<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y181I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 16
Patients 37
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Kantor (2002)TCDD-31TCDD-31_1AY0908573TC, D4T, DDINVPM41L, D67N, L74V, T215YY181IS3C, E6D, V35T, T39E, K122E, D123S, I142V, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D, A272P, K275R, Q278H, K281R, T286A, V292I, I293V, R307KC
Non-B Workgroup (2005)UK1386bUK1386bAY901368D4T, 3TC, ABC, AZT, DDINVPA62AV, K65R, V75I, F77L, Y115F, F116Y, Q151M, M184VY181IV8I, K20R, I31L, V35T, T39E, S48T, K49R, S68G, T69TI, K122E, D123G, K173A, D177G, T200A, Q207E, R211K, F214LC
Marconi (2008)SW011sw011EU308029AZT, 3TCNVPD67N, K70R, M184V, T215F, K219QK103N, Y181IS48T, K49R, V60I, K102Q, K122E, D123S, I135L, E138A, E169D, K173A, Q174K, D177E, G196E, T200A, Q207E, F214L, V245QC
Waleria-Aleixo (2008)08PR05031608PR050316FJ591344NRTINNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219WK103N, Y181IV35T, E36D, T39D, I94L, K122E, K173A, D177E, T200A, I202V, Q207E, R211K, L228H, V245Q, D250E, A272P, E291D, V292I, I293V, P294T, G335DC
Deshpande (2009)Pat23831artFJ530703NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219WV106M, V108I, Y181IV21I, V35T, T39D, S48T, V60I, W88S, K101S, F116FL, K122E, D123DN, I135V, N136NI, T139R, V148VM, P150PL, W153WL, S162N, K166R, K173A, Q174R, D177E, T200A, Q207E, R211K, V245QC
 Pat053336aRTFJ530888NRTINNRTI Y181IV35T, T39D, S48T, V60I, D121Y, K122E, I135V, T139R, S162A, E169KR, K173E, D177E, T200A, Q207E, R211K, F214FL, V245QC
 Pat026373rtFJ530915AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FY181IV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
 Pat005445RTFJ530936AZT, 3TC, D4TNVP, EFVM41L, D67S, T69S_SG, V75M, M184V, T215FK101EQ, V106M, Y181I, G190A, F227FLV35T, T39E, S48T, V60I, V90I, I94L, L109I, D121Y, K122E, I135L, S162D, Q174R, D177E, T200A, Q207E, R211K, D218E, V245Q, D250EC
Hosseinipour (2009)87608760GQ228308D4T, 3TCNVPK65R, T69~, K70R, V75I, F77L, F116Y, Q151MY181IT39E, E53D, S68G, K122E, D123S, I132L, P157A, S162Q, K173T, T200A, Q207GR, V245EKC
 94029402GQ228335D4T, 3TCNVPM41L, D67N, K70R, M184V, T215F, K219WK101H, Y181IT39E, V60I, T69X, K122E, D123G, I135T, T139I, K173A, V179I, G196K, T200A, Q207E, H208Y, R211K, D218E, L228H, V245QC
 93269326GQ228350D4T, 3TCNVPA62AV, K65R, V75I, Q151M, M184VY181IT39E, S48ST, S68G, K122E, I132L, K173T, Q174K, T200A, I202IV, Q207E, F214L, V245EC
 93559355GQ228354D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YV108I, Y181IE44D, S48T, V118I, K122E, D123S, I135L, S162D, K173A, D177E, V179I, G196E, T200AE, E203K, Q207E, H208Y, R211K, H221Y, V245QC
 93639363GQ228357D4T, 3TCNVPM41L, D67N, L74I, V75S, M184V, L210W, T215Y, K219NV108VI, Y181IT39E, E44D, S48T, V118I, K122E, E138A, A158S, S162A, K166R, K173A, V179I, T200A, Q207A, R211K, D218E, V245QC
Wallis (2009)GT00190091GT00190091 AZT, 3TCEFVD67N, T69D, T215FK103N, Y181IV35T, T39E, S48T, K122E, I135T, K173T, Q174K, D177E, T200A, Q207N, R211K, D218E, V245Q, A272P, K277R, E291D, V292I, I293VC
van Zyl (2011)A198A198JN638118D4T, 3TCNVPD67N, K70R, M184V, K219HQY181IV35T, E36A, T39E, S48T, V60I, K122E, D123G, I132V, I135IV, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, F214L, H221Y, V245QC
Van Zyl (2013)190211.ZA.GT1707KC423508TDF, 3TCNVPA62V, K65R, M184VV108I, Y181IV35T, E36A, T39D, S48T, K122E, D123G, S162A, K173T, Q174K, T200A, Q207E, R211K, D250EC
Wallis (2014)4125041250KM458573NRTINNRTID67G, K70R, M184V, T215YK103N, Y181IK11R, I31L, V35T, E36A, T39E, S48T, K64KR, T69TN, K122E, D123N, K166R, K173A, D177E, V179I, T200A, I202V, Q207R, R211KC
 4109041090KM458614NRTINNRTIA62V, D67G, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181II31L, V35T, T39E, K43KR, S48T, E53D, S68N, K104R, V111I, K122E, D123S, I167IV, K173A, D177E, T200A, Q207E, R211K, H221YC
Saravanan (2015)CTLA427CTLA427KP994030NRTINNRTID67N, F116Y, Q151M, M184VK103N, Y181IV35K, T39D, S48T, V60I, K122E, I135T, S162A, T165I, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214LC
 CTLA332CTLA332KP993935NRTINNRTIM41L, D67N, M184V, L210W, T215YY181IT27S, E28K, V35T, T39D, E44D, V60I, V118I, D121Y, K122E, I135T, T139R, S162A, K173A, Q174K, N175Y, D177E, V179I, G196E, T200A, E203D, H208Y, R211K, K223EC
 CTLA258CTLA258KP993861NRTINNRTIM41L, M184V, T215YY181IV35T, T39D, S48T, K49R, V60I, D121Y, K122E, I135T, S162A, S163ST, T165L, K173A, D177E, V179I, I180IV, G196K, T200A, Q207EC
 CTLC32CTLC32KP993581NRTINNRTID67N, F116Y, Q151M, M184VK103N, Y181IV35K, T39D, S48T, V60I, K122E, I135T, S162A, T165I, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214LC
 CTLA250CTLA250KP993853NRTINNRTIM41L, M184V, T215YY181IV35T, T39D, S48T, K49R, V60I, T69A, D121Y, K122E, I135T, S162A, S163T, T165L, K173A, D177E, V179I, G196K, T200A, Q207EC
 CTLA365CTLA365KP993968NRTINNRTIM41L, D67N, T69D, M184V, L210W, T215YK101E, Y181I, G190SV35T, T39E, E44D, V60I, D121Y, K122E, I135T, S162A, I167V, K173T, D177E, G196E, T200A, E203K, Q207E, R211KC
 CTLA341CTLA341KP993944NRTINNRTIM41L, D67N, V75M, M184V, T215F, K219WK101EQ, Y181IV35T, T39E, K49R, V60I, D121Y, K122E, I135R, S162D, K173A, D177E, I178M, V179I, T200A, Q207R, L210S, R211Q, L228HC
Seu (2015)ZM.HIVDRM.49ZM.HIVDRM.49KP995659AZT, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K103R, K122E, D123N, E138G, K173T, Q174K, T200A, Q207E, R211K, V245KC
 ZM.HIVDRM.50ZM.HIVDRM.50KP995660TDF, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K122E, D123N, T131TP, E138G, K173T, Q174K, T200A, E203ED, Q207E, R211K, V245K, I257L, K281R, E291D, V292I, I293VC
 ZM.HIVDRM.63ZM.HIVDRM.63KP995673AZT, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K122E, D123N, E138G, E169ED, K173T, Q174K, T200A, Q207E, R211K, V245K, I257IL, K281R, E291D, V292I, I293VC
Skhosana (2015)11ZALS07511ZALS075KM115801TDF, 3TCNVPM41L, K65R, D67G, V75I, Q151M, M184V, K219EY181IV35T, E36A, T39D, S48T, V60I, S68G, K122E, D123G, K126KQ, I132L, S162A, T165TI, K173T, Q174E, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, V292I, I293V, P294T, E297D, E300EK, Q334N, G335DC
 11ZALS03611ZALS036KM115719TDF, 3TCEFVD67N, K70R, M184V, K219KEY181IV35T, T39D, V60I, K122E, D123DN, I135T, I142R, S162N, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, D324EC
 11ZALS01111ZALS011KM115809TDF, 3TCNVPK65R, Y115FY181IK20R, V35T, E36EA, T39E, S48T, V60I, K122E, D123S, S134SN, K173T, Q174KR, T200A, Q207A, R211K, F214L, H221HY, V245Q, T286A, E291D, V292I, I293V, E308KC
Karade (2016)BJMC-53BJMC-53KR816063NRTINNRTIK65R, Y115F, M184MVY181IV35T, T39A, S48T, V60I, D121Y, K122E, I135L, A158S, S162A, K173T, D177E, Q197K, T200A, Q207E, R211K, V245Q, E248AC
Lam (2016)2101200121012001KR868022TDF, FTCNVPK65R, Y115F, M184VY181IV35T, E36A, T39D, S48T, V60I, K101R, K122E, D123N, A158T, T165I, K173T, Q174K, I178L, V179VI, Q197K, T200A, Q207A, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334D, G335DC
Kityo (2017)8320783207KY061763NRTINNRTIK65R, Y115YF, M184VY181IP52PA, N57NY, S68SG, K122E, D123S, K166R, K173A, D177E, V179VI, G196K, T200A, I202IV, Q207G, R211KC
 8321583215KY061771NRTINNRTID67G, K70R, M184VA98G, Y181IS48T, V60I, S68G, K122E, D123N, I135L, S162Y, K173R, D177E, T200A, E203T, Q207E, R211K, F214L, K219G, H221YC
 8311883118KY061675NRTINNRTIA62V, K65R, T69~, K70Y, K219RL100I, K103N, Y181IK46Q, S48T, A98AS, D121F, K122E, I135IM, E138A, S162C, R172K, K173A, Q174K, D177E, I178L, V179I, T200A, I202V, E204D, Q207D, R211K, F214FL, H221Y, L228RC
 8324483244KY061799NRTINNRTIM41L, V75I, Y115F, M184V, T215YY181IE44D, S48T, K101Q, K122E, D123S, I135L, E138A, I142V, V179I, T200A, Q207D, L210LS, R211KC