<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation E138A
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 10
Patients 29
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gibb (2002)DMG104104_w66 AZT, 3TCNoneM184V K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, E138A, A158S, K173T, Q174K, T200A, Q207E, R211K, V245Q, E248D, D250DE, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, K311R, Q334DH, G335D, R356K, M357MR, G359T, I375V, T377R, S379C, K390R, E396D, T397VC
 DMG8585_w29 ABC, 3TCNone  K20KR, V35T, E36A, T39E, S48T, V60VI, K122E, D123N, E138A, I142IV, A158S, K173T, Q174K, T200A, Q207E, R211K, V245Q, E248DN, D250DE, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, G359T, I375IV, T377M, S379SC, K390R, E396D, T397VC
 DMG9595_w75 ABC, 3TCNoneL74V, Y115F, M184VV179VDV35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397IC
Kantor (2002)TCDD-23TCDD-23_1AY090850DDC, AZTNoneD67G, K70R, K219Q V35T, T39E, S48T, K64N, V90I, K122E, D123S, E138A, K173T, Q174K, T200A, E203K, Q207E, R211K, F214L, L228R, V245E, E248DC
Johnston (2003)TC-51TC-51 DDINoneK65KR, L74LV V35T, E36EA, T39E, S48T, V60I, K122EV, D123S, E138A, K173A, D177E, I178L, T200AE, E204K, Q207D, R211K, P243T, V245Q, A272P, K277KR, T286TA, E291D, I293V, A299XC
 TC-71TC-71 DDI, AZT, 3TCNoneA62V, K65R, F116Y, Q151M, M184V V8I, V35T, T39E, V60I, S68R, W88S, K101Q, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, E248DC
Dumans (2004)205205AY390192AZT, DDI, 3TC, D4TNone  V35T, E36A, T39D, K43R, S48T, V60I, K122E, D123G, E138A, I142V, K173Q, R211K, V245Q, A272P, E291D, V292I, I293V, G335D, R356K, G359T, K366R, T377Q, K390R, E404D, V435A, L452M, V466I, S468T, D471E, H483Q, L484I, L491S, S519N, K530R, A534S, A554NC
Non-B Workgroup (2005)IL198IL198a AZT, D4TNone  T39E, S48T, K122E, D123S, R125RS, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, V245QC
  IL198b AZT, D4T, DDINone  T39E, S48T, T58TN, K82KR, K122DE, D123S, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, K223KI, V245QC
  IL198cAY901358AZT, D4T, DDINone  T39E, S48T, P119PS, K122E, D123S, K126KE, E138A, A158AS, S162C, K173E, T200A, Q207A, R211K, V245QC
 UK2109UK2109AY901401ABC, AZT, 3TCNoneD67N, K70R, M184V K20R, V35T, T39E, K43KR, S48T, K104R, K122E, D123N, I135T, E138A, K173I, Q174K, I195IM, T200A, E203EK, Q207E, L210LM, R211K, F214LC
 SA78_DR20SA78_DR20AY901712D4T, 3TCNoneM184V P4H, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135IV, E138A, K173A, D177G, R199RT, T200A, Q207A, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, K311E, V317AC
 SA81_DR26SA81_DR26AY901714D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
 IL77IL77aAY901740D4T, DDINoneK70KQ T39E, E40ED, D121DH, K122E, E138A, A158S, S162SC, K166KR, K173A, T200A, Q207G, V245QC
 IL183IL183b AZT, 3TCNone  T39E, S48T, K122E, D123S, E138A, A158S, S162C, K173E, D177DEKN, T200A, Q207A, R211K, V245QC
  IL183c AZT, 3TCNone  T39EK, S48T, K122E, D123S, E138A, A158S, S162C, K173E, S191SF, T200A, K201KN, Q207A, R211K, V245QC
  IL183e AZT, 3TCNone  T39E, G45R, S48T, E79EG, K122E, D123S, E138A, A158S, S162C, K173E, T200A, Q207A, R211K, G231V, V245QC
  IL183fAY901750AZT, 3TC, D4TNoneK70KQ, M184MV T39E, I47N, S48Y, P95PQ, F116L, K122E, D123S, E138A, A158S, S162C, K173E, T200A, Q207A, R211K, V245QC
 IL184IL184b AZT, 3TC, D4TNoneM184V T39E, S48T, K122E, D123S, E138A, S162C, T200A, Q207A, R211K, D237DE, V245QC
  IL184c AZT, 3TC, D4TNoneM184V T39E, S48T, K122E, D123S, E138A, S162C, K173KE, T200A, Q207A, R211K, V245QC
 TK1021TK1021 AZT, 3TC, D4T, ABC, DDINoneK65R, M184V V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123S, I135V, E138A, K166R, K173T, E194X, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
  TK1021a AZT, 3TC, D4T, ABC, DDINone  V35T, E36A, T39E, S48T, V60I, S68SG, V90I, K122E, D123S, I135V, E138A, K166R, K173T, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293VC
Weber (2005)F65692F65692AY677545AZT, DDINoneT215Y V35T, E36A, T39EG, S48T, K122E, D123G, I135IV, E138A, K173A, D177G, T200A, I202V, Q207D, V245Q, L260V, A272P, K277R, T286A, E291D, V292I, I293V, L310LQ, K311R, E312NC
 M62159M62159AY6775613TC, D4TNone  V35T, E36A, T39E, S48T, K122E, D123N, E138A, I142T, V148VG, K173T, Q174K, N175Y, I178IM, V179X, T200A, Q207E, R211K, V245KQ, A272S, K277R, T286A, E291D, V292I, I293V, H315YC
Pillay (2008)DR60DR60AY589912AZT, D4T, DDINoneM41L, D67N, L210W, T215Y P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, E138A, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQC
 DR2002ZA.DR20AY589881D4T, 3TCNoneM184V P4H, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135IV, E138A, K173A, D177G, R199RT, T200A, Q207A, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, K311E, V317AC
 DR2602ZA.DR26AY589883D4T, DDINoneA62V, K65R, V75T I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E138A, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317AC
Kassaye (2009)TCDD-13TC13_2003FJ445709DDI, AZT, 3TCNoneM184V V35T, T39E, S48T, K49KE, K122E, D123S, E138A, Y144YC, K173V, Q174K, D177E, T200A, Q207A, P243T, V245QC
 TCDD-23TC23_2003FJ445712DDC, AZTNoneD67G, T69T_T, K70R, K219Q V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, E138A, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248DC
Rodrigues (2010)327_07BR07SC327GQ401322AZT, 3TCNone  V21I, V35T, E36A, T39D, K43R, S48T, V60I, K122E, D123S, E138A, K173T, Q174K, I195L, T200A, Q207A, R211KC
Van Zyl (2013)15672032KC423577AZT, 3TCNoneM184VV179DK20R, V35T, E36A, T39E, S48T, W88C, K102R, K103R, V118I, K122E, D123N, I135L, E138A, T139A, S162C, Q174K, T200A, Q207E, R211I, F214LC
 13831989KC423545ABC, 3TCNoneM184MV K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, E138A, S162A, T165I, R172RK, K173T, Q174K, D177E, T200A, Q207T, R211K, F214L, V245Q, E248DC
 12671486KC423176D4T, 3TCNoneM184MV V8VI, V35T, E36A, T39E, S48T, V60I, K122KE, D123N, E138A, S162C, K173A, D177E, T200A, R211K, V245QC
 16231394KC423117D4T, 3TCNoneM184V V35T, E36A, T39D, S48T, K122E, D123N, E138A, T165I, K173A, D177G, T200K, I202V, Q207A, V245KC
 1246349KC424000D4T, 3TCNoneM184V V35T, E36A, T39E, S48T, D86E, W88S, V118I, K122E, D123DN, I135T, E138A, K173T, Q174R, T200A, Q207E, R211K, F214L, V245Q, P247A, E248DC
 74074KC424258D4T, 3TCNone  V8VI, V35T, E36A, T39E, S48T, K122E, D123G, I135T, E138A, S162C, K173A, Q174K, I178IM, T200A, Q207E, V245QC
 13481306KC423044ABC, 3TCNoneM184V V35T, T39E, S48T, D121Y, K122E, E138A, S162C, K173A, Q174N, D177E, R211K, F214L, V245QC