184V, T215FYA98G, G190EV35T, T39E, K43R, K101R, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207E, R211KC
Wallis (2009)TJC2455335TJC2455335 D4T, 3TCEFVK65R, V75A, F77L, F116Y, Q151MG190E, P225HK20R, V35T, T39E, S48T, S68G, T69TI, K73M, W88S, K101R, K122E, E138A, P157A, R172K, K173A, V179G, T200A, Q207E, F214L, V245Q, A272P, T286A, V292I, I293VC
 TJC2368272TJC2368272 D4T, 3TCEFVD67N, M184VK101E, E138K, G190EK20R, E28G, V35T, T39E, S48T, K122E, D123S, Q174K, V179G, G196E, T200A, E203K, Q207E, R211K, V245Q, A272S, K275Q, K277R, T286A, E291D, V292I, I293V, P294T, I329V, Q334NC
Manasa (2013)RES257RES257KC951750D4T, 3TCEFVV75M, F77L, M184V, K219NA98G, G190ET27S, V35M, E36A, T39E, S48T, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, G196E, Q197K, T200A, Q207E, F214L, V245N, D250E, A272P, K275R, T286A, V292I, I293VC
 RES369RES369KC951822D4T, 3TC, AZTEFVM184VG190EV35T, E36A, T39E, E40D, V90I, I94L, K101R, I135T, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, T286V, E291D, I293V, P294T, E297KC
 RES017RES017KC951642D4T, 3TCEFVM184V, K219NG190EV35T, E36A, T39E, W88C, K101R, K103R, K122E, D123G, I135V, E138A, K173T, T200A, Q207T, R211K, F214L, L228R, V245E, V261I, A272S, K281R, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS107CAS107 TDF, 3TCEFVK65R, D67N, V75I, Y115F, K219EV106A, G190EV35T, E36A, T39E, S48T, V60I, K102R, K103R, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207A, R211K, V245K, A272P, V276T, K277R, T286V, V292I, I293VC
 CAS033CAS033 D4T, 3TCEFVM41L, K65R, L74V, V75T, Y115FG190EK20R, V35T, T39E, S48T, V60I, S68G, D121H, K122E, I135V, I142V, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, K275R, V276T, E291D, V292I, I293V, I329VC
 CAS079CAS079 TDF, 3TCEFVK65R, Y115FG190EV21I, V35T, T39E, V60I, T69N, K122E, I135V, K173T, D177E, T200A, Q207N, V245E, A272S, T286A, E291D, V292I, I293V, D324EC
 CAS109CAS109 TDF, 3TCEFVK65R, T69~K101E, E138K, G190EV35T, E36A, T39E, S48T, V90I, K122E, K173T, D177E, T200A, Q207E, V245K, A272P, R284K, T286A, E291D, V292I, I293VC
 CAS066CAS066 TDF, 3TCEFVK65RG190EV35T, T39K, S48T, V60I, K122E, D123S, K173A, Q174K, G196E, T200A, Q207K, R211A, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 CAS035CAS035 TDF, 3TCEFVK65R, L74V, Y115FG190ES3SC, V35T, T39E, S48T, V60I, K122E, D123S, K173A, D177E, I178M, T200A, Q207E, V245Q, D250E, S251D, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, D324EC
Theys (2013)8073580735KC219000TDF, 3TCEFVK65RG190ET39A, S48T, K122E, D123S, K173T, D177E, T200A, Q207E, V245QC
 44284428KC219364NRTI, TDFNNRTID67N, K70R, T215I, K219QG190ES48T, V60I, K103R, K122E, D123S, I135T, E138A, K173T, Q174K, T200A, Q207E, F214L, H221YC
Van Zyl (2013)109912.ZA.EC196KC423869TDF, 3TCEFVD67G, K70E, V75I, Y115FG190EK20R, V35T, E36A, T39D, V60I, K122E, D123S, E138A, K173T, Q174K, G196GR, T200A, Q207E, F214L, H221HY, V245QC
 199212.ZA.GT2329KC423967TDF, 3TCEFVK65R, L74V, Y115FG190EK20R, E28K, K32E, V35T, E36A, T39E, K46Q, S48T, V60I, S68G, I142IT, K173T, Q174K, D177E, I178M, G196E, T200A, Q207A, H221Y, V245E, D250EC
 86212.ZA.WC212KC423848TDF, 3TCEFVK65RK101KPQT, G190EV35T, T39E, S48ST, K122E, E138A, K173A, V179G, T200A, K201I, I202V, E204KR, Q207D, R211K, H221HY, V245QC
 324208.ZA.GT438KC423401D4T, 3TCEFVA62V, K65R, D67G, K219NG190EP4S, V35T, T39E, S48T, K101KT, K103KR, K122E, D123S, E138A, T165I, K173A, Q174K, T200A, Q207A, R211K, V245QC
 95812.ZA.WC229KC423678D4T, 3TC, TDFEFVK65RY181C, G190EV35T, T39E, S48T, S68G, A98S, L109M, K122E, D123S, I135R, S162A, K173T, Q174K, D177E, T200E, Q207A, H221Y, V245Q, D250TC
 442812.ZA.EC166KC423807D4T, 3TCEFVK70KE, M184VG190EV35T, E36A, T39E, S48T, S68SG, D121H, K122E, D123DE, I135V, E138Q, S162C, K173A, D177E, T200A, Q207G, R211K, H221Y, V245QC
 305711.ZA.GT1828KC423613D4T, 3TCEFVM184VG190ET7P, V35T, T39E, S48T, R78RK, D121H, I135V, K173A, Q174K, D177E, G196V, T200A, Q207N, R211K, V245QC
 295708.ZA.GT455KC423530AZT, 3TCEFVD67N, K70R, M184V, K219EG190EV35T, T39K, S48T, V60I, K101R, K122E, I135V, K173A, Q174R, D177E, T200A, Q207E, V245QC
 81710.ZA.GT1294KC423126D4T, 3TC, AZT, DDIEFVK65R, D67H, L74V, Y115F, M184V, K219DG190EV35T, E36A, T39E, S68N, T69A, K122E, D123N, I135V, I142V, K173A, D177E, T200E, E203K, Q207E, R211K, V245QC
 335908.ZA.GT563KC423952D4T, 3TCEFVV75M, M184VG190EE6EK, V35T, E36A, T39N, L109I, K122E, D123E, I135R, K173A, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245QC
 221611.ZA.GT1783KC423573TDF, 3TCNVPK65R, T69~, L74V, Y115FG190EV35T, T39E, S48T, K122E, D123N, K173T, Q174K, D177E, V179G, T200A, E203EK, Q207K, R211E, V245KC
 43111.ZA.WC175KC423556D4T, 3TC, AZT, DDIEFVD67N, K70R, M184V, T215F, K219EG190EK20KR, V35T, T39E, T69TN, K101R, K103R, K122E, D123S, I135V, E138S, K173A, Q174E, D177G, T200A, Q207N, V245Q, E248EDC
Steegen (2014)11ZAKS08911ZAKS089KJ176371D4T, 3TCEFVK65R, V75I, Y115F, F116YG190EV35T, T39E, S48T, S68G, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, F214L, V245Q, A272P, T286A, E291D, V292IC
 11ZAKS15111ZAKS151KJ176433D4T, 3TCEFVA62AV, M184VG190EK20R, V35L, T39E, S48T, K101R, K122E, D123G, E138A, K166R, K173A, I178M, T200A, Q207D, R211K, L228R, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, S322AC
Seu (2015)ZM.HIVDRM.5ZM.HIVDRM.5KP995616D4T, 3TCEFVD67G, K70R, M184V, T215I, K219EG190EK20R, V35T, E36A, T39D, S48T, T69N, I94IL, K102R, K122E, D123G, I135V, E138A, T165TI, K173T, Q174R, T200A, Q207E, R211K, V245Q, E248D, D250E, K277R, T286A, E291D, V292I, I293V, P294T, L295M, E297K, D324E, Q334HN, G335DC
 ZM.HIVDRM.38ZM.HIVDRM.38KP995648TDF, FTCEFVA62AV, K65R, D67N, L74I, M184V, K219EG190EK20R, E28V, K32E, V35T, E36A, T39K, K102R, K122E, D123N, I135R, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245E, A272P, K275R, E291D, V292I, I293VC
Skhosana (2015)12ZALS14612ZALS146KM115750TDF, 3TCEFVA62AV, D67N, K70E, V75I, M184V, K219KEG190EK11Q, V35T, T39E, S48T, V90VI, K101KR, K122E, D123N, I135R, T139TK, S162Y, K173T, Q174N, T200A, Q207E, R211K, V245Q, S251D, A272S, K277R, T286A, E291D, V292I, E297R, P313Q, H315Y, Q334H, G335D, R356K, G359T, A376S, T377L, T386I, K390R, A400T, T403S, E404DC
Dinesha (2016)T87T87KX275131TDF, 3TCEFVL74V, M184VG190EV35T, T39E, S48T, K122E, D123S, I135R, S162C, K173A, Q174K, D177E, T200A, Q207E, R211KC
Lam (2016)1601201416012014KR868069TDF, 3TCEFVK65R, M184MVK101KE, E138EAKT, G190EV35T, E36A, T39D, S48T, V60I, V90VL, D121Y, K122E, D123E, I135T, S162H, T165I, K173T, Q174K, D177E, T200A, Q207E, R211RK, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V314VI, S322A, G335NC
Neogi (2016)223913.ZA.GT2614KT593003TDF, 3TCEFVK65R, L74V, Y115F, M184MVG190EV35T, E36A, T39E, K46Q, S48T, S68G, V90I, K122E, D123S, I135V, R172K, K173A, Q174R, D177E, V179G, T200E, E203Q, Q207D, R211K, H221HY, V245Q, D250EC
Steegen (2016)GFWCB002GFWCB002KU127780TDF, 3TCEFVK65R, L74V, Y115FG190EV35T, T39E, S48T, V60I, S68G, K102R, K122E, K173A, D177E, T200A, Q207E, R211K, V245QC
 GFKZB256GFKZB256KU128163TDF, 3TC, AZTEFV, NVPK65R, D67H, Q151M, K219EK101E, E138K, G190EV35T, T39E, S48T, K49R, V60I, S68G, T69N, V90I, S105A, L109I, K122E, D123G, K173A, D177E, V179G, T200A, E203K, R211K, D218E, K223Q, V245Q, D250E, S251I, A272S, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, A360S, K366RC
 GFGPB028GFGPB028KU127641TDF, 3TCEFVA62V, K65R, V75IG190EI31R, V35L, E36A, T39E, K46KQ, S68SG, V90I, A98S, K101T, I135T, E138A, K173A, Q174K, V179G, T200A, Q207A, R211K, V245Q, A272P, T286A, E291D, V292I, G333E, G359T, T377Q, K390R, A400T, E404DC
 GFMPB048GFMPB048KU127956TDF, 3TCEFVL74V, M184VG190EK20R, V35T, E36A, T39E, S48T, K103KR, K122E, D123N, E138A, K166R, K173T, D177G, T200K, Q207D, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, Y342F, R356K, M357I, G359T, K366R, T377Q, K390R, A400T, E404DC
 GFGPB101GFGPB101KU127773TDF, 3TCEFVM184IG190EV35T, T39E, S48T, K103R, K122E, D123S, E138A, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297K, Q334H, G335D, R356K, G359T, T377R, K390R, A400T, T403A, E404DC
 GFGPB012GFGPB012KU127622TDF, 3TCEFVA62V, K65R, Y115F, M184VG190EE6K, V35T, T39E, S48T, K103R, K122E, E138A, K173T, T200A, R211K, H221Y, V245Q, A272P, E291D, V292I, I293V, V317AC
 GFMPB098GFMPB098KU128048TDF, 3TCEFVK65R, L74IV, Y115F, M184V, K219NG190EV35T, E36A, T39E, S68G, T69TI, K101R, K103R, K122E, D123G, E138A, K173A, D177E, I178L, T200A, Q207N, R211K, V245Q, A272P, K275R, K277KR, Q278H, T286A, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, M357R, G359A, T369A, Q373H, T377Q, K390R, A400T, E404DC
 GFLPB004GFLPB004KU127828TDF, 3TCEFVA62V, K65R, M184IG190EV35T, T39E, S68N, K102R, K122E, D123N, T139K, I142V, K173T, Q174K, D177E, V189VI, T200A, Q207N, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297K, Q334H, R356K, G359T, T377Q, K390R, A400T, E404DC
 GFKZB066GFKZB066KU127934D4T, 3TC, TDFNVPK65R, K70T, V75S, M184VK101E, E138K, G190EP4S, E6K, V35T, E36A, T39D, S48T, K49R, T58S, S68N, V118I, K122E, T165I, K173A, Q174K, D177E, V179G, T200A, Q207E, F214L, H221Y, V245K, A272P, K275R, T286A, E291D, V292I, I293V, V317A, M357I, G359TC
 GFKZB187GFKZB187KU128079TDF, 3TC, FTCEFVD67G, K70EE138K, G190EK32T, V35T, T39E, V60I, T69N, V90I, K122E, D123G, I142V, K173A, Q174K, D177E, V179G, T200A, Q207E, R211K, H221Y, L228R, V245K, K249Q, A272P, K275Q, E291D, V292I, I293V, D324EC
 GFKZB265GFKZB265KU128177TDF, 3TC, FTCEFVK65R, L74V, Y115F, M184V, K219NG190EV35T, T39E, S68KR, K102KR, K104R, K122E, D123N, E138A, K173T, Q174K, T200A, I202V, Q207E, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, V292I, E297A, P313Q, V317VA, Q334E, R356K, G359T, T377Q, K390RC
 GFGPB020GFGPB020KU127621TDF, 3TCEFVL74V, V75A, M184VG190EV35I, T39D, S48T, K103R, I135V, E138A, P157A, K173T, Q174K, V179I, T200A, Q207E, R211K, P243S, V245E, E248D, D250E, A272P, K277R, E291D, V292I, I293V, E297K, Q334H, G335D, R356K, G359T, A376T, T377M, T386A, K390RC
 GFKZB104GFKZB104KU127963TDF, 3TCEFVK65R, D67N, K219EG190EK11Q, V35T, T39E, S48T, S68G, T69N, W88S, D121Y, K122E, E138A, P157A, S162C, K173T, Q174K, T200A, Q207E, V245Q, S251V, A272P, T286V, E291D, V292I, I293V, E297K, Q334N, G335D, Q336H, R358K, G359T, V365I, T377R, K390RC
 GFWCB035GFWCB035KU127806TDF, 3TCEFVK65R, V75I, Y115FK101KE, E138K, G190EV35T, T39E, S48T, K64R, K122E, D123S, K173A, D177E, V179G, T200A, Q207E, R211K, V245QC
 GFECB054GFECB054KU127781TDF, 3TCEFVK65R, V75M, Y115FG190EE6K, V35T, T39E, S48T, V60I, E89EQ, K122E, K173A, D177E, T200A, Q207E, R211K, H221Y, V245Q, A272P, K277KR, E291D, V292I, I293V, D324E, Q334DN, G335D, R356K, M357R, G359T, A360AT, T377Q, S379C, K390R, A400I, E404DC
 GFGPB097GFGPB097KU127767TDF, 3TCEFVD67N, K70E, V75I, Y115FK101KE, E138K, G190EV35T, T39E, S48T, V60VI, K122E, D123G, K173A, D177E, V179G, T200A, Q207E, H221Y, L228R, V245Q, D250E, A272P, V276I, T286A, E291D, V292I, I293V, D324E, Q334D, G335NC
 GFNWB038GFNWB038KU128271TDF, 3TCEFVM184V, K219EG190EV35T, T39E, K64KR, V111VA, L120LS, K122E, D123S, I135R, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, D250E, A272P, K275R, E291D, I293V, E297K, Q334N, G335D, R356K, M357R, G359T, K366R, I375V, T377Q, T386I, K390R, E399D, A400T, E404DC
 GFGPB091GFGPB091KU127762TDF, 3TCEFVK65RG190EV35T, T39E, S48T, K122E, D123S, I135T, E138G, S162Y, K173A, D177E, T200A, E204D, Q207K, R211G, V245Q, A272Q, T286A, V292I, I293IV, E297K, G335D, R356K, G359SC