<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation A98G
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 30
Patients 54
Isolates 58
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Lin (1994)PFL-012PFL012B AZTNone A98GV35I, R83K, R211K, D250E, K277R, I293V, E297A, I329L, M357I, R358K, A360T, T386I, A400T, V435E, D460NB
Shafer (1995)JIDP9JIDP9W104AF021315AZT, DDINoneM41L, L210W, T215YA98GR83K, T165I, Q207D, R211K, W239C, V241VAEGB
 JIDP22JIDP22W104AF021316AZT, DDINoneM41L, D67N, L210W, T215YA98G, V108IE44D, V60I, R83K, V118I, R211K, V245EB
Ruiz (1996)JCS-C17C17BZ99310DDC, AZTNoneM41L, L74V, L210W, T215YA98GV35I, S68T, R83K, V118I, K122E, D123N, Q207E, R211KB
  C17W24Z99311DDC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215YA98GI31Y, T39A, K43Q, R72RG, R83K, K122E, Q207E, R211KB
Hammer (1997)ACTG320_15871587 AZT, DDINoneM41L, L74LV, L210L*W, T215YA98GK22KR, K43KQ, E44ED, K102KQ, V118VI, K122KE, D123E, A158S, S162A, E169D, I178M, R211RK, A272P, I326V, E344ED, R356K, T403M, V435IB
 ACTG320_767767 AZT, DDI, DDC, 3TC, D4TNoneD67N, K70KR, T215IV, K219QA98GK20R, V35M, K103R, K122KE, D123DE, Q174E, D177E, F214L, V245I, A272ST, I293V, E312N, R356K, A360T, A376T, V381VI, H483Y, G490GEB
Nijhuis (1997)PT-C0001C0001W126 3TC, AZTNoneM41L, D67N, M184VA98GR211KB
  C0001W179 3TC, AZTNoneM41L, D67N, T69D, M184V, L210W, T215YA98GE44D, G196E, T200I, E203K, Q207E, H208Y, R211KB
Shafer (1998)HMDR-44AF047299AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, L74I, M184V, L210W, T215Y, K219NA98GK43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218EB
Cabana (1999)Cab-cC17AF102337DDC, AZT, 3TC, D4TNoneD67N, K70R, M184V, T215F, K219QA98GK64H, T69N, D113N, K122P, I135V, D177E, Q207E, L228HB
Masquelier (1999)DRO-1DRO1M8AJ239229AZT, 3TCNoneM41L, D67N, K70KIRT, M184V, T215Y, K219EA98GK32R, E44D, R78RI, V118VL, G196E, R211KB
Venturi (1999)GV-21Vent21W24AF169083AZT, DDCNoneK70R, T215YA98GV35L, E79EV, R83K, D123E, Q174E, D177E, T200A, Q207EB
 GV-30Vent30BAF169100AZTNoneT215DA98G, K103KTR83K, K122E, D123E, I167IL, D177E, I178M, T200A, R211KB
Zolopa (1999)CA635CA3141AF088102AZT, DDC, 3TC, D4T, DDINoneD67N, K70R, M184MV, T215F, K219QA98GK64KR, D123E, I135T, Q207K, F214L, T286A, K287RB
Bacheler (2000)LB3-P59P59-0 NRTINoneM41L, M184V, L210W, T215YA98GE44D, T200A, E203DB
Balotta (2000)CB-154CB-154AF252017AZT, D4T, 3TC, DDINoneM41L, D67N, T69D, M184V, L210W, T215YA98GK43N, K122E, D123S, I135T, I142IFLM, V179VIB
 CB-212CB-212AF252065D4T, 3TC, DDC, AZT, DDINoneD67N, T69D, K70R, T215F, K219QA98GK20R, V60I, V118I, K122E, D123E, I135T, S162Y, Q174K, D177E, I178V, V179I, G196E, I202V, F214L, L228H, Q242H, V245EB
 CB-276CB-276AF252058AZT, D4T, 3TC, DDINoneD67N, K70R, M184V, T215F, K219QA98GV118I, K122E, I135IV, T139K, Q207K, R211Q, F214L, V245MB
 CB-4CB-4AF186769AZT, DDC, D4T, 3TCNoneD67E, T69S_SG, L210W, T215YA98GP4S, K20R, V118I, K122E, K154KE, K173T, G196E, R211K, L228HB
Baxter (2000)GART-G88GART-88 NRTI, AZT, 3TCNoneM41L, D67N, K70KR, M184V, L210W, T215Y, K219KEA98GK173Q, I178L, R211K, K223KR, V245M, E248Q, N265NS, Y271YD, A272P, I293V, E297QB
Parkin (2000)SD-2SD-2_10AF294519NRTI, AZT, 3TC, ABC, D4TNoneM41L, M184V, L210W, T215YA98GT39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292I, I293IVB
  SD-2_18AF294520NRTI, AZT, 3TC, ABC, D4TNoneM41L, M184V, L210W, T215YA98GT39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, V292I, I293IVB
  SD-2_22AF294521NRTI, AZT, 3TC, ABC, D4TNoneM41L, M184MV, L210W, T215YA98GT39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292IB
Venturi (2000)V2000-7V2000-7PAF158759AZT, DDINoneT215TSA98GK102R, D123E, K166R, D177E, Q207EB
Albrecht (2001)ACTG364_57195719 AZT, 3TCNoneD67N, T69D, K70R, M184V, K219QA98GV35VM, V60I, K122P, D123E, I135T, K166R, D177E, I202V, F214L, A272P, K277R, I293VB
Delgado (2001)ED_V40ED_V40AY016950AZT, 3TCNoneM41L, D67N, L210W, T215YA98GT39A, E44D, R83K, V118I, D177E, T200R, E203ED, H208Y, R211QB
 ED_V54ED_V54AY016964AZT, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219QA98GK43Q, V60I, D123E, I202V, R211KB
Eshleman (2001)A104AF357705AF357705AZT, DDINoneM41ML, T215FA98GK20KR, T39A, K82R, R83K, V118I, D123E, T165I, F214L, V245KR, A272P, Q278N, T286P, I293V, E297KB
Gonzales (2001)CA1332CA3345AY030529AZT, 3TCNoneM41L, M184V, T215YA98GV21I, V35E, T39A, K122E, I135K, S162C, T200A, R211K, L283I, I293VB
 CA1860CA4982AY030764AZT, 3TC, D4T, DDINoneM41L, D67N, T69D, K70R, T215F, K219QA98GK20R, V35E, T39A, V60I, K103R, V118I, K122E, I135K, F214L, L228H, I293V, E297K, T386I, K390R, A400T, A437V, V458I, Q509Y, K527N, A554TB
 CA3898CA9097AY030903D4T, DDINoneD67N, K70R, T215F, K219QA98GV60I, I142V, I202V, V245M, A272P, V276T, I293V, E297AB
 CA4725CA11587AY031387AZT, D4T, DDI, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215YA98GV35I, E44D, V60I, R83K, V118I, K122E, D123N, I135M, D177E, I178L, R211K, V245E, A272P, K277R, I293V, L295LP, E297A, E300EVB
 CA6335CA15812AY032294DDI, AZT, 3TC, ABC, D4TNoneD67N, K70R, T215F, K219QA98GV35T, V60I, K64R, K102R, D123E, I135V, K166KR, D177E, Q207E, F214L, A272P, E297AB
Masquelier (2001)BM-28BM-28AF315251NRTI, D4T, 3TCNoneT69G_SG, T215YA98GV35I, D123E, S162C, D177E, I178L, D237XB
Brindeiro (2002)TVSP19TVSP19AY145815AZT, 3TC, D4TNoneM41L, A62V, M184V, T215FA98GV106I, K122E, I135T, F214L, K249Q, A272P, K277R, E297A, V317AB
 TVGG1TVGG1AY145782AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GK20R, K32R, S162C, G196E, I293V, E297KB
Tural (2002)191730191730 AZT, DDI, 3TC, D4TNoneM41L, M184V, T215YA98GR83K, K122E, D123N, I135V, Q174E, D177G, V189I, T200I, I202VB
Monno (2003)ML_pt8ML1229AY263498AZT, 3TC, D4TNoneM41ML, D67N, K70R, M184MV, T215F, K219QA98G, K101KE, G190GVR83EK, K103KR, S117SP, D123E, S162SG, E169EG, V179VI, Q182QR, G196GE, Q197QR, I202V, E203EK, R206RK, Q207QH, D218DE, E224EK, V245EB
Saah (2003)AS-18AS-18 DDC, AZT, DDI, D4T, 3TCNoneM41L, L210W, T215YA98GV35M, R83K, K122E, R211KB
Dumans (2004)227227AY390130DDI, AZT, 3TCNoneM41L, D67N, M184V, L210WA98GE44D, K102Q, V118I, K122X, I135T, G196E, E203D, H208Y, R211KB
 229229AY390142DDI, AZTNoneM41L, L210W, T215YA98GE44D, E79D, V118I, I135M, R211KB
 237237AY390127AZT, DDI, 3TCNoneM41L, D67N, V75M, L210W, T215YA98GK43N, E44D, K82R, K122E, D123E, I167V, D177E, H208Y, R211K, D218EB
 167167AY390089AZT, DDI, 3TCNoneD67N, K70R, M184V, T215F, K219QA98GI135T, V179I, T200A, F214L, D218EB
Machado (2004)cs199cs199AY313399AZT, DDI, 3TC, D4TNoneM41L, D67N, T69D, V75M, M184V, L210W, T215YA98GK43Q, E44D, V118I, K122E, I135T, S162C, D177N, G196E, E203K, Q207E, H208Y, R211K, K223QB
Montes (2004)MB_patAVO01_AVO720AJ577732DDC, AZT, 3TC, D4TNoneA62V, M184I, L210W, T215SA98GR83K, I135V, S162C, T165V, I202VB
Ochoa de Echaguen (2005)B-0308B-0308AY833580D4T, 3TC, ABCNoneM41L, L74LV, M184V, L210W, T215YA98GI135M, R211K, A272T, V292I, I293VB
Rhee (2005)CA4060CA17428AY801253AZT, 3TC, ABCNoneM41L, D67N, K70R, L74I, M184V, T215F, K219QA98GV60I, I135V, D177E, G196E, D218E, V245T, D256DV, I293V, I326LV, I329V, A371V, T386I, K390Q, T403R, V435VI, V467VI, L491LS, V531I, A534AS, A554TB
 CA4344CA10542AY801307AZT, DDI, D4TNoneD67N, T69T_L, K70R, K219QA98G, V179EK64N, K102E, K104R, K166R, Q207H, R211KB
 SWC-0503P503-29 AZT, NRTI, DDC, DDI, 3TCNoneM41L, D67N, M184V, T215YA98GV35I, K43E, V60I, R83K, K122E, D218EB
 CA5218CA13056AY801519AZT, 3TC, D4T, DDINoneD67N, K70R, T215F, K219QA98GR83K, I178M, D218E, M230MV, V245E, E248D, A272P, V292I, E300RB
 CA7933CA20000AY801852AZT, 3TCNoneM41L, M184V, T215YA98GE6D, K11R, K20KR, R83RK, I135L, K166R, T200E, I202V, R211K, A272P, K277R, T286A, I293V, E297K, R356K, G359S, V365I, A400S, D460N, V467I, Q524EB
 CA8385CA21114AY801984AZT, D4TNoneM41L, L210W, T215YA98GV35I, T39A, R83K, H208HY, R211K, I293V, M357T, K395R, A400T, S468P, T470N, H483Y, G490E, K512RB
 CA8441CA21202AY802020D4T, 3TCNoneT215SA98GS68G, D123E, I178LV, V179I, E204EK, Q207E, R211K, A272AGV, Q278QH, T286A, E291D, P294QB
 CA16262CA38675AY802466AZT, D4T, 3TC, ABCNoneM41L, D67HN, K70R, L74I, M184V, L210W, T215F, K219QA98GV8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293V, I329V, G333E, R356K, A371V, K390R, E399D, K454R, V466T, V467I, H483Y, E492D, S519N, Q547R, A554TB
 CA16359CA38873AY802491ABC, AZT, 3TCNone A98GE28A, V35I, R83K, D123E, D177E, V245E, E248S, V276T, T286A, I293V, E297QB
 CA16488CA39164AY802519ABC, AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GI135T, V245KB
von Wyl (2007)494821915EF449891NRTINoneM184V, T215V, K219QA98GK20R, V21VI, V60I, V118I, K122E, I135T, I202V, R211K, F214LB