Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	N348T
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	4
Patients	19
Isolates	19

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Baxter (2006)	12-1094	1094-40614	DQ879100	NRTI	NNRTI	M41L, T69D, L210W, T215Y	K101P	V111I, V118I, I142T, T200A, H208Y, R211K, L228H, A272S, A288S, S322T, I329L, N348T, M357T, A360V, E399D	B
	48-3002	3002-30225	DQ877912	NRTI	NNRTI	M41ML, D67N, K70R, L74IV, Y115YF, M184V, T215F, K219Q	Y188L	V60I, T69N, D123E, I135T, T139I, K166R, D177E, V179I, T200A, F214L, D218E, A272P, K277R, E297K, Q334L, N348T, R356K, A360V, V365VI, A376T, E399D	B
	48-3021	3021-30313	DQ877931	NRTI	NNRTI	M41L, D67N, T69D, L74V, L210W, T215Y, K219R	K101E, Y181C, G190A	T39A, E44D, V111I, V118I, K122E, I135T, E203K, H208Y, R211Q, K223Q, V245T, K277R, Q278E, T286A, E297R, N348T, R356K, T362S, E370D, K385KR, T386TI, K390R	B
	48-3083	3083-30313	DQ877992	NRTI	NNRTI	M41L, D67N, L74IV, M184V, L210W, T215Y	V108I, Y181YC	K20R, V35VI, K43E, E44D, K102Q, V118I, K122E, D123E, S162Y, V179VI, V189VI, E203K, Q207E, H208HY, R211K, K223PT, A272P, K277R, T286A, I293V, E297R, G335S, N348T, R356K, G359S, A360T, K366R, A371V, K385KR, K390R	B
	48-4079	4079-30225	DQ878308	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	K103N, Y181C, G190A	K20R, V35I, D121H, K122E, I135T, Q174A, D177E, T200A, E203A, Q207E, L228H, V245VE, A272P, K277R, T286P, A288S, P294T, E297K, I326V, Q334L, N348T, R356K, G359S, A360T, T377N, T386I, K390R, E399D	B
	48-7201	7201-30808	DQ879026	NRTI	NNRTI		K103N, V106A	E6K, I50L, K122E, S162C, T200A, E203D, R211K, I293V, I329L, N348T, G359S, T377V, K390R, E399D	B
Riddler (2008)	62447	161337Ib	HM056583	D4T, 3TC	EFV	M184V	K103N	K20R, T165L, I178M, R211K, F214L, V245A, A272P, A288S, I293V, A327V, G335D, N348T, M357T, A360AT, T369A, A376T, K390R, E399D, A400T, T403S, V435I, G436E, L452E, V466I, V467VI, H483Y, K512R, S519C, V548I, A554K, K558R	B
Dau (2010)	07157A	07157A	GU581823	NRTI	NNRTI	M41L, L74LV, L210W, T215Y	K103N, Y181C	K20R, E44D, V118I, I135V, S162C, V179VI, R211K, L228R, Q242QL, V245EK, I293V, N348T, M357T	B
	07215A	07215A	GU581824	NRTI	NNRTI	M184V, T215Y	K103N	K20R, E138A, S162C, T200A, R211K, K277R, T286A, E297K, E312A, I326V, P345Q, N348T, A376S, T377L, T386I	B
	10961A	10961A	GU582025	NRTI	NNRTI	M41L, D67N, K70R, M184V, T215FY, K219E	K103N, Y181YC	V35K, T39A, V60I, K102R, I135T, I178IM, T200TA, D218DE, L228H, T286A, E297K, K311KR, Q334QE, N348T, A360T, K366KR, S379G, T386I, K390R	B
	11025A	11025A	GU582029	NRTI	NNRTI	M41L, D67N, V75LM, F77L, M184V, L210W, T215Y	K103N, Y318F	V35L, T39K, E40F, K43E, V118I, K122E, I135M, E138Q, T200TAEK, Q207DE, R211K, Q278H, A288S, I293V, E297A, D324DE, N348T, M357T, T386I, K390R	B
	11817A	11817A	GU582053	NRTI	NNRTI	L74V, Y115F, T215Y	K101E, Y181C, G190A	V35M, K43E, S68G, A98S, D121C, K122E, T165TA, D177EG, V179I, T200A, P243S, I244IV, T286A, I293V, E297K, N348T, M357T, K366KR, A376S, K385R	B
Jones (2012)	139475	139475	JN669577	NRTI	NNRTI	M41L, D67N, L210W, T215Y, K219R	K103N, V106M	E44D, K102R, K122E, D123E, I135T, V179I, G196E, T286P, V292I, I293V, E297K, S322T, N348T, G359S, A371T, K388R, E399D	B
	154971	154971	JN669828	NRTI	NNRTI	M41L, D67N, K70R, T215F, K219E	L100LI, K103N, G190GA	E6EK, K22R, V35T, T39TA, V60I, W88C, V90VI, A98AS, V118I, K122E, I135T, R211K, F214L, L228H, V245Q, K275KR, I293V, E297R, I341V, N348T, V365I, L368I, I375V, V381I, T386I, K390R	B
	158997	158997	JN669937	NRTI	NNRTI	M41L, L210W, T215Y, K219R		T39A, K122E, I135T, S162C, I202IV, L228R, V245E, E248D, K277R, I293V, I329IL, N348T, A360T, K390R	B
	166492	166492	JN670129	NRTI	NNRTI	M41L, M184V, T215Y		V35T, K49KR, D123E, I135V, K166KR, V179I, T200TK, Q207E, K223KE, V261I, A272P, V276I, T286A, I293V, P294A, E297K, N348T, A376T, Q394L	B
	166819	166819	JN670135	NRTI	NNRTI	K70G, M184V		A98S, D121H, K122E, I135T, Q174K, Q197E, F214L, N255K, T286P, A288S, I293V, E297A, S322T, D324E, I329L, N348T, T386I, K390R, I393NS, Q394E	B
	176311	176311	JN670392	NRTI	NNRTI	M41ML, D67N, K70R, T215F, K219KE	Y181C	K32Q, K122E, I135R, I142V, K166R, T200A, I202V, R211K, H221Y, A272P, I293V, Q334L, N348T, A376T, V381I, T386I	B
	199213	199213	JN671154	NRTI	NNRTI	M41L, D67N, T69D, K70R, M184V, L210LW, T215F, K219Q		V35L, T39E, V118VI, K122E, I135T, K173KQ, V179I, D218E, L228H, A272P, T286P, I293V, K311R, N348T, R356RK, A360AT, E370D, A376T, T386V, K390R, E399EG	B

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