<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 22
Isolates 24
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Marconi (2008)SW093SW093EU308102AZT, 3TCEFVM184VK103N, Y188LS48T, V60I, K122P, I132IV, E138Q, Q145QE, K173A, Q174K, D177E, Q197P, T200A, Q207A, R211K, V245QC
Deshpande (2009)Pat122212RTFJ530819NRTINNRTID67N, T69D, K70R, M184V, K219QK103NV35T, T39E, S48T, V60I, A62P, K102KR, K122E, D123S, I135T, E138Q, K173A, Q174R, D177E, T200A, E203K, Q207E, R211KC
Hosseinipour (2009)88218821GQ228379D4T, 3TCNVPD67N, M184V, T215YK103NT39E, A98S, V118VI, K122E, D123S, I135IT, E138Q, S162C, K173A, Q174K, N175NY, D177E, I178IM, G196M, T200A, Q207E, H208HY, R211RK, V245TC
Deshpande (2010)34IND43534IND435GU108161AZT, 3TCNVPM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219WK103N, V108VI, Y181CV35T, E36A, T39D, V60I, D121Y, K122E, D123E, I135T, E138Q, S162A, K173A, D177EG, T200A, Q207E, R211K, L228H, V245KC
El-Khatib (2010)Pat05410ZA_SAVE2320HQ012332D4T, 3TCEFVM184VY188LV35T, E36A, T39E, S48T, V106L, V118I, K122E, D123N, E138Q, T165TI, K173IRT, Q174K, T200A, Q207E, R211K, F214L, V245Q, D250EC
Ngo-Giang-Huong (2011)PHPT3789PHPT3789RTHQ996467D4T, 3TCNVPM184VK101E, G190AK32R, V35T, T39K, S48T, A98S, K122E, E138Q, K166R, K173A, Q174R, D177E, I178M, G196M, T200A, E203K, Q207DN, R211KQ, F214LC
Sigaloff (2011)GP00022848GP00022848_1JN381557D4T, 3TCEFVM184VK103N, P225HV35T, T39E, S48T, V60I, K122E, D123S, I135L, E138Q, K173A, Q174K, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293VC
  GP00022848_2JN381558D4T, 3TCEFVM184VK103N, P225HP14PT, M16MK, D17DY, G18GA, V35T, T39E, S48T, V60I, K122E, D123S, I135L, E138Q, K173A, Q174K, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293VC
van Zyl (2011)A98A98JN638230AZT, 3TCEFVM184VV106MV35T, T39E, S48T, V60I, T69S, K122E, D123S, I135T, E138Q, K173A, T200A, I202V, E204K, Q207E, R211K, F214L, V245QC
Hoffmann (2013)5652456524KJ081300TDF, FTCEFVM184VK103N, V108VI, P225HV35T, E36A, T39E, E40D, S48T, V60VI, K122E, D123N, I135L, E138Q, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250EC
 418251418251KJ081321TDF, FTCNVPK65R, D67N, M184VG190AV35T, T39E, S48T, K102R, D121H, K122E, E138Q, S162C, K173T, D177E, I178L, T200A, Q207K, R211K, V245KC
Van Zyl (2013)18272736KC423807D4T, 3TCEFVK70KE, M184VG190EV35T, E36A, T39E, S48T, S68SG, D121H, K122E, D123DE, I135V, E138Q, S162C, K173A, D177E, T200A, Q207G, R211K, H221Y, V245QC
 12451114KC422890D4T, 3TCEFVM184VK101E, K103N, G190AV35T, T39E, S48T, K49R, S68G, K82R, K122E, D123N, I135IT, E138Q, E169K, K173E, D177EG, T200A, Q207KN, R211RK, V245Q, D250EC
 17622754KC423814D4T, 3TCEFVY115YF, M184VK103N, P225HK20R, V35T, E36A, T39E, S48E, D123S, E138Q, L149LP, K173T, Q197R, T200A, Q207K, R211K, V245Q, D250EC
 4581290KC423033D4T, 3TCEFVA62V, M184VK103N, V106ME6D, K20R, V35T, T39E, S48T, V60I, K122E, E138Q, T165I, K173T, D177E, T200A, I202V, Q207A, R211K, L228LR, D237DN, V245EC
 1266962KC424398D4T, 3TCEFVM184VK103KN, V106M, V179VDK20R, V21VI, V35T, E36A, T39K, K43E, V60I, K122E, E138Q, T165I, K173A, Q174K, E194D, T200A, Q207E, R211K, F214L, V245QC
 8261141KC422909AZT, D4T, 3TCNVP, EFVM184VK103N, V108IV35T, E36A, T39E, S48T, V60I, K122E, D123N, I135M, E138Q, K173T, D177E, I178L, T200A, Q207D, R211K, K219S, V245QC
  1640KC423290AZT, D4T, 3TCNVP, EFVM184VK103N, V108IK20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, I135M, E138Q, K173T, D177E, I178L, I180IV, T200A, Q207D, R211K, V245QC
Steegen (2014)12ZAKS21312ZAKS213KJ176493ABC, 3TC, D4TEFVL74V, M184VK103N, V106MV35T, T39E, S48T, V60I, K122E, D123S, E138Q, K173A, Q174K, T200A, Q207A, R211K, F214L, T240A, V245Q, A272P, K277R, E291D, V292I, I293V, Q334D, G335DC
 11ZAKS12711ZAKS127KJ176409D4T, 3TCEFVD67N, K70R, M184V, K219Q, N348IK103N, K238T, Y318FV35T, T39E, T69N, K122E, D123S, E138Q, S162C, K173A, Q174K, N175Y, I178L, E194D, G196V, T200A, K201KI, E203K, Q207E, L228H, E233ED, Q242QE, V245Q, P247A, E248D, D250E, A272P, E291D, V292I, I293V, K311R, D324E, Q334H, G335DC
 12ZAKS20512ZAKS205KJ176485D4T, 3TCEFVM184VK103N, P225HP4PT, K20R, V35T, T39E, S48T, V60I, V118I, K122E, D123G, I135L, E138Q, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, K277R, T286A, E291D, I293V, D324E, I329L, Q334H, G335DC
 12ZAKS36112ZAKS361KJ176640D4T, 3TCNVPA62AV, M184VK101KE, G190AI5IV, E6EK, V8I, M16MV, K20R, V35T, E36A, T39E, S48T, K122E, I135T, E138Q, S162SC, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, I329V, Q334H, G335D, R356K, G359T, E370Q, A371V, T377Q, I382IT, K390R, E396D, A400T, E404DC
 10ZAKS03410ZAKS034KJ176316D4T, 3TCEFVM184V, T215FK101KE, G190QK20R, V35T, E36A, T39E, S48T, K49KR, V60I, L109I, D121Y, K122E, E138Q, K173A, T200A, Q207E, V245Q, D250E, A272P, K275Q, K277R, Q278H, L283LI, T286A, E291D, V292I, I293VC
 11ZAKS13011ZAKS130KJ176412D4T, 3TCEFVD67N, K70KR, M184V, K219KQK103N, V106MK20R, V35T, E36A, T39E, S48T, K102KR, K122E, E138Q, K173A, D177G, T200A, Q207E, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, I293V, E308K, K311R, S322A, Q334H, G335DC