<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation Y181C
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 6
Patients 21
Isolates 21
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1428aUK1428aAY901335D4T, DDINone Y181CT27S, V35K, T39E, E42K, K122E, D123S, I135R, S162A, E169D, K173A, D177E, T200A, Q207E, H221YC
Deshpande (2009)Pat20821RTFJ530733D4T, 3TCNoneM184VA98G, Y181CV10G, V35T, T39D, S48T, V60I, D121Y, K122E, T139K, S162SC, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245QC
Van Zyl (2013)91911.ZA.WC137KC423382ABC, D4TNoneK70R, M184VV108I, Y181CV8I, V35T, T39A, S48T, K122E, D123N, I135T, S162SC, E169G, K173A, T200A, Q207T, R211K, H221Y, V245KC
 438108.ZA.GT617KC424191D4T, 3TCNoneM184MIY181CK20R, V35T, E36A, T39E, S48T, K122E, D123G, K166R, K173A, T200A, Q207A, R211K, V245QC
 251612.ZA.GT2173KC423851AZT, 3TCNone Y181CV35IT, T39E, S48T, V60I, D121H, K122E, I135R, K173A, Q174K, D177E, T200A, I202V, Q207A, R211K, F214L, H221HY, V245QC
 40409.ZA.WC038KC424312AZT, DDINoneM184MV, T215YY181CV35T, T39Q, S48T, K49KR, K122E, D123G, T139R, K173A, D177E, T200A, E203K, Q207E, V245QC
 339107.ZA.GT317KC424108D4T, 3TCNoneM184VY181CP4PS, K22KR, V35T, T39EK, S48T, T69N, K122KE, A158S, K173A, D177E, T200A, Q207E, V245QC
 26012.ZA.NL010KC423765AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EA98G, K101E, Y181CV35T, E36A, T39E, S48T, V60I, K122E, D123S, T139R, E169A, K173A, Q174E, T200A, E203K, Q207E, F214L, V245KC
 96611.ZA.WC171KC423550ABC, 3TCNoneL74V, M184V, K219NY181CV35T, S48T, V60I, T165I, K173I, Q174K, T200A, Q207A, R211K, F214L, V245QC
 366610.ZA.GT1225KC423069D4T, 3TCNone Y181CV35T, T39E, S48T, T69N, K122E, D123N, K173T, Q174K, T200A, Q207A, R211K, V245QC
 65210.ZA.WC091KC423149ABC, 3TCNoneM184VA98G, Y181CT39E, S48T, K49R, K122E, D123G, A158S, S162A, T165L, K173A, D177E, I178M, T200A, I202V, E204Q, L205T, Q207AC
Acharya (2014)DGP040DGP040KJ185210TDF, 3TCNone Y181CV35T, T39E, V60I, D86E, D121H, K122E, I135R, K173A, D177E, I178L, Q207E, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297TC
Steegen (2014)11ZAKS08611ZAKS086KJ176368D4T, 3TCNone Y181CP4S, V35T, E36A, T39E, S48T, V60I, K122E, D123S, S162A, K173A, D177E, T200A, Q207D, R211K, V245Q, D250DN, A272Q, E291D, V292I, I293VC
 12ZAKS25512ZAKS255KJ176534ABC, 3TCNoneL74V, M184IY181CV35T, T39K, S48T, V90I, K122E, S162C, K173A, D177E, T200A, Q207G, R211K, V245Q, A272P, Q278N, L279I, T286A, E291D, V292I, I293V, I329L, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, A400TC
 09ZAKS00209ZAKS002KJ176286D4T, 3TCNone Y181CP4S, V35T, E36A, T39E, M41MT, S48AT, V60I, K122E, D123S, S162A, K173A, D177E, T200A, Q207D, R211K, V245Q, A272Q, E291D, V292I, I293VC
 10ZAKS04310ZAKS043KJ176325D4T, 3TCNone Y181CP4S, V35T, E36A, T39E, S48T, V60I, K122E, D123S, S162A, K173A, D177E, T200A, Q207D, R211K, V245Q, A272Q, E291D, V292I, I293V, Q334D, G335DC
 12ZAKS20412ZAKS204KJ176484ABC, 3TCNoneD67N, K70R, M184V, K219EY181CE6K, V35T, E36A, T39E, S48T, V60I, K122E, S162C, K173A, D177E, T200A, Q207N, R211K, H221Y, V245Q, A272P, Q278H, K281R, E291D, V292I, S322T, Q334D, G335DC
Neogi (2016)95513.ZA.WC329KT593521ABC, 3TCNoneL74V, Y115F, M184VK101E, Y181CP9S, V35T, E36A, T39E, S48T, V60I, W88C, K122E, D123G, E138A, Q174E, T200A, Q207E, R211Q, F214L, H221Y, V245Q, E248DC
 14513.ZA.NL081KT593453TDF, 3TCNoneM184VY181CP4S, V35T, T39E, S48T, V60I, S68G, T69N, D121Y, K122E, I135R, T139R, S162C, K173A, V179I, T200A, Q207D, R211K, F214L, H221Y, D237DN, V245QC
 99413.ZA.WC338KT593529ABC, 3TCNone Y181CV35T, E36LV, T39E, S48T, K49R, V60I, K122E, D123G, K166R, K173A, Q174R, D177E, T200A, Q207E, R211K, V245QC
 322713.ZA.GT2920KT593231AZT, 3TCNoneK70R, K219KQA98G, Y181CV35T, E36A, T39E, S48T, T69N, K101Q, K122E, K173A, Q174K, D177E, T200A, Q207T, R211K, F214L, L228R, V245Q, D250EC