<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y188L
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 6
Patients 23
Isolates 25
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Deshpande (2009)Pat20527RTFJ530736D4T, 3TCNoneM41L, M184V, T215YY188LV35T, T39N, S48T, V60I, D121H, K122E, K173A, D177E, T200A, Q207E, R211K, V245Q, K249NC
Van Zyl (2013)405411.ZA.GT1891KC423663TDF, FTCNoneM41L, D67DN, L74LV, M184V, T215YA98AG, Y188LV35IT, E36AD, T39DE, E40EK, S48T, V60VI, K64KHNQ, V106VI, K122E, D123DN, T128TI, W153W*, K173A, D177G, T200A, Q207N, R211K, V245QC
 106211.ZA.EC133KC423745TDF, 3TCNoneM184VY188LV35T, E36A, T39E, E40D, S48T, K122E, D123N, N147NI, S162A, K173T, D177E, T200A, Q207E, V245QC
 389211.ZA.GT1703KC423502ABC, 3TCNoneM184VY188LV35T, E36A, T39E, K122E, D123N, K173S, D177G, T200A, Q207E, E248NC
 353108.ZA.GT537KC423830ABC, 3TCNoneM184VY188LK20R, K32KR, V35T, E36A, T39E, S48T, K122E, D123DN, T139A, S162C, T200A, Q207E, R211K, V245QC
Acharya (2014)DGP190DGP190KJ185360AZT, 3TCNone Y188LV8I, V35T, E36A, T39D, S48T, V60I, D121H, K122E, I135T, A158S, S162A, K173T, D177E, T200A, Q207E, H221Y, V245Q, A272P, K277R, T286A, V292I, I293VC
 DGP179DGP179KJ185349AZT, 3TCNoneM184V, T215FY188LV35T, T39D, S48T, V60I, D121H, K122E, K173A, Q174R, D177E, I178L, Q197K, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P294TC
 DGP089DGP089KJ185259TDF, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219EY188LV35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, K281R, E291D, V292I, I293VC
Steegen (2014)12ZAKS20012ZAKS200KJ176480ABC, 3TCNoneM184IY188LV35T, T39E, S48T, V90VI, K122E, D123S, S163T, T165I, K166R, T200A, Q207K, R211Q, V245Q, D250E, S251N, D256E, A272P, K277R, T286A, E291D, V292I, I293V, S322T, Q334H, G335DC
 12ZAKS29512ZAKS295KJ176574TDF, D4T, 3TCNoneM184V, T215FV179E, Y188LV8I, V35K, T39E, V60I, K102W, I135T, K173A, Q174K, D177E, T200A, Q207QE, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357K, R358K, G359S, E370D, T377M, K390R, K395R, E399D, A400T, E404D, E430RC
Neogi (2016)714313.ZA.EC707KT592854D4T, 3TCNoneD67N, K70R, M184V, L210LW, T215F, K219EY188LI2V, V8I, V35K, T39E, S48T, V60I, T69N, A98S, V118VI, D121H, K122E, K173T, Q174K, D177E, V179VI, T200E, E203K, Q207E, H208HY, D218E, V245QC
 58913.ZA.EC749KT592881TDF, 3TCNoneM41L, M184V, T215YY188LV8I, V35T, T39N, S48T, V60I, K122E, D123G, S162C, K173A, D177E, I178IL, V179VI, T200A, Q207S, R211K, V245QC
 711513.ZA.EC535KT592738AZT, 3TCNoneM41L, M184V, T215FY188LV35IT, E36*L, T39E, S48T, V60I, S68SG, L109I, K122E, D123G, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, D218E, K238R, V245QC
 712113.ZA.EC566KT592763D4T, 3TCNoneA62V, K65R, M184VY188LV35T, T39E, S48T, S68N, K122E, D123S, I135T, E138D, S162C, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, V245QC
 106513.ZA.EC558KT592756AZT, DDINoneD67N, K70R, K219EY188LV35T, E36A, T39E, S48T, V60I, T69S, K122E, D123S, K173T, D177G, I180IV, T200A, E203K, Q207E, V245QC
Posada Cespedes (2017)539812.ZA.NL037KX542424TDF, 3TCNoneM184VV179D, Y188LV35T, T39E, S48T, V60I, S68G, K103R, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, F214FL, V245QC
 128714.ZA.EC1501 AZT, 3TCNoneM184VV179D, Y188LV35T, E36A, T39D, S48T, V60I, V106I, K122E, D123N, T139R, T165TI, K173A, T200A, Q207E, R211K, F214FL, V245LC
 528711.ZA.EC050KX540937AZT, 3TCNoneM184VK101H, Y188LP4S, V35T, E36A, T39E, E40D, S48T, V106I, K122E, K166KR, K173A, Q174R, D177E, Q197P, T200A, Q207E, R211K, F214FL, K238R, V245Q, D250EC
 96014.ZA.WC379KX544653ABC, 3TCNoneM184VY188LT27S, V35T, T39DE, S48T, K122E, D123N, I135IL, K166KR, K173A, T200A, Q207K, R211K, V245LC
 510215.ZA.GT4212 AZT, 3TCNoneM184VY188LV35T, E36A, T39E, S48T, S105ST, V106I, K122E, D123S, K166R, K173T, D177DE, G196E, T200A, E203K, Q207E, Q242H, V245QC
 154014.ZA.GT3358 TDF, 3TCNoneM184VY188LV35T, T39E, S48T, K122E, D123N, I135V, K173T, T200A, Q207K, R211K, F214LC
 242215.ZA.GT4126 AZT, 3TCNoneM184VY188LV35T, T39E, S48T, S68G, K102R, V106I, K122E, D123E, I135T, K173A, Q174K, D177E, T200A, Q207D, R211K, D250EC
  15.ZA.GT4488 AZT, 3TCNoneM184VY188LV35T, T39E, S48T, K102KR, V106I, K122E, D123DEKN, I135T, K173A, Q174K, D177E, T200A, Q207D, R211K, D250EC
 450614.ZA.WC503KX544760ABC, 3TCNoneM184VV179D, Y188LI5V, K20R, E28K, K32E, V35T, E36A, T39E, S48T, V60I, K122E, D123G, S163T, K173A, Q174K, D177E, T200A, Q207E, V245K, D250EC
  14.ZA.WC519 ABC, 3TCNoneM184VV179D, Y188LI5V, K20R, E28K, K32E, V35T, E36A, T39E, S48T, V60I, K122E, D123G, F160L, Q161E, S163T, K173A, Q174K, D177E, T200A, Q207E, V245K, D250EC