<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K101P
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 68
Isolates 69
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Deshpande (2009)Pat062324RTFJ530879NRTINNRTIM184V, T215FK101P, G190AP1S, V35T, T39E, S48T, V60I, K102Q, D121Y, K122E, I135T, K166R, K173T, T200A, Q207D, R211K, F214L, D237E, V245QC
Wallis (2009)TJC2443711TJC2443711 D4T, 3TCEFVM184VK101P, K103NK20R, V35T, T39E, S48T, V60I, K122E, D123G, I135IT, E138A, T139A, K166R, K173T, Q174R, I202V, R211K, F214L, V245Q, D250DE, A272P, K277R, T286A, V292I, I293V, E297EK, Q334EC
 TJC2371599TJC2371599 D4T, 3TCEFVM184VK101P, K103NV35T, E36A, T39D, K49R, V60I, K122E, K173T, Q174K, D177E, I178M, V179VI, T200A, Q207E, R211RK, V245Q, A272P, E291D, V292I, E297EKC
 GP00005761GP00005761 AZT, 3TCEFVM41L, D67G, K70R, L74V, M184V, K219QK101P, G190SK20KR, V35T, T39E, S48T, V60I, S68G, K122E, D123GS, I135M, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, L228LH, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E308EK, I309IV, D324EC
Deshpande (2010)35IND43635IND436GU108162D4T, 3TCNVP, EFVM41ML, M184V, T215F, K219K*RWK101P, G190AV35IT, T39E, S48T, V60I, K102Q, D121Y, K122E, I135T, K166R, K173T, T200A, Q207D, R211K, F214L, L228LH, V245QC
van Zyl (2011)A290A290JN638179D4T, 3TCNVPM184VK101P, K103SE28A, K32E, V35K, E36A, T39E, S48T, E53D, K122E, D123S, I135T, T139TS, I142IL, S162H, K173T, T200A, Q207DE, R211K, F214L, V245QC
Manasa (2013)RES480RES480KC951847D4T, 3TCNVP, EFVD67N, M184VK101P, K103NK20R, E28A, V35T, E36A, T39E, S48T, V60I, T69N, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, Q207E, R211M, V245E, T286A, E291D, V292I, I293VC
 RES354RES354KC951809D4T, 3TCEFVD67N, M184VK101P, K103NE28K, K32E, V35T, T39E, S48T, V60I, D121C, K122E, K173T, Q174K, D177E, T200A, Q207E, R211K, A272P, T286A, E291D, V292I, I293VC
Van Zyl (2013)O16431756KC423381TDF, 3TCEFVK65R, M184VK101P, K103NP4T, K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, A158S, K173A, Q174K, T200A, Q207E, R211K, F214L, V245QC
 212411.ZA.GT1674KC423466D4T, DDIEFVD67N, T69D, K70R, K219QK101P, K103SK22R, V35T, E36A, T39E, E40D, S48T, V60I, K102R, K122E, D123N, E138G, A158S, K173T, Q174K, V179I, T200A, E203EQ, Q207E, F214L, D218E, L228HC
 271409.ZA.GT902KC424394D4T, 3TCEFVM184VK101P, K103NE28EK, V35I, T39DE, S48T, E53D, K122E, D123G, K173T, Q174K, T200A, R211K, V245Q, D250EC
 262208.ZA.GT394KC424171AZT, 3TCEFVD67N, K70R, M184V, T215TNSY, K219EK101P, K103NV35K, T39D, S48T, V60I, T69N, K122E, D123G, K173T, Q174K, V179VI, T200A, I202IV, Q207K, R211K, V245Q, D250DEC
 527210.ZA.GT1440KC423229D4T, 3TCEFVM184V, T215YK101P, K103NP4S, V35T, E36A, T39E, K122E, I142K, A158S, K173T, T200A, Q207D, R211K, V245QC
 276207.ZA.GT123KC423073D4T, 3TCEFVM184VK101P, K103NV35K, T39D, S48T, K122E, D123G, I135L, E138A, K173A, Q174R, D177E, G196T, T200A, R211K, F214FL, V245QC
 203511.ZA.GT1724KC423518TDF, 3TCNVPD67N, K70KN, F116Y, Q151M, M184VK101P, K103NK22R, V35T, T39E, S48T, E53D, K122E, D123DN, K173I, D177E, I178L, V179I, G196E, T200A, E204K, Q207D, R211K, F214L, V245Q, E248EKC
 331707.ZA.GT299KC424100D4T, 3TCEFVM184VK101P, K103NT27A, V35T, E36A, T39E, K122E, D123G, I135T, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, G231X, E233X, V245Q, D250EC
 185009.ZA.GT734KC424267D4T, 3TCEFVM184VK101P, K103NV35T, E36A, T39E, E40D, K122E, D123A, K173T, Q174K, D177E, I178M, T200A, E203D, Q207D, R211K, V245QC
 282707.ZA.GT175KC424014D4T, 3TCEFVD67DN, M184VK101P, K103NSV35T, E36A, T39D, S48T, V60I, K122E, D123G, I142V, K173A, D177E, I178L, V179I, T200A, Q207N, R211K, V245QC
 301607.ZA.GT209KC424038ABC, 3TCEFVM184VK101P, K103N, P225PHQK20KR, V35T, T39E, S48T, K122E, D123S, K173A, Q174K, D177G, Q197E, T200A, Q207N, R211K, V245Q, D250EC
 286511.ZA.GT1656KC423450D4T, 3TC, ABCEFVL74V, Y115F, M184VK101P, K103NK20KR, V35K, E36D, T39E, S48T, V60I, K122E, K173A, D177E, T200A, Q207N, R211K, F214L, V245Q, K249QC
 281309.ZA.GT934KC424425D4T, 3TCEFVM184VK101P, K103NE6EK, K20R, V35T, T39K, K122E, I135V, S162C, K173A, Q174KR, D177E, I178IL, E194ED, T200A, Q207E, R211K, F214L, V245QC
  10.ZA.GT1439KC423228D4T, 3TC, ABCEFVM184VK101P, K103NE6K, K20R, V35T, T39K, K122E, I135V, S162C, K173A, Q174R, D177E, D192DN, T200A, Q207E, R211K, F214L, V245QC
Steegen (2014)12ZAKS36212ZAKS362KJ176641D4T, 3TCEFVM41L, D67N, V75M, M184V, T215FK101P, K103S, V106ME28A, V35T, T39D, S48T, V60I, K122E, D123G, I135T, K173A, Q174K, D177E, V179VI, T200A, Q207E, R211K, D218E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359S, T377M, S379C, K390R, A400LC
 12ZAKS30412ZAKS304KJ176583D4T, 3TCEFVM184VK101P, K103NV35T, E36A, T39E, S48T, V90I, K102R, K122E, D123S, A158S, E169A, K173A, D177E, T200A, Q207A, R211K, V245Q, D250E, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359S, T369A, K374R, T377L, K388R, K390RC
 11ZAKS11111ZAKS111KJ176393D4T, 3TCEFVM184VK101P, K103NV35T, T39E, S48T, V60I, K122E, D123S, I135R, K166R, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K275R, K277R, E291D, V292I, I293V, D324DEC
 12ZAKS29612ZAKS296KJ176575ABC, 3TCEFVL74V, M184VK101P, K103NV35T, T39K, K43Q, K102KQ, K104KR, K122E, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, V314A, Q334H, G335D, R356RK, G359T, T377L, K390R, A400T, E404DC
 11ZAKS17011ZAKS170KJ176451D4T, 3TCEFVM184VK101P, K103NSV8I, V35T, T39K, E40D, K102Q, K122E, D123G, K173A, G196K, T200E, E203EK, Q207E, R211RK, V245Q, A272P, T286A, E291D, V292I, K311R, Q334L, G335DC
 12ZAKS34512ZAKS345KJ176624D4T, 3TCEFVM184VK101P, K103NP4S, V35T, T39E, S48T, V60I, V90I, K122E, D123S, I135R, V148L, S162F, K173A, Q174K, Q197E, T200A, Q207G, V245K, A272P, T286A, E291D, V292I, I293V, L301F, P313T, Q334N, G335D, R356K, G359T, K366R, A371V, T377L, K390R, A400T, E404D, V435IC
 11ZAKS10111ZAKS101KJ176383D4T, 3TCEFVM41L, L74V, M184V, L210W, T215YK101P, K103NV35T, T39E, K122E, D123S, I135T, K173A, Q174K, N175NY, D177E, I178IM, T200A, R211K, V245K, A272P, K277R, E291D, V292I, I293V, E308K, I309V, L310CC
 11ZAKS14111ZAKS141KJ176423D4T, 3TCEFVM184VK101P, K103NSV35T, E36A, T39E, S48T, K122E, D123S, K166R, K173A, D177E, T200A, Q207D, R211K, V245Q, E248T, A272P, K277R, K281R, E291D, V292I, I293V, Q334D, G335HC
 12ZAKS32112ZAKS321KJ176600D4T, 3TCEFVM184V, N348IK101P, K103NE28EAKT, V35T, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, R358K, G359S, T377Q, K390R, A400T, T403S, E404DC
 12ZAKS22712ZAKS227KJ176507D4T, 3TCEFVM184VK101P, V106M, F227FLP4S, V35T, T39E, S48T, E53D, V90VI, K122E, D123S, I135M, E138A, S162HY, K173T, Q174K, V179I, T200A, E203A, Q207E, R211K, F214FL, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, L310I, Q334H, G335DC
 12ZAKS28312ZAKS283KJ176562D4T, 3TCEFVM184V, T215YK101P, K103NT27TS, E28EA, V35T, T39E, S48T, K122E, D123GS, K166R, K173A, D177E, V179I, T200K, Q207A, R211K, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, I293V, D324E, G333D, Q334H, R356K, M357I, G359T, D364E, A371AV, T377Q, K390R, A400T, E404D, A408V, E413G, Q428RC
Rossouw (2015)RP081RP081KT032024D4T, 3TCEFVD67N, K70R, M184V, K219QK101P, K103NK20R, V35T, E36A, T39E, S48ST, V60I, K122E, D123N, I135T, K173A, D177EG, T200A, Q207D, D218E, L228LH, V245Q, A272P, E291D, V292I, I293V, L301F, V317A, D324DE, I326IV, I329IV, Q334H, G335D, R356K, M357R, G359T, A371V, I375IV, T377Q, K390R, A400T, E404D, V435IC
 RP107-1RP107-1KT032038D4T, 3TCEFVM184VK101P, K103SE6EK, E28A, V35T, T39E, E40D, K102R, K122E, D123N, K173T, Q174K, T200A, I202IV, R211K, V245Q, K277R, L283I, T286A, V292VI, I293V, E297KC
 RP003RP003KT031999D4T, 3TCEFVL74LV, M184VK101P, K103NV35L, E36N, I37F, T39K, K122E, D123A, K173A, D177G, T200A, Q207E, V245QC
Skhosana (2015)11ZALS04811ZALS048KM115845D4T, 3TCEFVD67N, K70G, F116Y, Q151M, M184VK101P, K103NV35T, T39E, S48T, S68SN, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 12ZALS14512ZALS145KM115862TDF, 3TCEFVA62V, K65R, M184VK101P, K103NV35T, T39E, S48T, S68N, K122E, D123N, K173A, Q174QK, D177E, I178L, T200A, E204K, Q207E, R211K, P243Q, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377Q, S379C, K390R, E399K, A400T, E404DC
 12ZALS14012ZALS140KM115783D4T, 3TCEFVF116Y, Q151M, M184VK101P, K103N, P225HV35T, T39E, S68G, K102R, K104R, K122E, D123N, K173T, Q174K, D177E, D192N, T200A, Q207E, R211K, V245Q, A272P, K277T, E291D, V292I, Q334N, G335D, R356K, M357K, G359T, K366R, T369A, T377M, K390R, E399D, A400T, T403S, E404DC
 12ZALS12412ZALS124KM115745D4T, 3TCEFVK70KE, M184VK101P, K103NE6K, V35T, T39E, K122E, I135ILST, E138A, K173A, Q174K, T200A, Q207D, R211K, V245Q, A272P, K275R, K277KR, Q278H, K281KR, T286A, E291D, V292I, I293V, P313T, D324DE, I329L, Q334D, G335D, G359T, A360T, T369A, T377L, K390R, A400T, E404DC
 11ZALS01211ZALS012KM115822D4T, 3TCEFVM41L, D67DN, L74V, M184V, T215F, K219WK101P, K103NK20R, V35T, T39E, S48T, K102R, K104R, K122E, D123DN, I135IT, S162Y, K173AT, Q174R, D177E, I178IM, T200A, Q207N, R211K, V245Q, K277R, T286A, E291D, V292I, I293VC
Dinesha (2016)T79T79KX275123TDF, 3TCEFVK70E, M184VK101P, Y181C, G190AV35T, T39D, K49R, V60I, K122E, I135R, S162D, E169R, K173E, D177E, V179I, T200A, E203K, Q207E, L228QC
 T123T123KX275167TDF, 3TCEFVL74I, M184VK101P, K103NV35T, T39D, S48T, V60I, K122E, D123N, K173A, D177E, T200A, Q207A, R211KC
 T113T113KX275157TDF, 3TCEFVM184MIVK101P, K103NV35T, E36A, T39D, S48T, V60I, V90VI, D121Y, K122KE, I135V, S162A, K173A, D177G, T200A, Q207E, W212WG, L228LFC
Lam (2016)2002201820022018KR868118D4T, 3TCNVPM184VK101P, K103NV35T, T39E, S48T, K102R, K122KE, K173T, Q174K, I178L, T200A, Q207E, R211K, F214L, V245LM, A272P, Q278N, V292I, I293V, V317A, Q334H, G335DC
 1601201516012015KR867902AZT, 3TCEFVD67N, T69D, K70R, M184V, T215F, K219QA98G, K101P, K103NV35K, T39D, V60I, D121Y, K122E, I135V, S162A, K173A, Q174K, D177E, V179I, T200A, E203D, Q207QE, R211K, F214L, L228H, V245Q, A272P, L283I, I293V, D324E, I329L, Q334E, G335DC
 1601202816012028KR868140D4T, 3TCNVPD67N, K70R, L74V, M184V, K219QK101P, G190AV35T, E36EA, T39D, V60I, K64NY, D121Y, K122E, I135V, S162SA, K173A, Q174K, D177E, V179VI, T200A, E203K, Q207E, R211K, L228H, V245Q, A272P, K277R, L283I, E291D, V292I, I293V, E297K, K311Q, D324DEC
Neogi (2016)713713.ZA.EC676KT592835TDF, 3TCEFVK65R, K70T, M184VK101P, K103NV8I, K20R, T27TS, E28A, V35T, E42D, S48T, E53D, V60I, S68G, V111I, K122E, D123N, I135T, I142IT, K166R, K173A, V179VI, T200A, Q207E, R211RK, F214L, V245QC
 157213.ZA.GT3024KT593311TDF, 3TC, AZTEFVK65RK101P, K103NK20R, V35T, T39E, S48T, S68K, K122E, D123N, I135IR, E138A, T139V, K173A, Q174K, V179L, T200A, Q207E, F214L, V245Q, E248DC
 443613.ZA.EC702KT592851D4T, 3TCEFV K101P, K103NV35T, T39E, K122E, D123S, I135T, E138EA, S162C, T165L, K173A, D177EG, T200A, Q207K, R211Q, V245QC
 118813.ZA.EC910KT592970TDF, 3TCEFVK65R, Y115F, M184VK101P, K103NK20R, V35T, E36A, T39E, S48T, V60I, S68N, K102N, K122E, D123G, S163T, K173T, Q174K, D177E, I178V, T200A, Q207E, R211K, V245QC
 335413.ZA.GT2699KT593067TDF, 3TCEFVM184VK101P, K103NV35T, E36A, T39E, S48T, V90VI, K122E, D123N, K173A, D177E, I178M, T200A, E204K, Q207E, R211K, F214L, V245QC
 423513.ZA.GT2758KT593117TDF, 3TCEFVK70E, M184VK101P, K103ST27S, E28A, V35T, T39E, S48T, V60VI, K102R, K122E, D123G, I135V, K173AT, D177DE, T200A, Q207E, R211K, L228H, V245QC
 553113.ZA.EC602KT592787AZT, 3TCEFVM184V, L210LW, T215FK101P, K103NI31L, V35T, T39E, K122E, D123S, D177N, T200A, Q207E, R211K, V245QC
 422913.ZA.GT2720KT593084TDF, 3TCEFVA62V, K65R, M184VK101P, K103NS, K238TE28EK, E29EK, V35T, E36A, T39K, K43E, E53D, S68N, K122E, D123S, S162H, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, V245QC
Steegen (2016)GFECB050GFECB050KU127770D4T, 3TC, TDFEFVK70E, M184VK101P, K103SV35T, E36A, T39E, S48T, V60I, V90I, K122E, D123S, I135V, S162W, K173A, D177G, T200A, Q207GV, R211K, V245Q, A272P, Q278N, T286A, E291D, V292I, I293IV, L310I, D324DE, Q334E, R356K, M357R, R358RK, G359T, K366R, A371V, T377L, K390R, A400T, E404DC
 GFKZB110GFKZB110KU127989TDF, 3TCEFVK65R, M184IVK101P, K103NV8I, I31IL, V35T, E36A, T39D, K122E, D123G, K173T, Q174R, T200A, Q207E, R211K, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334H, G335A, R356K, G359T, T377L, K390R, A400T, E404DC
 GFKZB386GFKZB386KU128295D4T, 3TC, TDF, FTCEFVK65R, M184VK101P, K103NE6EK, E28K, V35T, T39E, S48T, K122E, K166KR, K173KE, D177E, I178L, V179I, T200A, E204K, Q207D, R211K, V245N, A272P, K277R, T286A, E291D, V292I, I293V, P294PT, D324E, Q334N, G335D, R356K, G359T, K390R, A400T, T403A, E404DC
 GFWCB003GFWCB003KU127592D4T, 3TC, AZTEFVK70R, M184VK101P, K103N, K238TV35T, T39E, S48T, T69N, E138Q, K173A, Q174R, D177E, I178L, V179I, T200A, R206T, Q207T, F214L, L228R, V245QC
 GFKZB193GFKZB193KU128104D4T, 3TC, TDFNVPD67N, K70KHNQ, F116Y, Q151M, M184VK101P, K103NV35T, E36A, T39E, S48T, K102R, V111I, K122E, D123N, K173A, D177G, T200A, I202V, Q207E, R211K, V245E, A272S, K277KR, T286V, V292I, I293V, E300A, Q334N, G335D, R356K, G359T, A360T, V365VI, K366KR, T377Q, K390R, A400T, E404D, V435AC
 GFMPB030GFMPB030KU127901D4T, 3TCEFVD67DN, M184V, L210LW, T215FYK101P, K103S, G190AI2V, E28EA, V35T, T39E, E44D, S48T, V60VI, V118I, K122E, I135T, A158S, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, L228H, V245Q, S251D, A272P, R284K, E291D, V292I, I293V, E297K, G333GR, Q334H, G335GD, R356K, G359T, V365VI, K366R, T369A, A376S, T377L, K390R, I393VC
 GFLPB029GFLPB029KU128071TDF, FTCEFVK70E, M184VK101P, K103NV35T, T39E, S48T, K122E, D123G, K173A, D177E, I178L, T200A, E204EK, Q207E, R211K, V245Q, A272P, E291D, V292I, K311KR, Q334N, G335D, R356K, M357R, G359A, K388T, K390R, A400T, T403S, E404DC
 GFMPB006GFMPB006KU127857D4T, 3TCEFVV75T, M184VK101P, K103NK20KR, V35T, T39E, K104R, K122E, I135L, E138A, K173T, Q174R, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, T286V, E291D, V292I, I293V, P294T, V317A, Q334H, G335D, A355S, R356K, G359T, A376S, T377L, K390R, A400T, E404DC
 GFKZB254GFKZB254KU128168D4T, 3TC, TDF, FTCEFVK65R, M184VK101P, K103S, V106MI5IL, K20R, V35T, E36EA, T39D, S48T, V60I, S68SDGN, K122E, D123S, T139K, K173A, Q174K, D177E, T200A, E203D, Q207DE, R211RK, F214L, V245Q, A272P, E291D, V292I, I293V, I326V, E328D, Q334E, R356K, M357S, G359S, T377L, K390R, A400T, E404D, V435AC
 GFKZB169GFKZB169KU128050TDF, FTCEFVA62V, K65R, M184VK101P, K103N, E138EK, Y181YC, G190AV8VI, K20R, V35T, T39E, S68N, K122E, K173T, Q174R, T200A, Q207E, R211K, V245Q, E248ED, A272P, K277R, E291D, V292I, I293V, D324DE, Q334N, G335D, R356K, G359T, T377L, S379C, K390R, A400T, E404D, E432D, V435AC
 GFGPB074GFGPB074KU127740TDF, 3TCEFVD67A, K70E, M184VK101P, K103NV35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293VC
 GFKZB389GFKZB389KU128308D4T, 3TC, TDF, FTCEFVK65R, M184VK101P, K103NS, P225HK20KR, E28K, K32E, V35T, E36A, T39D, S48T, S68N, K173T, Q174K, T200A, Q207E, R211K, V245N, D250DE, A272P, K275Q, Q278QH, K281R, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377V, K390R, A400T, E404D, P421H, V435M, A437VC
 GFGPB078GFGPB078KU127734TDF, 3TCEFVK65R, M184VK101P, K103NE6K, V35T, E36A, T39E, S48T, V60I, S68SDGN, K122E, K173A, D177E, I178M, G196E, T200A, E204K, Q207E, V245Q, E248D, D250E, A272P, K277R, E291D, I293V, G333E, Q334D, G335D, R356K, M357R, G359T, K366KR, T377R, S379C, K390R, A400T, E404DC
 GFKZB199GFKZB199KU128105TDF, 3TC, FTCEFVK70E, M184VK101P, K103SK20KR, V35T, T39E, S48T, V60VI, K122E, D123S, E138G, K173T, Q174K, D177E, I178L, T200A, E203EK, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, K311KR, Q334N, G335D, R356K, G359TC