<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y188C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 21
Isolates 22
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL53431101839 TDF, 3TCEFVA62AV, M184VV106M, Y188CV35T, K122E, K173A, D177E, I178L, E194EK, G196E, T200A, E204EG, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, D324EC
Kurle (2007)NVP-1212-M2DQ838764NoneNVP Y188CV35T, T39D, S48T, V60I, D121Y, K122E, I135T, S162A, K173A, D177E, T200E, Q207G, V245Q, A272P, K277R, T286A, V292I, I293V, P313Q, G335D, R356K, M357Q, G359TC
Marconi (2008)SW061sw061EU308072D4T, DDIEFV V106M, Y188CS48T, K122E, D123G, S162C, K173A, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245QC
Pillay (2008)DR39DR39AY589895D4T, DDIEFVD67DGV106M, Y188CV35T, T39K, S48T, V60I, K122E, D123G, K173I, Q174E, D177E, I178L, T200A, E204K, Q207E, V245Q, A272P, K277R, Q278N, T286TA, E291D, V292I, I293V, S322E, D324DE, G333EC
 DR69DR69AY589918D4T, DDIEFVK65R, D67NV106M, V179D, Y188CV35T, T39D, S48T, K122E, D123S, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, H315HQC
Hosseinipour (2009)82618261GQ228385D4T, 3TCNVPA62V, K65R, K70R, V75I, F116Y, Q151M, K219EV106M, Y188CT39E, S48T, S68G, A98S, K122E, T139TA, A158S, K173A, Q174K, D177E, I178M, G196T, T200A, I202V, Q207K, H208HY, H221Y, E224D, P243PT, V245QC
Wallis (2009)GT00130674GT00130674 D4T, 3TCEFVA62V, D67G, M184IV106M, Y188CV35T, T39E, S48T, V90I, K122E, I135M, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 TJC2389852TJC2389852 AZT, 3TCEFVD67N, K70R, M184V, K219EA98G, K103KN, V106VIM, V108VI, Y188CV35T, E36A, T39E, K122E, D123GS, K173A, Q174K, D177E, T200A, E203ED, Q207E, R211K, F214L, V245Q, A272P, K277R, V292I, I293V, I309V, L310X, I329LC
 23622102362210 AZT, 3TCEFVM184V, L210LW, T215YV106M, Y188C, M230MLV35T, T39E, K122E, D123S, K173A, Q174K, D177E, T200A, Q207A, R211K, A272P, K277R, E291D, V292I, I293VC
 GT00256420GT00256420 AZT, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
 TJC2407731TJC2407731 D4T, 3TCEFVK65R, V75VIK103KN, V106M, E138K, V179VD, Y188CK20R, V35T, T39E, S48T, V60I, S68G, W88C, D121H, K122E, D123G, T165I, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, Q334YC
 GT00034325GT00034325 D4T, 3TCEFVA62V, M184VV106M, Y188CP14S, K20R, V35T, S48T, K122E, D123S, K173A, Q174K, D177E, T200A, Q207E, R211K, L228R, V245Q, A272P, L279M, T286A, E291D, V292I, I293VC
 22838712283871 D4T, 3TCEFVA62AV, V75VAIT, M184VV106M, Y188CK20R, V35T, T39R, E40R, M41W, T69TN, K122E, K173A, Q174QK, D177E, V179I, T200A, Q207E, R211K, V245Q, D250E, K277R, E291D, V292I, I293V, H315L, D324DEC
El-Khatib (2010)Pat01410ZA_SAVE1186HQ012292AZT, 3TCEFVM184VV106M, Y188CK11T, V21I, V35T, E36A, T39E, E40D, S48T, K122E, D123G, S163T, K173A, D177E, T200A, Q207E, F214L, V245QC
Green (2011)707PKE09F707PKE09FHM623500D4T, 3TCEFVK70R, M184VV106M, Y188CK20KR, V35K, T39E, S48T, T58S, V60I, T69N, V118A, S162Y, K173T, Q174R, D177E, T200A, I202IV, Q207KNRS, R211Q, L228LH, V245Q, D250E, V292VI, I293V, E297K, P321S, D324E, Q334EC
 707PKE17F707PKE17FHM623507D4T, 3TCEFVF116Y, Q151M, M184VV106M, Y188C, G190GAE6K, V35T, T39E, S48T, S68SG, T69TN, K102KNRS, K122E, I135IV, T139TA, K173A, Q174K, D177E, T200A, I202V, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, Q334EC
Sigaloff (2011)GT00256420GT00256420JN381584D4T, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
van Zyl (2011)A133A133JN638081D4T, 3TCEFV V106M, Y188CV35T, E36A, T39E, K122E, D123S, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 A236A236JN638135D4T, 3TCEFVK65R, D67NV106M, Y188CE6D, V35T, E36A, T39E, S48T, V60I, K122E, D123N, K173A, Q174G, D177E, T200A, Q207A, R211K, V245Q, E248DC
 A254A254JN638150D4T, 3TCNVPM41ML, K65R, D67NV106M, Y188CV35T, E36A, T39D, W88S, K104KR, K122E, D123N, K173E, T200A, Q207E, R211K, F214LC
 A63A63JN638219D4T, 3TCNVPM184VY188CV35T, E36A, T39E, S48T, V60I, K101Q, K122E, D123G, I135V, K173A, T200A, Q207D, R211K, L228LF, V245QC
Brehm (2012)43ZA43ZA.24JN601986D4T, 3TCNVPM184V, N348NIV106VM, Y188CV35T, T39K, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207A, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, E297A, Q334E, G335D, R356K, M357R, G359T, A376C, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452IV, V467I, S468T, T470TN, D471E, H483Q, L491S, L517I, S519N, Q524E, K530KR, A534S, A554SC

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