<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation K101H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 22
Patients 70
Isolates 72
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1457UK1457AY901339AZT, 3TCNVPM184VK101H, G190AV35T, E36A, T39E, S48T, K122E, D123N, K173T, Q174K, I178L, T200A, Q207E, R211KC
Doualla-Bell (2006)Pt17FDB_Pt17EF434890AZT, 3TC, D4T, DDIEFVM41L, L74LV, V75M, M184MV, T215YK101H, K103N, G190AP4S, V35T, E36A, T39E, S48T, V60VI, V90I, K122E, I135V, S162A, K173A, D177E, Q197K, Q207E, R211K, V245Q, A272P, T286A, E291D, I293V, E297DC
Marconi (2008)SW063sw063EU308074D4T, 3TCEFVD67N, M184VK101H, K103N, G190AS48T, V60I, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207D, R211K, V245QC
Hawkins (2009)R347ZZR347FJ931374AZT, 3TCNVPM184V, T215FK101H, G190A, M230LT7A, V35T, T39E, S48T, V60I, D121H, K122E, I135R, S162C, K173T, Q174KR, D177E, V179VI, T200A, Q207E, R211K, V245Q, A272P, K275Q, K277KR, L283I, E291D, V292I, I293V, Q334NC
Hoffmann (2009)pat051MD052585 AZT, 3TCEFVA62V, M184VK101H, K103N, V106MV35T, E36A, T39E, K122E, D123GS, I135T, K173T, D177E, T200A, R211RK, F214L, V245Q, A272PC
Hosseinipour (2009)94029402GQ228335D4T, 3TCNVPM41L, D67N, K70R, M184V, T215F, K219WK101H, Y181IT39E, V60I, T69X, K122E, D123G, I135T, T139I, K173A, V179I, G196K, T200A, Q207E, H208Y, R211K, D218E, L228H, V245QC
 94149414GQ228338D4T, 3TCNVPM184V, T215YK101H, Y181C, G190AT39A, E44ED, S48T, V118VI, K122E, D123S, T139R, K173I, Q174K, D177G, G196E, T200A, Q207E, L210LS, R211RK, F214FL, D218DE, V245QC
 85148514GQ228381D4T, 3TCNVPM41L, D67N, M184V, L210LW, T215FK101H, K103N, G190AT39E, S48T, V60I, K122E, D123S, I135T, K173T, D177DN, T200A, Q207E, D218DE, V245QC
Wallis (2009)TJC2384408TJC2384408 AZT, 3TCEFVM41L, D67N, K70R, V75M, F77L, M184V, L210W, T215Y, K219KQK101H, V106M, G190A, F227LV35I, E36A, T39E, S48T, T69N, K122E, D123N, I135T, K173T, T200A, Q207E, R211K, F214FL, A272P, K275Q, K277R, T286A, A288T, E291D, V292I, I293VC
 TJC2382305TJC2382305 D4T, 3TCNVPM184VK101H, G190AK32N, V35K, E36A, T39E, S48T, V90I, K122E, D123S, I135T, S162F, K173A, Q174K, N175Y, D177E, V179VI, T200A, Q207E, R211K, V245Q, A272P, K277R, T286V, V292I, I293VC
 TJC2389178TJC2389178 AZT, 3TCEFVM184VK101H, G190SV8VA, G18X, V35T, E36A, T39E, S48T, K122E, D123G, E169EA, K173A, Q174K, D177E, V179VAIT, T200A, Q207E, R211K, V245Q, A272P, L279M, E291D, I293VC
 TJG4623653TJG4623653 D4T, 3TCEFVM41L, D67N, K70R, M184V, T215Y, K219EK101H, G190AE6P, V35T, T39E, K103R, K122E, D123G, I135T, S162D, K166R, K173A, D177E, T200A, E204K, Q207E, V245Q, A272P, K277R, T286TA, E291D, V292I, I293VC
El-Khatib (2010)Pat02310ZA_SAVE1379HQ012301D4T, 3TCEFVD67DN, M184VK101H, V106M, G190A, F227FLV35T, T39E, S48T, K122E, D123N, I135IT, A158S, K173A, Q174K, D177E, I195L, G196E, T200A, Q207E, R211K, F214L, Y232YH, P243PS, V245QC
 Pat04610ZA_SAVE2237HQ012324D4T, 3TCEFVM184V, T215FK101H, V106M, P225H, M230LV35T, T39E, K122E, T139A, K173A, Q174K, D177E, E203D, Q207E, R211K, V245K, D250EC
 Pat08311ZA_SAVE1302JF960533D4T, 3TCEFVM184VK101H, K103N, G190AE28K, K32E, V35T, E36A, T39E, S48T, K122E, D123G, K173A, D177E, G196R, T200A, Q207R, R211K, F214FL, V245Q, A272P, Q278HC
Green (2011)707PKE26F707PKE26FHM623515D4T, 3TCEFVM41ML, K70KR, M184V, K219KRK101H, V106M, G190AP4T, K20KR, V35T, E36A, T39E, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, V245Q, E248ED, D250NS, A272P, T286A, E291D, V292I, I293V, P313Q, Q334EC
Kouri (2012)CU1913-09CU1913-09JQ585321NRTINNRTID67N, K70R, M184V, T215F, K219EK101H, Y181C, G190SV35T, E36A, T39D, V60I, K122E, D123G, Q174K, D177E, T200A, E203D, Q207KR, R211Q, L228H, V245Q, A272P, K277R, K281R, E291D, V292IC
Manasa (2013)RES174RES174KC951724D4T, 3TCEFVM184VK101H, K103N, G190AV35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174R, D177E, T200A, Q207D, R211K, P243T, V245Q, E248T, A272S, K275Q, E291D, V292I, I293VC
 RES076RES076KC951686D4T, 3TC, TDFEFVD67N, K70G, M184V, K219QK101H, V106M, G190A, F227LV35K, T39E, S48T, V60I, L109I, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, V179I, T200A, Q207K, F214L, V245Q, A272P, K277R, Q278N, E291D, V292I, I293VC
 RES259RES259KC951751D4T, 3TCNVP, EFVM184VK101H, Y181C, G190AV35T, E36A, T39E, S48T, K103R, K122E, T139I, K173T, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292IC
 RES401RES401KC951826D4T, 3TCEFVD67N, M184VK101H, V106M, F227L, K238TV35T, E36A, T39E, E40D, S48T, V60I, K122E, D123S, D177E, T200A, Q207K, R211A, K219T, V245T, A272P, E291D, V292I, I293VC
 RES071RES071KC951681D4T, 3TCNVPM184VK101H, G190AV35T, T39E, S48T, K122E, D123S, I135T, K166R, K173I, Q174K, I178L, T200A, Q207N, R211K, V245Q, E248T, D250E, A272P, K277R, I293VC
Theys (2013)159400159400 AZT, 3TCEFVD67N, K70R, M184V, K219QK101H, V106M, F227LP9PS, I31V, V35M, T39E, S48T, D123E, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, V245K, E248D, D250E, A272P, E291D, V292I, I293V, V317A, S322LC
Van Zyl (2013)341509.ZA.GT632KC424206D4T, 3TCEFVA62V, M184VK101H, G190SE6K, V35T, T39E, K122E, I142V, K173T, Q174R, D177E, I178L, T200A, Q207E, V245EC
 181709.ZA.GT754KC424282D4T, 3TCEFVM184VK101H, K103N, G190AE6D, V35T, T39E, S48T, K122E, D123S, K173R, Q174K, G196R, T200A, Q207E, V245K, E248NC
 309108.ZA.GT525KC423775D4T, 3TCEFVM184V, T215FK101H, V106M, P225H, M230LV35T, T39E, K122E, T139AV, K173A, Q174K, D177E, E203D, Q207E, R211K, V245K, D250EC
 194707.ZA.GT161KC423251AZT, 3TCNVPD67DN, K70KR, M184V, T215TFISK101H, V106M, Y181CV35T, E36A, T39E, S48T, K122E, D123S, T139L, K173A, Q174K, D177E, T200A, Q207E, F214L, V245Q, E248D, K249KRC
 535212.ZA.EC186KC423847TDF, 3TCNVPK65R, M184VK101H, Y181C, G190AV35T, E36A, T39D, S48T, E53D, K122E, D123G, S162C, K173A, Q174K, D177E, I178L, T200A, K201KR, Q207E, R211K, F214FL, V245Q, D250EC
 82611.ZA.GT1816KC423606D4T, 3TCEFVM184VK101H, Y188L, G190GAV35K, T39E, S48T, V60I, K122E, D123G, K173T, D177E, T200A, Q207K, F214FL, V245Q, D250DEC
 271210.ZA.GT1299KC423131D4T, 3TCEFVM184VK101H, G190ST27S, V35R, T39E, S48T, K122E, D123G, S162C, K173I, Q174K, T200A, Q207E, R211K, K238R, V245QC
 278607.ZA.GT072KC424419D4T, 3TCEFVM184VK101H, V106M, G190AE6KT, K11KR, K32KR, V35T, E36A, T39E, S48T, K122E, T165I, K173A, D177E, T200A, Q207E, F214L, V245K, A272P, Q278H, T286A, E291D, V292I, I293V, I326V, Q334EC
 357610.ZA.GT1130KC422963D4T, 3TCEFVM184VK101H, V106M, V179D, F227LV35T, T39G, D123S, S162SC, K173A, T200A, Q207E, R211RK, V245QC
  12.ZA.GT2082KC423789D4T, 3TCEFVK70KR, M184VK101H, V106M, V179D, F227LV35T, T39G, K122E, D123S, R125RK, S162C, K173A, T200A, Q207E, F214FL, V245QC
 165209.ZA.GT638KC424199D4T, 3TCEFVM184V, T215VK101H, V179E, Y188LV35T, E36A, T39D, S48T, K122E, D123N, E138A, V148VA, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, P243T, V245Q, E248DC
  10.ZA.GT1120KC422970D4T, 3TCEFVM184V, T215FK101H, V179E, Y188LV35T, E36A, T39D, S48T, K49R, K122E, D123N, I135IT, E138A, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211K, F214LC
Steegen (2014)12ZAKS27412ZAKS274KJ176553D4T, 3TCEFVL74V, M184V, T215YK101H, K103N, G190AV35M, E36A, T39E, S105A, K122E, D123N, A158S, K173T, T200A, Q207D, V245E, A272P, K277R, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359TC
 10ZAKS04210ZAKS042KJ176324D4T, 3TCEFVA62V, M184VK101H, V106M, F227LV35T, T39E, S48T, V90I, A98S, D121H, K122E, I135IT, K166R, K173T, Q174QR, D177E, I178L, T200A, Q207E, R211K, D250E, A272P, K277R, T286A, E291A, V292I, I293VC
 12ZAKS32712ZAKS327KJ176606D4T, 3TCEFVM184VK101H, G190SP4PT, E6KR, V35T, E36A, T39E, W88S, K122E, I135V, K173KT, T200A, Q207E, F214FL, K277KR, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359T, T369V, E370EG, T377M, K390R, A400T, E404D, E413GC
Wallis (2014)4145041450KM458524NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219QA98G, K101H, V106M, Y181C, G190AV35K, T39D, S48T, V60I, D121Y, K122E, I135T, S162A, T165V, K173A, D177E, T200V, I202IV, Q207E, R211K, F214L, L228HC
Saravanan (2015)CTLA236CTLA236KP993839NRTINNRTIM41L, D67DN, M184V, T215YA98G, K101H, Y181C, G190A, P225H, F227LV35I, T39E, E42K, K49E, V60I, D121Y, K122E, D123E, I135L, K173A, Q174K, D177E, T200A, Q207N, L210S, R211K, H221YC
 CTLA131CTLA131KP993734NRTINNRTIM41L, D67DN, M184V, T215FYK101H, Y181YC, G190AV35T, T39D, S48T, V60I, D121H, K122E, I135T, K166R, K173T, D177E, T200A, E203D, Q207D, H208HY, R211RKC
 CTLA307CTLA307KP993910NRTINNRTID67N, T69D, K70R, M184V, T215FK101H, V106M, Y181VT27S, V35T, T39E, V60I, A98AS, I135K, S162A, K173A, I178L, V179I, T200A, E203K, Q207E, R211K, L228HC
 CTLA289CTLA289KP993892NRTINNRTIM41L, T69D, M184V, L210W, T215Y, K219RK101H, Y181C, G190AV35A, T39D, E44D, V60I, K102Q, V118I, D121H, K122E, D123DN, I135V, S162C, K173T, Q174K, D177E, I178L, V189I, I195IT, G196E, T200E, E203K, Q207D, H208Y, R211K, K223Q, L228KC
 CTLC29CTLC29KP993578NRTINNRTIM184VK101H, V108I, G190AV35K, T39D, S48T, V60I, F87FI, D121Y, K122E, I135T, S162H, T165I, K173A, Q174K, D177E, T200Q, Q207E, F214FLC
 CTLA271CTLA271KP993874NRTINNRTIM41L, L74I, M184V, T215YA98G, K101H, Y181C, G190AV35K, T39D, S48T, V60I, D121H, K122E, I135T, K173A, D177E, T200A, Q207G, R211KC
 CTLA305CTLA305KP993908NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YK101H, V108I, G190AV35T, T39N, K49KR, V60I, K82R, D121HY, K122E, I135T, S162C, K173AT, Q174QK, D177E, I178L, G196E, T200A, E203K, Q207E, H208Y, R211KC
 CTLA81CTLA81KP993684NRTINNRTIM41L, M184V, T215YA98G, K101H, V108VI, Y181C, G190AV35I, T39E, E42K, K49E, V60I, D121Y, K122E, D123E, I135ILPT, K173A, Q174K, D177E, T200A, Q207N, R211K, H221Y, L228HC
 CTLA391CTLA391KP993994NRTINNRTIM41ML, L74LV, M184VK101H, G190SV35T, T39DN, S48T, V60I, S68SG, K122E, I135V, S162A, S163ST, K173A, D177E, V179I, T200A, Q207E, R211RK, F214FLC
 CTLA42CTLA42KP993645NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219QK101H, Y181C, G190AE28K, V35T, T39D, V60I, D121H, K122E, I135T, K173T, D177E, I178L, T200A, Q207E, H208HY, H221YC
 CTLA450CTLA450KP994053NRTINNRTIM41L, L74V, M184V, L210W, T215YK101H, K103N, G190AV35T, T39A, S48E, V60I, V118I, I135T, K166R, K173E, D177E, I178M, T200A, Q207E, R211KC
Skhosana (2015)12ZALS15612ZALS156KM115770D4T, 3TCNVPM41L, D67N, V75I, M184V, T215YK101H, V106M, F227LK20R, L34I, V35T, T39E, L109I, K122E, D123S, E138A, S162C, K173A, Q174K, D177E, V179I, T200A, I202T, Q207D, R211K, H221Y, V245Q, E248N, D250E, A272P, K275R, E291D, V292I, I293V, V314A, Q334N, G335D, R356K, M357T, G359T, K366R, A376AST, T377Q, S379C, K390R, A400T, E404D, K431TC
 12ZALS14112ZALS141KM115780D4T, 3TCNVPM184VK101H, Y181C, G190AV35T, T39K, K43E, S48T, V60I, K122E, D123G, T139K, K173A, Q174K, T200A, Q207E, R211RK, F214L, D218E, L228HR, V245Q, E248V, A272P, K277R, T286A, E291D, V292I, Q334N, G335D, R356K, G359T, V365I, A376G, T377L, K390R, A400L, T403KR, E404DC
 12ZALS09512ZALS095KM115764D4T, 3TCEFVD67N, T69D, K70R, V75T, M184V, K219QK101H, V106M, V179D, G190AK20R, V35T, T39E, S48T, V60I, K122E, D123DN, I135T, E138A, S162F, T165L, K173A, Q174K, N175Y, D177E, T200E, E203K, Q207E, R211K, F214L, D218E, L228N, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297AC
Dinesha (2016)T154T154KX275198TDF, 3TCEFVK65R, M184V, K219EK101H, V106M, Y181C, G190AK20R, V35T, E36EA, T39E, S48T, V60I, S68K, D121Y, K122E, D123DE, K166R, K173A, D177E, E194D, G196K, T200A, I202V, E204D, Q207K, R211RK, F214LC
Lam (2016)1601202716012027KR868098TDF, FTCEFVD67N, K70R, M184V, T215I, K219QK101H, K103N, V108I, Y181C, G190AV35T, T39D, K46Q, V60I, T69N, D121H, K122E, I135R, S162A, E169A, K173A, D177E, G196E, T200A, Q207K, R211K, H221Y, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, E297A, G335DC
 2002202020022020KR868120D4T, 3TCEFVM184VK101H, V106M, G190AV35T, T39E, K43KM, E44ED, S48T, K122E, D123N, A158S, K173A, Q174K, D177E, E194EK, I195L, G196GE, T200A, Q207E, R211K, F214L, V245Q, A272P, I274V, K275R, Q278N, T286A, E291D, V292I, I293V, E297EAKT, V317A, Q334D, G335DC
 2002202820022028KR868060D4T, 3TCEFVM184V, T215FK101H, K103N, G190AV8I, K11Q, V35T, T39K, S48T, S68G, V90I, D121DE, K122E, D123G, S162CY, K173T, Q174K, D177E, T200A, Q207D, R211K, V245Q, A272P, K275R, T286V, E291D, V292I, I293V, D324E, Q334Y, G335GDC
Neogi (2016)13513.ZA.NL084KT593456ABC, 3TC, AZT, DDIEFVM41L, D67N, K70R, T215F, K219QK101H, V106M, G190AK32R, V35T, T39K, K43E, V60I, A98S, K122E, D123G, S162D, K173A, Q174K, D177E, T200A, Q207E, V245QC
 714713.ZA.EC760KT592889D4T, 3TCEFVM184V, T215YK101H, K103N, G190AV8VI, M16MT, K20KR, V35T, T39E, K122E, D123S, S162H, K173T, Q174QK, D177E, T200A, Q207E, R211K, V245Q, E248D, D250EC
 549813.ZA.EC525KT592733TDF, 3TCEFVK65R, M184VK101H, K103N, G190AV35T, E36A, T39E, S48T, E53D, S68N, R72T, K122E, S162C, K173T, Q174K, D177E, T200A, Q207K, R211A, V245QC
 424113.ZA.GT2839KT593176ABC, 3TCEFVT69DN, M184VK101H, K103N, G190AP4S, K11T, K20R, V35T, T39E, V60I, K122E, D123S, A158S, K173A, Q174K, D177G, E194P, G196E, T200A, Q207T, R211K, F214L, V245QC
Steegen (2016)GFGPB124GFGPB124KU127952D4T, 3TC, TDFNVPM184VK101H, V108VI, Y181C, G190GAK32R, V35I, T39E, E40D, K122E, D123E, I135R, K173A, D177E, T200A, Q207G, R211RK, H221HY, V245Q, T253S, A272P, K277R, V292I, I293V, G335Y, I341V, E344D, R356K, G359T, T369A, A371V, T377Q, S379A, K390R, A400T, E404DC
 GFMPB056GFMPB056KU128020D4T, 3TC, AZTEFVM41L, T69D, M184V, L210W, T215Y, N348IK101H, K103N, Y181C, G190AV35T, T39E, K122E, D123S, I135R, K173A, Q174K, D177E, I178L, T200A, Q207A, R211K, K223Q, L228R, P243Q, V245Q, A272P, V276T, L283I, T286V, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, A360T, K366R, I375V, A376S, T377Q, T386I, K390R, A400IM, E404DC
 GFECB076GFECB076KU127872TDF, 3TCEFVK65R, Y115F, M184VK101H, V108VI, Y181C, G190AK20R, V35T, E36A, T39E, S48T, K102Q, D123E, S162C, K173T, Q174K, D177E, I178IV, T200A, Q207D, R211K, V245E, E248D, D250E, A272P, I274V, V276T, K281R, T286A, E291D, V292I, I293V, P294Q, L295M, D324E, Q334H, G335D, R356K, G359A, Q373H, S379C, K390R, E396D, A400TC
 GFKZB064GFKZB064KU127903TDF, 3TCEFVK65R, M184VK101H, V106M, Y181C, G190A, F227LK11KR, V35T, E36A, T39D, S48T, S68N, V90I, K122E, D123N, K173A, D177E, E194A, T200A, I202V, Q207K, R211K, V245L, A272P, T286A, E291D, V292VI, I293V, E297EG, I329L, G335D, Y342F, R356K, M357R, G359T, A376C, T377M, T386I, K390R, A400IC
 GFECB027GFECB027KU127718TDF, 3TCEFVA62V, K65R, M184VK101H, Y181C, G190SE28EA, V35T, T39E, S68N, K122E, D123N, I142V, S162C, K173A, D177E, V179I, T200A, Q207K, R211K, H221Y, V245Q, D250E, A272P, K275Q, K277R, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, K366R, T369V, T377M, K385R, K390R, A400T, E404DC
 GFKZB307GFKZB307KU128223TDF, FTCEFVM184V, T215FK101H, K103N, G190AK20KR, V35T, T39E, S48T, K122E, D123DN, K173A, Q174KR, N175NY, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292VI, I293V, D324EC
Kityo (2017)8337283372KY061927NRTINNRTIM184VK101H, V106M, Y188FS48T, D121H, K122E, K173T, P176PQ, V179VI, T200A, Q207E, R211KC
 8323783237KY061792NRTINNRTIL74V, Y115F, M184VK101H, G190AK122E, D123N, I135M, E138G, K173T, Q174K, D177E, I178M, T200A, Q207E, L210S, D237EC
 8322783227KY061783NRTINNRTID67N, K70R, M184V, T215I, K219QA98G, K101H, G190AV60VI, K122E, D123S, I135IL, A158AS, T165TI, K173T, Q174K, N175Y, T200A, E203ED, Q207E, R211K, P236PSC
 8333183331KY061886NRTINNRTIM41L, A62V, L74V, V75T, M184V, T215FK101H, G190AS48T, V118I, K173I, Q174K, I178M, G196E, T200A, Q207A, R211K, D237EC
 8289382893KY061459NRTINNRTIM41L, D67G, K70R, L74V, M184V, T215FY, K219KEK101H, Y181C, G190SE44D, S48T, S68G, K122KE, D123DN, S162CY, K173A, D177E, T200A, E203EAKT, Q207E, H208HY, R211K, K223KE, L228LHC