<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K101Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 53
Isolates 55
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE73SE73AF388136NoneNVP K103KNV35T, E36A, T39E, E40D, K43R, S48E, E53D, K101Q, K122E, D123G, E138A, S162Y, K173A, D177G, V179I, G196E, T200A, Q207D, V245Q, T253TP, A272P, K277R, T286A, E291D, V292I, K311RC
Eshleman (2004) SE73_7dAY428676NoneNVP K103KN, V106VAV35T, E36A, T39E, E40D, K43R, S48E, E53D, K101Q, K122E, D123DG, E138A, S162Y, K173AT, D177G, V179I, G196E, T200A, Q207DN, V245Q, A272P, K277R, T286A, E291D, V292I, K311R, Q334EC
Non-B Workgroup (2005)TK1020TK1020b AZT, DDI, 3TC, ABCEFVM41L, D67N, L74V, M184V, T215YK103NV35R, T39D, E44D, S48ST, K101Q, V118VI, K122E, D123G, K173T, Q174K, D177E, T200A, Q207E, L210S, R211K, D218E, V245Q, A272P, K277R, V292I, I293V, E297AC
Sen (2007)T073NPT73-PLEF186964D4T, 3TCNVPM184VG190AV35T, T39D, S48T, V60I, K101Q, K122E, I135T, E138G, K166R, K173A, G196E, T200A, Q207G, R211K, V245Q, D250E, A272P, K277R, K281KR, E291D, V292I, I293V, Q334E, G335D, R356K, G359T, E370ED, T377R, S379C, I382IV, K390R, A400TC
 T006NPT6-PLEF186984AZT, 3TCNVPD67N, T69DN, K70R, M184V, T215F, K219EA98G, Y181C, G190AV35T, E36A, T39E, S48T, V60I, K101Q, K104R, D121Y, K122E, I135L, K166R, K173A, D177E, T200A, Q207E, R211K, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, Q334Y, G335D, R356K, G359N, T377M, K390R, E404D, Q428R, K431T, V435A, N447S, L452T, V466I, D471E, H483YC
Marconi (2008)ICH23ICH23EU308013D4T, AZT, 3TCEFVD67N, M184V, K219EK103N, G190AS48T, V60I, V90VI, K101Q, K122E, D123N, I135V, I142T, K173T, D177G, T200A, Q207A, R211K, V245QC
 SW017sw017EU308034D4T, 3TCEFVM184VK103NS48T, V60I, K101Q, K122E, D123S, K173A, Q174K, D177E, T200A, Q207A, R211K, V245QC
 SW042SW042EU308055D4T, DDI, AZT, 3TCEFVM184VV106M, V179VEE40R, S48T, S68G, K101Q, K102R, K104R, K122E, D123S, E138A, K173I, Q174QK, D177DE, T200A, Q207E, R211K, F214L, V245QC
Pillay (2008)DR9303ZA.DR93AY589932D4T, 3TCEFVD67N, T69D, K70R, K219QV106M, V179VD, G190GA, F227FLA33G, V35T, E36A, T39E, K101Q, K122E, D123N, K173A, D177E, Q197L, T200A, Q207E, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, V317AC
Deshpande (2009)Pat2241RTFJ530717D4T, 3TCNVPD67N, K70R, M184V, K219Q V35T, T39D, K43R, V60I, K101Q, D121Y, K122E, I135R, S162A, K173A, D177E, V179I, Q197K, T200A, E203D, Q207QAEP, R211K, V241VI, V245Q, K249NC
 Pat19056RTFJ530751D4T, 3TCEFVM184VV106M, G190A, F227FLV8I, K13N, V35M, T39E, K101Q, D121DY, K122E, I135T, K173A, Q174K, D177E, T200A, Q207EG, R211K, L228LH, V245QC
 Pat17692RTFJ530765D4T, 3TCNVPM184VG190AV35T, T39E, S48T, K101Q, K104R, K122E, D123S, K173A, D177E, T200A, Q207E, R211T, V245QC
 Pat074293RTFJ530867D4T, 3TCNVPD67N, F77L, F116Y, Q151M, M184V, T215YY181C, G190AI2S, K11I, V35T, E36A, T39E, S48T, V60I, K101Q, D121Y, K122E, K166R, K173A, D177E, T200A, Q207E, R211K, H221HY, W239C, V245EC
 Pat009433RTFJ530932D4T, 3TCEFV  V8I, V35T, E36A, T39D, S48T, K101Q, D121C, K122E, S162C, K173T, Q174R, D177E, T200A, Q207E, R211K, V245QC
Hoffmann (2009)pat074MD57113 AZT, 3TCEFVL74LV, M184VK103NI31L, V35T, T39E, S48T, T69TN, A98S, K101Q, D121Y, K122E, D123E, K173I, Q174K, D177E, Q197L, T200A, Q207E, R211K, V245Q, D250E, A272PC
Hosseinipour (2009)94339433GQ228367D4T, 3TCNVPA62V, K65R, V75I, F77L, F116Y, Q151M, M184VY181VT39E, S48ST, E53D, S68G, T69TI, K101Q, V118I, D121HY, K122E, I135T, K173A, Q174K, D177E, T200A, I202V, Q207D, L210F, R211K, F214L, V245QC
Wallis (2009)23450232345023 D4T, 3TCEFVM184VY188LK30KE, V35T, T39K, S48T, V90I, K101Q, K122E, D123S, I135IT, K173A, I178L, V179I, T200A, Q207N, R211K, V245Q, E248EK, A272S, K277R, L283LF, T286TA, E291D, V292I, I293V, L303LWC
El-Khatib (2010)Pat07210ZA_SAVE2469HQ012350D4T, 3TCEFVM184VV106M, Y188HLV35T, T39E, S48T, K101Q, K122E, D123G, K173T, T200A, Q207E, R211K, Y232YH, V245H, S251NC
 Pat09911ZA_SAVE2062JF960549NRTI, AZT, DDINNRTIM184VK103NV8I, V35T, T39A, S48T, V60I, K101Q, K122E, D123G, I135T, K173A, D177E, I178M, T200A, Q207E, V245Q, A272PC
Rodrigues (2010)346_07BR07SC346GQ401328AZT, 3TCEFVM184VK103N, P225HV35K, E36A, T39D, K43R, S48E, V90I, K101Q, K104R, S162A, D177E, T200A, Q207E, R211KC
Green (2011)707PKE23F707PKE23FHM623512D4T, 3TCEFVM184VK103N, P225HV8I, V35T, T39N, S48T, V60I, K101Q, K122E, I135T, E138A, K173A, Q174K, G196E, T200A, I202IV, Q207E, R211K, F214L, L228LI, V245Q, E248ED, A272P, E291D, V292I, I293V, K311RC
Sigaloff (2011)GT00011000GT00011000_1JN381563D4T, 3TCEFVM41ML, M184V, T215YK103NV35T, T39AE, E42EK, S48T, V60I, D76X, K101Q, K122E, D123S, I135L, E138A, R172RM, K173A, I178L, S191Y, T200A, Q207K, R211K, V245Q, A272P, E291D, I293V, E308XC
van Zyl (2011)A182A182JN638107D4T, 3TCEFVD67DN, M184IV106MI31L, V35T, E36A, T39E, S48T, V90VI, K101Q, K122E, D123S, T165I, K173T, D177E, T200A, Q207E, R211KC
 A63A63JN638219D4T, 3TCNVPM184VY188CV35T, E36A, T39E, S48T, V60I, K101Q, K122E, D123G, I135V, K173A, T200A, Q207D, R211K, L228LF, V245QC
 A79A79JN638224D4T, 3TCEFVM184VK103NV8IT, V35T, T39K, S48T, V60I, K101Q, K122E, D123G, I135K, S162SC, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245QC
Theys (2013)8214382143KC219032TDF, 3TCEFVA62V, K65R, M184VK103N, V106MT39E, S68SN, K101Q, K122E, I135T, Y144YS, S162C, K173T, Q174K, D177E, T200A, Q207E, R211K, V245QC
Van Zyl (2013)88317KC423335D4T, 3TCEFVM184VK103N, P225HV35T, T39A, S48T, K101Q, K102R, K122E, D123N, K173T, D177E, T200A, K201X, Q207D, R211K, H221X, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335DC
 6942668KC423773TDF, 3TCEFVD67N, K70E, M184VV106M, Y181C, G190AP4S, E6EK, V35T, E36A, T39E, S48T, Y56F, K66R, K101Q, K122E, D123DEG, K166R, K173S, D177E, T200A, Q207DEKN, R211K, L228LH, V245QC
 462493KC423730TDF, 3TCNVPK65R, M184V, K219EV179D, Y181C, G190AV35T, E36A, T39E, S48T, V60I, S68N, K101Q, K103R, K122E, D123G, K166KR, K173T, D177E, T200A, Q207E, R211K, V245Q, D250EC
 314166KC423306D4T, 3TCEFVV75I, M184VK103NE6K, V35T, E36A, T39E, S48T, A98S, K101Q, K122E, I132L, E138G, K173A, D177E, I178L, T200I, Q207E, R211K, V245QC
 5681110KC422886D4T, 3TCEFVM184VV106M, G190GA, F227LV35T, E36A, T39D, S48T, V60I, K101Q, K122E, K173A, Q174K, D177E, T200A, R211A, V245QC
 12843030KC423935D4T, 3TCEFVM184VK103N, P225HK20R, V35T, T39E, K49R, A98S, K101Q, K122E, D123G, I135K, K173A, Q174K, D177E, I178L, G196E, T200A, E204Q, Q207D, R211K, V245QC
 7791617KC423272TDF, 3TCEFVM184VK103N, V108VI, P225HE6K, V35T, E36A, T39E, S48T, K101Q, K122E, K173T, D177E, T200A, Q207E, V245QC
 14901727KC423358AZT, D4T, 3TC, TDFNVP, EFVD67DN, M184VK103S, V106MK20KR, V35T, T39E, S48T, V60VI, K101Q, K122E, D123S, I135T, E138A, I142V, K173M, Q174K, T200A, Q207A, R211K, F214L, V245Q, E248DC
 11761851KC423459D4T, 3TCEFVM184VK103N, P225HV35T, E36A, T39E, S48T, K101Q, K122E, D123S, K166KR, F171Y, K173A, Q174K, D177E, I178L, T200A, Q207E, V245QC
 5031833KC423446D4T, 3TCEFVM184VY188L, G190AP4S, V8I, L34I, V35T, T39N, V60I, A98S, K101Q, V106VI, K122E, D123S, E138A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250EC
 62173KC423668TDF, 3TCEFVD67NS, T69DN, K70R, M184V, T215IV, K219QV106M, Y188C, G190AK22KR, T39E, V60I, I94L, K101Q, K122E, D123S, T139R, K173A, Q174K, D177E, V179I, T200A, I202V, Q207E, R211K, P243T, V245QC
 17482448KC423715AZT, D4T, 3TC, TDFNVP, EFVM184VK103NP4T, V35T, E36A, T39K, K43E, S48T, V60I, K101Q, V118I, D121Y, K122E, T139S, K173T, Q174K, T200A, I202V, Q207E, F214LC
 10831528KC423206D4T, 3TCEFVM184VV106M, G190AK20R, V35T, E36EA, T39K, K43E, V60I, I94L, K101Q, K122E, D123S, K173A, Q174K, T200A, R211K, F214L, V245QC
 6791533KC423209D4T, 3TCEFVM184VK103N, P225H, K238TK20R, V35T, T39E, K43KR, S48T, V60I, K101Q, K122E, D123S, E138A, S162T, K166R, K173T, I178L, T200A, Q207D, R211K, V245KC
 18012655KC423764AZT, D4T, 3TC, TDFNVP, EFVM184VK103NV35K, T39E, S48T, K101Q, K122KE, I135IM, K173T, Q174K, T200A, E203D, Q207A, R211K, V245N, E248D, D250EC
 1641839KC424308D4T, DDIEFV K103N, L234IV35T, E36A, T39E, S48T, V90I, K101Q, K122E, D123G, S162HY, K173T, D177E, T200A, Q207E, H221Y, V245Q, D250DNC
  1011KC422803D4T, DDI, AZT, 3TCEFV K103N, L234IV35T, E36A, T39E, S48T, V90I, K101Q, K122E, D123G, S162HY, K173T, D177E, T200A, Q207E, H221Y, V245Q, D250DNC
 481413KC423133D4T, 3TCEFVM184VY188LV35T, T39E, S48T, K101Q, K122E, D123S, K173A, Q174K, D177E, I178V, T200A, E204K, Q207E, R211RK, F214L, V245Q, E248D, D250EC
 14971824KC423436AZT, D4T, 3TCNVP, EFVK65RK103N, Y181C, G190AP14A, K20R, V35T, E36A, T39E, E40D, S68N, W88C, K101Q, K122E, D123N, I135T, I142V, T200A, I202IV, Q207A, R211K, F214L, H221Y, V245L, D250EC
 5311623KC423278TDF, 3TCNVPK65R, M184VK103N, P225HV35T, E36A, T39E, S48T, A98S, K101Q, K122E, D123G, I135T, K173A, Q174K, D177E, T200A, Q207E, V245Q, D250DNC
 1046939KC424381AZT, D4T, 3TC, ABCNVP, EFV K103NV35T, T39E, S48T, K101Q, K122E, D123S, E138A, Q174K, N175Y, T200E, Q207E, R211K, V245Q, E248D, D250EC
 738375KC424020D4T, 3TCEFVM184VK103N, P225HK20R, V35K, T39E, K101Q, D121Y, K122E, S162NY, K173A, D177E, T200E, Q207E, R211K, V245QC
 498771KC424277D4T, 3TCEFVM184VV106M, V179DK20R, V21I, V35T, E36A, T39D, S48T, V60I, W88C, K101Q, K122E, D123N, E138A, K173A, D177E, T200K, Q207A, R211K, F214L, V245QC
 4021000KC422794D4T, 3TCEFVM41MLV106M, G190A, F227LK20KR, V35T, T39E, S48T, V60I, S68SG, K101Q, S105V, K122E, D123N, I135K, K173T, Q174K, D177E, I178L, V179I, T200A, Q207E, H221Y, P243S, V245E, D250EC
Steegen (2014)11ZAKS12611ZAKS126KJ176408D4T, 3TCEFVD67N, K70R, M184VK103S, V106MV35T, T39N, E40D, S48T, K49R, V60I, K101Q, K122E, D123G, I135L, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297EKC
 11ZAKS18911ZAKS189KJ176470D4T, 3TCEFVM184V, T215YK103N, K238TK20R, E28A, V35T, T39D, S48T, K101Q, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, I178L, T200A, E204Q, Q207D, R211K, V245Q, A272P, K275QR, K277R, T286A, E291D, V292I, I293V, Q334D, G335DC
 12ZAKS28912ZAKS289KJ176568ABC, 3TC, D4TEFVL74LV, M184VK103N, M230LV35T, E36A, T39E, S48T, K101Q, V106I, K122E, S162C, K166KR, K173A, Q174K, D177E, I178V, T200A, I202V, R206RI, Q207E, L228LR, V245Q, E248ED, A272P, K277R, L283I, E291D, V292I, I293V, Q334H, G335D, F346Y, R356K, G359T, T377R, S379SC, K390R, A400T, E404DC
 12ZAKS26212ZAKS262KJ176541D4T, 3TCEFVM184VK103N, P225HV35T, T39N, S48T, K101Q, K122E, E169D, Q174E, T200A, I202V, Q207K, R211K, V245Q, A272S, T286A, E291D, V292I, I293V, V314A, D324E, Q334E, R356K, G359T, K366R, T377L, K390R, E399D, A400I, E404DC
 11ZAKS15911ZAKS159KJ176441D4T, 3TCEFVM184VK103N, P225HV35T, E36EA, T39E, K101Q, K122E, D123S, S162C, K173A, D177G, T200A, Q207E, R211K, V245Q, A272S, E291D, V292I, V314A, Q334H, G335DC