<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y188C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 43
Isolates 45
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL53431101839 TDF, 3TCEFVA62AV, M184VV106M, Y188CV35T, K122E, K173A, D177E, I178L, E194EK, G196E, T200A, E204EG, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, D324EC
Kurle (2007)NVP-1212-M2DQ838764NoneNVP Y188CV35T, T39D, S48T, V60I, D121Y, K122E, I135T, S162A, K173A, D177E, T200E, Q207G, V245Q, A272P, K277R, T286A, V292I, I293V, P313Q, G335D, R356K, M357Q, G359TC
Marconi (2008)SW061sw061EU308072D4T, DDIEFV V106M, Y188CS48T, K122E, D123G, S162C, K173A, Q174R, D177E, T200A, E203EK, Q207E, R211K, V245QC
Pillay (2008)DR39DR39AY589895D4T, DDIEFVD67DGV106M, Y188CV35T, T39K, S48T, V60I, K122E, D123G, K173I, Q174E, D177E, I178L, T200A, E204K, Q207E, V245Q, A272P, K277R, Q278N, T286TA, E291D, V292I, I293V, S322E, D324DE, G333EC
 DR69DR69AY589918D4T, DDIEFVK65R, D67NV106M, V179D, Y188CV35T, T39D, S48T, K122E, D123S, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, H315HQC
Hosseinipour (2009)82618261GQ228385D4T, 3TCNVPA62V, K65R, K70R, V75I, F116Y, Q151M, K219EV106M, Y188CT39E, S48T, S68G, A98S, K122E, T139TA, A158S, K173A, Q174K, D177E, I178M, G196T, T200A, I202V, Q207K, H208HY, H221Y, E224D, P243PT, V245QC
Wallis (2009)GT00130674GT00130674 D4T, 3TCEFVA62V, D67G, M184IV106M, Y188CV35T, T39E, S48T, V90I, K122E, I135M, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 TJC2389852TJC2389852 AZT, 3TCEFVD67N, K70R, M184V, K219EA98G, K103KN, V106VIM, V108VI, Y188CV35T, E36A, T39E, K122E, D123GS, K173A, Q174K, D177E, T200A, E203ED, Q207E, R211K, F214L, V245Q, A272P, K277R, V292I, I293V, I309V, L310X, I329LC
 23622102362210 AZT, 3TCEFVM184V, L210LW, T215YV106M, Y188C, M230MLV35T, T39E, K122E, D123S, K173A, Q174K, D177E, T200A, Q207A, R211K, A272P, K277R, E291D, V292I, I293VC
 GT00256420GT00256420 AZT, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
 TJC2407731TJC2407731 D4T, 3TCEFVK65R, V75VIK103KN, V106M, E138K, V179VD, Y188CK20R, V35T, T39E, S48T, V60I, S68G, W88C, D121H, K122E, D123G, T165I, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, Q334YC
 GT00034325GT00034325 D4T, 3TCEFVA62V, M184VV106M, Y188CP14S, K20R, V35T, S48T, K122E, D123S, K173A, Q174K, D177E, T200A, Q207E, R211K, L228R, V245Q, A272P, L279M, T286A, E291D, V292I, I293VC
 22838712283871 D4T, 3TCEFVA62AV, V75VAIT, M184VV106M, Y188CK20R, V35T, T39R, E40R, M41W, T69TN, K122E, K173A, Q174QK, D177E, V179I, T200A, Q207E, R211K, V245Q, D250E, K277R, E291D, V292I, I293V, H315L, D324DEC
El-Khatib (2010)Pat01410ZA_SAVE1186HQ012292AZT, 3TCEFVM184VV106M, Y188CK11T, V21I, V35T, E36A, T39E, E40D, S48T, K122E, D123G, S163T, K173A, D177E, T200A, Q207E, F214L, V245QC
Green (2011)707PKE09F707PKE09FHM623500D4T, 3TCEFVK70R, M184VV106M, Y188CK20KR, V35K, T39E, S48T, T58S, V60I, T69N, V118A, S162Y, K173T, Q174R, D177E, T200A, I202IV, Q207KNRS, R211Q, L228LH, V245Q, D250E, V292VI, I293V, E297K, P321S, D324E, Q334EC
 707PKE17F707PKE17FHM623507D4T, 3TCEFVF116Y, Q151M, M184VV106M, Y188C, G190GAE6K, V35T, T39E, S48T, S68SG, T69TN, K102KNRS, K122E, I135IV, T139TA, K173A, Q174K, D177E, T200A, I202V, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, Q334EC
Sigaloff (2011)GT00256420GT00256420JN381584D4T, 3TCEFVD67N, K70R, M184VY188C, M230LV35T, T39E, S48E, V106L, D123E, T139R, S162A, E169R, K173E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297DC
van Zyl (2011)A133A133JN638081D4T, 3TCEFV V106M, Y188CV35T, E36A, T39E, K122E, D123S, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 A236A236JN638135D4T, 3TCEFVK65R, D67NV106M, Y188CE6D, V35T, E36A, T39E, S48T, V60I, K122E, D123N, K173A, Q174G, D177E, T200A, Q207A, R211K, V245Q, E248DC
 A254A254JN638150D4T, 3TCNVPM41ML, K65R, D67NV106M, Y188CV35T, E36A, T39D, W88S, K104KR, K122E, D123N, K173E, T200A, Q207E, R211K, F214LC
 A63A63JN638219D4T, 3TCNVPM184VY188CV35T, E36A, T39E, S48T, V60I, K101Q, K122E, D123G, I135V, K173A, T200A, Q207D, R211K, L228LF, V245QC
Brehm (2012)43ZA43ZA.24JN601986D4T, 3TCNVPM184V, N348NIV106VM, Y188CV35T, T39K, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207A, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, E297A, Q334E, G335D, R356K, M357R, G359T, A376C, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452IV, V467I, S468T, T470TN, D471E, H483Q, L491S, L517I, S519N, Q524E, K530KR, A534S, A554SC
Sunpath (2013)CAS044CAS044 TDF, 3TCEFVK65RV106M, Y188CV35T, E36A, T39E, E44D, S48T, K122E, D123S, I135T, S162C, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, A272P, K281R, T286A, E291D, V292I, I293VC
 CAS042CAS042 TDF, 3TC, D4TEFVM184VV106M, Y188CP4S, V35T, E36A, T39E, S48T, V60I, V118I, K122E, D123S, E138A, T165I, K173A, Q174K, N175H, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, A272P, K275Q, K277R, A288S, E291D, I293V, E297K, V314IC
 CAS048CAS048 TDF, 3TCEFVK65RV106M, Y188CV8I, V35T, E36A, T39D, V60I, K122P, D123E, I142R, K173T, Q174K, D177E, I178L, G196E, T200A, Q207D, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, K311RC
 CAS036CAS036 D4T, 3TC, TDFEFVM41L, L74V, M184VV106M, V179D, Y188C, G190GEV35T, E36A, T39E, S48T, V60I, K103R, K122E, K173A, D177E, Q207E, R211K, F214L, V245E, K277R, T286A, E291D, V292I, I293V, D324EC
 CAS039CAS039 D4T, 3TC, TDFEFVK65R, K70R, V75I, Y115FV106M, Y188CV35T, T39E, G45E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, Y271H, A272S, K277R, T286A, E291D, V292I, I293V, H315YC
Van Zyl (2013)897936KC424378D4T, 3TCEFVK65R, D67HN, Y115YFV106M, Y188CV35T, T39E, S48T, V60I, T69P, W88C, K122E, D123N, I135IM, T165I, K173A, Q174K, D177E, T200A, Q207E, D218DE, V245KC
 1140202KC423567D4T, 3TCEFVM184VV106M, Y188CE6K, V35T, E36A, T39E, S48T, K102KR, K122E, K173T, D177E, T200A, Q207E, R211K, V245QC
 15732496KC423731ABC, 3TCEFVA62V, K65R, L74I, Y115F, M184VV106M, Y188CV35T, T39E, S48T, K49KR, K122E, D123N, I135T, S162C, S163I, K173A, D177E, T200A, Q207A, R211K, V245QC
 913352KC424002D4T, 3TCEFVD67DNV106M, Y188CV35T, T39E, S48T, E53D, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, E248DC
 15163094KC423966TDF, 3TCEFVK65R, D67N, K70E, Y115FV106M, Y188CV35T, T39E, S48T, T58S, S68G, K122E, D123N, K173T, V179I, T200A, E204Q, Q207A, R211K, L228R, P243T, V245QC
 14671741KC423371TDF, 3TCEFVK65RV106M, Y188CK20R, V35T, T39E, S48T, V60I, S68SG, K104R, K122E, D123S, K173A, Q174K, D177E, Q207N, R211K, F214L, V245QC
 1041457KC424070D4T, 3TCEFVA62V, K65RK101KE, V106M, Y188CV35T, E36A, T39E, K122E, D123N, I135R, I142IATV, S162C, K173A, Q174K, D177E, I178L, T200A, I202V, Q207E, R211K, V245QC
 3222065KC423593AZT, 3TCEFVM41L, M184V, T215YA98G, V106M, Y188CT27S, V35T, E36A, T39E, S48T, V60I, L109I, G196R, T200A, Q207A, D218E, V245Q, D250EC
  1971KC423537AZT, 3TCEFVM41L, M184V, T215YA98G, V106M, Y188CT27S, V35T, E36A, T39E, S48T, V60I, L109I, G196R, T200A, Q207A, D218E, V245Q, D250EC
 62173KC423668TDF, 3TCEFVD67NS, T69DN, K70R, M184V, T215IV, K219QV106M, Y188C, G190AK22KR, T39E, V60I, I94L, K101Q, K122E, D123S, T139R, K173A, Q174K, D177E, V179I, T200A, I202V, Q207E, R211K, P243T, V245QC
 14661792KC423412D4T, 3TCEFVM184VV106M, Y188CV35T, T39DN, K122E, D123N, I135T, S162C, K173A, Q174R, D177E, T200A, Q207E, R211K, V245Q, E248DC
 13621142KC422910AZT, 3TCEFVM184VV106M, Y188CV35T, E36K, T39E, E40D, S48T, K122E, K173A, D177E, I178L, G196K, T200E, E204Q, Q207E, R211K, F214L, V245QC
 1973071KC423954D4T, 3TCEFVM184VV106M, Y188CV35T, T39E, S48T, K104KR, K122E, D123N, K173T, Q174K, I178L, T200A, Q207E, R211K, F214L, V245Q, E248NC
 1005932KC424375TDF, 3TCEFVD67N, M184IK101E, Y188CV35T, T39E, S48T, V106L, K122E, I135R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 212532KC424122D4T, 3TCEFVM184VV106M, Y188CV35T, T39A, A98S, K122E, D123S, I135R, K173A, Q174K, D177E, V179I, Q197K, T200A, Q207E, R211K, F214L, V245Q, E248TC
 14131435KC423143D4T, 3TCEFV V106M, Y188CV35T, T39E, S48T, V60I, K122E, D123G, I135V, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, F214LC
 11181174KC422936TDF, 3TCEFVK65R, T69~, K219RV106M, Y188CV21VI, V35T, T39A, S48E, V60I, I63L, S68G, W88S, K122E, D123S, P157A, S162C, Q174E, D177E, I178M, T200A, Q207E, R211K, F214L, K223E, E224EK, V245QC
 14252141KC423647D4T, 3TCEFVD67N, M184VV106M, Y188CK20R, K32R, V35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245EC