<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y188H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 43
Isolates 43
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)16241624_7985EF026217AZT, DDINNRTIL74V, T215YV106M, Y188H, M230LV35T, E36A, T39E, K122E, D123S, I142T, K173A, D177E, I178M, V179VI, T200A, E204K, Q207D, R211K, P243T, V245Q, A272P, K275R, Q278Y, E291D, V292I, I293VC
Marconi (2008)SW029sw029EU308042AZT, 3TCEFVD67NV106M, Y188HE44EG, S48T, V60I, R72RT, K122E, D123G, K173A, Q174K, D177E, T200E, I202V, Q207E, I244V, V245QC
Deshpande (2009)Pat25404artFJ530687D4T, 3TCEFVV75M, M184V, T215FIK103N, Y188HT7P, V35T, T39D, G51R, V60I, A98AS, V111I, D121H, K122E, I135T, S162H, K173A, Q174R, D177E, V179IT, G196E, T200A, I202IV, Q207E, R211K, L228LQ, Q242QH, V245QC
 Pat057329aRTFJ530884NRTINNRTIM41L, D67DN, V75M, F77L, Q151QKLM, M184V, T215FK103N, Y188HV35T, T39D, V60I, T69TN, V111I, D121H, K122E, I135T, E138EQ, S162H, K173A, Q174R, D177E, V179T, G196E, T200A, I202IT, Q207E, R211K, L228Q, Y232YH, Q242H, V245Q, K249NC
Hoffmann (2009)pat022MD035457 AZT, 3TCEFVM184VV106M, Y188HV35T, E36A, T39E, S48T, K173M, Q174K, D177E, G196T, T200A, Q207E, R211K, V245Q, A272PC
Wallis (2009)TJC2386028TJC2386028 D4T, 3TCEFVM184VK103N, Y188HV35T, E36A, T39E, S48T, W88C, K122E, S162AD, K173A, Q174K, T200E, I202V, Q207E, R211K, V245E, A272P, K281R, E291D, V292I, I293V, H315QC
 AACS7925AAACS7925A AZT, 3TCEFVD67N, K70R, M184V, K219EK103N, Y188HK20R, V35T, E36A, T39E, E40D, V60I, D121H, K122E, K173RT, Q174K, D177E, I178L, G196E, T200A, Q207E, L228H, V245E, D250DE, S251SCG, A272P, K277KR, T286A, E291D, V292IC
 TJC2378119TJC2378119 D4T, 3TCEFVD67N, F116Y, Q151M, M184IK103N, Y188HV35T, E36A, T39E, K122E, D123S, I142V, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, E248T, E291D, V292I, I293V, I309V, K311RC
El-Khatib (2010)Pat04210ZA_SAVE2197HQ012320D4T, 3TCEFVL74IV, M184VK103S, Y188HV35T, T39E, S48T, E53D, S68G, K122E, D123N, K173T, T200A, Q207E, R211K, V245N, S251NC
Sigaloff (2011)HIV101055HIV101055JN132260D4T, 3TCEFVM184VK103N, Y188HV8I, V35T, E36A, T39D, A129X, K173A, T200A, I202IV, Q207K, R211K, V245E, A272P, T286A, E291D, V292I, I293V, E308K, I309V, L310PSC
van Zyl (2011)A280A280JN638171D4T, 3TCEFV V106M, Y188HE6K, V35T, E36A, T39E, S48T, V60I, K122E, K166Q, K173A, Q174K, D177E, T200A, Q207A, R211K, V245QC
Brehm (2012)53ZA53ZA.48JN602008D4T, 3TCEFVA62V, M184VV106M, Y188HV35T, E36A, T39E, K122E, D123S, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, E432D, V435A, L452I, R461Q, V466I, V467VI, S468T, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, A534S, A554SC
Manasa (2013)RES011RES011KC951638D4T, 3TCEFVM184VV106M, Y188HT27S, V35M, T39A, S48T, S68G, K122A, D177E, V179I, G196E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294TC
 RES315RES315KC951771D4T, 3TC, TDFEFVK65R, T69~K103N, Y181C, Y188HK20R, V35T, T39E, E40D, K101R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, A288S, E291D, V292I, I293VC
Van Zyl (2013)393310.ZA.GT1297KC423129D4T, 3TCEFVM184IK103N, Y188HV35T, T39E, S48T, K122E, D123DN, I142K, K173V, Q174K, G196MT, T200E, I202V, R211K, F214L, V245Q, D250EC
 282406.ZA.GT054KC424302D4T, 3TCEFVD67DN, M184IV, T215TSK103N, Y188HK20KR, V35T, T39E, V60I, A98S, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278E, T286A, E291D, V292I, Q334N, G335DC
 219811.ZA.GT1560KC423344D4T, 3TCEFV K103N, Y188HV35T, E36A, T39E, S48T, T69P, K122E, I135V, S162C, K173A, Q174A, D177E, T200A, Q207E, R211K, H221Y, V245QC
 225912.ZA.GT2237KC423902D4T, 3TC, TDFEFVK65R, T69~K103HN, V179E, Y181C, Y188HV35T, E36A, T39D, S48T, S68N, K102R, D121H, K122E, S162A, K173T, Q174K, T200A, Q207E, R211K, V245E, D250EC
 90712.ZA.WC228KC423672D4T, 3TC, AZT, DDIEFVD67N, K70KRA98G, K103N, Y188HK20R, K32R, V35IT, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, T200A, R211K, L228LH, V245Q, E248X, Q258HC
 438611.ZA.GT1702KC423501D4T, 3TCEFVK65KR, M184MIK103N, Y188HP4T, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, V189I, T200A, Q207E, R211K, F214L, V245Q, D250EC
 91509.ZA.WC025KC424269ABC, AZTEFVM41L, D67N, K70R, T215Y, K219QK103N, V106M, Y188HV35T, E36A, T39E, V60I, K102R, K122E, D123S, I135V, T200A, E203K, Q207E, R211K, F214L, K223E, L228R, V245QC
 198909.ZA.GT1001KC422858D4T, 3TCEFVA62V, M184VV106M, Y188HV35T, T39E, S48T, V90I, K122E, D123S, K173T, Q174T, E194P, G196E, T200A, Q207E, V245Q, E248DC
 303311.ZA.GT1733KC423526D4T, 3TCEFVM184VV106M, Y188HV21I, V35T, T39K, S48T, K122E, D123N, S162SC, S163T, K173A, Q174K, D177E, D192N, T200A, Q207E, V245QC
 321111.ZA.GT1850KC423631D4T, 3TCEFVM184VL100I, K101E, Y188H, G190AK20R, T27S, V35T, E36A, T39E, V60I, K122E, D123N, I135V, E138A, K173V, T200E, Q207E, F214L, H221Y, V245QC
 315511.ZA.GT1598KC423389D4T, 3TCEFV K103N, Y188H, P225PHV35T, T39E, K102Q, K122E, D123N, K173T, D177E, I178M, T200A, R211T, V245Q, E248DC
 386310.ZA.GT1043KC422892D4T, 3TCEFVV75M, M184VV106M, Y188HV35T, T39D, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, E248DC
Neogi (2014)5028550285 TDF, FTCEFV V106M, Y188HT39E, D121H, K122E, I142V, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272S, K277R, T286A, E291D, V292I, I293VC
Steegen (2014)12ZAKS21912ZAKS219KJ176499D4T, 3TC, ABCEFVM41ML, V75M, M184VV106M, Y188HK20R, V35T, T39E, K43KR, S48T, K122E, D123G, K173A, Q174K, D177E, I178V, Q197E, T200A, Q207A, R211K, L228Q, V245Q, E248D, A272AS, K277R, E291D, V292VI, I293V, E297K, I326V, Q334N, G335N, R356K, G359S, T377L, K390RC
Lam (2016)9902203399022033KR867999AZT, 3TCEFVM184IK103N, Y188HV8I, V35K, T39E, S48T, K104R, K122E, K173A, Q174K, D177E, T200A, I202IV, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, Q334DN, G335DC
Neogi (2016)224913.ZA.GT2777KT593131ABC, 3TCEFVL74V, Y115F, M184VV106M, Y188HP4S, K22R, V35T, T39E, S48T, K122E, D123S, S162C, K166R, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, V245QC
 424813.ZA.GT2896KT593216AZT, 3TCEFVK70KE, M184V, T215YK103N, Y188HK20R, V35T, E36EK, T39E, V111VM, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, L228H, V245EC
Steegen (2016)GFMPB021GFMPB021KU127871TDF, 3TCEFVK65R, K70R, V75L, M184IK103N, Y188HV35T, T39E, S48T, S68N, K122E, K173A, D177E, T200A, I202V, E204K, Q207E, R211K, F214L, H221HY, V245Q, A272P, K277R, L283LI, T286TA, E291D, V292VI, I293V, I329V, Q334D, G335D, R356K, G359T, T369V, E370Q, A371V, I375V, T377L, K390R, A400IMT, E404DC
 GFKZB070GFKZB070KU127931TDF, 3TCEFVK70Q, V75L, M184IK103N, Y188HK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, I135IM, T165I, Q174K, G196E, T200A, I202V, Q207D, R211K, V245Q, A272P, K275KQ, E291D, V292I, I293V, E297KC
 GFMPB080GFMPB080KU128113D4T, 3TC, TDFEFVK65KR, D67DN, K70RT, M184MV, K219KEK103N, Y188HK20KR, V35T, T39E, S48T, V60VI, S68SG, K122E, D123N, E138EG, K173A, D177E, V189VI, T200A, I202V, Q207QK, R211K, L228LHQ, V245Q, A272P, Q278N, K281R, T286TA, E291D, V292I, I293V, P294T, G333E, Q334R, G335GE, R356K, G359T, A371V, T377M, K388R, K390R, A400T, E404DC
 GFFSB074GFFSB074KU127775TDF, 3TCEFVK65R, V75VL, M184MIK103N, Y188HE6K, V35T, E36A, T39D, S68SDGN, W88WG, K122E, S162C, K173A, Q174K, D177E, T200A, I202V, Q207A, R211K, H221HYC
 GFMPB032GFMPB032KU127911TDF, 3TCEFVK65KR, M184VV106M, Y188HP4T, V35T, E36A, T39E, E40EK, S48T, S68G, A98S, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, V245Q, I257L, A272P, K275R, T286A, E291D, V292I, I293V, E297K, E300EK, D324E, Q334N, I341V, R356K, M357MV, R358RK, G359T, T377R, T386I, K390RC
 GFMPB022GFMPB022KU127888TDF, 3TCEFVA62V, K65R, K70T, M184IK103S, V106M, Y188HP4S, K22R, E28A, V35T, T39E, S48T, S68G, W88S, V90I, K122E, D123N, S162Y, K173A, Q174K, D177E, I178L, T200A, Q207E, V245Q, A272P, K275R, E291D, V292I, I293V, Q334N, G335D, F346H, K350R, R356K, M357R, G359T, K374Q, T377R, S379SC, K390R, A400T, E404DC
 GFNWB036GFNWB036KU128273TDF, 3TC, FTCEFVD67N, K70R, V75L, M184I, K219QK103N, Y188HV35M, T39E, S48T, V90I, A98S, K102KR, K122E, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, L210S, R211K, V245Q, A272S, K281R, E291D, V292I, Q334H, G335D, R356K, G359AT, K366R, T377M, K390R, E404D, V435T, A437VC
Hunt (2017)KZN05B074KZN05B074 TDF, 3TCEFVK65RK103N, Y188HK22R, V35T, E36A, T39E, S48T, K122E, D123S, K173I, Q174K, D177E, I178L, T200A, Q207E, F214L, H221HYC
Posada Cespedes (2017)539112.ZA.EC295KX541759TDF, 3TCEFVK65RV106M, Y181C, Y188HV35T, T39E, K43R, S48T, V60L, K122E, I142V, K166R, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250EC
 429414.ZA.GT3234KX544141TDF, 3TCEFVD67N, K70R, M184V, K219EK103N, Y188HE6A, V21I, K22KR, V35T, E36A, T39E, S48T, W88S, K122E, D123S, S163T, K173A, D177G, T200A, Q207E, R211K, V245QC
 347915.ZA.GT4540KY205638TDF, FTCEFVK65KR, K70KE, Y115F, M184VK103T, V106M, Y188HT27S, V35IT, T39E, E40EK, S48T, S68SG, T69TI, K122E, D123N, K173A, Q174K, D177E, I178M, G196E, T200A, E203EK, Q207T, H208HL, R211K, F214L, H221HY, K223KE, V245QC
 70013.ZA.EC710KX542743ABC, 3TCEFVL74V, M184VK103N, Y188HV35T, T39E, S48T, K122E, I135V, K173A, Q174K, D177E, G196E, T200A, Q207K, R211M, V245QC