<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138A
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 12
Patients 49
Isolates 60
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gibb (2002)DMG104104_w66 AZT, 3TCNoneM184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, E138A, A158S, K173T, Q174K, T200A, Q207E, R211K, V245Q, E248D, D250DE, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, K311R, Q334DH, G335D, R356K, M357MR, G359T, I375V, T377R, S379C, K390R, E396D, T397VC
 DMG8585_w29 ABC, 3TCNone  K20KR, V35T, E36A, T39E, S48T, V60VI, K122E, D123N, E138A, I142IV, A158S, K173T, Q174K, T200A, Q207E, R211K, V245Q, E248DN, D250DE, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, G359T, I375IV, T377M, S379SC, K390R, E396D, T397VC
 DMG9595_w75 ABC, 3TCNoneL74V, Y115F, M184VV179VDV35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397IC
Kantor (2002)TCDD-23TCDD-23_1AY090850DDC, AZTNoneD67G, K70R, K219Q V35T, T39E, S48T, K64N, V90I, K122E, D123S, E138A, K173T, Q174K, T200A, E203K, Q207E, R211K, F214L, L228R, V245E, E248DC
Johnston (2003)TC-51TC-51 DDINoneK65KR, L74LV V35T, E36EA, T39E, S48T, V60I, K122EV, D123S, E138A, K173A, D177E, I178L, T200AE, E204K, Q207D, R211K, P243T, V245Q, A272P, K277KR, T286TA, E291D, I293V, A299XC
 TC-71TC-71 DDI, AZT, 3TCNoneA62V, K65R, F116Y, Q151M, M184V V8I, V35T, T39E, V60I, S68R, W88S, K101Q, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, E248DC
Non-B Workgroup (2005)IL198IL198a AZT, D4TNone  T39E, S48T, K122E, D123S, R125RS, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, V245QC
  IL198b AZT, D4T, DDINone  T39E, S48T, T58TN, K82KR, K122DE, D123S, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, K223KI, V245QC
  IL198cAY901358AZT, D4T, DDINone  T39E, S48T, P119PS, K122E, D123S, K126KE, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, V245QC
 UK2109UK2109AY901401ABC, AZT, 3TCNoneD67N, K70R, M184V K20R, V35T, T39E, K43KR, S48T, K104R, K122E, D123N, I135T, E138A, K173I, Q174K, I195IM, T200A, E203EK, Q207E, L210LM, R211K, F214LC
 SA78_DR20SA78_DR20AY901712D4T, 3TCNoneM184V P4H, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135IV, E138A, K173A, D177G, R199RT, T200A, Q207A, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, K311E, V317AC
 SA81_DR26SA81_DR26AY901714D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 IL77IL77aAY901740D4T, DDINoneK70KQ T39E, E40ED, D121DH, K122E, E138A, A158S, S162SC, K166KR, K173A, T200A, Q207G, V245QC
 IL183IL183b AZT, 3TCNone  T39E, S48T, K122E, D123S, E138A, A158S, S162C, K173E, D177DEKN, T200A, Q207A, R211K, V245QC
  IL183c AZT, 3TCNone  T39EK, S48T, K122E, D123S, E138A, A158S, S162C, K173E, S191SF, T200A, K201KN, Q207A, R211K, V245QC
  IL183e AZT, 3TCNone  T39E, G45R, S48T, E79EG, K122E, D123S, E138A, A158S, S162C, K173E, T200A, Q207A, R211K, G231V, V245QC
  IL183fAY901750AZT, 3TC, D4TNoneK70KQ, M184MV T39E, I47N, S48Y, P95PQ, F116L, K122E, D123S, E138A, A158S, S162C, K173E, T200A, Q207A, R211K, V245QC
 IL184IL184b AZT, 3TC, D4TNoneM184V T39E, S48T, K122E, D123S, E138A, S162C, T200A, Q207A, R211K, D237DE, V245QC
  IL184c AZT, 3TC, D4TNoneM184V T39E, S48T, K122E, D123S, E138A, S162C, K173KE, T200A, Q207A, R211K, V245QC
 TK1021TK1021 AZT, 3TC, D4T, ABC, DDINoneK65R, M184V V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123S, I135V, E138A, K166R, K173T, E194X, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
  TK1021a AZT, 3TC, D4T, ABC, DDINone  V35T, E36A, T39E, S48T, V60I, S68SG, V90I, K122E, D123S, I135V, E138A, K166R, K173T, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
Weber (2005)F65692F65692AY677545AZT, DDINoneT215Y V35T, E36A, T39EG, S48T, K122E, D123G, I135IV, E138A, K173A, D177G, T200A, I202V, Q207D, V245Q, L260V, A272P, K277R, T286A, E291D, V292I, I293V, L310LQ, K311R, E312NC
 M62159M62159AY6775613TC, D4TNone  V35T, E36A, T39E, S48T, K122E, D123N, E138A, I142T, V148VG, K173T, Q174K, N175Y, I178IM, V179X, T200A, Q207E, R211K, V245KQ, A272S, K277R, T286A, E291D, V292I, I293V, H315YC
Pillay (2008)DR60DR60AY589912AZT, D4T, DDINoneM41L, D67N, L210W, T215Y P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQC
 DR2002ZA.DR20AY589881D4T, 3TCNoneM184V P4H, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135IV, E138A, K173A, D177G, R199RT, T200A, Q207A, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, K311E, V317AC
 DR2602ZA.DR26AY589883D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
Kassaye (2009)TCDD-13TC13_2003FJ445709DDI, AZT, 3TCNoneM184V V35T, T39E, S48T, K49KE, K122E, D123S, E138A, Y144YC, K173V, Q174K, D177E, T200A, Q207A, P243T, V245QC
 TCDD-23TC23_2003FJ445712DDC, AZTNoneD67G, T69T_T, K70R, K219Q V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, E138A, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248DC
Rodrigues (2010)327_07BR07SC327GQ401322AZT, 3TCNone  V21I, V35T, E36A, T39D, K43R, S48T, V60I, K122E, D123S, E138A, K173T, Q174K, I195L, T200A, Q207A, R211KC
Van Zyl (2013)377711.ZA.GT1759KC423545ABC, 3TCNoneM184MV K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, E138A, S162A, T165I, R172RK, K173T, Q174K, D177E, T200A, Q207T, R211K, F214L, V245Q, E248DC
 72810.ZA.WC086KC423117D4T, 3TCNoneM184V V35T, E36A, T39D, S48T, K122E, D123N, E138A, T165I, K173A, D177G, T200K, I202V, Q207A, V245KC
 54811.ZA.EC064KC423577AZT, 3TCNoneM184VV179DK20R, V35T, E36A, T39E, S48T, W88C, K102R, K103R, V118I, K122E, D123N, I135L, E138A, T139A, S162C, Q174K, T200A, Q207E, R211I, F214LC
 359710.ZA.GT1364KC423176D4T, 3TCNoneM184MV V8VI, V35T, E36A, T39E, S48T, V60I, K122KE, D123N, E138A, S162C, K173A, D177E, T200A, R211K, V245QC
 294907.ZA.GT154KC424258D4T, 3TCNone  V8VI, V35T, E36A, T39E, S48T, K122E, D123G, I135T, E138A, S162C, K173A, Q174K, I178IM, T200A, Q207E, V245QC
 153507.ZA.GT132KC424209D4T, 3TCNone  V35T, E36A, T39E, S48T, A98S, K104R, K122E, D123N, E138A, K173T, T200A, Q207K, R211A, W212R, V245QC
 292510.ZA.GT1162KC422999AZT, DDINone  V35M, E36A, T39E, S48T, A98S, D121Y, K122E, E138A, I142V, E169Q, K173T, Q174E, V179I, T200A, I202V, Q207E, V245CC
 293706.ZA.GT010KC424033AZT, DDINone  K20R, V35T, E36A, T39E, S48T, K122E, D123S, E138A, K173I, Q174K, D177E, T200A, Q207N, R211K, V245Q, D250E, A272P, K277R, L279M, T286A, E291D, V292I, I293V, V317A, Q334N, G335DC
 357208.ZA.GT600KC424000D4T, 3TCNoneM184V V35T, E36A, T39E, S48T, D86E, W88S, V118I, K122E, D123DN, I135T, E138A, K173T, Q174R, T200A, Q207E, R211K, F214L, V245Q, P247A, E248DC
 351511.ZA.GT1794KC423588AZT, DDINone  K20R, K32R, V35T, T39E, K43R, S48T, V60I, K122E, E138A, K173A, D177N, T200A, I202V, Q207E, R211K, F214L, V245QC
 176609.ZA.GT646KC424212AZT, DDINone  V35T, T39E, S48T, K122E, D123N, E138A, K173I, Q174K, T200A, Q207E, R211K, F214L, V245EC
 115211.ZA.NL004KC423718AZT, 3TC, DDINoneD67N, K70R, M184V, K219QA98G, K101EK20R, V35T, T39E, S48T, V60I, K122E, D123N, I135V, E138A, S162C, K173T, Q174KR, V179I, G196E, T200A, Q207K, R211T, D237N, V245QC
 371710.ZA.GT1205KC423044ABC, 3TCNoneM184V V35T, T39E, S48T, D121Y, K122E, E138A, S162C, K173A, Q174N, D177E, R211K, F214L, V245QC
 224810.ZA.GT1436KC423227AZT, DDINoneM41ML, D67N, K70R, T215F, K219QK101KEV35T, T39E, S48ST, V60VI, E89EG, K122E, D123N, I135IL, E138A, K173A, D177E, I178L, T200A, Q207D, R211K, V245Q, E248DC
 523810.ZA.WC103KC423245AZT, DDINoneD67N, K70R, T215I, K219Q V35T, T39E, S48T, E53D, K122E, D123G, E138A, K166R, K173A, E194A, Q197P, T200A, Q207D, R211K, F214L, V245QC
 291110.ZA.GT1381KC423192TDF, 3TCNoneK70E, M184V V35T, E36A, T39E, S48T, K102KR, K122E, D123G, E138A, K173A, G196R, T200E, Q207G, R211K, V245QC
  12.ZA.GT2344KC423977TDF, 3TCNoneM184MV V35T, E36A, T39E, S48T, K122E, D123G, E138A, K173A, T200E, Q207G, R211K, V245QC
 306907.ZA.GT096KC424150AZT, DDINone  V35T, T39E, S48T, V60I, V118I, K122E, D123N, I135T, E138A, K173T, Q174R, T200A, Q207E, R211Q, F214L, V245Q, E248D, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, I329L, G335DC
  07.ZA.GT188KC424037AZT, DDINone  V35T, T39E, S48T, V60I, V118I, K122E, D123N, I135T, E138A, K173T, Q174R, T200A, Q207E, R211Q, F214L, V245Q, E248DC
 211711.ZA.GT1637KC423432AZT, DDINone  T27TS, V35T, E36A, T39D, S48T, V60I, K122E, D123S, E138A, T139M, K173A, Q174K, D177E, T200AC
  12.ZA.GT2326KC423964AZT, DDI, 3TCNone  T27TS, V35T, E36A, T39D, S48T, V60I, K122E, D123S, E138A, T139M, K173A, Q174K, D177E, V179VI, T200A, Q207E, R211K, F214L, V245Q, E248VC
Grossman (2014)18331833 AZT, 3TCNone  I37FL, T39E, S48T, K104R, K122E, D123G, E138A, S162SC, K173AT, Q174K, T200A, Q207E, R211K, V245QC
Steegen (2014)10ZAKS06710ZAKS067KJ176349D4T, 3TCNoneM184MV V35T, T39E, S48T, W88S, K122E, D123N, E138A, K173T, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K275R, T286A, E291D, V292I, I293V, N306X, R307SC
 12ZAKS31912ZAKS319KJ176598D4T, 3TCNoneD67N, K70R, M184V I2V, V35T, T39E, S48T, K122E, I135L, E138A, I142T, S162C, G196E, T200A, Q207G, R211RK, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, D324E, I329L, Q334N, G335D, R356K, G359T, T377R, S379C, K390R, E399D, A400T, E404D, V417I, E432D, V435AC
 11ZAKS15511ZAKS155KJ176437D4T, 3TCNoneM184V, T215Y V21I, T27S, V35T, T39E, K43R, S48T, V60I, K122E, D123G, E138A, S162C, K173A, Q174K, T200A, Q207D, R211K, V245Q, A272P, E291D, V292I, I293V, Q334D, G335DC
 12ZAKS25112ZAKS251KJ176530D4T, 3TCNoneM184V K20R, V35T, E36A, T39E, S48T, V60I, K104R, V118I, K122E, D123S, I135T, E138A, K173T, Q174K, T200K, Q207E, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292T, I293V, P313S, V317A, I329V, Q334H, G335D, R356K, G359T, A371V, S379G, T386I, K390R, A400T, E404DC
 11ZAKS18611ZAKS186KJ176467ABC, 3TCNoneL74V, Y115F, M184V E6D, V35T, E36A, T39E, S48T, K122E, D123S, E138A, T165I, K173T, Q174R, V179A, T200A, Q207E, R211K, F214L, T240TA, V245Q, E248D, A272P, K277KR, T286A, E291D, V292I, I293V, V317A, I329IV, G335DC
 12ZAKS28812ZAKS288KJ176567ABC, 3TCNoneL74V, Y115F, M184V E6D, V35T, E36A, T39E, S48T, K122E, D123S, E138A, T165I, K173T, Q174R, V179A, T200A, Q207E, R211K, F214L, T240TA, V245Q, E248D, A272P, K277KR, T286A, E291D, V292I, I293V, V317A, I329IV, G335D, Y342F, A355S, R356K, G359T, T369TA, A371V, A376T, T377TIM, T386A, K390R, E396D, A400T, E404DC
 11ZAKS14311ZAKS143KJ176425D4T, 3TCNoneM184V V21I, K32KR, V35T, E36A, T39E, E40D, S48T, K122E, D123S, E138A, K173I, Q174K, T200A, Q207DE, R211RK, V245Q, E248DN, A272P, K277R, T286A, E291D, V292I, I293V, P313QC
 12ZAKS24712ZAKS247KJ176526D4T, 3TCNone V179DE6N, V35T, T39E, S48T, V118I, K122E, D123N, E138A, T139V, K173T, Q174K, D177N, T200E, Q207K, R211E, F214L, V245Q, E248D, A272P, G273R, K275R, Q278Y, K281R, E291D, V292I, I293V, A304E, P313T, Q334N, G335D, Y342F, Q343KC
Rossouw (2015)RP030RP030KT032003D4T, 3TCNoneM184V V35L, E36N, I37F, T39E, S48T, K122E, D123G, E138A, K173T, T200A, Q207A, R211K, V245L, L246IC