<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y188H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 27
Isolates 27
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)16241624_7985EF026217AZT, DDINNRTIL74V, T215YV106M, Y188H, M230LV35T, E36A, T39E, K122E, D123S, I142T, K173A, D177E, I178M, V179VI, T200A, E204K, Q207D, R211K, P243T, V245Q, A272P, K275R, Q278Y, E291D, V292I, I293VC
Marconi (2008)SW029sw029EU308042AZT, 3TCEFVD67NV106M, Y188HE44EG, S48T, V60I, R72RT, K122E, D123G, K173A, Q174K, D177E, T200E, I202V, Q207E, I244V, V245QC
Deshpande (2009)Pat25404artFJ530687D4T, 3TCEFVV75M, M184V, T215FIK103N, Y188HT7P, V35T, T39D, G51R, V60I, A98AS, V111I, D121H, K122E, I135T, S162H, K173A, Q174R, D177E, V179IT, G196E, T200A, I202IV, Q207E, R211K, L228LQ, Q242QH, V245QC
 Pat057329aRTFJ530884NRTINNRTIM41L, D67DN, V75M, F77L, Q151QKLM, M184V, T215FK103N, Y188HV35T, T39D, V60I, T69TN, V111I, D121H, K122E, I135T, E138EQ, S162H, K173A, Q174R, D177E, V179T, G196E, T200A, I202IT, Q207E, R211K, L228Q, Y232YH, Q242H, V245Q, K249NC
Hoffmann (2009)pat022MD035457 AZT, 3TCEFVM184VV106M, Y188HV35T, E36A, T39E, S48T, K173M, Q174K, D177E, G196T, T200A, Q207E, R211K, V245Q, A272PC
Wallis (2009)TJC2386028TJC2386028 D4T, 3TCEFVM184VK103N, Y188HV35T, E36A, T39E, S48T, W88C, K122E, S162AD, K173A, Q174K, T200E, I202V, Q207E, R211K, V245E, A272P, K281R, E291D, V292I, I293V, H315QC
 AACS7925AAACS7925A AZT, 3TCEFVD67N, K70R, M184V, K219EK103N, Y188HK20R, V35T, E36A, T39E, E40D, V60I, D121H, K122E, K173RT, Q174K, D177E, I178L, G196E, T200A, Q207E, L228H, V245E, D250DE, S251SCG, A272P, K277KR, T286A, E291D, V292IC
 TJC2378119TJC2378119 D4T, 3TCEFVD67N, F116Y, Q151M, M184IK103N, Y188HV35T, E36A, T39E, K122E, D123S, I142V, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, E248T, E291D, V292I, I293V, I309V, K311RC
El-Khatib (2010)Pat04210ZA_SAVE2197HQ012320D4T, 3TCEFVL74IV, M184VK103S, Y188HV35T, T39E, S48T, E53D, S68G, K122E, D123N, K173T, T200A, Q207E, R211K, V245N, S251NC
van Zyl (2011)A280A280JN638171D4T, 3TCEFV V106M, Y188HE6K, V35T, E36A, T39E, S48T, V60I, K122E, K166Q, K173A, Q174K, D177E, T200A, Q207A, R211K, V245QC
Brehm (2012)53ZA53ZA.48JN602008D4T, 3TCEFVA62V, M184VV106M, Y188HV35T, E36A, T39E, K122E, D123S, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, E432D, V435A, L452I, R461Q, V466I, V467VI, S468T, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, A534S, A554SC
Manasa (2013)RES011RES011KC951638D4T, 3TCEFVM184VV106M, Y188HT27S, V35M, T39A, S48T, S68G, K122A, D177E, V179I, G196E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294TC
 RES315RES315KC951771D4T, 3TC, TDFEFVK65R, T69~K103N, Y181C, Y188HK20R, V35T, T39E, E40D, K101R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, A288S, E291D, V292I, I293VC
Van Zyl (2013)14701407KC423129D4T, 3TCEFVM184IK103N, Y188HV35T, T39E, S48T, K122E, D123DN, I142K, K173V, Q174K, G196MT, T200E, I202V, R211K, F214L, V245Q, D250EC
 59683KC424302D4T, 3TCEFVD67DN, M184IV, T215TSK103N, Y188HK20KR, V35T, T39E, V60I, A98S, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278E, T286A, E291D, V292I, Q334N, G335DC
 4691071KC422858D4T, 3TCEFVA62V, M184VV106M, Y188HV35T, T39E, S48T, V90I, K122E, D123S, K173T, Q174T, E194P, G196E, T200A, Q207E, V245Q, E248DC
 9231766KC423389D4T, 3TCEFV K103N, Y188H, P225PHV35T, T39E, K102Q, K122E, D123N, K173T, D177E, I178M, T200A, R211T, V245Q, E248DC
 16671901KC423501D4T, 3TCEFVK65KR, M184MIK103N, Y188HP4T, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, V189I, T200A, Q207E, R211K, F214L, V245Q, D250EC
 8211943KC423526D4T, 3TCEFVM184VV106M, Y188HV21I, V35T, T39K, S48T, K122E, D123N, S162SC, S163T, K173A, Q174K, D177E, D192N, T200A, Q207E, V245QC
 9602119KC423631D4T, 3TCEFVM184VL100I, K101E, Y188H, G190AK20R, T27S, V35T, E36A, T39E, V60I, K122E, D123N, I135V, E138A, K173V, T200E, Q207E, F214L, H221Y, V245QC
 14271117KC422892AZT, D4T, 3TCNVP, EFVV75M, M184VV106M, Y188HV35T, T39D, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, E248DC
 6381710KC423344D4T, 3TCEFV K103N, Y188HV35T, E36A, T39E, S48T, T69P, K122E, I135V, S162C, K173A, Q174A, D177E, T200A, Q207E, R211K, H221Y, V245QC
 7022940KC423902AZT, D4T, 3TC, TDFNVP, EFVK65R, T69~K103HN, V179E, Y181C, Y188HV35T, E36A, T39D, S48T, S68N, K102R, D121H, K122E, S162A, K173T, Q174K, T200A, Q207E, R211K, V245E, D250EC
 1709757KC424269AZT, D4T, 3TC, ABCNVP, EFVM41L, D67N, K70R, T215Y, K219QK103N, V106M, Y188HV35T, E36A, T39E, V60I, K102R, K122E, D123S, I135V, T200A, E203K, Q207E, R211K, F214L, K223E, L228R, V245QC
 1619756KC424268AZT, D4T, 3TC, DDINVP, EFVM41L, D67N, K70R, T215Y, K219QK103N, V106M, Y188HV35T, E36A, T39E, V60I, K102R, K122E, D123S, I135V, I142T, T200A, E203K, Q207E, R211K, F214L, K223T, L228R, V245QC
 17052189KC423672AZT, D4T, 3TC, DDINVP, EFVD67N, K70KRA98G, K103N, Y188HK20R, K32R, V35IT, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, T200A, R211K, L228LH, V245Q, E248X, Q258HC
Steegen (2014)12ZAKS21912ZAKS219KJ176499D4T, 3TC, ABCEFVM41ML, V75M, M184VV106M, Y188HK20R, V35T, T39E, K43KR, S48T, K122E, D123G, K173A, Q174K, D177E, I178V, Q197E, T200A, Q207A, R211K, L228Q, V245Q, E248D, A272AS, K277R, E291D, V292VI, I293V, E297K, I326V, Q334N, G335N, R356K, G359S, T377L, K390RC