<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y181V
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 20
Isolates 20
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Sen (2007)T113NPT113-PLEF186967AZT, D4T, 3TCNVPM184V, N348IY181VV35T, E36A, T39E, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, T200A, Q207E, F214L, V245Q, D256E, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, G359T, A376T, T377R, K390R, E396D, A400T, E404DC
Marconi (2008)SW034sw034EU308047D4T, 3TCNVPM184VY181VS48T, V90I, K122E, D123G, I135IM, I142T, S162Y, K166R, K173I, Q174R, D177E, V179I, T200A, E204EK, L205L*, Q207E, L210L*, R211K, E224EA, V245QC
Deshpande (2009)Pat17494RTFJ530767D4T, 3TCNVPA62AV, K65R, F116Y, Q151M, M184IY181VV35T, T39N, S48T, S68G, T69TI, V90I, D121H, K122E, I135T, S162A, T165I, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245QC
 Pat123211RTFJ530818D4T, 3TCNVPM41L, D67N, T69D, K70R, V75M, M184V, T215F, K219WV106M, Y181V, F227LV35T, T39D, V60I, L109I, D121Y, K122E, I135T, S162A, K173I, Q174K, D177E, T200A, I202V, Q207E, H208Y, R211KC
 Pat017418rtFJ530924D4T, 3TCNVPM41L, D67N, M184V, T215YA98G, K101E, Y181V, G190AK32KQ, V35T, T39DN, S48T, V60I, D121Y, K122E, I135K, S162A, T165I, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, H221Y, V245QC
 Pat006444RTFJ530935D4T, 3TCNVPM41L, L74LV, M184V, T215YK103N, V106VM, V108I, Y181VK30KN, V35T, T39N, S48T, V60I, L109LI, K122E, D123Y, I135T, K173A, D177E, V179VI, T200A, Q207E, R211K, D218E, V245KC
Hosseinipour (2009)93089308GQ228318D4T, 3TCNVPM41L, D67N, M184I, T215YK103N, Y181VT39E, V90VI, K102R, K122E, T139I, K173T, Q174E, D177E, T200A, Q207G, R211K, D218E, V245QC
 93609360GQ228356D4T, 3TCNVPM184V, T215TNSYA98G, Y181VT39D, S48T, K122E, I135ILM, K166R, K173T, I195IT, T200A, Q207AE, V245QC
 94339433GQ228367D4T, 3TCNVPA62V, K65R, V75I, F77L, F116Y, Q151M, M184VY181VT39E, S48ST, E53D, S68G, T69TI, K101Q, V118I, D121HY, K122E, I135T, K173A, Q174K, D177E, T200A, I202V, Q207D, L210F, R211K, F214L, V245QC
Deshpande (2010)41IND44241IND442GU108168D4T, 3TCNVPM41L, L74V, M184V, T215YK103N, V108I, Y181VK20R, W24WG, V35T, T39N, S48T, V60I, L109I, K122E, D123N, I135T, K173T, D177E, T200A, I202V, Q207E, R211K, H221Y, V245KC
Ndembi (2010)16740D_P116740GQ409590AZT, 3TCNVPM184V, T215IY181VV35T, E36A, T39G, S48T, K122E, D123S, A158S, K173T, Q174K, D177E, T200A, Q207E, R211KC
van Zyl (2011)A201A201JN638121AZT, 3TCNVPM184IK103RS, Y181VV8I, V35T, T39E, S48T, K122E, S163T, T165I, K173A, Q174R, D177E, I178M, G196E, T200A, E203EK, Q207E, R211K, H221HY, V245Q, D250EC
Manasa (2013)RES349RES349KC951804D4T, 3TCNVPM184VY181VV35T, E36A, T39E, S48T, V60I, K122E, D123N, I135V, K173A, Q174K, D177E, V179I, T200A, Q207D, R211K, F214L, H221Y, V245Q, A272P, K277R, E291D, V292I, I293VC
 RES309RES309KC951765D4T, 3TC, TDFNVPM184V, T215FK103N, Y181VE28K, K32E, V35T, E36A, T39E, S48T, K122E, D123G, I135T, S162A, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293VC
Theys (2013)BM19837BM19837 AZT, 3TCEFVM184VK103N, Y181VE28EK, K32E, V35T, E36A, T39EK, E40D, S48T, T69N, K101Q, K122E, I135T, K173A, D177G, T200A, Q207E, F214FL, V245Q, A272S, T286A, E291D, V292I, I293V, L310I, P313S, V317A, I329VC
Seu (2015)ZM.HIVDRM.35ZM.HIVDRM.35KP995645TDF, 3TCNVPM184VY181VE6D, V8I, V35T, T39E, S48T, W88C, K122E, D123N, I135T, K173T, D177E, T200A, E203EK, Q207E, H221Y, V245E, E248D, D250E, A272P, K277R, E291D, V292I, I293VC
Skhosana (2015)11ZALS08511ZALS085KM115753D4T, 3TCNVPK65R, T69~, K219RY181VK22R, V35T, T39E, S48T, W88S, K122E, D123S, I135T, P157A, A158T, T165I, E169D, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E291D, V292I, I293V, V317A, Q334E, G335SC
Neogi (2016)96513.ZA.WC332KT593524ABC, 3TCEFVL74V, M184VY181VV35T, E36A, T39D, K122E, D123S, I135T, S162A, M164L, K173T, D177E, I178V, G196K, T200A, R206RK, Q207E, R211K, F214L, V245Q, D250EC
Steegen (2016)GFGPB152GFGPB152KU127861AZT, 3TC, ABCEFVM184V, T215F, N348IY181VP4S, V35T, T39X, E40ED, S48ST, A98S, K101Q, V118VI, K122E, I135K, S162A, T165I, K173A, Q174K, D177E, V179I, G196E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, V292I, I293V, V317VA, Q334D, G335D, R356K, G359T, A376T, T377R, K390R, A400T, E404DC
 GFECB066GFECB066KU127813D4T, 3TC, TDFNVPK65R, M184VA98G, Y181VV35T, E36A, T39E, S48A, S68N, K122E, D123G, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245E, D250G, A272P, T286A, E291D, V292I, Q334H, G335D, K350R, R356K, R358K, G359T, V365I, T377M, K390R, E399G, A400T, E404DC