<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138G
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 43
Isolates 43
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Novitsky (2007)15991599_2995EF026213AZT, DDINNRTID67N, K70R, T215F, K219KEK101E, K103NE28K, K32E, V35T, E36A, T39E, S48T, K122E, D123G, E138G, K173A, Q197K, T200E, Q207E, V245Q, A272P, K277R, T286A, E291D, V292IC
Sen (2007)T073NPT73-PLEF186964D4T, 3TCNVPM184VG190AV35T, T39D, S48T, V60I, K101Q, K122E, I135T, E138G, K166R, K173A, G196E, T200A, Q207G, R211K, V245Q, D250E, A272P, K277R, K281KR, E291D, V292I, I293V, Q334E, G335D, R356K, G359T, E370ED, T377R, S379C, I382IV, K390R, A400TC
El-Khatib (2010)Pat09611ZA_SAVE2019JF960546NRTI, AZT, DDINNRTI K103N, P225HP4S, K11KT, K20KR, V35T, T39E, S48T, V60VI, K122E, D123S, E138G, T139TS, A158S, K173A, Q174QK, D177E, G196GE, T200A, Q207E, R211RK, V245Q, A272PC
van Zyl (2011)A48A48JN638213D4T, 3TCNVPM184VV106M, F227LT27S, V35T, E36A, T39D, S48T, K122E, D123S, I135T, E138G, S162C, K173A, T200A, Q207A, R211K, V245QC
Manasa (2013)RES336RES336KC951792D4T, 3TCEFV, NVPM184VK103S, V106ME6K, V35T, T39E, S48T, V60I, K122E, I135L, E138G, K173A, D177E, V179I, T200A, Q207K, R211Q, F214L, V245M, D250E, A272P, K277R, E291D, V292I, I293VC
 RES451RES451KC951844D4T, 3TCEFVM184V, T215FK101E, V106M, G190A, M230LP4S, K20R, V35T, T39E, S48T, V60I, K122E, D123G, E138G, K173A, D177E, T200A, Q207E, D237N, V245K, A272P, E291D, V292I, I293VC
 RES329RES329KC951785D4T, 3TCNVPD67N, K70R, M184V, K219QK103NV35T, T39E, S48T, V60I, K122E, D123S, I135L, E138G, K166R, K173A, D177E, I178IM, T200A, Q207E, V245Q, K277R, T286A, E291D, V292I, I293VC
Van Zyl (2013)O1249832KC424304D4T, 3TCEFVM184VK103N, P225HV35T, E36A, T39D, S48T, V60VI, K122E, D123N, I135L, E138G, K173A, Q174K, T200A, Q207A, R211K, V245QC
 251809.ZA.GT926KC424412TDF, 3TCEFVM184V, T215FK101E, V106M, G190A, F227FLK20KR, V35T, E36A, T39E, S48T, K122E, D123S, E138G, K173I, Q174K, I178L, T200A, Q207E, V245Q, E248DC
 340309.ZA.GT785KC424320AZT, 3TCNVPM184VM230LE6D, V35T, E36A, T39E, S48T, W88C, K102Q, K122E, D123G, E138G, K173A, D177E, I178L, T200A, K201R, E204K, Q207D, R211K, V245QC
 212411.ZA.GT1674KC423466D4T, DDIEFVD67N, T69D, K70R, K219QK101P, K103SK22R, V35T, E36A, T39E, E40D, S48T, V60I, K102R, K122E, D123N, E138G, A158S, K173T, Q174K, V179I, T200A, E203EQ, Q207E, F214L, D218E, L228HC
 536212.ZA.EC230KC423924D4T, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, K122E, D123N, I135L, E138G, A158S, K173A, Q174K, D177E, T200A, Q207E, V245Q, D250EC
 178908.ZA.GT427KC423306D4T, 3TCEFVV75I, M184VK103NE6K, V35T, E36A, T39E, S48T, A98S, K101Q, K122E, I132L, E138G, K173A, D177E, I178L, T200I, Q207E, R211K, V245QC
 101911.ZA.EC068KC423581TDF, 3TCEFVA62V, K65R, Y115F, M184VV106M, V179DE6K, V35T, T39E, S68N, K122E, E138G, A158S, K173A, Q174K, D177E, I178M, T200A, Q207A, R211K, L228Q, V245Q, E248DC
 292809.ZA.GT631KC424202ABC, 3TCEFVM184VV106M, V179DK20R, K32N, V35K, E36A, T39D, S48T, K103R, K122E, D123N, I135V, E138G, K166R, K173T, D177E, T200A, I202IV, Q207AE, F214FL, Y232H, V245QC
 212.ZA.EC165KC423806TDF, 3TCEFVM184VK103N, P225HT69X, K122E, D123G, I135L, E138G, S162A, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
Wallis (2014)4113641136KM458555NRTINNRTIM41L, D67N, M184V, T215FYK101E, G190A, F227FLK20R, E28K, K32E, V35T, T39E, E44D, V118I, K122E, D123S, I135L, E138G, K173A, Q174QR, D177E, T200A, E203EDKN, Q207D, H208HY, L210LF, R211K, H221HYC
 4154241542KM458596NRTINNRTIM184VK103NV35T, T39E, K122E, I135L, E138G, K173A, D177E, I178M, T200A, Q207E, R211KC
 4112841128KM458543NRTINNRTID67N, K70R, M184V, K219QA98G, K103NK20R, V35T, T39E, S48T, V60I, K122E, D123N, I135L, E138G, K173AV, Q174K, D177E, I178L, D186E, G196GE, T200A, E203ED, Q207K, R211K, D218EC
Rossouw (2015)RP144RP144KT032052D4T, 3TCEFVM184VK103N, P225H, K238TV35T, E36A, T39E, V90VI, A98S, K122E, D123S, I135L, E138G, S163AT, T165I, K173A, Q174K, D177E, I178L, V179I, T200A, Q207D, I244IV, V245Q, E248D, A272P, K277R, I293VC
Seu (2015)ZM.HIVDRM.49ZM.HIVDRM.49KP995659AZT, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K103R, K122E, D123N, E138G, K173T, Q174K, T200A, Q207E, R211K, V245KC
 ZM.HIVDRM.50ZM.HIVDRM.50KP995660TDF, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K122E, D123N, T131TP, E138G, K173T, Q174K, T200A, E203ED, Q207E, R211K, V245K, I257L, K281R, E291D, V292I, I293VC
 ZM.HIVDRM.63ZM.HIVDRM.63KP995673AZT, 3TCNVPA62AV, K65R, Y115F, M184VV179D, Y181I, Y188LK20KR, V35T, T39E, S48T, K122E, D123N, E138G, E169ED, K173T, Q174K, T200A, Q207E, R211K, V245K, I257IL, K281R, E291D, V292I, I293VC
Skhosana (2015)11ZALS08211ZALS082KM115742TDF, 3TCEFVK70Q, V75M, M184VA98AG, K103N, V108I, P225HK13KR, V35T, T39K, S48T, V60I, K122E, D123G, I135L, E138G, K173R, Q174K, D177E, V189I, T200E, Q207A, V245Q, A272P, K277R, T286A, E291D, V292I, S322A, Q334N, G335D, Y342F, Q343KC
 11ZALS01411ZALS014KM115721TDF, 3TCEFVK65R, M184IL100I, K103N, M230LV35M, T39DGNS, K122E, D123N, I135T, E138G, K173A, D177E, I178M, T200A, E204K, Q207E, R211K, F214L, P243Q, V245Q, D250E, A272P, K275R, Q278N, T286A, E291S, V292I, I293V, P294Q, E308EKC
Lam (2016)1601202316012023KR868046D4T, 3TCNVPD67DN, K70R, M184V, K219KQK103NK20R, V35T, E36EA, T39DE, S48T, K49KR, V60I, V90I, D121Y, K122E, I135T, E138G, S162H, K173A, D177E, T200A, E203EK, Q207E, R211RK, Y232H, V245Q, A272P, K277R, K281KR, E291D, V292I, I293V, E297EA, G335DC
 1601104416011044KR867925AZT, 3TCNVPM41L, M184V, T215YK103NV35T, T39D, S48T, V60I, D121Y, K122E, I135T, E138G, S162Y, T165L, K173A, Q174K, T200A, Q207AT, R211K, V245Q, D250E, A272P, K275R, K281R, E291D, V292I, I293V, H315F, G333EC
Neogi (2016)4613.ZA.EC705KT592853TDF, 3TCEFVD67G, T69D, K70R, M184V, K219QL100I, K103NK20R, V35T, T39E, V60I, K122E, D123G, I135V, E138G, T139Q, I142T, K173A, D177G, V179I, T200AE, E203K, Q207E, L228H, V245QC
 17613.ZA.FS027KT592988TDF, 3TCNVPK65R, M184VY188LK20R, V35T, T39E, S48T, S68N, K122E, D123S, E138G, K166KR, K173T, T200E, I202V, E204Q, Q207E, R211K, F214L, T240AC
 715513.ZA.EC848KT592933TDF, 3TCEFVM41L, K65R, L74V, Y115F, M184VK103N, V106AK20R, K32I, V35T, T39K, S48T, S68G, T69TI, K102KR, V118I, K122E, D123S, E138G, T139TA, I142IT, K173T, T200TI, I202V, Q207E, R211K, F214L, Y232H, V245Q, D250E, S251NC
 558913.ZA.EC773KT592901TDF, 3TCEFVK65R, M184IV106M, V179D, M230LK20R, K32R, V35T, T39E, S48T, V60I, S68G, K103KR, K122E, D123G, E138G, K173T, D177E, T200A, Q207E, R211K, F214L, V245QC
 372613.ZA.GT2844KT593180TDF, 3TCEFVK65R, L74LI, V75VIM, M184VK103N, P225HV35T, T39E, S48T, K49R, E53D, S68SDGN, T69TI, V90I, A98AS, K122E, D123DN, I135L, E138G, S162D, K166R, E169R, K173E, I178M, T200A, Q207E, R211K, V245MC
Steegen (2016)GFKZB236GFKZB236KU128129FTC, 3TCEFVK65R, L74I, Y115F, M184V, K219EK101E, V108I, Y181C, G190AV35T, E36S, T39E, S48T, V60I, S68K, K122E, D123S, E138G, K173T, D177E, V189I, I195L, G196E, T200A, Q207A, R211K, D218E, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294A, G335D, R356K, M357R, G359T, T377Q, S379C, K390R, A400T, E404DC
 GFKZB041GFKZB041KU127841D4T, 3TCEFVM184V, N348IK103N, P225HK20R, V35T, E36A, T39E, S48T, K122E, D123NS, I135L, E138G, T165V, K173A, Q174KR, T200A, Q207E, R211K, F214L, V245E, A272P, T286TA, E291D, V292I, I293V, E297EA, Q334H, R356K, G359S, V365I, V372I, Q373QH, S379G, K390R, A400T, E404DC
 GFKZB304GFKZB304KU128221TDF, 3TCEFVL74I, M184VK103N, P225HP4S, K20R, V35T, E36A, T39E, S48T, V60I, K101Q, K122E, D123S, I135M, E138G, K173A, T200A, Q207D, R211K, V245Q, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, M357T, T377S, K390R, A400I, E404DC
 GFGPB053GFGPB053KU127662TDF, 3TCEFV K103N, V106MK20R, V35T, T39E, K122E, D123N, E138G, I142V, K173T, D177E, I178L, T200A, E204K, Q207E, R211K, F214L, V245Q, A272P, K275Q, K277R, E291D, I293V, E297K, Q334D, G335D, R356K, G359T, T377M, K390R, E396D, A400T, E404DC
 GFNWB003GFNWB003KU127978D4T, 3TC, TDFEFVA62V, K65R, M184VK103N, V106MV35T, T39E, K49R, S68G, T69TI, K102R, K122E, D123N, E138G, S162D, E169R, K173AE, Q174K, D177DE, T200A, I202V, Q207E, R211K, F214L, L228Q, P243T, V245Q, A272P, K275R, T286A, E291D, V292I, I293V, P313Q, S322A, D324E, I329V, Q334N, G335D, R356K, G359T, A371V, S379C, K390R, E396D, A400T, E404D, V435TC
 GFKZB135GFKZB135KU128018D4T, 3TC, TDF, FTCEFVM184VA98G, K103N, P225HE6EK, K20R, V35T, T39A, S48T, V60I, K122E, D123S, I135L, E138G, K173A, Q174K, T200A, Q207QK, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, Q334D, G335D, R356K, G359T, T369A, T377LV, K390R, A400T, E404D, E432D, V435A, A437VC
 GFMPB101GFMPB101KU128034D4T, 3TC, TDFEFVK70G, M184VK101E, V106M, G190A, F227LV35T, T39E, T69I, K122E, D123G, E138G, K173T, Q174E, D177E, I178L, V179VI, T200A, Q207N, R211K, V245H, D250E, S251R, A272P, K275R, E291D, V292I, I293VC
 GFMPB052GFMPB052KU127980D4T, 3TCEFVM41L, D67N, T69D, L74V, M184V, T215FA98G, K103N, F227L, M230LI2V, V35T, T39E, E44D, S48T, E53D, S117A, V118I, K122E, D123E, E138G, K173T, Q174K, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, A272P, K275Q, L283LI, E291D, V292I, I293V, D324P, Q334N, G335S, R356K, G359T, T377L, K390R, Q394S, A400T, E404D, V435PC
 GFKZB090GFKZB090KU127959TDF, 3TCEFVA62V, K65R, L74I, M184VV106M, V179E, F227LV35T, E36A, T39E, S48T, S68N, K122E, D123G, I135L, E138G, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I329L, Q334H, G335D, R356K, G359T, T369A, T377I, K390R, A400T, E404DC
 GFGPB091GFGPB091KU127762TDF, 3TCEFVK65RG190EV35T, T39E, S48T, K122E, D123S, I135T, E138G, S162Y, K173A, D177E, T200A, E204D, Q207K, R211G, V245Q, A272Q, T286A, V292I, I293IV, E297K, G335D, R356K, G359SC
 GFKZB199GFKZB199KU128105TDF, 3TC, FTCEFVK70E, M184VK101P, K103SK20KR, V35T, T39E, S48T, V60VI, K122E, D123S, E138G, K173T, Q174K, D177E, I178L, T200A, E203EK, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, K311KR, Q334N, G335D, R356K, G359TC