<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y181V
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 16
Patients 40
Isolates 40
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Sen (2007)T113NPT113-PLEF186967AZT, D4T, 3TCNVPM184V, N348IY181VV35T, E36A, T39E, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, T200A, Q207E, F214L, V245Q, D256E, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, G359T, A376T, T377R, K390R, E396D, A400T, E404DC
Marconi (2008)SW034sw034EU308047D4T, 3TCNVPM184VY181VS48T, V90I, K122E, D123G, I135IM, I142T, S162Y, K166R, K173I, Q174R, D177E, V179I, T200A, E204EK, L205L*, Q207E, L210L*, R211K, E224EA, V245QC
Deshpande (2009)Pat17494RTFJ530767D4T, 3TCNVPA62AV, K65R, F116Y, Q151M, M184IY181VV35T, T39N, S48T, S68G, T69TI, V90I, D121H, K122E, I135T, S162A, T165I, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 Pat123211RTFJ530818D4T, 3TCNVPM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219WV106M, Y181V, F227LV35T, T39D, V60I, L109I, D121Y, K122E, I135T, S162A, K173I, Q174K, D177E, T200A, I202V, Q207E, H208Y, R211KC
 Pat017418rtFJ530924D4T, 3TCNVPM41L, D67N, M184V, T215YA98G, K101E, Y181V, G190AK32KQ, V35T, T39DN, S48T, V60I, D121Y, K122E, I135K, S162A, T165I, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, H221Y, V245QC
 Pat006444RTFJ530935D4T, 3TCNVPM41L, L74LV, M184V, T215YK103N, V106VM, V108I, Y181VK30KN, V35T, T39N, S48T, V60I, L109LI, K122E, D123Y, I135T, K173A, D177E, V179VI, T200A, Q207E, R211K, D218E, V245KC
Hosseinipour (2009)93089308GQ228318D4T, 3TCNVPM41L, D67N, M184I, T215YK103N, Y181VT39E, V90VI, K102R, K122E, T139I, K173T, Q174E, D177E, T200A, Q207G, R211K, D218E, V245QC
 93609360GQ228356D4T, 3TCNVPM184V, T215TNSYA98G, Y181VT39D, S48T, K122E, I135ILM, K166R, K173T, I195IT, T200A, Q207AE, V245QC
 94339433GQ228367D4T, 3TCNVPA62V, K65R, V75I, F77L, F116Y, Q151M, M184VY181VT39E, S48ST, E53D, S68G, T69TI, K101Q, V118I, D121HY, K122E, I135T, K173A, Q174K, D177E, T200A, I202V, Q207D, L210F, R211K, F214L, V245QC
Deshpande (2010)41IND44241IND442GU108168D4T, 3TCNVPM41L, L74V, M184V, T215YK103N, V108I, Y181VK20R, W24WG, V35T, T39N, S48T, V60I, L109I, K122E, D123N, I135T, K173T, D177E, T200A, I202V, Q207E, R211K, H221Y, V245KC
Ndembi (2010)16740D_P116740GQ409590AZT, 3TCNVPM184V, T215IY181VV35T, E36A, T39G, S48T, K122E, D123S, A158S, K173T, Q174K, D177E, T200A, Q207E, R211KC
van Zyl (2011)A201A201JN638121AZT, 3TCNVPM184IK103RS, Y181VV8I, V35T, T39E, S48T, K122E, S163T, T165I, K173A, Q174R, D177E, I178M, G196E, T200A, E203EK, Q207E, R211K, H221HY, V245Q, D250EC
Manasa (2013)RES349RES349KC951804D4T, 3TCNVPM184VY181VV35T, E36A, T39E, S48T, V60I, K122E, D123N, I135V, K173A, Q174K, D177E, V179I, T200A, Q207D, R211K, F214L, H221Y, V245Q, A272P, K277R, E291D, V292I, I293VC
 RES309RES309KC951765D4T, 3TC, TDFNVPM184V, T215FK103N, Y181VE28K, K32E, V35T, E36A, T39E, S48T, K122E, D123G, I135T, S162A, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293VC
Theys (2013)BM19837BM19837 AZT, 3TCEFVM184VK103N, Y181VE28EK, K32E, V35T, E36A, T39EK, E40D, S48T, T69N, K101Q, K122E, I135T, K173A, D177G, T200A, Q207E, F214FL, V245Q, A272S, T286A, E291D, V292I, I293V, L310I, P313S, V317A, I329VC
Saravanan (2015)CTLA245CTLA245KP993848NRTINNRTID67N, K70R, M184V, T215I, K219QY181VV35T, T39E, S48ST, V60I, T69TN, D121Y, K122E, T139R, K173A, D177E, I178M, Q197K, T200A, Q207EC
 CTLA307CTLA307KP993910NRTINNRTID67N, T69D, K70R, M184V, T215FK101H, V106M, Y181VT27S, V35T, T39E, V60I, A98AS, I135K, S162A, K173A, I178L, V179I, T200A, E203K, Q207E, R211K, L228HC
 CTLA346CTLA346KP993949NRTINNRTID67N, K70R, V75M, M184V, T215F, K219QK101E, V106M, V108I, Y181V, G190AE36DG, V60I, V90I, I94L, D121C, K122E, E138EA, S162H, K173T, D177E, I178M, V179I, T200A, Q207E, R211K, D218E, H221YC
 CTLA58CTLA58KP993661NRTINNRTIM41L, M184V, T215FV108I, Y181VT27S, V35T, T39D, S48T, V60I, D121Y, K122E, K166R, K173A, D177E, V179I, T200A, Q207G, R211KC
 CTLA11CTLA11KP993614NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219WY181VV35M, T39D, V60I, W88C, V90I, K102KR, D121C, K122E, I135T, S162H, T165L, K166R, K173I, Q174K, D177E, V179I, T200A, Q207E, L210LI, R211KC
 CTLA196CTLA196KP993799NRTINNRTIM41L, D67N, M184V, L210W, T215YY181VV35T, T39D, E44D, S48T, V60I, S117A, V118I, D121Y, K122E, I135R, S162A, K173T, D177E, V179I, T200A, Q207G, D218EC
 CTLA14CTLA14KP993617NRTINNRTID67N, K70R, M184V, T215F, K219EY181VV35T, E36A, I37N, T39E, S48ST, V60I, K122E, D123N, I135T, K166R, F171Y, K173A, Q174K, D177E, V179VI, T200A, I202V, Q207EC
 CTLA416CTLA416KP994019NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EK101E, V108I, Y181VV35T, T39N, E44EAD, V60I, D121Y, K122E, I135R, T139I, S162A, K173A, D177E, T200A, E203K, Q207E, L210S, H221Y, L228HC
 CTLA156CTLA156KP993759NRTINNRTIM41L, M184V, T215FY181VV35T, T39D, V60I, D121Y, K122E, I135R, S162A, K166KR, K173T, D177DE, V179I, T200A, Q207E, R211K, F214L, D218E, H221YC
 CTLA97CTLA97KP993700NRTINNRTID67N, K70R, M184V, T215F, K219QY181VV35T, T39E, S48T, V60I, T69TN, D121Y, K122E, T139R, K173A, D177E, I178M, Q197K, T200A, Q207EC
Seu (2015)ZM.HIVDRM.35ZM.HIVDRM.35KP995645TDF, 3TCNVPM184VY181VE6D, V8I, V35T, T39E, S48T, W88C, K122E, D123N, I135T, K173T, D177E, T200A, E203EK, Q207E, H221Y, V245E, E248D, D250E, A272P, K277R, E291D, V292I, I293VC
Skhosana (2015)11ZALS08511ZALS085KM115753D4T, 3TCNVPK65R, T69~, K219RY181VK22R, V35T, T39E, S48T, W88S, K122E, D123S, I135T, P157A, A158T, T165I, E169D, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E291D, V292I, I293V, V317A, Q334E, G335SC
Chimukangara (2016)NC8NC8KU508594AZT, 3TC, ABC, TDFNVPD67S, K70R, M184V, T215F, K219EY181V, P225HT7A, V35T, E36A, T39D, S48T, V60I, T69N, D121H, K122E, I135T, D177E, V179I, T200A, Q207E, R211KC
Neogi (2016)96513.ZA.WC332KT593524ABC, 3TCEFVL74V, M184VY181VV35T, E36A, T39D, K122E, D123S, I135T, S162A, M164L, K173T, D177E, I178V, G196K, T200A, R206RK, Q207E, R211K, F214L, V245Q, D250EC
Steegen (2016)GFGPB152GFGPB152KU127861AZT, 3TC, ABCEFVM184V, T215F, N348IY181VP4S, V35T, T39X, E40ED, S48ST, A98S, K101Q, V118VI, K122E, I135K, S162A, T165I, K173A, Q174K, D177E, V179I, G196E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, V292I, I293V, V317VA, Q334D, G335D, R356K, G359T, A376T, T377R, K390R, A400T, E404DC
 GFECB066GFECB066KU127813D4T, 3TC, TDFNVPK65R, M184VA98G, Y181VV35T, E36A, T39E, S48A, S68N, K122E, D123G, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245E, D250G, A272P, T286A, E291D, V292I, Q334H, G335D, K350R, R356K, R358K, G359T, V365I, T377M, K390R, E399G, A400T, E404DC
Kityo (2017)8326183261KY061816NRTINNRTIM41L, D67N, T69D, L74LV, M184V, L210W, T215YK101E, V106VM, Y181V, G190A, F227FLE44D, S48T, V90I, K103KR, L109LI, K122E, S162A, K173T, D177E, T200A, E203D, Q207E, R211RKC
 8335583355KY061910NRTINNRTID67N, M184V, L210W, T215YV106M, V108VI, Y181V, F227FLE44D, S48T, K122E, D123N, K173A, D177E, G196R, T200A, Q207E, R211K, K223QC
 8322383223KY061779NRTINNRTID67N, K70R, M184V, L210W, T215Y, K219EY181VE44D, S117A, V118I, K122E, I135T, P140PT, K173T, Q174K, N175Y, G196E, T200A, E203V, Q207E, R211RK, F214L, D218E, L228HC
 2838628386KY061379NRTINNRTIM41L, D67DN, M184V, T215YY181VP25T, V35T, T39E, E44ED, S48T, D121Y, K122E, K173T, D177EG, I180IV, T200A, Q207E, R211K, V241M, V245Q, S251N, A272P, K275KR, K281R, T286A, E291D, V292IC
 8337483374KY061929NRTINNRTID67N, M184V, T215YY181VE44D, S48T, K102Q, K122E, D123S, I135IT, I142V, K173A, D177E, I178IM, V179I, G196E, T200A, E204D, Q207K, R211M, D218EC
 8321483214KY061770NRTINNRTID67N, M184V, L210W, T215YY181VS48T, V118VI, K122E, K173V, Q174K, D177E, I178M, T200A, Q207E, R211K, D218EC
 8357483574KY062128NRTINNRTIM41L, M184V, T215FY181VS48T, K122E, K173T, D177E, I178M, T200A, Q207E, H221YC
 8307583075KY061633NRTINNRTID67N, K70R, M184V, T215FI, K219EK103N, Y181VS48T, V60I, T69TN, K102R, K122E, D123N, K173A, D177E, G196K, T200A, I202V, Q207A, R211K, L228HC
 8312283122KY061679NRTINNRTID67N, K70R, M184V, K219QY181VG45GR, V60I, K122E, D123GS, I135T, S162SN, K166R, K173T, D177E, T200A, Q207A, R211K, D218E, L228LHC