<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K101R
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 49
Isolates 50
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Johnston (2003)TC-62TC-62 D4T, DDI, AZT, 3TCNVP, EFVM184VG190AP4S, V21I, V35T, E36A, T39E, S48T, W88C, K101R, K122E, E138A, K173I, Q174K, D177G, T200A, Q207E, R211K, F214P, V245Q, E248DC
Soares (2003)BR57BR57AY2757943TC, D4T, AZTEFV  I50L, K101R, K122E, D123S, T200A, Q207E, R211KC
Non-B Workgroup (2005)TK2006TK2006 AZT, DDI, 3TC, D4TEFV  V35T, E36A, T39D, S48T, K101R, K122E, D123G, I135IV, S162Y, K166KR, K173A, Q174K, D177E, G196M, T200A, Q207E, L209LF, R211K, V245Q, D250E, A272P, K277R, E291D, I293V, V317AC
  TK2006a AZT, DDI, 3TC, D4TEFVM184VK103KN, V179FL, Y188LV35T, T39D, S48T, V90I, K101R, K122E, D123G, S162Y, K166KR, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, I293V, E297K, V317VAC
Seoighe (2007)PL12906_PL129V2EF382074NoneNVP K103KN, Y181YC, G190GAK32R, V35T, E36EA, T39E, S48T, V60I, K101R, K104KR, K122E, D123GS, K173A, Q174QK, D177E, T200A, Q207E, R211K, V245Q, A272AP, I274IV, K275KQ, K277KR, Q278N, T286A, V292I, I293VC
von Wyl (2007)1485055699EF449802NRTINNRTIM184V, T215FYA98G, G190EV35T, T39E, K43R, K101R, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207E, R211KC
Waleria-Aleixo (2008)08PR05036408PR050364FJ591389NRTINNRTIM41ML, D67N, T215F V35T, E36A, T39E, S48T, K101R, K122E, D123S, I135T, K166R, K173T, D177Q, T200A, Q207G, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335DC
Deshpande (2009)Pat110238RTFJ530831NRTINNRTIK219RA98GV35T, T39D, K43R, S48T, V60I, W88S, G93GR, K101R, D121Y, K122E, I135R, S162A, K166R, K173A, D177E, T200A, Q207E, K220N, V245QC
 Pat037344FJ530904AZT, 3TCNVPV75I, M184VK103N, P225HV35T, T39N, V60I, K101R, K122E, D123S, I132L, K173A, Q174K, D177G, T200E, Q207E, R211K, L228LIPT, V245EC
Wallis (2009)TJC2455335TJC2455335 D4T, 3TCEFVK65R, V75A, F77L, F116Y, Q151MG190E, P225HK20R, V35T, T39E, S48T, S68G, T69TI, K73M, W88S, K101R, K122E, E138A, P157A, R172K, K173A, V179G, T200A, Q207E, F214L, V245Q, A272P, T286A, V292I, I293VC
Kebe (2013)SNA3-220SNA3-220HM002517NRTINVPT69D, M184VV108I, Y181CV35T, E36A, T39E, K49R, A98S, K101R, D123N, K166Q, R172K, Q174K, D177E, I178L, T200A, Q207E, R211K, H221Y, E224D, V245Q, D250E, A272P, K277RC
Manasa (2013)RES315RES315KC951771D4T, 3TC, TDFEFVK65R, T69~K103N, Y181C, Y188HK20R, V35T, T39E, E40D, K101R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, A288S, E291D, V292I, I293VC
 RES371RES371KC951824D4T, 3TCEFVM184VK103NV35T, E36A, T39E, S48T, V60I, K101R, K122E, D123S, I135M, K173T, Q174K, D177E, T200A, Q207E, R211K, V245K, T286A, E291D, V292I, I293VC
 RES040RES040KC951661D4T, 3TCNVPM41L, M184V, T215FV108I, Y181CV35T, T39A, S48T, V60I, K101R, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, V179I, T200A, Q207D, R211K, H221Y, V245K, D250E, K277R, E291D, V292I, I293VC
 RES369RES369KC951822D4T, 3TC, AZTEFVM184VG190EV35T, E36A, T39E, E40D, V90I, I94L, K101R, I135T, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, T286V, E291D, I293V, P294T, E297KC
 RES017RES017KC951642D4T, 3TCEFVM184V, K219NG190EV35T, E36A, T39E, W88C, K101R, K103R, K122E, D123G, I135V, E138A, K173T, T200A, Q207T, R211K, F214L, L228R, V245E, V261I, A272S, K281R, T286A, E291D, V292I, I293VC
Theys (2013)8087780877KC219003NRTI, TDFNNRTI K103N, G190GRST39A, S48T, K101R, K122KE, K166R, K173A, T200A, Q207E, R211K, V245QC
Van Zyl (2013)O17242983KC423918D4T, 3TCEFV  V35T, E36A, T39E, S48T, E53D, V60I, K101R, K104N, K122E, D123N, K166R, K173A, T200A, Q207E, R211K, V245QC
 90811.ZA.WC158KC423507ABC, AZTEFVT69DK103N, Y181C, G190AV35T, E36D, T39KN, S48T, V60I, K101R, K122E, D123S, K173A, D177E, I178V, T200A, Q207E, R211K, V245QC
 287311.ZA.GT1845KC423626ABC, 3TCEFVK65R, M184VK103N, P225H, K238TV35T, T39E, S48T, V60I, K101R, K122E, D123N, L168LS, K173T, Q174K, T200A, Q207E, V245QC
 336308.ZA.GT474KC423646D4T, 3TCEFVK65R, L74I, Y115F, M184VK103N, V106MV35T, T39E, S48T, S68G, W88C, V90I, K101R, V118I, K122E, D123S, T139K, I142T, S162A, T165I, K173A, Q174K, T200A, E204Q, Q207E, R211K, F214LC
 295708.ZA.GT455KC423530AZT, 3TCEFVD67N, K70R, M184V, K219EG190EV35T, T39K, S48T, V60I, K101R, K122E, I135V, K173A, Q174R, D177E, T200A, Q207E, V245QC
 351708.ZA.GT618KC424192D4T, 3TCEFV  K20R, V35T, T39E, S48T, K101R, K122E, D123N, E138A, K173T, T200A, I202V, Q207E, R211K, V245Q, D250EC
 43111.ZA.WC175KC423556D4T, 3TC, AZT, DDIEFVD67N, K70R, M184V, T215F, K219EG190EK20KR, V35T, T39E, T69TN, K101R, K103R, K122E, D123S, I135V, E138S, K173A, Q174E, D177G, T200A, Q207N, V245Q, E248EDC
Steegen (2014)11ZAKS15111ZAKS151KJ176433D4T, 3TCEFVA62AV, M184VG190EK20R, V35L, T39E, S48T, K101R, K122E, D123G, E138A, K166R, K173A, I178M, T200A, Q207D, R211K, L228R, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, S322AC
 12ZAKS36512ZAKS365KJ176644D4T, 3TCNVPM41L, D67N, T69D, K70KR, V75M, M184V, T215F, K219W, N348IV108I, Y181CV8L, V21VI, V35IKLQ, E36EA, T39EK, K43Q, S48T, K49R, E53D, V60I, V90I, K101R, V118I, K122E, D123N, S162H, K173T, Q174K, D177E, T200A, E203D, Q207E, R211RK, K223Q, L228H, V245Q, R284RK, T286A, T290S, E291D, V292I, I293V, D324DE, Q334DN, G335D, R356K, M357R, G359S, A360T, T377R, K390KR, A400AITV, E404DC
Wallis (2014)4144841448KM458533NRTINNRTIK65R, K70TV106M, Y188LV35T, E36A, T39D, P52S, V60I, S68G, K101R, D121HY, K122E, I135V, T139A, S162C, K173A, D177E, T200A, Q207E, F214FL, H221HYC
 4143441434KM458530NRTINNRTID67DN, M184VK103N, G190AV35T, T39E, S48T, V60I, A98S, K101R, D121H, K122E, D123E, I135T, E138A, K166R, D177E, T200A, I202V, Q207EC
 4150341503KM458547NRTINNRTIK65R, K70R, V75I, F77L, Q151M, K219KRV179D, Y181CK20KR, L34V, V35T, E36A, T39E, S48T, S68G, T69X, K101R, V118I, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, I202V, Q207E, R211K, F214FL, H221Y, F227FYC
Saravanan (2015)CTLA116CTLA116KP993719NRTINNRTID67N, T69D, K70R, M184V, T215S, K219EL100I, K103NV35T, E36A, T39E, S48T, V60I, K101R, V118I, I135T, Q145H, M164ML, K166KR, K173T, D177E, T200A, I202V, E204Q, Q207E, R211K, F214L, L228IC
 CTLA259CTLA259KP993862NRTINNRTIA62AV, D67G, K70E, Q151M, M184VY181CV35T, E36A, T39E, S48T, V60I, K101R, K122KE, I132IV, I135T, D177E, T200A, Q207E, R211K, D218EC
 CTLA28CTLA28KP993631NRTINNRTIM41L, L74V, M184V, T215YK103S, G190AV35T, T39K, S48T, V60I, K101R, D121Y, K122E, I135T, S162A, K173T, Q174R, D177E, T200A, Q207E, R211KC
 CTLA68CTLA68KP993671NRTINNRTID67N, M184V, T215FK103N, V108IV35T, T39E, S48T, V60I, V90VI, K101R, D121Y, K122E, I135T, E138Q, S162T, K173A, D177E, I178L, T200A, Q207E, H208Y, R211K, L228FC
Seu (2015)ZM.HIVDRM.16ZM.HIVDRM.16KP995626D4T, 3TCNVPA62V, D67N, M184VV106A, F227LT27TS, V35T, T39E, S48T, K101R, K122E, D123Q, E138A, K166R, Q174R, D177E, I178L, T200A, Q207K, R211Q, L228F, V245E, D250E, S251N, A272P, K277R, L283I, T286A, E291D, V292I, I293VC
Chimukangara (2016)NC28NC28KU508578D4T, 3TC, ABCEFVM184VK103N, Y181C, Y188LV35L, T39E, S48T, E53D, V90I, K101R, S162N, K173A, I195L, G196E, T200A, I202V, Q207E, H221Y, L228RC
Lam (2016)2101200121012001KR868022TDF, FTCNVPK65R, Y115F, M184VY181IV35T, E36A, T39D, S48T, V60I, K101R, K122E, D123N, A158T, T165I, K173T, Q174K, I178L, V179VI, Q197K, T200A, Q207A, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334D, G335DC
Neogi (2016)415613.ZA.GT2631KT593014TDF, 3TCEFVK65R, Y115FK103N, V106M, Y181CP4S, V35T, E36A, T39E, S48T, V90I, K101R, K122E, D123N, Q174E, D177N, T200A, Q207K, R211K, F214L, K223KE, V245QC
 715213.ZA.EC821KT592924TDF, 3TCEFVK65KR, K70KR, M184V, K219KEK103N, V108I, Y181CV35T, E36A, T39E, E40D, K101R, K122E, D123N, S162ST, K173A, D177E, T200A, H221Y, V245LC
 376713.ZA.GT2615KT593004ABC, 3TCEFVK65KR, Y115YF, M184MVL100LI, K103N, P225PHK20KR, V35T, E36A, T39E, S48T, V60VI, W88S, K101R, K102KQ, L109LV, T139R, K173T, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248DC
Steegen (2016)GFWCB010GFWCB010KU127598AZT, TDF, 3TCNVP, EFVK65R, M184VL100I, K103NV35T, T39AE, S48T, V60I, S68N, K101R, V111I, K122E, T139K, K166KR, K173A, D177G, V189VI, T200A, Q207AT, R211K, V245Q, D250EC
 GFMPB098GFMPB098KU128048TDF, 3TCEFVK65R, L74IV, Y115F, M184V, K219NG190EV35T, E36A, T39E, S68G, T69TI, K101R, K103R, K122E, D123G, E138A, K173A, D177E, I178L, T200A, Q207N, R211K, V245Q, A272P, K275R, K277KR, Q278H, T286A, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, M357R, G359A, T369A, Q373H, T377Q, K390R, A400T, E404DC
 GFKZB190GFKZB190KU128096TDF, FTCEFVD67N, K70E, M184IK103N, V106M, Y181CV35T, T39E, S48T, V90I, K101R, K122E, D123S, K173A, Q174R, D177E, I178L, G196K, T200A, E203Q, Q207E, F214L, H221Y, V245Q, A272P, K275R, K277T, K281R, E291D, V292I, I293V, D324E, R356K, G359S, A376G, T377L, K390R, A400I, E404D, Y405H, A408VC
 GFKZB175GFKZB175KU128069TDF, 3TC, FTCEFVM184I, K219KEK103N, Y181C, G190A, P225PHV8VI, V35T, E36A, T39E, E40D, S48T, T69TA, V90I, K101R, K122E, D123N, S163SI, T165I, K173A, Q174K, D177E, G196KR, T200A, Q207A, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335GD, E344D, R356K, G359T, I382T, K390R, A400I, E404DC
 GFKZB057GFKZB057KU127913TDF, 3TCEFVK65R, L74LI, Y115F, M184V, N348IK103N, Y181C, G190AV35T, T39E, A98S, K101R, K122E, S162SN, K173T, Q174R, D177E, T200A, I202IV, Q207E, R211K, V245Q, A272P, V292I, I293V, D324E, Q334N, G335D, R356K, M357R, R358K, G359AC
 GFKZB267GFKZB267KU128173TDF, 3TC, FTCNVP, EFVA62V, K65R, M184VV106M, Y181C, G190AT27S, V35T, T39E, E40D, S48T, S68N, K101R, K173T, D177E, T200A, Q207E, R211K, L228Q, V245E, E248D, A272P, K277R, E291D, V292I, I293V, E297A, K311R, Q334H, G335D, R356K, M357ML, G359T, T369V, E370G, I375V, T377L, S379C, K385R, K390R, A400T, E404D, V435AC
 GFKZB345GFKZB345KU128246TDF, 3TC, FTCNVP, EFVK65R, Y115F, M184VV106M, Y181C, G190GAK20KR, T27S, V35T, E36A, T39D, S48T, S68N, K101R, K122E, K173A, Q174K, D177E, I178V, V179I, T200A, I202V, Q207EK, R211KQ, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297AT, G333A, Q334E, R356K, M357MR, G359T, Q367M, T369TA, I375V, T377L, T386I, K390R, A400T, E404DC
Kityo (2017)2859328593KY061386NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EY181CK20R, K32E, V35T, E36A, T39E, E44Y, V90I, K101R, S117A, K122A, I135T, K173V, D177E, V179VI, T200AE, I202IV, E203K, Q207E, H208Y, D218E, L228LH, Q242K, V245Q, E248D, D250E, A272P, K275KR, E291D, V292I, I293VC
 8309883098KY061655NRTINNRTIK65R, V75I, M184MIVY181CS48T, V90VI, K101R, K122E, I132L, I142IV, K173K*ST, Q174K, D177E, T200A, Q207E, L228RC
 8337683376KY061931NRTINNRTIA62V, K65R, D67G, V75I, F77FL, Y115F, F116Y, Q151M, M184V, K219EK103N, V179F, Y181C, G190AS48T, S68G, K101R, K122E, D123N, S162A, T165I, K173A, Q174K, T200A, I202V, Q207E, R211KC
 8346283462KY062016NRTINNRTIK65R, T69~, V75A, F77L, K219RK103N, Y181CS48T, P52PL, V60I, S68G, K101R, K122E, D123S, I142T, P157A, K173E, Q174K, D177E, I178M, T200A, Q207E, H221YC