<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138K
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 50
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)18911891_0851EF026224AZT, DDINNRTID67DN, K70KR, T215TNSYE138K, V179DG, G190EV35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, D250E, T286A, E291D, V292I, I293VC
Marconi (2008)SW065SW065EU308076D4T, AZT, 3TCEFV V106M, E138KS48T, K122E, I135T, K173T, Q174K, Q197P, T200A, Q207E, R211K, F214LC
 SW070SW070EU308081D4T, 3TC, AZTEFVD67N, K70RE138K, V179DS48T, V60I, K103R, V106I, K122E, D123N, I135M, K173A, Q174K, D177E, T200A, Q207D, R211K, F214L, V245QC
Riddler (2008)6404264042w8 TDF, 3TC, D4TEFVM184IV106M, E138KV35T, T39E, K122E, D123S, I135R, I142V, K173A, Q174K, D177E, G196D, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, P345Q, R356K, G359T, T377L, S379C, K390RC
Waleria-Aleixo (2008)08PR06070108PR060701FJ591526NRTINNRTIM184VL100I, K103N, E138KV35T, T39E, S48T, D123E, I135T, K173T, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, P294T, E297D, I329VC
 RES281RES281FJ591980NRTINNRTIT215F, K219EE138K, Y181YCV35T, E36A, T39E, K43R, K122E, D123S, K173A, Q174K, T200A, H221Y, V245TC
Deshpande (2009)Pat18567RTFJ530756AZT, 3TCNVPM184V, T215TNSY, K219RV106A, E138K, F227FLV35T, T39D, S48T, T58S, V60I, D121H, K122E, S162A, K173A, D177E, I178M, T200A, E203D, E204K, Q207E, R211K, V245QC
Hoffmann (2009)pat028MD24064 AZT, 3TCEFVM184VK101E, E138K, Y188LT27S, V35T, E36A, T39E, S48T, P52S, K103R, K122E, D123S, I135V, S162C, K173T, D177E, T200A, Q207A, R211K, V245Q, A272PC
  MD118823 AZT, 3TCEFVM184VK101E, E138K, Y188L, G190AT27S, V35T, E36A, T39E, S48T, K103R, K122E, D123S, I135V, S162C, K173T, D177E, T200A, Q207A, R211K, V245Q, D250DE, A272PC
Wallis (2009)TJC2368272TJC2368272 D4T, 3TCEFVD67N, M184VK101E, E138K, G190EK20R, E28G, V35T, T39E, S48T, K122E, D123S, Q174K, V179G, G196E, T200A, E203K, Q207E, R211K, V245Q, A272S, K275Q, K277R, T286A, E291D, V292I, I293V, P294T, I329V, Q334NC
 TJC2407731TJC2407731 D4T, 3TCEFVK65R, V75VIK103KN, V106M, E138K, V179VD, Y188CK20R, V35T, T39E, S48T, V60I, S68G, W88C, D121H, K122E, D123G, T165I, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272S, T286A, E291D, V292I, I293V, Q334YC
 GT00327585GT00327585 D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
Sigaloff (2011) GT00327585_1JN381602D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
  GT00327585_2JN381603D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
van Zyl (2011)A183A183JN638108D4T, 3TCNVPM184VE138K, G190A, M230LP4S, K11Q, V35T, T39E, S48T, V60I, S68G, L80LV, D121Y, K122E, K166R, K173A, T200A, E204K, Q207D, R211K, V245QC
Manasa (2013)RES041RES041KC951662D4T, 3TCEFVM184VV106M, E138K, F227LK20R, V35T, T39E, S48T, V60I, K122E, D123S, I135R, K166R, K173A, D177E, T200A, I202V, V245K, A272P, K277R, T286A, E291D, I293V, E297KC
 RES170RES170KC951720D4T, 3TC, TDFEFVD67G, K70R, M184V, T215I, K219EV106M, E138K, Y188LV8T, V35T, T39K, S48T, V60I, S68G, S105L, V118I, K122E, D123G, K173T, Q174R, T200A, Q207A, R211K, F214L, V245Q, E248D, A272P, K277R, E291D, V292I, I293VC
 RES454RES454KC951846D4T, 3TCNVPM184V, T215FK101E, E138K, G190SP4S, K20R, V35T, E36A, T39D, S48T, V60I, K122E, D123S, I135T, K173A, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, A272P, E291D, V292I, I293V, P294T, E297KC
 RES340RES340KC951796D4T, 3TC, TDFEFVM41L, K65R, V75MV106M, E138K, F227LV35T, E36A, T39D, S48T, V60I, K122E, D123S, I132V, I135V, K166R, K173T, D177E, T200A, Q207E, R211K, H221Y, V245Q, D250N, K277R, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS109CAS109 TDF, 3TCEFVK65R, T69~K101E, E138K, G190EV35T, E36A, T39E, S48T, V90I, K122E, K173T, D177E, T200A, Q207E, V245K, A272P, R284K, T286A, E291D, V292I, I293VC
Van Zyl (2013)703311.ZA.GT1555KC423339D4T, 3TCEFVA62V, M184VV106M, E138KK20KR, V35T, E36A, T39D, W88S, K102Q, K122E, D123S, I135T, S162H, K173T, Q174K, D177N, D192N, T200A, Q207A, R211K, F214L, E224K, T240A, V245H, D250EC
 75310.ZA.WC072KC422997D4T, 3TC, AZT, DDIEFVD67N, K70R, T215TI, K219QE138KP1L, V8I, V35T, T39E, S48T, K122E, D123G, I135V, S162C, K173A, Q174K, D177E, T200A, Q207G, R211K, V245QC
 88909.ZA.WC056KC422827D4T, 3TCEFVV75M, M184VL100I, V106M, E138K, Y188YFE6K, V35T, E36A, T39E, S48T, K104R, K122E, K173A, Q174K, D177E, G196MT, T200A, E203EK, Q207E, R211K, F214L, L228R, V245QC
 704411.ZA.EC097KC423701ABC, 3TCEFVL74V, Y115F, M184VL100I, E138K, V179DK32Q, V35T, T39E, S48T, V60I, K82KR, K103R, K122E, D123S, I135V, K173A, D177G, T200A, I202V, Q207E, R211RK, H221Y, L228R, V245LQC
 361410.ZA.GT1213KC423051D4T, 3TCEFVD67N, K70KR, V75M, M184V, K219NE138K, G190QV35T, T39E, S48T, V60I, K122E, D123G, K173A, D177E, T200A, Q207E, V245QC
 172107.ZA.GT094KC422894AZT, 3TCEFVK70R, M184VV106M, E138K, Y188LV35T, T39E, S48T, V60I, D121H, K122E, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, Q334N, G335DC
 267010.ZA.GT1090KC422946ABC, 3TCEFVL74V, M184VL100I, K103N, E138KV35T, T39E, S48T, K104KR, K122E, D123S, K173A, Q174R, D177E, I178L, G196T, T200A, Q207E, R211K, V245QC
 322307.ZA.GT124KC423081D4T, 3TCEFVM184VL100I, K103N, E138KE6D, V35T, T39E, S48T, K49KR, V60VI, K122E, D123G, S162C, K173A, Q174R, D177E, I178L, E203EK, Q207E, R211K, V245KC
Acharya (2014)DGP081DGP081KJ185251TDF, 3TCNVP V106M, E138KV35T, T39D, V60I, D121H, K122E, I135K, S162A, K173E, D177E, I178L, T200A, E204K, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, E297AC
Steegen (2014)12ZAKS34412ZAKS344KJ176623D4T, 3TCEFVM184VV106M, E138K, F227LV35T, T39E, S48T, D121H, K122E, K173A, D177E, I178L, Q197K, T200A, Q207D, R211K, V245T, E248D, A272P, V292I, I293V, P294T, E297K, E308K, K323RC
Saravanan (2015)CTLA273CTLA273KP993876NRTINNRTIM184VV106M, E138KV35T, E36AS, T39E, S48ST, V60I, K122E, D123S, I135R, S162C, K173A, Q174K, D177E, T200A, Q207E, L228HC
 CTLA315CTLA315KP993918NRTINNRTID67N, K70R, V75M, M184V, T215FI, K219QA98G, V106M, E138K, V179D, F227LT27S, V35T, T39D, S48T, V60I, I94L, D121Y, K122E, I135R, I142V, S162A, K173A, D177E, T200A, I202V, Q207E, R211RKC
 CTLA488CTLA488KP994091NRTINNRTIM184VV106M, E138K, V179DV35T, T39D, S48T, V60I, D121Y, K122E, I135R, S162A, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, F214LC
 CTLA436CTLA436KP994039NRTINNRTIM184VV106M, V108I, E138KV35T, E36A, T39E, S48T, V60I, V90VI, D121Y, K122E, I135T, S162Y, K173T, D177E, T200A, Q207E, R211K, F214LC
 CTLA479CTLA479KP994082NRTINNRTIM184VE138KV35M, T39E, S48T, V60I, D121Y, K122E, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, H221Q, Q222K, L228HC
 CTLA152CTLA152KP993755NRTINNRTIM41L, D67N, M184V, T215SE138K, Y188L, G190AV35T, T39D, E44D, S48T, V60I, S162Y, K173A, D177E, V179I, T200A, E203EV, Q207E, L210S, R211KC
Dinesha (2016)T34T34KX275078TDF, 3TCEFVK65R, D67N, M184V, K219EL100I, K101E, V106M, E138K, F227LV35T, T39E, S48ST, V60I, S68ST, V90I, D121H, K122E, I135R, T165TI, K173T, Q174R, D177DE, V179VI, T200A, I202V, Q207E, R211K, D237EC
 T29T29KX275073TDF, 3TCEFVM41L, K65R, K70T, M184MVK103N, V106M, E138KK22KN, V35T, T39D, S48T, V60I, S68G, D121Y, K122E, I135R, S162T, K173A, Q197QH, T200I, H208HL, R211KC
Karade (2016)BJMC-20BJMC-20KR816053NRTINNRTIM184VV106M, E138K, F227LK20KR, K32KN, V35T, T39A, S48T, V60VI, D121H, K122E, I135R, K173A, D177E, Q197K, T200A, Q207A, R211K, V245Q, E248EKC
 YCM-250YCM-250KR816085NRTINNRTIK70KR, M184VV106M, E138KK20R, V35T, T39D, S48T, V60I, D121Y, K122E, I135T, K173A, Q174R, D177E, I178L, T200A, E203EK, Q207E, R211K, F214FL, F227M, V245QC
Lam (2016)1601104116011041KR868149TDF, 3TCNVPM41ML, D67N, K70R, V75VIM, M184V, T215Y, K219EK101KE, V106M, E138K, F227LV35T, E36A, T39D, V60I, D121Y, K122E, D123E, I135R, S162A, K173T, D177E, T200A, E203EK, Q207E, V245Q, A272P, K277R, R284RK, T286A, E291D, V292I, I293V, G335DC
Neogi (2016)58113.ZA.EC596KT592784ABC, 3TCEFVK65R, K70T, Y115F, M184VV106M, E138K, F227CV21I, V35T, T39E, S48T, K49R, V60I, S68G, K122P, I135T, R172K, K173A, D177E, I178L, T200A, I202V, E203K, E204K, Q207E, R211K, V245QC
 33313.ZA.EC741KT592876D4T, 3TCEFVM184VK103N, E138K, P225H, M230LV35T, T39E, S48T, T69N, A98S, K122E, D123DG, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 15313.ZA.EC547KT592747TDF, 3TCEFVD67N, K70R, V75M, M184V, K219KEL100I, K103N, E138KV35T, T39E, S48T, K49KR, V60I, K122E, D123N, I135T, S162SN, K166KR, K173I, Q174K, D177E, T200A, Q207E, R211K, V245EC
Steegen (2016)GFKZB256GFKZB256KU128163TDF, 3TC, AZTEFV, NVPK65R, D67H, Q151M, K219EK101E, E138K, G190EV35T, T39E, S48T, K49R, V60I, S68G, T69N, V90I, S105A, L109I, K122E, D123G, K173A, D177E, V179G, T200A, E203K, R211K, D218E, K223Q, V245Q, D250E, S251I, A272S, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, A360S, K366RC
 GFGPB004GFGPB004KU127611TDF, 3TCNVPL74I, Y115F, M184VE138K, G190AP4S, V35T, T39E, S48T, V118VI, K122E, D123N, I135R, S162C, K173T, Q174K, L187M, T200A, Q207N, R211K, V245N, D250E, A272P, Q278N, K281R, L283I, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, A371V, T377M, K390R, A400T, E404DC
 GFFSB021GFFSB021KU127656TDF, 3TCEFVA62V, K65R, K219RV106M, E138K, V179DV35T, T39E, S48T, S68~, W88S, S105SA, K122E, D123N, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214LC
 GFGPB026GFGPB026KU127634TDF, 3TCEFVK65R, Y115YF, M184VL100I, K103N, V108I, E138KE6K, K20R, V35T, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, E248D, D250E, A272P, K277R, E291D, V292I, I293V, S322A, Q334N, G335D, R356K, G359T, S379C, K390R, A400T, E404DC
 GFKZB066GFKZB066KU127934D4T, 3TC, TDFNVPK65R, K70T, V75S, M184VK101E, E138K, G190EP4S, E6K, V35T, E36A, T39D, S48T, K49R, T58S, S68N, V118I, K122E, T165I, K173A, Q174K, D177E, V179G, T200A, Q207E, F214L, H221Y, V245K, A272P, K275R, T286A, E291D, V292I, I293V, V317A, M357I, G359TC
 GFKZB187GFKZB187KU128079TDF, 3TC, FTCEFVD67G, K70EE138K, G190EK32T, V35T, T39E, V60I, T69N, V90I, K122E, D123G, I142V, K173A, Q174K, D177E, V179G, T200A, Q207E, R211K, H221Y, L228R, V245K, K249Q, A272P, K275Q, E291D, V292I, I293V, D324EC
 GFWCB035GFWCB035KU127806TDF, 3TCEFVK65R, V75I, Y115FK101KE, E138K, G190EV35T, T39E, S48T, K64R, K122E, D123S, K173A, D177E, V179G, T200A, Q207E, R211K, V245QC
 GFGPB097GFGPB097KU127767TDF, 3TCEFVD67N, K70E, V75I, Y115FK101KE, E138K, G190EV35T, T39E, S48T, V60VI, K122E, D123G, K173A, D177E, V179G, T200A, Q207E, H221Y, L228R, V245Q, D250E, A272P, V276I, T286A, E291D, V292I, I293V, D324E, Q334D, G335NC
Kityo (2017)8289082890KY061456NRTINNRTIM41L, M184V, T215YK101E, V106M, E138K, G190A, F227FLS48T, K122E, I142IV, K173A, Q174K, D177E, V179VI, T200A, E203V, Q207DE, R211KC