<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype C
Gene RT
Mutation L100I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 53
Isolates 60
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patNIB01_NIB719AJ577965AZT, DDI, 3TC, ABCEFVK65R, L74V, M184VL100I, K101E, K103N, V106MK20R, V35T, E36A, T39E, S48T, K122E, D123N, K173A, D177E, T200A, Q207E, R211KC
Non-B Workgroup (2005)TK3010TK3010 DDC, D4T, DDI, 3TC, ABCEFVD67N, T69D, K70R, K219QA98G, L100I, K103NT7S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, A129G, I135V, N136H, T165TI, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, R211K, V245Q, A272P, T286TA, V292I, I293V, K311R, V317A, Q334H, G335DC
  TK3010a DDC, D4T, DDI, 3TC, ABC, AZTEFVD67N, T69D, K70R, V75I, K219QA98G, L100I, K103NV35T, E36A, T39D, S48T, V60I, K122E, D123G, I135V, S162C, K166KR, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, R211K, V245Q, A272P, V292I, I293V, K311R, V317A, Q334H, G335D, Q340X, Y342XC
 TK3019TK3019 D4T, DDI, AZT, 3TC, ABCNVP, EFVM41L, D67N, T69D, K70R, L74V, M184V, T215YA98G, L100I, K103ND17DE, G18GV, V35T, T39A, E44D, S48T, V60I, K122E, D123S, K173A, Q174R, G196K, T200A, Q207E, H208Y, W212M, D218E, V245Q, A272P, K277R, E291D, V292I, I293VC
  TK3019a D4T, DDI, AZT, 3TC, ABCNVP, EFVM41L, D67N, T69D, K70R, L74V, T215F, K219WA98G, L100I, K103NV35T, T39A, E44D, S48T, V60I, S117A, V118I, K122E, D123S, K173A, G196E, T200A, E203V, Q207E, H208Y, W212G, G213W, D218E, L228H, V245Q, A272P, K277R, E291D, V292I, I293VC
Marconi (2008)ICH28ICH028EU308018D4T, 3TCEFVM184V, T215FL100I, K103NK122E, I135L, E138R, K173A, D177G, T200A, E203K, Q207D, R211K, Q242R, V245RC
 SW030sw030EU308043D4T, 3TCEFVD67DN, K70KR, L74I, V75IT, M184V, K219EA98AG, L100I, K103N, P225HS48T, V60I, K122E, D123N, I135IMT, K173A, D177E, G196K, T200A, Q207E, R211K, V245QC
 SW033sw033EU308046AZT, 3TCEFVD67N, K70R, M184V, T215Y, K219EL100I, K103N, Y181YFS48T, V60I, K122E, D123S, I135L, S162D, S163T, E169A, K173A, Q174K, D177E, V179VI, G196E, T200A, E203K, Q207E, V245QC
 SW098SW098EU308106D4T, DDIEFVD67G, K70R, K219EL100I, K103NV60I, T69TN, K122E, D123G, K173A, Q174K, D177E, T200E, I202V, Q207E, R211K, F214L, V245QC
Pillay (2008)DR5DR5AY589870AZTEFVD67N, K70RL100I, K103NK20R, V35T, E36A, T39D, V60I, K122E, D123S, K173A, D177E, I178L, T200A, E203K, Q207E, R211Q, V245Q, E248N, D250E, A272P, T286A, E291D, V292I, I293VC
Wallis (2009)GT00240772GT00240772 AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293VC
 23583052358305 D4T, 3TCEFVD67N, M184V, T215YL100I, K103NV35T, T39E, K122E, D123S, T139K, K173A, D177E, I178L, G196T, T200A, Q207E, P243T, V245Q, E248D, A272P, L279M, E291D, I293VC
 GT00327585GT00327585 D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
 TJC2416769TJC2416769 D4T, 3TCEFVD67DN, M184V, T215TFISL100I, K103N, P225PHL34LI, V35T, T39E, S48T, K122E, D123N, Q174L, D177DN, T200A, Q207E, R211K, F214L, D218DE, H221HY, V245Q, E248N, D250E, A272P, E291D, V292I, I293VC
El-Khatib (2010)Pat05510ZA_SAVE2324HQ012333AZT, 3TCEFVV75I, M184MIVL100I, K101KE, V106M, G190GAK22R, I31L, V35T, T39A, E40D, S48T, K64R, W88S, V90VI, V118I, K122E, E138A, T165I, K173I, Q174K, T200A, Q207E, R211K, F214L, H221HY, V245Q, E248NC
Green (2011)707PKE06F707PKE06FHM623498D4T, 3TCEFVD67N, T69TADN, K70R, M184V, K219QL100I, K103N, P225PHV35T, T39E, S48ST, V60I, K122E, I135IT, K173T, Q174K, D177E, T200A, Q207A, H221Y, V245Q, A272P, K277KR, T286A, A288AT, E291D, V292I, I293V, D324DEC
Sigaloff (2011)GT00240772GT00240772_1JN381581AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293V, V317XC
  GT00240772_2JN381582AZT, 3TCEFVD67N, K70R, M184V, T215F, K219EL100I, K103NV35T, T39E, S48T, T69N, V90I, K122E, D123G, T139K, K173A, D177E, T200A, E204Q, R211K, L228R, V245Q, A272P, K281R, E291D, I293VC
 GT00327585GT00327585_1JN381602D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
  GT00327585_2JN381603D4T, 3TCEFVD67N, M184VL100I, K103N, E138KV35T, T39D, S48T, V90I, K122E, D123G, T165IV, K173A, T200A, Q207K, R211K, V245Q, D250DE, A272P, K281R, L283I, E291D, V292I, I293VC
 GT00443767GT00443767JN381616D4T, 3TCEFVA62AV, K65R, Y115YF, M184VL100I, K103NK20KR, V35T, T39E, K122E, D123DN, I142K, K173T, Q197P, T200A, Q207E, L228LR, D250E, A272P, T286A, E291D, V292I, I293V, A304EC
van Zyl (2011)A72A72JN638221D4T, 3TCEFVM184VL100I, K103NI5V, V35T, T39A, S48T, V60I, V90I, K122E, D123G, I135T, S162Y, K173A, D177E, G196K, T200A, Q207E, R211K, F214L, V245QC
Sunpath (2013)CAS096CAS096 TDF, 3TCEFVK65R, M184VL100I, K103S, Y318FK20R, V35R, T39D, S48T, K122E, D123S, I135T, K173T, T200A, Q207E, F214L, V245K, A272P, T286A, E291D, V292IC
 CAS090CAS090 TDF, 3TCEFVK65RL100I, K103N, V106MV35T, T39E, E40Q, S48T, K122E, D123N, I135M, T139A, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, E297AC
Van Zyl (2013)476102KC422810AZT, D4T, 3TC, DDINVP, EFVD67N, K70R, T215I, K219EL100I, K103NK20R, V35T, E36A, T39E, S48T, E89X, K122E, P157A, A158S, K166R, K173A, Q174R, T200A, Q207A, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335DC
 15562418KC423701ABC, 3TCEFVL74V, Y115F, M184VL100I, E138K, V179DK32Q, V35T, T39E, S48T, V60I, K82KR, K103R, K122E, D123S, I135V, K173A, D177G, T200A, I202V, Q207E, R211RK, H221Y, L228R, V245LQC
 112412KC422957D4T, 3TCEFVK65R, K70~, V75M, M184V, K219RL100I, K103NL34I, V35T, T39N, E40K, K46Q, E53D, S68K, T69F, S162A, K173A, D177E, V179I, T200A, I202IV, E203K, Q207E, R211K, F214L, K223E, L228R, V245Q, A272P, K277R, L283I, V292I, I293V, S322T, Q334H, G335DC
 775129KC423032D4T, 3TCEFVM184VL100I, K103NV35T, E36A, T39E, S48T, V60I, T69A, K122E, D123G, T139K, K173A, Q174R, D177E, I178M, V179T, T200A, E203G, Q207E, R211K, V245QC
 541829KC423441D4T, 3TCEFVM184VL100I, K103NV35R, T39E, S48ST, V60I, T69N, K122E, I142T, T165K, K166R, E169D, K173T, D177E, I178M, T200A, Q207K, V245QC
 13061028KC422817ABC, 3TCEFVL74V, M184V, K219KDENL100I, K103NV35T, T39E, E40EG, S48T, V60I, W88C, V118I, K122E, D123G, I135R, K173A, Q174K, D177E, G196E, T200A, I202V, Q207A, H208HL, R211K, F214L, K223KE, V245Q, D250EC
 5142905KC423887D4T, 3TCEFVM184VL100I, K103NK122E, S162A, K173T, Q174K, T200A, Q207E, R211K, H221HY, V245IM, D250EC
 242717KC423797AZT, D4T, 3TC, TDFNVP, EFVD67N, K70Q, M184IA98G, L100I, Y188LK20KR, V35T, E36A, T39E, S48T, V60I, K122E, D123S, S163T, T165I, K173T, D177E, T200A, Q207E, R211K, F214L, H221Y, V245QC
 971135KC423081AZT, D4T, 3TCNVP, EFVM184VL100I, K103N, E138KE6D, V35T, T39E, S48T, K49KR, V60VI, K122E, D123G, S162C, K173A, Q174R, D177E, I178L, E203EK, Q207E, R211K, V245KC
 7872191KC423674TDF, 3TCEFVK65R, M184V, K219EL100I, K103NT27S, V35T, E36A, T39E, S48T, E53D, S68G, K122E, D123N, I142V, K173T, Q174K, T200A, Q207E, R211K, V245EC
 817671KC424219AZT, D4T, 3TCNVP, EFVD67N, K70R, M184VL100I, K103N, P225HE6K, K32R, V35T, T39E, S48T, V60I, K122E, D123S, T139R, K173E, N175H, Q197E, T200A, R211K, V245QC
 10601517KC423200AZT, D4T, 3TC, TDFNVP, EFVM184VL100I, K103NK32R, V35T, T39K, S48T, T69N, K122E, S163C, K173A, D177E, T200A, Q207E, R211K, V245QC
 874391KC424034D4T, 3TCEFVM184VL100I, K103NV35IT, T39E, E40D, S48T, V60I, K122E, D123G, T139R, K173A, Q174QR, D177E, I178L, I195L, T200A, Q207E, R211K, V245QC
 7312860KC423859AZT, D4T, 3TC, TDFNVP, EFVK65R, M184MVL100I, Y188LV35T, T39EK, S48T, A98S, K122E, D123E, K166R, K173A, Q174N, D177E, T200A, Q207E, R211K, V245Q, E248DN, D250EC
 2751183KC422946ABC, 3TCEFVL74V, M184VL100I, K103N, E138KV35T, T39E, S48T, K104KR, K122E, D123S, K173A, Q174R, D177E, I178L, G196T, T200A, Q207E, R211K, V245QC
 222915KC423893AZT, D4T, 3TC, TDFNVP, EFVK70R, M184V, K219QL100I, K103NT27S, V35T, T39E, S48T, T69N, K122E, D123N, A158AS, T165L, K173M, Q174R, T200A, I202V, Q207E, R211K, F214L, L228RC
 14692159KC423657ABC, 3TCEFVL74V, M184VL100I, K103NK20R, V35T, T39E, N54ND, V60I, K122E, D123S, K173R, Q174K, T200A, I202V, R211K, F214L, H221Y, V245Q, D250EC
 15012074KC423598D4T, 3TCEFVK65R, M184VL100I, K103NK20KR, V35T, E36A, T39E, S48T, S68G, K122E, D123N, I135V, T139A, K173KE, T200A, Q207E, F214FL, V245EQC
 16911041KC422827D4T, 3TCEFVV75M, M184VL100I, V106M, E138K, Y188YFE6K, V35T, E36A, T39E, S48T, K104R, K122E, K173A, Q174K, D177E, G196MT, T200A, E203EK, Q207E, R211K, F214L, L228R, V245QC
 15102577KC423750AZT, D4T, 3TCNVP, EFVK65R, M184V, K219EL100I, K103NV35T, E36A, T39E, V60I, S68G, K122E, D123S, T139V, K173A, D177E, V179VI, T200A, E203K, Q207A, R211K, D218E, V245QC
 140690KC424229TDF, 3TCEFVK65R, M184I, K219EL100I, K103N, M230LV35T, E36A, T39E, S68G, K122E, D123S, K173A, D177E, V179I, I202V, Q207K, R211K, V245QC
 9602119KC423631D4T, 3TCEFVM184VL100I, K101E, Y188H, G190AK20R, T27S, V35T, E36A, T39E, V60I, K122E, D123N, I135V, E138A, K173V, T200E, Q207E, F214L, H221Y, V245QC
 206445KC424065D4T, 3TCEFVM184VL100I, K103NV35T, T39A, E40D, S48T, V60I, W88C, I135V, T139R, T165V, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248DNC
  1655KC423302D4T, 3TCEFVM184VL100I, K103NK20R, V35I, T39A, E40D, S48T, V60I, W88C, I135V, T139K, T165L, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, L228H, V245Q, E248DC
 12561080KC422866ABC, 3TCEFVL74V, M184VL100I, K103N, P225HV35T, T39E, S48T, V60I, K102Q, K122E, D123S, I135T, S162Y, K173A, D177E, T200A, Q207E, R211K, H221HY, V245QC
 13801672KC423314D4T, 3TCEFVK65R, T69~L100I, K103NV35T, E36A, T39E, S48T, V60I, W88C, A98S, K122E, D123G, I135IT, K173A, Q174K, D177E, G196E, T200A, E203K, Q207D, R211K, H221HY, V245QC
 9701368KC423097D4T, 3TCEFVL74V, M184IL100I, K103N, M230LV35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, I178L, T200A, E204K, Q207D, R211K, L228LR, V245QC
 13591561KC423233ABC, 3TCEFVL74V, Y115YF, M184VL100I, K103N, V106VMP4S, E28A, V35T, T39E, S48T, E53D, A98S, K122E, D123S, I135V, S162A, K173A, Q174K, D177E, I178L, T200A, Q207E, V245QC
 4092052KC423589D4T, 3TCEFVM184VL100I, K103NK20R, V35T, E36A, T39E, S48T, V111VG, K122E, D123S, T139A, K173T, T200A, Q207K, R211K, F214L, H221HY, V241L, V245QC
 8341909KC423505ABC, 3TCEFVL74V, M184VL100I, K103NV21D, V35T, T39E, E40X, S48T, K102R, K122E, K173A, Q174R, D177E, G196V, T200A, E203K, Q207E, K223T, V245M, D250EC
 13671068KC422854ABC, 3TCEFVL74V, Y115YF, M184VL100I, K103N, P225HV35T, T39E, S48T, V60VI, K104R, K122E, D123S, I135T, E138A, T139A, K173T, Q174K, D177N, T200A, I202V, Q207E, R211K, F214L, V245Q, E248DC
 2381042KC422828D4T, 3TCEFVM184V, T215FL100I, K103NV35T, T39E, K49R, W88C, D121H, K122E, I159L, S162D, K166R, E169R, K173T, D177E, T200A, Q207A, R211K, F214L, V245KC
 7232067KC423595ABC, 3TCEFVL74V, M184VL100I, K103N, V108IT27H, E28R, V35T, E36A, T39E, E44K, G45K, T107S, L109I, K122P, D123S, K173E, Q174K, D177E, I178L, V179T, T200A, Q207E, R211K, V245E, E248NC
 4011781KC423403D4T, 3TCEFVM184VL100I, K103NV35R, T39E, S48T, V60I, K122E, D123N, I135IT, I142T, D177E, G196E, T200A, Q207E, L228R, V245Q, D250EC
 735239KC423692ABC, 3TCEFVK65R, Y115F, M184VL100I, K103NV35T, T39K, S48T, K122E, D123S, I135T, T165I, K173A, D177E, G196K, T200A, I202V, Q207A, R211K, V245K, E248D, D250EC
 17342154KC423654TDF, 3TCEFVD67G, T69D, K70R, M184V, K219QL100I, K103NV35T, T39E, S48T, K122E, T139K, K173A, Q174K, D177E, G196T, T200A, Q207E, R211K, L228R, V245QC