<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation G190E
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 32
Isolates 32
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)18911891_0851EF026224AZT, DDINNRTID67DN, K70KR, T215TNSYE138K, V179DG, G190EV35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, D250E, T286A, E291D, V292I, I293VC
von Wyl (2007)1485055699EF449802NRTINNRTIM184V, T215FYA98G, G190EV35T, T39E, K43R, K101R, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207E, R211KC
Wallis (2009)TJC2455335TJC2455335 D4T, 3TCEFVK65R, V75A, F77L, F116Y, Q151MG190E, P225HK20R, V35T, T39E, S48T, S68G, T69TI, K73M, W88S, K101R, K122E, E138A, P157A, R172K, K173A, V179G, T200A, Q207E, F214L, V245Q, A272P, T286A, V292I, I293VC
 TJC2368272TJC2368272 D4T, 3TCEFVD67N, M184VK101E, E138K, G190EK20R, E28G, V35T, T39E, S48T, K122E, D123S, Q174K, V179G, G196E, T200A, E203K, Q207E, R211K, V245Q, A272S, K275Q, K277R, T286A, E291D, V292I, I293V, P294T, I329V, Q334NC
Manasa (2013)RES257RES257KC951750D4T, 3TCEFVV75M, F77L, M184V, K219NA98G, G190ET27S, V35M, E36A, T39E, S48T, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, G196E, Q197K, T200A, Q207E, F214L, V245N, D250E, A272P, K275R, T286A, V292I, I293VC
 RES369RES369KC951822D4T, 3TC, AZTEFVM184VG190EV35T, E36A, T39E, E40D, V90I, I94L, K101R, I135T, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, T286V, E291D, I293V, P294T, E297KC
 RES017RES017KC951642D4T, 3TCEFVM184V, K219NG190EV35T, E36A, T39E, W88C, K101R, K103R, K122E, D123G, I135V, E138A, K173T, T200A, Q207T, R211K, F214L, L228R, V245E, V261I, A272S, K281R, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS107CAS107 TDF, 3TCEFVK65R, D67N, V75I, Y115F, K219EV106A, G190EV35T, E36A, T39E, S48T, V60I, K102R, K103R, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207A, R211K, V245K, A272P, V276T, K277R, T286V, V292I, I293VC
 CAS033CAS033 D4T, 3TCEFVM41L, K65R, L74V, V75T, Y115FG190EK20R, V35T, T39E, S48T, V60I, S68G, D121H, K122E, I135V, I142V, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, K275R, V276T, E291D, V292I, I293V, I329VC
 CAS079CAS079 TDF, 3TCEFVK65R, Y115FG190EV21I, V35T, T39E, V60I, T69N, K122E, I135V, K173T, D177E, T200A, Q207N, V245E, A272S, T286A, E291D, V292I, I293V, D324EC
 CAS109CAS109 TDF, 3TCEFVK65R, T69~K101E, E138K, G190EV35T, E36A, T39E, S48T, V90I, K122E, K173T, D177E, T200A, Q207E, V245K, A272P, R284K, T286A, E291D, V292I, I293VC
 CAS066CAS066 TDF, 3TCEFVK65RG190EV35T, T39K, S48T, V60I, K122E, D123S, K173A, Q174K, G196E, T200A, Q207K, R211A, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 CAS035CAS035 TDF, 3TCEFVK65R, L74V, Y115FG190ES3SC, V35T, T39E, S48T, V60I, K122E, D123S, K173A, D177E, I178M, T200A, Q207E, V245Q, D250E, S251D, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, D324EC
Theys (2013)8073580735KC219000TDF, 3TCEFVK65RG190ET39A, S48T, K122E, D123S, K173T, D177E, T200A, Q207E, V245QC
 44284428KC219364NRTI, TDFNNRTID67N, K70R, T215I, K219QG190ES48T, V60I, K103R, K122E, D123S, I135T, E138A, K173T, Q174K, T200A, Q207E, F214L, H221YC
Van Zyl (2013)18272736KC423807D4T, 3TCEFVK70KE, M184VG190EV35T, E36A, T39E, S48T, S68SG, D121H, K122E, D123DE, I135V, E138Q, S162C, K173A, D177E, T200A, Q207G, R211K, H221Y, V245QC
 8472095KC423613D4T, 3TCEFVM184VG190ET7P, V35T, T39E, S48T, R78RK, D121H, I135V, K173A, Q174K, D177E, G196V, T200A, Q207N, R211K, V245QC
 17852874KC423869TDF, 3TCEFVD67G, K70E, V75I, Y115FG190EK20R, V35T, E36A, T39D, V60I, K122E, D123S, E138A, K173T, Q174K, G196GR, T200A, Q207E, F214L, H221HY, V245QC
 16792834KC423848TDF, 3TCEFVK65RK101KPQT, G190EV35T, T39E, S48ST, K122E, E138A, K173A, V179G, T200A, K201I, I202V, E204KR, Q207D, R211K, H221HY, V245QC
 1072307KC423952D4T, 3TCEFVV75M, M184VG190EE6EK, V35T, E36A, T39N, L109I, K122E, D123E, I135R, K173A, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245QC
 748195KC423530AZT, 3TCEFVD67N, K70R, M184V, K219EG190EV35T, T39K, S48T, V60I, K101R, K122E, I135V, K173A, Q174R, D177E, T200A, Q207E, V245QC
 6622029KC423573TDF, 3TCNVPK65R, T69~, L74V, Y115FG190EV35T, T39E, S48T, K122E, D123N, K173T, Q174K, D177E, V179G, T200A, E203EK, Q207K, R211E, V245KC
 17312199KC423678AZT, D4T, 3TC, TDFNVP, EFVK65RY181C, G190EV35T, T39E, S48T, S68G, A98S, L109M, K122E, D123S, I135R, S162A, K173T, Q174K, D177E, T200E, Q207A, H221Y, V245Q, D250TC
 981178KC423401D4T, 3TCEFVA62V, K65R, D67G, K219NG190EP4S, V35T, T39E, S48T, K101KT, K103KR, K122E, D123S, E138A, T165I, K173A, Q174K, T200A, Q207A, R211K, V245QC
 15342006KC423556AZT, D4T, 3TC, DDINVP, EFVD67N, K70R, M184V, T215F, K219EG190EK20KR, V35T, T39E, T69TN, K101R, K103R, K122E, D123S, I135V, E138S, K173A, Q174E, D177G, T200A, Q207N, V245Q, E248EDC
 4713095KC423967TDF, 3TCEFVK65R, L74V, Y115FG190EK20R, E28K, K32E, V35T, E36A, T39E, K46Q, S48T, V60I, S68G, I142IT, K173T, Q174K, D177E, I178M, G196E, T200A, Q207A, H221Y, V245E, D250EC
 1361404KC423126AZT, D4T, 3TC, DDINVP, EFVK65R, D67H, L74V, Y115F, M184V, K219DG190EV35T, E36A, T39E, S68N, T69A, K122E, D123N, I135V, I142V, K173A, D177E, T200E, E203K, Q207E, R211K, V245QC
Steegen (2014)11ZAKS08911ZAKS089KJ176371D4T, 3TCEFVK65R, V75I, Y115F, F116YG190EV35T, T39E, S48T, S68G, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, F214L, V245Q, A272P, T286A, E291D, V292IC
 11ZAKS15111ZAKS151KJ176433D4T, 3TCEFVA62AV, M184VG190EK20R, V35L, T39E, S48T, K101R, K122E, D123G, E138A, K166R, K173A, I178M, T200A, Q207D, R211K, L228R, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, S322AC
Seu (2015)ZM.HIVDRM.5ZM.HIVDRM.5KP995616D4T, 3TCEFVD67G, K70R, M184V, T215I, K219EG190EK20R, V35T, E36A, T39D, S48T, T69N, I94IL, K102R, K122E, D123G, I135V, E138A, T165TI, K173T, Q174R, T200A, Q207E, R211K, V245Q, E248D, D250E, K277R, T286A, E291D, V292I, I293V, P294T, L295M, E297K, D324E, Q334HN, G335DC
 ZM.HIVDRM.38ZM.HIVDRM.38KP995648TDF, FTCEFVA62AV, K65R, D67N, L74I, M184V, K219EG190EK20R, E28V, K32E, V35T, E36A, T39K, K102R, K122E, D123N, I135R, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245E, A272P, K275R, E291D, V292I, I293VC
Skhosana (2015)12ZALS14612ZALS146KM115750TDF, 3TCEFVA62AV, D67N, K70E, V75I, M184V, K219KEG190EK11Q, V35T, T39E, S48T, V90VI, K101KR, K122E, D123N, I135R, T139TK, S162Y, K173T, Q174N, T200A, Q207E, R211K, V245Q, S251D, A272S, K277R, T286A, E291D, V292I, E297R, P313Q, H315Y, Q334H, G335D, R356K, G359T, A376S, T377L, T386I, K390R, A400T, T403S, E404DC