<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K103R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 5
Patients 30
Isolates 30
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patMUK03_MUK733AJ577958DDI, AZT, D4T, 3TCNoneD67N, K219Q K20G, V35T, E36A, T39E, K103R, K122E, D123S, I135T, K173A, D177E, I178V, T200V, E203K, Q207E, R211K, F214LC
Van Zyl (2013)74012.ZA.WC226KC423973D4T, 3TCNoneM184MV K20R, V35T, E36A, T39D, K103R, K122E, D123N, I135T, I142V, K173KE, D177EQ, T200A, E203D, Q207T, R211K, V245QC
 357910.ZA.GT1360KC423173ABC, 3TCNoneM184VV106M, V179DV8I, V35I, T39K, K43Q, S48T, V60I, K103R, K122E, D123S, I135L, K173A, Q174K, D177E, T200A, Q207E, R211K, V245QC
 366909.ZA.GT920KC424407D4T, 3TCNoneM184V V21I, V35T, T39E, S48T, V60I, K103R, K122E, D123G, S162C, K173A, D177E, T200A, Q207E, R211K, V241VI, V245QC
 274411.ZA.GT1494KC423284TDF, AZTNone V106M, V179DE28A, V35T, T39E, S48T, V60I, K103R, K122E, D123S, I135IL, K173T, Q174R, G196E, T200A, E204ED, Q207E, R211K, F214LC
 54811.ZA.EC064KC423577AZT, 3TCNoneM184VV179DK20R, V35T, E36A, T39E, S48T, W88C, K102R, K103R, V118I, K122E, D123N, I135L, E138A, T139A, S162C, Q174K, T200A, Q207E, R211I, F214LC
 192711.ZA.GT1575KC423361AZT, DDINone V106VIM, V179DK20KR, V35T, E36A, T39E, E40D, K103R, V118I, K122E, D123N, I135R, A158S, K173T, T200A, Q207G, F214L, D250EC
 274511.ZA.GT1916KC423705TDF, AZTNoneM41LV106M, V179DE28A, V35T, T39E, V60I, K103R, K122E, D123S, I135L, K173T, Q174R, G196E, T200A, E204D, Q207E, R211K, F214L, V245Q, D250E, N255XC
 283612.ZA.GT2204KC423878AZT, DDINone  V35T, T39E, P55L, K103R, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, P243A, V245KC
 280306.ZA.GT037KC424098AZT, DDINone V179DP4S, V8I, V35T, T39E, S48T, K102Q, K103R, K122E, I159IV, K173A, D177E, G196T, T200A, Q207E, R211K, L228I, V245EK, E248D, D250E, Q258P, A272P, K277N, Q278R, E291D, I293V, P294T, S322SL, Q334N, G335D, Q340Q*C
 175611.ZA.GT1646KC423440AZT, DDINoneD67N, K70R, K219E V35T, T39N, S48T, V60I, K103R, K122E, K173T, Q174R, T200A, Q207A, R211K, F214L, V245Q, D250EC
 366512.ZA.GT2154KC423840AZT, 3TCNoneM184VV106M, V179DV35T, E36A, T39D, S48T, V60I, K102R, K103R, K122E, D123S, I132V, K166R, K173A, Q174K, D177E, I195L, G196AE, Q197R, T200A, I202V, Q207E, R211K, F214L, V245Q, D250DEC
Rossouw (2015)RP096RP096KT032032D4T, 3TCNoneM184V V35T, E36A, T39E, S48T, A98S, K103R, K122E, D123E, I135T, K173A, D177G, T200A, Q207A, F214L, V245Q, A272P, K277R, I293V, S322A, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, V435AC
Neogi (2016)107013.ZA.EC839KT592931TDF, AZT, 3TCNoneK65R, M184VL100I, V179DK20R, V35T, T39E, S48T, K103R, K122E, D123S, K173A, D177G, T200A, Q207A, V245QC
Posada Cespedes (2017)718215.ZA.WC614 D4T, 3TCNone  V8I, V35T, E36A, T39E, S48T, K102Q, K103R, K122E, D123S, K166R, K173I, Q174K, T200A, Q207E, R211K, F214L, V245H, D250EC
 14712.ZA.NC003KX542397AZT, DDINoneM41L, D67N, K70R, V75M, T215Y E6K, K20R, V35T, T39E, E44D, S48T, V60I, K103R, V111VI, V118I, K122E, I135T, T139TA, K173V, Q174K, N175Y, D177E, V179T, G196E, T200A, Q207D, H208Y, R211K, D218E, V245QC
 441215.ZA.WC568 TDF, FTC, 3TCNoneM184VV106M, V179DV35T, T39A, E40D, S48T, E53D, K103R, K122E, D123S, T139A, T200A, Q207E, R211K, F214L, L228LFPSC
 539812.ZA.NL037KX542424TDF, 3TCNoneM184VV179D, Y188LV35T, T39E, S48T, V60I, S68G, K103R, K122E, D123S, I135T, K166R, K173A, D177E, T200A, Q207E, R211K, F214FL, V245QC
 575415.ZA.WC605 AZT, 3TCNoneM41L, M184VV179DV35T, T39A, S48T, E53D, K103R, K122P, I135X, K173T, Q174K, D177E, T200A, Q207D, R211K, F214L, V245QC
 403112.ZA.GT2367KX542195ABC, 3TCNone  V35T, T39E, S48T, K103R, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245K, E248DC
 530511.ZA.EC091KX540976AZT, DDINone V179DK20R, V35T, T39E, S48T, V60VI, K103R, K122E, D123N, I135IT, S162C, I178IL, T200A, E204K, Q207E, R211K, F214L, V245QC
 574015.ZA.EC1591 TDF, 3TCNone G190AV35IT, E36A, T39E, S48T, A98S, K103R, K122E, D123DN, K166R, K173T, D177E, E194D, T200A, Q207A, R211K, V245QC
 277207.ZA.GT342 AZT, DDINone V179DV35T, T39N, S48T, V60I, K103R, D121N, K122E, K173T, Q174R, T200A, Q207AE, R211K, F214L, V245Q, D250EC
 414713.ZA.GT3084KX543348D4T, 3TCNoneK65R, M184VV106M, V179DK20R, V35T, T39E, S48T, S68K, K103R, K122E, D123G, I135T, E138A, K173N, Q174K, N175Y, Q197QL, T200A, I202V, Q207E, F214L, V245L, E248DC
 431614.ZA.GT3529KX544372AZT, 3TCNone K101E, K238TE6ED, V35T, T39E, K103R, K122E, D123G, I135T, E138A, S162C, T165I, K173A, Q174K, D177E, I178L, V179T, T200A, Q207E, R211K, V245QC
 439011.ZA.GT1578KX541108AZT, DDINone V106M, V179DE6EK, V35T, T39E, S48T, K102R, K103R, K104R, K122E, D123N, E138A, K173I, Q174K, T200A, I202V, E204Q, Q207E, R211K, F214L, V245Q, E248D, D250EC
 433214.ZA.GT3624KX544450AZT, 3TCNoneA62V, M184VV106M, V179DV35T, E36A, T39E, E40D, S48T, K103R, D123E, I135IV, K166R, K173AT, D177E, T200A, Q207E, F214L, V245Q, D250EC
 575315.ZA.EC1666 AZT, 3TCNoneA62V, M184VV179DE6EK, K11Q, E28K, K32E, V35T, E36A, T39E, K103R, K122E, D123G, I135L, K173A, Q174R, D177E, I178M, T200A, E203D, Q207E, V245QC
 91611.ZA.WC127KX541552AZT, 3TC, DDINoneD67G, K70R, M184V, K219QV106M, V179DV35K, E36A, T39D, E40D, S48T, S68G, V90I, K103R, K122E, D123S, I135M, S162A, K173A, T200A, E203A, Q207E, R211K, F214L, V245QC
 258411.ZA.GT1501KX541044ABC, 3TCNoneM184MI V35T, T39E, G45GR, S48T, K103R, K122E, S162C, K166KR, K173A, D177E, T200A, Q207E, R211K, E224EG, V245E, E248NC