<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation V179I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 20
Patients 68
Isolates 69
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE73SE73AF388136NoneNVP K103KNV35T, E36A, T39E, E40D, K43R, S48E, E53D, K101Q, K122E, D123G, E138A, S162Y, K173A, D177G, V179I, G196E, T200A, Q207D, V245Q, T253TP, A272P, K277R, T286A, E291D, V292I, K311RC
Eshleman (2004) SE73_7dAY428676NoneNVP K103KN, V106VAV35T, E36A, T39E, E40D, K43R, S48E, E53D, K101Q, K122E, D123DG, E138A, S162Y, K173AT, D177G, V179I, G196E, T200A, Q207DN, V245Q, A272P, K277R, T286A, E291D, V292I, K311R, Q334EC
Gulick (2004)RG315RG315w104 AZT, 3TCEFV  T39D, S48T, V60I, D121HY, K122E, K166KR, K173A, D177E, V179I, T200A, I202V, E204K, Q207DE, R211RK, V245QC
Non-B Workgroup (2005)TK2015TK2015 AZT, 3TC, D4TNVPM184V P4S, V35T, E36A, T39D, S48T, K122E, D123G, S162Y, K173A, Q174K, D177E, V179I, I195L, G196M, T200A, Q207E, R211K, P225PL, V245Q, D250DE, A272P, E291D, V317A, D320X, P321X, S322SL, K323XC
 TK2018TK2018 AZT, 3TC, D4T, DDI, ABCNVPD67N, K70R, M184V, T215Y, K219EA98G, Y181CE28X, V35LM, T39E, S48T, K49R, K122E, D123G, I135T, K173A, D177E, V179I, T200A, I202V, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293VC
 TK4004TK4004 AZT, 3TC, ABC, D4TNVPM41ML, D67N, T69D, K70R, T215Y, K219EA98G, Y181CV35T, E36A, T39E, S48T, V60I, D121Y, K122E, S163SI, K173T, D177E, V179I, T200A, Q207E, L228R, V245Q, E291D, V292I, I293VC
 TK4011TK4011 DDC, AZT, D4T, 3TC, ABC, DDIEFVM41L, A62V, D67N, K70R, L74I, M184V, T215Y, K219EV106M, G190AP4S, T7P, V35T, E36A, T39D, E44D, K122E, D123E, S162Y, K173T, Q174K, N175Y, D177E, V179I, T200A, E203D, Q207E, H208Y, R211K, W212R, H221Y, L228H, V245Q, D250E, A272P, E291D, V292I, E297KC
 PL4804587649 3TC, DDIEFVM184VK103N, V106MV35T, T39D, S48T, V60I, W88S, D121H, K122E, I135X, E138A, T139A, K173A, Q174K, I178L, V179I, T200A, Q207E, R211K, F214FL, V245Q, E248D, A272P, K275R, Q278H, K281KR, L283I, T286A, E291D, V292I, I293V, V317VA, I329VC
Weber (2005)00M387800M3878AY677526D4T, 3TC, AZTNVPM184VK103N, Y181CE28K, K32E, V35T, E36A, T39E, K122E, D123N, K173T, Q174K, D177E, V179I, T200A, Q207D, R211K, H221Y, V245Q, D250E, A272P, K275R, Q278G, L283I, V292I, I293VC
 F16446F16446AY677543DDC, AZT, 3TC, D4T, DDI, ABCNVPD67N, M184V, T215Y, K219KQY188LV35T, T39E, S48T, K64KR, K122E, E138S, V148VG, S162C, K173T, Q174K, D177E, I178L, V179I, G196E, T200A, Q207D, R211K, D237N, V245Q, D250E, I257L, A272S, K281R, E291D, V292I, I293V, E297EK, H315YC
Baxter (2006)48-14371437-30320DQ877826NRTINNRTI  V35VM, E36EA, T39E, S48T, V60VI, K122E, D123G, I135T, K173A, D177E, V179I, T200A, I202V, Q207D, R211K, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V, V317A, I329IL, Q334N, G335D, R356K, G359T, A376T, T377M, V381VI, K390RC
 48-22542254-30930DQ877888NRTINNRTID67N, K70R, M184V, T215F, K219WA98G, K101E, V108I, Y181CV8VI, K20R, E28K, K32E, V35K, T39E, V118I, K122E, D123S, I135T, E138A, K173A, D177G, V179I, T200A, E203K, L205F, Q207D, H208Y, L210S, R211K, D218E, K223Q, L228H, Q242K, V245Q, K275Q, T286A, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, T377L, K385R, K390RC
Novitsky (2007)16171617_9067EF026216AZT, DDINNRTI Y181CV35T, T39E, S48T, K122E, D123S, T139A, K173T, Q174R, D177E, I178L, V179I, T200A, I202V, Q207E, R211K, V245Q, D250E, K277R, E291D, V292I, I293VC
Sen (2007)T112NPT112-PLEF186966AZT, D4T, 3TC, DDINVPK70R, F116Y, Q151M, K219QK103N, Y181CV35T, E36A, T39E, S48T, V60I, T69N, D121Y, K122E, S134C, I135T, S162A, T165I, K173A, P176T, D177E, V179I, Q182H, T200A, I202V, E204K, Q207E, R211K, F214L, L228R, V245Q, A272P, K275Q, E291D, V292I, I293V, Q334E, R356K, G359T, T377M, K390R, A400T, E404DC
 T013NPT13-PLEF186968D4T, 3TC, DDIEFVD67DN, K70R, L74LV, M184V, K219DEA98G, L100LI, V106VM, Y181C, G190GAV35T, E36A, T39E, S48T, V60I, K101KR, D121HY, K122E, I135T, S162A, K173A, Q174K, D177E, V179I, T200A, Q207E, D218E, V245Q, A272P, K277R, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, T377M, K390R, K395R, T403M, E404D, E432D, V435A, A437V, L452IC
 T102NPT102-PLEF186981D4T, 3TCNVPM184V, N348IV108VI, Y181CV35T, T39E, S48T, K49KR, V60I, D121Y, K122E, D123E, I135R, E169Q, K173E, Q174R, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, G335D, R356K, G359T, T377MR, K390R, A400TC
 T069NPT69-PLEF186987D4T, 3TCNVPL74I, M184VY181CV35T, E36A, T39E, S48T, V60I, K102Q, D121Y, K122E, I159V, D177E, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E432D, N447S, L452I, V466I, D471E, H483YC
Seoighe (2007)CHB26706_C267EF381851NoneNVP K103KNK11Q, V35T, E36A, T39E, S48T, V60VI, K122E, D123G, K173A, Q174K, V179I, Y183YH, Q197QH, T200A, Q207E, R211K, V245Q, S251ST, A272Q, K277R, T286A, E291D, V292I, I293VC
 KEH8606_K86EF382036NoneNVP K103KN, Y181YC, Y188YCV35IT, E36A, T39E, S48T, V60VI, K102Q, S162CY, K173T, D177DE, V179I, T200A, Q207E, R211K, V245Q, E248N, A272P, K275KQ, Q278QH, T286A, E291D, I293VC
 PL4606_PL46V2EF382232NoneNVP  V35T, E36A, T39E, S48T, V60I, V90I, K122E, D123G, K166R, K173ILST, Q174QK, D177E, V179I, T200A, I202V, Q207E, R211K, V245Q, A272P, E291D, V292I, I293VC
 PL32906_PL329V2EF382333NoneNVPM41LK103KNK20R, V35T, T39E, S48T, V60VI, K102Q, K122E, D123G, E138A, T139A, A158S, S162A, K173A, Q174K, V179I, T200A, Q207D, R211RK, V245KQ, A272P, E291D, V292I, I293VC
Marconi (2008)SW002sw002EU308021D4T, 3TCEFVM184VK101E, Y188LK122E, D123DG, G141GR, K173T, Q174K, V179I, T200A, Q207E, R211K, V245LC
 SW034sw034EU308047D4T, 3TCNVPM184VY181VS48T, V90I, K122E, D123G, I135IM, I142T, S162Y, K166R, K173I, Q174R, D177E, V179I, T200A, E204EK, L205L*, Q207E, L210L*, R211K, E224EA, V245QC
 SW074SW074EU308085D4T, 3TCEFVM184VK103N, V108VIS48T, V60I, S68G, V90I, K101G, D121Y, K122E, I135T, S162Y, K173S, Q174K, D177E, I178L, V179I, G196E, T200A, Q207E, R211K, V245QC
 SW076sw076EU308087D4T, AZT, 3TCEFV  S48T, V60I, K122E, D123S, K173T, Q174K, D177N, V179I, T200A, I202V, Q207N, R211K, F214LC
Nyombi (2008)TBK006TBK006EU251719NoneNVP  V35K, T39E, S48T, V60I, K122E, D123S, A158S, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, V245K, D250E, S251I, A272AS, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377MC
 TBK052TBK052EU251746NoneNVP  V35T, E36A, T39E, E40ED, K122E, D123N, I135T, K166R, K173A, D177E, I178V, V179I, T200A, I202V, E204K, Q207E, V245Q, E248D, D250E, A272S, K277R, T286A, E291D, V292I, I293V, V314A, G335D, F346H, R356K, G359T, A376T, T377QC
Deshpande (2009)Pat22846artFJ530713AZT, 3TCNVPM41L, M184V, L210W, T215YY188LV35T, T39DN, E44ED, S48T, V60I, D121H, K122E, K173KT, D177E, I178L, V179I, T200A, I202V, E203EA, Q207E, H208HY, R211K, H221HY, V245QC
 Pat2241RTFJ530717D4T, 3TCNVPD67N, K70R, M184V, K219Q V35T, T39D, K43R, V60I, K101Q, D121Y, K122E, I135R, S162A, K173A, D177E, V179I, Q197K, T200A, E203D, Q207QAEP, R211K, V241VI, V245Q, K249NC
 Pat17395RTFJ530768D4T, 3TCNVPM41L, D67N, K70R, M184V, L210L*W, T215Y, K219E V35T, T39E, E44D, V60I, T107S, D121Y, K122E, I135T, S162C, I167IV, K173A, D177E, V179I, T200A, E203EK, Q207E, H208HY, R211K, K223KE, L228H, V245EC
 Pat150164RTFJ530791NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215Y, K219KRK101E, K103KN, V106A, G190GA, F227LK20R, V35T, T39D, E44A, S48T, V60I, K82KR, A98AS, K122E, I135L, E138A, I142IV, K166R, K173A, I178L, V179I, T200A, Q207D, H208Y, R211KC
 Pat124210RTFJ530817NRTINNRTID67N, K70R, M184V, T215V, K219QK101EK20KR, T27S, V35T, T39D, K49R, V60I, T69N, K122E, D123DN, I135R, S162D, K166R, Q174R, D177E, V179I, T200A, I202V, Q207E, R211K, V245QC
 Pat117227RTFJ530824NRTINNRTIM41L, D67N, M184V, T215Y, K219NA98G, Y188LV35T, T39D, E44D, S48T, V60I, K102R, D121H, K122E, I142V, F160C, K173T, D177E, I178L, V179I, T200A, I202V, E203A, L205S, Q207E, H208Y, L210S, R211K, H221Y, V245Q, K249HC
 Pat115230RTFJ530826D4T, 3TCNVPM184VY181CV35K, T39D, S48T, D121H, K122E, I135T, K166R, K173T, D177E, I178M, V179I, T200A, Q207A, R211K, F214L, H221Y, V245E, K249NC
 Pat112234RTFJ530829D4T, 3TCNVPM184V, T215YY188LM16MT, K20R, K32N, V35K, T39D, V60I, A98AS, V118I, D121H, K122E, I135IT, K166R, K173A, D177E, V179I, E194D, T200A, Q207E, R211K, V245EC
 Pat084273RTFJ530857D4T, 3TCNVP  V35T, E36A, T39E, S48T, V60I, S117A, K122P, D123S, Q145QP, F160FL, D177E, I178L, V179I, T200A, K201R, Q207D, R211KC
 Pat073294RTFJ530868D4T, 3TCNVPM41L, A62V, D67N, V75I, F77L, Q151M, M184V, T215YY181CK20KR, V35T, T39D, E44D, V60VI, T69TN, V90I, D121Y, K122E, I135R, I142V, S162Y, K173A, Q174K, N175H, D177E, V179I, T200A, K201T, E203D, Q207E, R211K, F214L, H221Y, V245QC
 Pat047348aRTFJ530894AZT, 3TCEFVD67N, K70R, M184V, T215F, K219WV106M, Y181C, G190AI5M, K20R, V35R, T39D, I94L, K102Q, D121Y, K122E, D123E, I135T, S162C, K173A, D177E, V179I, T200A, Q207E, L210S, K223Q, L228H, V245QC
 Pat035350RTFJ530906D4T, 3TCNVPM41L, D67N, T69D, Q151M, M184V, T215YY188LK20KR, V35T, T39D, K43R, V60I, D121H, K122E, D123E, I135V, S162A, K173A, Q174K, D177E, V179I, T200AV, Q207E, R211K, F214L, V245QC
 Pat002VR012RTFJ530939D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK32R, A33AV, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
 Pat001VR014RTFJ530940D4T, 3TCNVPT69~, V75T, Q151M, M184VY188LV35T, I37M, T39N, S48T, V60I, S68G, D121Y, K122E, D123E, I142V, K173A, D177E, V179I, V189I, T200A, I202IV, Q207G, R211K, F214L, L228Q, V245QC
Hosseinipour (2009)81318131GQ228297D4T, 3TCNVPD67G, K70R, L74I, V75S, M184V, T215F, K219EA98G, V108I, Y181CT39E, S48T, S68G, K122E, I135T, S162Y, K173T, V179I, G196E, T200A, E203K, Q207E, L210F, R211K, D218DE, K223KE, L228H, Q242H, V245XC
 93729372GQ228329D4T, 3TCNVPM184VK101HQ, G190AT39E, S48T, S68SG, K122E, D123G, K173A, D177E, I178V, V179I, T200A, E204K, Q207E, F214L, V245QC
 94029402GQ228335D4T, 3TCNVPM41L, D67N, K70R, M184V, T215F, K219WK101H, Y181IT39E, V60I, T69X, K122E, D123G, I135T, T139I, K173A, V179I, G196K, T200A, Q207E, H208Y, R211K, D218E, L228H, V245QC
 93559355GQ228354D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YV108I, Y181IE44D, S48T, V118I, K122E, D123S, I135L, S162D, K173A, D177E, V179I, G196E, T200AE, E203K, Q207E, H208Y, R211K, H221Y, V245QC
 93639363GQ228357D4T, 3TCNVPM41L, D67N, L74I, V75S, M184V, L210W, T215Y, K219NV108VI, Y181IT39E, E44D, S48T, V118I, K122E, E138A, A158S, S162A, K166R, K173A, V179I, T200A, Q207A, R211K, D218E, V245QC
 82958295GQ228376D4T, 3TCNVPD67N, K70R, M184V, L210W, T215Y, K219EY181C, G190AT39E, V60I, V118VI, K122E, D123S, I135T, S162D, E169A, K173A, D177E, I178F, V179I, T200A, E203K, Q207E, H208Y, R211K, D218E, L228H, V245QC
 87708770GQ228382D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QY188LT39E, S48T, K122E, D123S, I135T, I167V, K173A, Q174K, D177E, V179I, G196T, T200A, I202V, Q207E, R211RK, V245RC
Wallis (2009)23450232345023 D4T, 3TCEFVM184VY188LK30KE, V35T, T39K, S48T, V90I, K101Q, K122E, D123S, I135IT, K173A, I178L, V179I, T200A, Q207N, R211K, V245Q, E248EK, A272S, K277R, L283LF, T286TA, E291D, V292I, I293V, L303LWC
 23464402346440 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 23499842349984 D4T, 3TCNVPK65R, V75I, F116Y, Q151M, M184VK101E, G190A, F227LV35T, T39E, S48T, V60I, S68G, V118I, K122E, D123S, I132L, E138A, T139A, K173T, Q174K, D177E, V179I, T200A, I202V, E204D, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329LC
 22838712283871 D4T, 3TCEFVA62AV, V75VAIT, M184VV106M, Y188CK20R, V35T, T39R, E40R, M41W, T69TN, K122E, K173A, Q174QK, D177E, V179I, T200A, Q207E, R211K, V245Q, D250E, K277R, E291D, V292I, I293V, H315L, D324DEC
 TJC2499250TJC2499250 AZT, 3TCEFVM41L, D67N, K70R, M184V, T215FY, K219EQY188LK20R, V35T, T39E, V90I, A98S, K102X, K103R, K104Q, K122E, D123G, S162Y, K173A, D177E, V179I, T200A, E203K, Q207E, F214FL, L228LH, V245Q, D250DE, A272P, K277R, L283I, T286A, A288T, V292I, I293V, S322A, D324EC
Deshpande (2010)12IND42512IND425GU108151D4T, 3TCNVPA62V, D67G, T69D, K70R, V75I, F77L, Q151M, M184IK103N, Y181CK20R, K32G, V35T, T39D, S48T, V90I, D121H, K122E, S162Y, K173A, Q174K, D177E, I178L, V179I, G196K, T200A, Q207E, R211K, H221Y, V245QC
 14IND42614IND426GU108152D4T, 3TCEFVT69~, V75T, Q151M, M184VY188LV35T, I37M, T39N, S48T, V60I, S68G, D121Y, K122E, D123E, I142V, K173A, D177E, V179I, V189I, T200A, I202V, Q207G, R211K, F214L, L228Q, V245QC
 22IND42922IND429GU108155D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YA98AG, K101E, V106VAMT, V108I, Y181IS, G190AK20R, V35T, T39D, E44D, K49R, V60I, I94L, V118I, K122E, D123S, I135T, S162A, T165L, K173A, D177E, V179I, V189VI, T200A, E203D, Q207E, R211K, H221Y, V245QC
 37IND43837IND438GU108164D4T, 3TC, AZTNVPM41L, D67N, K70R, V75M, M184V, T215YG190AK20KR, V35T, T39D, S48T, V60I, T69S, K102Q, D121Y, K122E, T139R, S162AT, K173T, D177E, I178M, V179I, T200A, Q207E, R211K, V245QC
 55IND44555IND445GU108171D4T, 3TCNVPM184VY181CV35T, T39D, S48T, V90I, K102Q, K122E, I135M, S162Y, K166R, K173A, D177E, I178L, V179I, L187LW, T200A, Q207E, L228R, V245QC
 66IND44966IND449GU108175D4T, 3TCNVPD67N, M184V, T215F, K219WK101E, Y181C, G190AV35T, T39E, S48T, V60I, V118I, D121H, K122E, I135R, T139K, S162D, K173T, V179I, T200A, Q207E, H208Y, R211K, K223E, V245Q, D250EC
El-Khatib (2010)Pat12111ZA_SAVE2421JF960571D4T, 3TCEFV  E6K, V35T, E36EA, T39E, K122E, D123S, K173T, Q174K, V179I, T200E, I202IV, E204K, Q207E, R211K, F214L, A272PC
Rodrigues (2010)322_07BR07SC322GQ401306AZT, 3TCNVP  V35Q, T39D, S48T, V60I, K122E, D123S, I135R, S162C, D177E, V179I, T200E, R211KC
Green (2011)707PKE10F707PKE10FHM623501D4T, 3TCEFV  K20KR, V35T, T39E, S48T, K122E, D123G, E138A, K173A, Q174K, D177G, V179I, T200AE, Q207A, R211K, V245Q, A272P, K277KR, K281KR, T286A, E291D, V292I, I293VC
 707PKE41F707PKE41FHM623528D4T, DDIEFVM41L, D67N, L210W, T215YA98G, G190S, K238TE6K, K20R, V35T, T39DE, V60I, V118I, K122E, D123G, K173A, D177E, V179I, T200A, Q207E, R211RK, V245K, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, D324E, I329LC
van Zyl (2011)A239A239JN638138D4T, 3TCEFVM184VG190AD123DE, I135IT, S162C, K166KR, K173A, Q174K, D177E, V179I, T200A, Q207E, R211RKC
 A247A247JN638144AZT, 3TCEFVA62V, M184VK103KN, V106M, F227LV35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, V179I, G196E, T200A, E203D, E204K, Q207E, R211K, H221Y, L228R, V245QC
 A256A256JN638152D4T, 3TCNVPM184VK103S, G190AE6EK, V35T, T39E, S48T, K122E, K173T, D177E, V179I, T200A, Q207E, R211K, V245QC
 A62A62JN638218D4T, 3TCEFVM184VV106M, Y188WV35T, E36A, T39D, S162SN, K173A, V179I, T200E, I202V, Q207E, R211K, V245QC
Luebbert (2012)LEU 010070101825 D4T, 3TCNVPM184VV108VI, Y181CK20KR, V35T, E36A, T39E, S48T, K122E, D123G, S134SN, I135V, T139A, I142IV, K173T, Q174K, N175NY, V179I, T200A, Q207E, R211K, H221Y, V245Q, T286A, E291D, V292I, E297A, A304EC
 LEU 010370101829 D4T, 3TCNVPM184VK103N, Y181CK20KR, V35T, T39E, K49KR, K122E, D123S, I142IV, Q145H, K173A, Q174K, V179I, T200A, Q207E, F214FL, H221Y, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC

Database

Resources

Team