<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation V106A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 30
Isolates 31
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Martinson (2007)KEH161BKEH161BEU152443NoneNVP V106AV35T, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, K259R, A272P, K277R, T286A, E291D, V292I, I293V, Q334DC
Sen (2007)T101NPT101-PLEF186969D4T, 3TCNVPM41ML, D67DN, K70KQ, M184V, T215FV106A, F227LT27TS, V35IT, T39N, V60I, D121Y, K122E, I142V, K173A, Q174R, D177E, I178L, T200A, E203A, Q207E, H208Y, R211K, K223KE, V245N, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297EK, L310I, E312Q, Q334H, G335D, R356K, M357MR, G359AT, V365VI, A371AV, T377Q, A400T, E404DC
Marconi (2008)SW068SW068EU308079NoneEFV, NVPM184VV106A, F227LS48T, V60I, K122E, D123S, K173A, Q174R, D177E, T200A, Q207E, R211K, V245EC
Deshpande (2009)Pat24716artFJ530694NRTINNRTIM184VV106A, F227LV35T, T39N, S48T, V60I, V90I, K122E, D123E, I135V, R143RI, S162A, K173A, D177E, T200A, Q207EG, R211K, V245QC
 Pat18567RTFJ530756AZT, 3TCNVPM184V, T215TNSY, K219RV106A, E138K, F227FLV35T, T39D, S48T, T58S, V60I, D121H, K122E, S162A, K173A, D177E, I178M, T200A, E203D, E204K, Q207E, R211K, V245QC
 Pat150164RTFJ530791NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215Y, K219KRK101E, K103KN, V106A, G190GA, F227LK20R, V35T, T39D, E44A, S48T, V60I, K82KR, A98AS, K122E, I135L, E138A, I142IV, K166R, K173A, I178L, V179I, T200A, Q207D, H208Y, R211KC
 Pat060326RTFJ530881NRTINNRTIM41L, D67N, M184V, L210W, T215FV106A, F227FLT27TS, K32R, V35T, T39D, V60I, V118VI, D121HY, K122E, D123E, I135T, S162A, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, K223E, V245QC
El-Khatib (2010)Pat02410ZA_SAVE1383HQ012302D4T, 3TCEFVK65RK103N, V106A, G190AT27S, V35T, E36A, T39E, S48T, K122E, D123N, I142V, K173A, Q174K, D177E, T200A, Q207E, R211K, P243T, V245Q, E248D, D250E, S251CC
van Zyl (2011)A114A114JN638072AZT, 3TCNVPD67N, M184VV106A, F227LV35T, T39E, S48T, K122E, K173A, Q174N, D177E, T200A, Q207E, R211K, V245QC
Brehm (2012)18ZA18ZA.24JN601931D4T, 3TCNVPM184VV106AV35T, E36A, T39E, S48T, V60I, K122E, K173A, Q174K, I178L, G196E, T200A, E203K, Q207E, V245Q, A272P, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, A376S, T377L, T386I, K390R, A400I, E404D, V435A, G436E, L452I, V466I, S468T, L469I, T470S, D471E, H483Q, L491P, S519N, K527Q, K530R, A534S, A554SC
  18ZA.36JN601932D4T, 3TCNVPM184V, N348NIV106A, F227FLV35T, E36A, T39E, S48T, V60I, K122E, K173A, Q174K, I178L, G196E, T200A, E203K, Q207E, V245Q, A272P, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, A376S, T377L, T386I, K390R, A400I, E404D, W410W*, V435A, G436E, L452I, V466I, S468T, L469I, T470S, D471E, H483Q, L491P, S519N, K527Q, K530R, A534S, A554SC
 56ZA56ZA.72JN602014D4T, 3TCNVP V106AV35T, E36A, T39D, S48T, K122E, I142IV, S162Y, K173A, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K275Q, L279LM, E291D, V292I, I293V, P321S, D324E, I326IV, Q334H, G335D, R356K, G359T, K366R, A371V, A376AS, T377LV, K390R, A400T, E404D, E413D, V435A, L452I, S468P, D471E, H483Q, L491S, S519N, K527KR, K530R, A534S, A554NC
Manasa (2013)RES331RES331KC951787D4T, 3TCNVPM184VV106AV35T, E36A, T39E, S48T, K49R, V60I, K122E, I135T, E138Q, K173A, Q174K, D177E, T200A, I202V, Q207A, R211K, H221Y, V245Q, A272P, T286A, E291D, V292I, I293VC
 RES104RES104KC951705D4T, 3TCNVPM184VK103N, V106A, F227LV35T, E36A, T39E, S48T, K49KR, V60I, K122E, D123S, E169D, Q174K, D177E, I178L, T200A, Q207E, F214L, V245Q, K277R, E291D, V292I, I293VC
 RES081RES081KC951691D4T, 3TC, TDFNVPM41L, D67N, K70Q, V75M, M184V, T215FV106A, F227LK20R, V35T, E36A, T39E, S48T, V60I, K102Q, K122E, I135T, K166R, K173A, D177E, I178L, T200A, Q207E, R211K, D218E, K238R, V245E, A272P, K277R, T286A, E291D, V292I, I293VC
Sunpath (2013)CAS107CAS107 TDF, 3TCEFVK65R, D67N, V75I, Y115F, K219EV106A, G190EV35T, E36A, T39E, S48T, V60I, K102R, K103R, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207A, R211K, V245K, A272P, V276T, K277R, T286V, V292I, I293VC
Theys (2013)45714571KC219376TDF, FTCEFVA62V, K65R, M184VK103N, V106A, P225HV111I, K122E, D123N, I135T, S162C, K173A, D177E, T200A, Q207A, R211KC
Van Zyl (2013)17793064KC423951D4T, 3TCNVPD67N, K70R, M184V, K219EK101E, V106AV35T, T39K, S48T, K122E, D123N, D177DG, T200A, Q207E, V245Q, D250EC
 807424KC424052AZT, 3TCNVPD67N, K70R, M184V, K219QK103N, V106A, P225HK22R, V35T, E36A, T39E, W88C, K104R, K122E, D123S, T139A, T200A, Q207E, R211K, F214L, H221Y, V245QC
 1321765KC424272D4T, 3TCNVPD67N, M184VV106A, F227LK20R, V35T, T39D, S48T, V60I, W88C, K122E, D123S, E138A, T165L, K173A, Q174R, I178L, T200A, R211K, F214L, V245QC
 1191811KC423427TDF, 3TCEFVM184V, K219EV106A, Y181C, F227CK20R, V35T, T39A, E40D, S48T, V90I, K101I, K122E, D123N, P157A, S162A, K173T, Q174K, T200A, Q207E, R211K, P225L, L228R, V245Q, E248DC
Wallis (2014)4208442084KM458580NRTINNRTIM41L, D67N, L74I, V75S, M184V, L210W, T215Y, K219NV106A, F227LV35T, T39E, S48T, A98S, L109I, V118I, K122E, E138A, K173A, Q174K, G196E, T200E, I202V, E203K, Q207E, H208Y, R211K, D218E, H221HYC
 4207142071KM458582NRTINNRTIA62V, K70Q, F116Y, Q151M, M184VV106A, V108I, F227LV35T, E36A, T39D, E53D, S68G, K122E, D123S, S162C, K173T, D177E, T200A, I202V, Q207E, R211K, F214L, H221Y, P225SC
 4088840888KM458486NRTINNRTIM184VV106A, F227FLV35T, T39E, S48T, V60I, K122E, I135IM, K173A, Q174K, D177E, I178L, T200A, Q207D, R211KC
 4113941139KM458562NRTINNRTID67N, K70R, M184V, K219QV106A, F227LV35T, E36L, T39E, S48T, V60I, T69TN, I135L, K173A, D177E, G196E, T200A, E203K, Q207E, R211KC
 4089140891KM458489NRTINNRTIT69D, M184V, T215FV106A, F227FL, M230LV35T, E36A, T39D, K122E, D123S, I135M, K173A, Q174K, T200A, Q207D, R211K, L228RC
Seu (2015)ZM.HIVDRM.16ZM.HIVDRM.16KP995626D4T, 3TCNVPA62V, D67N, M184VV106A, F227LT27TS, V35T, T39E, S48T, K101R, K122E, D123Q, E138A, K166R, Q174R, D177E, I178L, T200A, Q207K, R211Q, L228F, V245E, D250E, S251N, A272P, K277R, L283I, T286A, E291D, V292I, I293VC
 ZM.HIVDRM.65ZM.HIVDRM.65KP995675AZT, 3TCNVPM184VV106A, F227LE6K, V35T, T39E, S48T, A98S, F116FS, K122E, D123S, K173A, D177E, I178L, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293VC
Skhosana (2015)11ZALS06511ZALS065KM115861D4T, 3TCNVPD67DN, K70KR, M184VV106A, F227LK20R, V35T, T39E, S48T, V60I, K122E, D123N, I135V, E138A, S162SC, K173T, Q174R, T200A, I202IV, Q207A, R211K, F214L, H221HY, V245Q, E248D, D250E, A272P, K275R, K277R, Q278H, L283I, T286A, E291D, V292I, I293V, E297K, L310I, V317A, I326VC
 12ZALS12812ZALS128KM115863D4T, 3TCEFVA62V, M184V, N348IV106AE6D, V35T, E36A, T39E, E40D, S48T, K122E, D123N, I178L, T200A, Q207R, R211Q, V245Q, A272P, K277R, T286A, E291D, I293V, E297D, I329L, G335GD, R356K, G359T, T377L, K390R, E399D, A400I, E404D, V435AC
 11ZALS02211ZALS022KM115835D4T, 3TCNVPK65R, M184VK101HQ, V106A, Y181C, G190A, P225PHV35M, E36A, T39E, S48T, V60VI, K122E, D123G, I132IV, K173T, Q174K, D177E, G196E, T200A, Q207E, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, E297EK, I309V, L310R, D324E, Q334D, G335DC