Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	A98G
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	29
Patients	53
Isolates	57

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Lin (1994)	PFL-012	PFL012B		AZT	None		A98G	V35I, R83K, R211K, D250E, K277R, I293V, E297A, I329L, M357I, R358K, A360T, T386I, A400T, V435E, D460N	B
Shafer (1995)	JIDP9	JIDP9W104	AF021315	AZT, DDI	None	M41L, L210W, T215Y	A98G	R83K, T165I, Q207D, R211K, W239C, V241X	B
	JIDP22	JIDP22W104	AF021316	AZT, DDI	None	M41L, D67N, L210W, T215Y	A98G, V108I	E44D, V60I, R83K, V118I, R211K, V245E	B
Ruiz (1996)	JCS-C17	C17B	Z99310	DDC, AZT	None	M41L, L74V, L210W, T215Y	A98G	V35I, S68T, R83K, V118I, K122E, D123N, Q207E, R211K	B
		C17W24	Z99311	DDC, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y	A98G	I31Y, T39A, K43Q, R72X, R83K, K122E, Q207E, R211K	B
Hammer (1997)	ACTG320_1587	1587		AZT, DDI	None	M41L, L74LV, L210L*W, T215Y	A98G	K22KR, K43KQ, E44ED, K102KQ, V118VI, K122KE, D123E, A158S, S162A, E169D, I178M, R211RK, A272P, I326V, E344ED, R356K, T403M, V435I	B
	ACTG320_767	767		AZT, DDI, DDC, 3TC, D4T	None	D67N, K70KR, T215IV, K219Q	A98G	K20R, V35M, K103R, K122KE, D123DE, Q174E, D177E, F214L, V245I, A272ST, I293V, E312N, R356K, A360T, A376T, V381VI, H483Y, G490GE	B
Nijhuis (1997)	PT-C0001	C0001W126		3TC, AZT	None	M41L, D67N, M184V	A98G	R211K	B
		C0001W179		3TC, AZT	None	M41L, D67N, T69D, M184V, L210W, T215Y	A98G	E44D, G196E, T200I, E203K, Q207E, H208Y, R211K	B
Shafer (1998)	HMDR-4	4	AF047299	AZT, DDC, DDI, D4T, 3TC	None	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	A98G	K43E, E44A, K64R, R83K, V118I, Q161P, S163C, G196E, H208Y, R211K, D218E	B
Cabana (1999)	Cab-c	C17	AF102337	DDC, AZT, 3TC, D4T	None	D67N, K70R, M184V, T215F, K219Q	A98G	K64H, T69N, D113N, K122P, I135V, D177E, Q207E, L228H	B
Venturi (1999)	GV-21	Vent21W24	AF169083	AZT, DDC	None	K70R, T215Y	A98G	V35L, E79X, R83K, D123E, Q174E, D177E, T200A, Q207E	B
	GV-30	Vent30B	AF169100	AZT	None	T215D	A98G	R83K, K103X, K122E, D123E, I167X, D177E, I178M, T200A, R211K	B
Zolopa (1999)	CA635	CA3141	AF088102	AZT, DDC, 3TC, D4T, DDI	None	D67N, K70R, M184MV, T215F, K219Q	A98G	K64KR, D123E, I135T, Q207K, F214L, T286A, K287R	B
Bacheler (2000)	LB3-P59	P59-0		NRTI	None	M41L, M184V, L210W, T215Y	A98G	E44D, T200A, E203D	B
Balotta (2000)	CB-154	CB-154	AF252017	AZT, D4T, 3TC, DDI	None	M41L, D67N, T69D, M184V, L210W, T215Y	A98G	K43N, K122E, D123S, I135T, I142X, V179VI	B
	CB-212	CB-212	AF252065	D4T, 3TC, DDC, AZT, DDI	None	D67N, T69D, K70R, T215F, K219Q	A98G	K20R, V60I, V118I, K122E, D123E, I135T, S162Y, Q174K, D177E, I178V, V179I, G196E, I202V, F214L, L228H, Q242H, V245E	B
	CB-276	CB-276	AF252058	AZT, D4T, 3TC, DDI	None	D67N, K70R, M184V, T215F, K219Q	A98G	V118I, K122E, I135IV, T139K, Q207K, R211Q, F214L, V245M	B
	CB-4	CB-4	AF186769	AZT, DDC, D4T, 3TC	None	D67E, T69S_SG, L210W, T215Y	A98G	P4S, K20R, V118I, K122E, K154KE, K173T, G196E, R211K, L228H	B
Baxter (2000)	GART-G88	GART-88		NRTI, AZT, 3TC	None	M41L, D67N, K70KR, M184V, L210W, T215Y, K219KE	A98G	K173Q, I178L, R211K, K223KR, V245M, E248Q, N265NS, Y271YD, A272P, I293V, E297Q	B
Parkin (2000)	SD-2	SD-2_10	AF294519	NRTI, AZT, 3TC, ABC, D4T	None	M41L, M184V, L210W, T215Y	A98G	T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292I, I293IV	B
		SD-2_18	AF294520	NRTI, AZT, 3TC, ABC, D4T	None	M41L, M184V, L210W, T215Y	A98G	T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, V292I, I293IV	B
		SD-2_22	AF294521	NRTI, AZT, 3TC, ABC, D4T	None	M41L, M184MV, L210W, T215Y	A98G	T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292I	B
Venturi (2000)	V2000-7	V2000-7P	AF158759	AZT, DDI	None	T215TS	A98G	K102R, D123E, K166R, D177E, Q207E	B
Albrecht (2001)	ACTG364_5719	5719		AZT, 3TC	None	D67N, T69D, K70R, M184V, K219Q	A98G	V35VM, V60I, K122P, D123E, I135T, K166R, D177E, I202V, F214L, A272P, K277R, I293V	B
Delgado (2001)	ED_V40	ED_V40	AY016950	AZT, 3TC	None	M41L, D67N, L210W, T215Y	A98G	T39A, E44D, R83K, V118I, D177E, T200R, E203ED, H208Y, R211Q	B
	ED_V54	ED_V54	AY016964	AZT, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219Q	A98G	K43Q, V60I, D123E, I202V, R211K	B
Eshleman (2001)	A104	AF357705	AF357705	AZT, DDI	None	M41ML, T215F	A98G	K20KR, T39A, K82R, R83K, V118I, D123E, T165I, F214L, V245KR, A272P, Q278N, T286P, I293V, E297K	B
Gonzales (2001)	CA1332	CA3345	AY030529	AZT, 3TC	None	M41L, M184V, T215Y	A98G	V21I, V35E, T39A, K122E, I135K, S162C, T200A, R211K, L283I, I293V	B
	CA1860	CA4982	AY030764	AZT, 3TC, D4T, DDI	None	M41L, D67N, T69D, K70R, T215F, K219Q	A98G	K20R, V35E, T39A, V60I, K103R, V118I, K122E, I135K, F214L, L228H, I293V, E297K, T386I, K390R, A400T, A437V, V458I, Q509Y, K527N, A554T	B
	CA3898	CA9097	AY030903	D4T, DDI	None	D67N, K70R, T215F, K219Q	A98G	V60I, I142V, I202V, V245M, A272P, V276T, I293V, E297A	B
	CA4725	CA11587	AY031387	AZT, D4T, DDI, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y	A98G	V35I, E44D, V60I, R83K, V118I, K122E, D123N, I135M, D177E, I178L, R211K, V245E, A272P, K277R, I293V, L295LP, E297A, E300EV	B
	CA6335	CA15812	AY032294	DDI, AZT, 3TC, ABC, D4T	None	D67N, K70R, T215F, K219Q	A98G	V35T, V60I, K64R, K102R, D123E, I135V, K166KR, D177E, Q207E, F214L, A272P, E297A	B
Masquelier (2001)	BM-28	BM-28	AF315251	NRTI, D4T, 3TC	None	T69G_SG, T215Y	A98G	V35I, D123E, S162C, D177E, I178L, D237X	B
Ait-Khaled (2002)	MAK-1629	1629481	AJ425887	AZT, 3TC, ABC	None	D67DN, K70R	A98G	K64R, D123E, Y146S, K166R	B
Brindeiro (2002)	TVSP19	TVSP19	AY145815	AZT, 3TC, D4T	None	M41L, A62V, M184V, T215F	A98G	V106I, K122E, I135T, F214L, K249Q, A272P, K277R, E297A, V317A	B
	TVGG1	TVGG1	AY145782	AZT, DDI, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	K20R, K32R, S162C, G196E, I293V, E297K	B
Tural (2002)	191730	191730		AZT, DDI, 3TC, D4T	None	M41L, M184V, T215Y	A98G	R83K, K122E, D123N, I135V, Q174E, D177G, V189I, T200I, I202V	B
Saah (2003)	AS-18	AS-18		DDC, AZT, DDI, D4T, 3TC	None	M41L, L210W, T215Y	A98G	V35M, R83K, K122E, R211K	B
Dumans (2004)	227	227	AY390130	DDI, AZT, 3TC	None	M41L, D67N, M184V, L210W	A98G	E44D, K102Q, V118I, K122X, I135T, G196E, E203D, H208Y, R211K	B
	229	229	AY390142	DDI, AZT	None	M41L, L210W, T215Y	A98G	E44D, E79D, V118I, I135M, R211K	B
	237	237	AY390127	AZT, DDI, 3TC	None	M41L, D67N, V75M, L210W, T215Y	A98G	K43N, E44D, K82R, K122E, D123E, I167V, D177E, H208Y, R211K, D218E	B
	167	167	AY390089	AZT, DDI, 3TC	None	D67N, K70R, M184V, T215F, K219Q	A98G	I135T, V179I, T200A, F214L, D218E	B
Machado (2004)	cs199	cs199	AY313399	AZT, DDI, 3TC, D4T	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y	A98G	K43Q, E44D, V118I, K122E, I135T, S162C, D177N, G196E, E203K, Q207E, H208Y, R211K, K223Q	B
Montes (2004)	MB_patAVO	01_AVO720	AJ577732	DDC, AZT, 3TC, D4T	None	A62V, M184I, L210W, T215S	A98G	R83K, I135V, S162C, T165V, I202V	B
Ochoa de Echaguen (2005)	B-0308	B-0308	AY833580	D4T, 3TC, ABC	None	M41L, L74LV, M184V, L210W, T215Y	A98G	I135M, R211K, A272T, V292I, I293V	B
Rhee (2005)	CA4060	CA17428	AY801253	AZT, 3TC, ABC	None	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	A98G	V60I, I135V, D177E, G196E, D218E, V245T, D256DV, I293V, I326LV, I329V, A371V, T386I, K390Q, T403R, V435VI, V467VI, L491LS, V531I, A534AS, A554T	B
	CA4344	CA10542	AY801307	AZT, DDI, D4T	None	D67N, T69T_L, K70R, K219Q	A98G, V179E	K64N, K102E, K104R, K166R, Q207H, R211K	B
	SWC-0503	P503-29		AZT, NRTI, DDC, DDI, 3TC	None	M41L, D67N, M184V, T215Y	A98G	V35I, K43E, V60I, R83K, K122E, D218E	B
	CA5218	CA13056	AY801519	AZT, 3TC, D4T, DDI	None	D67N, K70R, T215F, K219Q	A98G	R83K, I178M, D218E, M230MV, V245E, E248D, A272P, V292I, E300R	B
	CA7933	CA20000	AY801852	AZT, 3TC	None	M41L, M184V, T215Y	A98G	E6D, K11R, K20KR, R83RK, I135L, K166R, T200E, I202V, R211K, A272P, K277R, T286A, I293V, E297K, R356K, G359S, V365I, A400S, D460N, V467I, Q524E	B
	CA8385	CA21114	AY801984	AZT, D4T	None	M41L, L210W, T215Y	A98G	V35I, T39A, R83K, H208HY, R211K, I293V, M357T, K395R, A400T, S468P, T470N, H483Y, G490E, K512R	B
	CA8441	CA21202	AY802020	D4T, 3TC	None	T215S	A98G	S68G, D123E, I178LV, V179I, E204EK, Q207E, R211K, A272X, Q278QH, T286A, E291D, P294Q	B
	CA16262	CA38675	AY802466	AZT, D4T, 3TC, ABC	None	M41L, D67HN, K70R, L74I, M184V, L210W, T215F, K219Q	A98G	V8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293IV	B
	CA16359	CA38873	AY802491	ABC, AZT, 3TC	None		A98G	E28A, V35I, R83K, D123E, D177E, V245E, E248S, V276T, T286A, I293V, E297Q	B
	CA16488	CA39164	AY802519	ABC, AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	I135T, V245K	B
von Wyl (2007)	49	4821915	EF449891	NRTI	None	M184V, T215V, K219Q	A98G	K20R, V21VI, V60I, V118I, K122E, I135T, I202V, R211K, F214L	B

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