<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138K
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 7
Patients 9
Isolates 9
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M1M1AY010449AZT, 3TCNoneM184VE138KV35T, E36A, T39D, K43KE, R83K, F87FL, E89ED, K101R, K102R, K122V, D123G, K173A, D177E, G196K, T200A, I202V, Q207G, R211K, L228LVC
Non-B Workgroup (2005)TK1026TK1026 ABC, AZT, 3TCNoneY115F, M184V, T215FE138K, V179DE6D, P14Q, V35T, E36A, T39D, I47IT, S48T, A98S, K122E, D123N, K173A, D177K, T200A, Q207E, R211K, F214L, K223KQ, E224EK, Y232YC, K238KE, I244IEKV, V245Q, A272P, T286V, E291D, V292I, I293VC
 TK4017TK4017 AZT, 3TC, ABCNoneM41L, M184V, L210W, T215NE138KV35T, T39G, K43R, A98S, K122E, D123S, A158S, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292IC
Pillay (2008)DR58DR58AY589910AZT, 3TCNoneM184VV108I, E138KV35M, E36EA, T39E, S48T, D123E, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, V317A, S322SAC
Van Zyl (2013)352210.ZA.GT1284KC423114D4T, 3TCNoneM184VE138KV35T, E36A, T39E, S48T, V60I, S68G, K122E, D123S, K173T, Q174K, D177E, T200A, E204D, V245QC
Steegen (2014)10ZAKS07210ZAKS072KJ176354D4T, 3TCNone K101E, E138KP4S, E6K, K11S, K20R, V35T, E36A, T39E, S48T, V90I, K122E, D123G, S162A, T165I, K173T, Q174K, D177DE, I178IM, V179A, T200A, I202IV, Q207E, R211K, F214L, V245Q, E248D, D250DE, A272P, K277KR, L283I, E291D, V292IC
Rossouw (2015)RP104RP104KT032036D4T, 3TCNoneM184VE138KK30KT, V35T, E36A, T39E, S48T, A98S, K103KE, K122E, K173A, Q174K, D177DE, V179I, Q197QR, T200A, I202IV, E203ED, Q207N, R211KT, F214FL, V245Q, A272P, K277R, L283I, I293V, E297EK, L303LW, Q334H, G335D, R356K, G359T, A371AV, T377Q, T386TI, K390R, A400L, E404D, V435AC
Posada Cespedes (2017)45813.ZA.WC344KX543611AZT, 3TCNoneV75VME138KP4PS, V35T, T39E, E40ED, S48T, V60I, K101Q, K122E, D123G, K173A, T200A, I202IV, Q207EG, R211K, F214L, V245QC
 318315.ZA.GT4435 AZT, 3TCNone K101E, E138KK20KR, V35T, E36A, T39E, S48T, K122E, S162N, K173A, Q174K, D177E, G196M, T200A, Q207E, R211K, V245Q, E248DC