<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K103S
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 17
Patients 51
Isolates 55
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)12-30823082-30430DQ880311NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219EK103ST39K, I63K, S68G, K102R, V106I, K122E, K173A, Q174R, T200A, Q207E, R211K, V245QC
Marconi (2008)SW032sw032EU308045AZT, 3TCEFVM184VK103S, G190GAS48T, V60I, K104R, K122E, K173A, D177E, T200AV, Q207E, R211K, V245QC
 SW057sw057EU308068D4T, 3TCEFVK65KR, M184MVK103S, V106MS48T, V60I, K122E, D123S, I142V, K166R, K173A, Q174A, D177E, I195L, Q197K, T200E, Q207A, R211K, F214L, D237E, V245QC
Pillay (2008)DR2302ZA.DR23AY589882D4T, DDI, ABC, AZT, 3TCMKC442D67N, K70R, M184V, T215TI, K219QK103S, E138KQK20KR, V35T, E36A, T39E, V60VI, K102R, K122E, D123G, I142K, S162A, K173T, Q174K, D177E, I178M, V179VI, T200A, Q207D, R211K, F214L, V245Q, A272P, K277KR, E291D, V292I, I293V, K311R, D324EC
Deshpande (2009)Pat050343aRTFJ530891D4T, 3TCEFVM41L, D67N, K70R, L74I, M184V, T215FY, K219WK103S, G190A, K238TV35T, T39E, V60I, I94IL, D121Y, K122E, I135T, K173E, Q174R, D177E, T200A, Q207E, H208Y, R211K, L228H, V245QC
 Pat048347aRTFJ530893AZT, 3TCNVPM41L, D67N, K70R, L74I, M184V, T215F, K219WK103S, G190A, K238TI5N, V35T, T39E, V60I, I94L, D121Y, K122E, I135T, K173E, Q174R, D177E, T200A, Q207E, H208Y, R211K, L228H, V245QC
 Pat046350aRTFJ530895AZT, 3TCEFV K103S, V106MI5N, V35T, T39N, S48T, V60VI, K122E, D123DN, K173AT, Q174R, D177E, I178M, T200A, L205LI, Q207E, R211K, V245QC
 Pat020394rtFJ530921D4T, 3TCNVPA62V, T69S_SA, M184V, T215FK103S, G190AE28K, K32E, V35T, E36A, T39E, S48T, K49R, V60I, K101S, D121Y, K122E, I135T, S162CY, E169A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
Hoffmann (2009)pat034MD31849 AZT, 3TCEFVM184VK103S, V106MV35T, E36A, T39E, S48T, K82R, A98S, K122E, D123G, I135V, K173A, D177E, Q197L, T200A, Q207E, V245Q, A272PC
Hosseinipour (2009)72947294GQ228300D4T, 3TCNVPM41L, M184V, T215YK103S, G190AT39E, S48T, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 93879387GQ228331D4T, 3TCNVPM184V, T215FK103S, G190AT39A, S48T, K122E, D123S, K173A, D177G, T200A, Q207E, R211K, P243T, V245QC
Orrell (2009)GT491GT4912005 D4T, 3TCEFVD67N, M184VK103S, V106MT39E, S48T, E53D, K122E, D123G, A158T, K173T, D177E, G196E, T200A, E204Q, Q207E, R211K, V245QC
Wallis (2009)GT00116583GT00116583 AZT, 3TCEFVM184VK103S, G190AK32R, V35T, E36A, T39E, S48T, K49R, K122E, D123S, I135IT, I142IV, E169KR, K173A, D177E, T200A, R211K, V245Q, T286A, E291D, V292I, I293VC
 TJC2375657TJC2375657 D4T, 3TCEFVM184VK103S, V106MV35T, T39E, S48T, V60I, K122V, I135L, K173T, D177E, I178IM, T200A, E203D, Q207A, R211RK, V245Q, A272P, E291D, V292I, I293VC
 23576622357662 D4T, 3TCEFVM41ML, D67G, K70KR, V75M, M184VK103S, V106MM16MV, V35T, T39E, S48T, V60VI, S68G, K101KQ, K102KR, K122E, D123G, I135L, K173A, Q174K, D177E, I195L, T200A, I202V, Q207E, R211K, V245Q, A272P, K277KR, T286V, I293V, E308K, I309IV, L310L*CFC
El-Khatib (2010)Pat04210ZA_SAVE2197HQ012320D4T, 3TCEFVL74IV, M184VK103S, Y188HV35T, T39E, S48T, E53D, S68G, K122E, D123N, K173T, T200A, Q207E, R211K, V245N, S251NC
 Pat07010ZA_SAVE2437HQ012348D4T, 3TCEFVM184VK103S, G190AV35T, E36A, T39D, V60I, D121Y, K122E, I135R, A158S, K173T, Q174K, D177E, T200A, Q207E, R211K, V245K, D250EC
 Pat12211ZA_SAVE2434JF960572NRTI, ABC, DDINNRTIM184VK103S, G190AV35T, E36A, T39E, S48T, K122E, D123N, K173A, D177E, I178IL, T200R, Q207E, R211K, P243PT, V245Q, E248D, D250E, A272P, K281RC
Green (2011)707PKE15F707PKE15FHM623505D4T, 3TCEFVM41L, D67N, L74V, M184V, T215Y, K219NK103S, V106M, M230LP4H, V35T, E36A, T39E, K43KQ, E44ED, S48T, V60I, A98AS, K102KR, V118I, K122E, D123S, K173A, Q174K, D177EG, I178IM, T200A, Q207A, R211K, K223E, V245Q, K277R, T286A, E291D, V292I, I293VC
Sigaloff (2011)GT00411974GT00411974JN381615TDF, 3TCEFVK65KR, K70E, M184V, K219KQK103S, V106ME6K, K20KR, K32R, V35K, T39E, S48T, K102R, K122E, S162C, K173A, D177E, I178L, T200A, E204K, Q207D, R211K, L228R, V245Q, D250E, S251N, A272P, E291D, V292I, I293VC
van Zyl (2011)A256A256JN638152D4T, 3TCNVPM184VK103S, G190AE6EK, V35T, T39E, S48T, K122E, K173T, D177E, V179I, T200A, Q207E, R211K, V245QC
 A283A283JN638174D4T, 3TCEFVM184VK103S, V106MV35T, E36A, T39E, S48T, E53D, K122E, D123G, I135V, S162C, K173T, Q174K, T200A, Q207T, R211K, F214L, V245QC
 A290A290JN638179D4T, 3TCNVPM184VK101P, K103SE28A, K32E, V35K, E36A, T39E, S48T, E53D, K122E, D123S, I135T, T139TS, I142IL, S162H, K173T, T200A, Q207DE, R211K, F214L, V245QC
 A331A331JN638196D4T, 3TCNVPM184VK103S, G190AV35K, T39E, S48T, V60VI, K122E, D123S, I135IT, S162SC, K173T, Q174K, D177N, G196E, T200A, Q207E, R211K, V245N, D250SC
 A358A358JN638206D4T, 3TCNVPA62V, D67N, M184VK103S, V106MK11Q, V35K, E36A, T39E, S48T, D121HY, K122E, I135T, S162C, K173MR, Q174K, D177E, T200A, Q207E, V245Q, D250EC
Brehm (2012)19ZA19ZA.24JN601934D4T, 3TCEFVM184IV, N348NIK103S, G190AK20R, E28EG, V35T, E36A, T39E, S48T, K122E, D123N, W153W*, Q174K, T200A, R211K, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294T, I329L, Q334H, G335D, R356K, G359T, T377L, K390R, E396DN, T397I, A400T, E404D, E449D, R461K, V466I, S468A, T470N, D471E, T477A, H483Q, L491P, E514D, L517I, S519T, K527T, K530R, A534S, A554SC
Kouri (2012)CU2076-10CU2076-10JQ585452NRTINNRTIM184VK103S, G190AV35T, E36A, T39E, F77FV, D121H, K122E, I135M, T139S, F160S, K173T, Q174R, D177E, T200A, Q207A, R211K, V245Q, A272P, K277R, V292I, E297K, G333E, Q334D, G335AC
Sunpath (2013)CAS096CAS096 TDF, 3TCEFVK65R, M184VL100I, K103S, Y318FK20R, V35R, T39D, S48T, K122E, D123S, I135T, K173T, T200A, Q207E, F214L, V245K, A272P, T286A, E291D, V292IC
Van Zyl (2013)13822035KC423578ABC, 3TCEFVL74V, M184VK103S, V106MK20R, V35T, T39E, S48T, K102R, K122E, D123N, I135T, S162SCT, K173A, D177E, I178M, T200A, R211GC
 4031914KC423511AZT, D4T, 3TC, TDFNVP, EFVD67N, K70E, V75T, M184VK103S, V106MK20R, V35T, E36A, T39E, S48T, K122E, D123G, I135T, S163T, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248DC
 76324KC423693AZT, D4T, 3TC, DDINVP, EFVT215YK103S, G190AV35T, T39E, S48T, K122E, D123S, K173I, Q174K, T200A, Q207A, V245M, D250E, A272P, K275Q, K277R, Q278N, T286A, E291D, V292I, I293V, Q334N, G335DC
  762KC424271AZT, D4T, 3TC, DDINVP, EFVT215YK103S, G190AV35T, T39E, S48T, K122E, D123S, K173I, Q174K, T200A, Q207A, V245M, D250EC
  1445KC423150AZT, D4T, 3TC, DDI, TDFNVP, EFVT215YK103S, G190AV35T, T39E, S48T, K122E, D123S, K173I, Q174K, T200A, Q207A, R211RK, P225PSC
 2581835KC423448D4T, 3TCEFVV75M, F77L, M184V, T215FK101E, K103S, G190AE6D, K11T, E28K, K32E, V35T, E36A, T39E, K122E, D123N, I135T, K173T, T200A, Q207E, R211KC
 10771228KC422978D4T, 3TCEFVM184VK103S, G190A, K238TK20KR, V35T, T39E, S48T, K49R, V60I, K122E, D123S, S162D, T165L, E169K, K173A, D177E, T200A, Q207E, P243A, V245QC
 4072861KC423860AZT, D4T, 3TC, DDINVP, EFVM184VK103S, G190AV35T, T39E, S48T, V60I, K122E, D123G, T139K, I142V, K173A, Q174K, D177E, I195R, T200A, R206K, Q207A, R211K, F214L, V245QC
 16031895KC423494D4T, 3TCEFVA62V, M184VK103S, V106MV35T, T39E, S48I, E53D, R78RK, K122E, D123N, I135T, E138A, K173A, Q174K, D177E, T200A, I202V, Q207S, R211K, H221Y, V245Q, K249QC
 445740KC424259AZT, D4T, 3TC, DDINVP, EFV K103S, V106MP4S, P14S, K20KR, V35T, T39E, S48T, K102R, V118I, K122E, D123S, K173EQ, T200A, Q207E, R211K, F214LC
 7471188KC422949D4T, 3TCEFVD67N, K70R, M184V, K219QK103S, G190A, P225HE29EK, V35T, T39E, S48T, E53D, K122E, D123G, K166R, K173A, D177E, T200A, Q207N, R211K, V245QC
 14901727KC423358AZT, D4T, 3TC, TDFNVP, EFVD67DN, M184VK103S, V106MK20KR, V35T, T39E, S48T, V60VI, K101Q, K122E, D123S, I135T, E138A, I142V, K173M, Q174K, T200A, Q207A, R211K, F214L, V245Q, E248DC
 17552439KC423709D4T, 3TCEFVM184VK103S, V106MK20KR, V35T, E36A, T39E, S48T, K122E, D123N, I135L, K173A, Q197P, T200A, Q207E, R211K, F214L, V245Q, D250EC
 15022120KC423633AZT, D4T, 3TC, DDINVP, EFV K101P, K103SV35T, T39E, S48T, V60I, K102KR, K122E, E138A, S162C, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245QC
 1202873KC424329AZT, D4T, 3TC, ABCNVP, EFVM184VK103S, V106M, F227LV35T, E36A, T39E, S48T, V60I, K102Q, K122E, D123S, I135V, I142V, T165I, K173A, G196R, T200E, Q207A, R211K, V245QC
 6911056KC422841AZT, D4T, 3TCNVP, EFVM184VK103S, V106ME6EK, K20R, V35M, E36A, T39E, S48T, K122E, D123S, S162C, K173T, Q174K, D177E, T200A, Q207E, R211K, V245QC
  1305KC423043AZT, D4T, 3TC, ABCNVP, EFVM184MLK103S, V106ME6EK, K20R, V35M, E36A, T39E, S48T, K102KR, K122E, D123S, S162SC, K173T, Q174K, D177E, T200A, Q207E, R211K, V245QC
  1780KC423402AZT, D4T, 3TC, ABCNVP, EFV K103S, V106ME6K, K20R, V35M, E36A, T39E, K122E, D123S, S162C, K173T, Q174K, D177E, T200A, Q207E, R211K, V245QC
 17692956KC423908D4T, 3TCEFVM184VK103S, V106MK20KR, V35T, E36A, T39E, S48T, V60I, K102R, K122E, D123NS, I135V, E169Q, K173A, D177E, T200A, Q207D, F214FL, V245QC
 5721865KC423466AZT, D4T, 3TC, DDINVP, EFVD67N, T69D, K70R, K219QK101P, K103SK22R, V35T, E36A, T39E, E40D, S48T, V60I, K102R, K122E, D123N, E138G, A158S, K173T, Q174K, V179I, T200A, E203EQ, Q207E, F214L, D218E, L228HC
 930255KC423743D4T, 3TCEFVM184VK103S, G190AV35T, E36A, T39E, S48T, K122E, D123N, R125RK, K173A, D177E, I178IL, T200IMRS, Q207E, R211K, P243TC
 110724KC424247D4T, 3TCEFVM184VK103S, V106MV35T, E36A, T39E, S48T, K122E, D123N, I135M, K173A, Q174X, D177E, T200A, Q207E, F214L, V245QC
Steegen (2014)12ZAKS36212ZAKS362KJ176641D4T, 3TCEFVM41L, D67N, V75M, M184V, T215FK101P, K103S, V106ME28A, V35T, T39D, S48T, V60I, K122E, D123G, I135T, K173A, Q174K, D177E, V179VI, T200A, Q207E, R211K, D218E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359S, T377M, S379C, K390R, A400LC
 11ZAKS12611ZAKS126KJ176408D4T, 3TCEFVD67N, K70R, M184VK103S, V106MV35T, T39N, E40D, S48T, K49R, V60I, K101Q, K122E, D123G, I135L, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297EKC
 11ZAKS18111ZAKS181KJ176462D4T, 3TCEFVM184VK103S, V106MV35T, E36A, T39E, S48T, K102R, K122E, D123N, T165L, K173A, Q174K, D177E, T200E, Q207E, R211K, F214FL, V245Q, E248ED, D250E, S251HN, A272P, L283I, V292I, I293V, K311R, Q334H, G335DC
 12ZAKS21712ZAKS217KJ176497D4T, 3TC, ABCEFVM184VK103S, V106M, F227LV35T, E36A, T39E, S48T, K122E, D123G, T139A, I142V, S162C, K173A, Q174K, D177E, I178L, G196E, T200A, Q207E, R211K, F214FL, V245Q, A272P, E291D, V292I, I293V, Q334N, G335DC
 10ZAKS04110ZAKS041KJ176323ABC, 3TC, D4TEFVM41L, L74V, Y115F, M184V, T215AK103S, V106MK20R, V35T, T39E, S48T, K122E, D123S, I135L, S162C, K173T, Q174K, D177N, G196E, T200A, Q207E, R211K, F214L, L228R, K277KR, E291D, V292I, I293VC