<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y181I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 9
Patients 18
Isolates 18
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Kantor (2002)TCDD-31TCDD-31_1AY0908573TC, D4T, DDINVPM41L, D67N, L74V, T215YY181IS3C, E6D, V35T, T39E, K122E, D123S, I142V, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D, A272P, K275R, Q278H, K281R, T286A, V292I, I293V, R307KC
Non-B Workgroup (2005)UK1386bUK1386bAY901368D4T, 3TC, ABC, AZT, DDINVPA62AV, K65R, V75I, F77L, Y115F, F116Y, Q151M, M184VY181IV8I, K20R, I31L, V35T, T39E, S48T, K49R, S68G, T69TI, K122E, D123G, K173A, D177G, T200A, Q207E, R211K, F214LC
Marconi (2008)SW011sw011EU308029AZT, 3TCNVPD67N, K70R, M184V, T215F, K219QK103N, Y181IS48T, K49R, V60I, K102Q, K122E, D123S, I135L, E138A, E169D, K173A, Q174K, D177E, G196E, T200A, Q207E, F214L, V245QC
Deshpande (2009)Pat23831artFJ530703NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219WV106M, V108I, Y181IV21I, V35T, T39D, S48T, V60I, W88S, K101S, F116FL, K122E, D123DN, I135V, N136NI, T139R, V148VM, P150PL, W153WL, S162N, K166R, K173A, Q174R, D177E, T200A, Q207E, R211K, V245QC
 Pat053336aRTFJ530888NRTINNRTI Y181IV35T, T39D, S48T, V60I, D121Y, K122E, I135V, T139R, S162A, E169KR, K173E, D177E, T200A, Q207E, R211K, F214FL, V245QC
 Pat026373rtFJ530915AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FY181IV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
 Pat005445RTFJ530936AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FK101EQ, V106M, Y181I, G190A, F227FLV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
Hosseinipour (2009)87608760GQ228308D4T, 3TCNVPK65R, T69~, K70R, V75I, F77L, F116Y, Q151MY181IT39E, E53D, S68G, K122E, D123S, I132L, P157A, S162Q, K173T, T200A, Q207GR, V245EKC
 94029402GQ228335D4T, 3TCNVPM41L, D67N, K70R, M184V, T215F, K219WK101H, Y181IT39E, V60I, T69X, K122E, D123G, I135T, T139I, K173A, V179I, G196K, T200A, Q207E, H208Y, R211K, D218E, L228H, V245QC
 93269326GQ228350D4T, 3TCNVPA62AV, K65R, V75I, Q151M, M184VY181IT39E, S48ST, S68G, K122E, I132L, K173T, Q174K, T200A, I202IV, Q207E, F214L, V245EC
 93559355GQ228354D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YV108I, Y181IE44D, S48T, V118I, K122E, D123S, I135L, S162D, K173A, D177E, V179I, G196E, T200AE, E203K, Q207E, H208Y, R211K, H221Y, V245QC
 93639363GQ228357D4T, 3TCNVPM41L, D67N, L74I, V75S, M184V, L210W, T215Y, K219NV108VI, Y181IT39E, E44D, S48T, V118I, K122E, E138A, A158S, S162A, K166R, K173A, V179I, T200A, Q207A, R211K, D218E, V245QC
Wallis (2009)GT00190091GT00190091 AZT, 3TCEFVD67N, T69D, T215FK103N, Y181IV35T, T39E, S48T, K122E, I135T, K173T, Q174K, D177E, T200A, Q207N, R211K, D218E, V245Q, A272P, K277R, E291D, V292I, I293VC
van Zyl (2011)A198A198JN638118D4T, 3TCNVPD67N, K70R, M184V, K219HQY181IV35T, E36A, T39E, S48T, V60I, K122E, D123G, I132V, I135IV, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, F214L, H221Y, V245QC
Van Zyl (2013)3971911KC423508TDF, 3TCNVPA62V, K65R, M184VV108I, Y181IV35T, E36A, T39D, S48T, K122E, D123G, S162A, K173T, Q174K, T200A, Q207E, R211K, D250EC
Skhosana (2015)11ZALS07511ZALS075KM115801TDF, 3TCNVPM41L, K65R, D67G, V75I, Q151M, M184V, K219EY181IV35T, E36A, T39D, S48T, V60I, S68G, K122E, D123G, K126KQ, I132L, S162A, T165TI, K173T, Q174E, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, V292I, I293V, P294T, E297D, E300EK, Q334N, G335DC
 11ZALS03611ZALS036KM115719TDF, 3TCEFVD67N, K70R, M184V, K219KEY181IV35T, T39D, V60I, K122E, D123DN, I135T, I142R, S162N, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, D324EC
 11ZALS01111ZALS011KM115809TDF, 3TCNVPK65R, Y115FY181IK20R, V35T, E36EA, T39E, S48T, V60I, K122E, D123S, S134SN, K173T, Q174KR, T200A, Q207A, R211K, F214L, H221HY, V245Q, T286A, E291D, V292I, I293V, E308KC