<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138K
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 21
Isolates 24
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)18911891_0851EF026224AZT, DDINNRTID67DN, K70KR, T215TNSYE138K, V179DG, G190EV35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, D250E, T286A, E291D, V292I, I293VC
Marconi (2008)SW065SW065EU308076D4T, AZT, 3TCEFV V106M, E138KS48T, K122E, I135T, K173T, Q174K, Q197P, T200A, Q207E, R211K, F214LC
 SW070SW070EU308081D4T, 3TC, AZTEFVD67N, K70RE138K, V179DS48T, V60I, K103R, V106I, K122E, D123N, I135M, K173A, Q174K, D177E, T200A, Q207D, R211K, F214L, V245QC
Riddler (2008)6404264042w8 TDF, 3TC, D4TEFVM184IV106M, E138KV35T, T39E, K122E, D123S, I135R, I142V, K173A, Q174K, D177E, G196D, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, P345Q, R356K, G359T, T377L, S379C, K390RC
Deshpande (2009)Pat18567RTFJ530756AZT, 3TCNVPM184V, T215TNSY, K219RV106A, E138K, F227FLV35T, T39D, S48T, T58S, V60I, D121H, K122E, S162A, K173A, D177E, I178M, T200A, E203D, E204K, Q207E, R211K, V245QC
Hoffmann (2009)pat028MD24064 AZT, 3TCEFVM184VK101E, E138K, Y188LT27S, V35T, E36A, T39E, S48T, P52S, K103R, K122E, D123S, I135V, S162C, K173T, D177E, T200A, Q207A, R211K, V245Q, A272PC
  MD118823 AZT, 3TCEFVM184VK101E, E138K, Y188L, G190AT27S, V35T, E36A, T39E, S48T, K103R, K122E, D123S, I135V, S162C, K173T, D177E, T200A, Q207A, R211K, V245Q, D250DE, A272PC
Wallis (2009)TJC2368272TJC2368272 D4T, 3TCEFVD67N, M184VK101E, E138K, G190EK20R, E28G, V35T, T39E, S48T, K122E, D123S, Q174K, V179G, G196E, T200A, E203K, Q207E, R211K, V245Q, A272S, K275Q, K277R, T286A, E291D, V292I, I293V, P294T, I329V, Q334NC
 TJC2407731TJC2407731 D4T, 3TCEFVK65R, V75VIK103KN, V106M, E138K, V179VD, Y188CK20R, V35T, T39E, S48T, V60I, S68G, W88C, D121H, K122E, D123G, T165I, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, Q334YC
 GT00327585GT00327585 D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
Sigaloff (2011) GT00327585_1JN381602D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
  GT00327585_2JN381603D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
van Zyl (2011)A183A183JN638108D4T, 3TCNVPM184VE138K, G190A, M230LP4S, K11Q, V35T, T39E, S48T, V60I, S68G, L80LV, D121Y, K122E, K166R, K173A, T200A, E204K, Q207D, R211K, V245QC
Sunpath (2013)CAS109CAS109 TDF, 3TCEFVK65R, T69~K101E, E138K, G190EV35T, E36A, T39E, S48T, V90I, K122E, K173T, D177E, T200A, Q207E, V245K, A272P, R284K, T286A, E291D, V292I, I293VC
Van Zyl (2013)15562418KC423701ABC, 3TCEFVL74V, Y115F, M184VL100I, E138K, V179DK32Q, V35T, T39E, S48T, V60I, K82KR, K103R, K122E, D123S, I135V, K173A, D177G, T200A, I202V, Q207E, R211RK, H221Y, L228R, V245LQC
 12801315KC423051D4T, 3TCEFVD67N, K70KR, V75M, M184V, K219NE138K, G190QV35T, T39E, S48T, V60I, K122E, D123G, K173A, D177E, T200A, Q207E, V245QC
 1211703KC423339D4T, 3TCEFVA62V, M184VV106M, E138KK20KR, V35T, E36A, T39D, W88S, K102Q, K122E, D123S, I135T, S162H, K173T, Q174K, D177N, D192N, T200A, Q207A, R211K, F214L, E224K, T240A, V245H, D250EC
 252112KC422894AZT, 3TCEFVK70R, M184VV106M, E138K, Y188LV35T, T39E, S48T, V60I, D121H, K122E, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, Q334N, G335DC
 971135KC423081AZT, D4T, 3TCNVP, EFVM184VL100I, K103N, E138KE6D, V35T, T39E, S48T, K49KR, V60VI, K122E, D123G, S162C, K173A, Q174R, D177E, I178L, E203EK, Q207E, R211K, V245KC
 2751183KC422946ABC, 3TCEFVL74V, M184VL100I, K103N, E138KV35T, T39E, S48T, K104KR, K122E, D123S, K173A, Q174R, D177E, I178L, G196T, T200A, Q207E, R211K, V245QC
 16911041KC422827D4T, 3TCEFVV75M, M184VL100I, V106M, E138K, Y188YFE6K, V35T, E36A, T39E, S48T, K104R, K122E, K173A, Q174K, D177E, G196MT, T200A, E203EK, Q207E, R211K, F214L, L228R, V245QC
 16361248KC422997AZT, D4T, 3TC, DDINVP, EFVD67N, K70R, T215TI, K219QE138KV8I, V35T, T39E, S48T, K122E, D123G, I135V, S162C, K173A, Q174K, D177E, T200A, Q207G, R211K, V245QC
 261261KC423755AZT, D4T, 3TC, DDINVP, EFVD67N, T215YK103N, E138K, G190AV35T, T39E, S48T, V60I, K122E, D123S, I142IV, K173A, Q174QK, D177E, T200A, Q207E, R211KC
Steegen (2014)12ZAKS34412ZAKS344KJ176623D4T, 3TCEFVM184VV106M, E138K, F227LV35T, T39E, S48T, D121H, K122E, K173A, D177E, I178L, Q197K, T200A, Q207D, R211K, V245T, E248D, A272P, V292I, I293V, P294T, E297K, E308K, K323RC