Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	Y318F
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	9
Patients	57
Isolates	61

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_1117	1117		AZT, DDI	DLV	D67N, K70R, T215F, K219Q	K103N, Y318F	V60I, R83K, V90I, K102Q, D123E, S162Y, Q174Q*, G196E, D324DE, R356RK, K390R, A400T, T419TI, G436GE, L452LS, D460N, V467I, H483Y	B
	ACTG320_1588	1588		AZT, DDI	DLV	L74LV	V179VD, Y181YC, Y318F	T69TN, R83K, S162C, I178L, H221HY, K281R, T286TA, K390R, A400L, V435VA, L452V, D460N, R461K, S468T	B
	ACTG320_2429	2429		AZT, DDI	DLV	K70R, K219Q	K103N, Y318F	K104N, V118I, K122E, T200A, F214L, L228LR, V245E, A272P, I293V, Q334Y, R356RK, A360T, K366R, A400T, R461RK, L469I	B
	ACTG320_533	533		AZT, DDI	DLV	M41ML, D67DE, T215Y	K103N, Y318F	K20R, K64R, T69S, I293V, Q334L, A371V, I375V, K390R, A400X, N447NS, S468P, H483X	B
	ACTG320_548	548		AZT, DDI	DLV	D67N, K70R, L74V, K219Q	Y181C, Y318F	K11R, K104N, K122E, D123N, E169D, D177E, I202IV, F227FY, D250DN, A272P, K277R	B
Gonzales (2001)	CA2092	CA7730	AY030799	AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, K70R, V75M, M184V, L210W, T215F, K219Q	K103N, Y318F	T39A, E44ED, V60I, K122E, I142V, D177E, I178M, I195L, G196E, E203D, H208Y, R211Q, D218E, A272P, L283I, V317A, Q334L, R356K, G359S, A371V, K390R, A400T, R461K, L469I, Q480E, E529ED, A554S	B
Margot (2002)	MM-287736669	2877366691		NRTI	NNRTI	M41L, T69D, V75M, M184V, L210W, T215Y	K103N, Y318F	E6EK, T39A, E44D, K64H, V118I, G196E, Q207E, R211K, L228R, I293V, V317A, R356K, M357L, A360V, T369A, I375V	B
Rhee (2005)	CA6585	CA48122	AY801682	AZT, 3TC, D4T, DDI, ABC, TDF	NVP, EFV, DLV	M41L, D67N, T69D, M184V, L210W, T215Y	A98G, Y188L, Y318F	S3A, V35I, T39A, K43Q, E44D, V118I, K122E, I135T, V179I, G196E, T200A, E203K, Q207E, H208F, R211K, H221L, K223Q, V245E, A272P, T286A, I293V, E297R, G333D	B
Baxter (2006)	12-2137	2137-31022	DQ879122	NRTI	NNRTI	M41L, D67N, K70R, M184I, T215Y, K219E	K103N, V108I, Y318F	S68G, K102Q, V118I, K122E, I135T, I178IM, T200A, Q207E, R211K, L228H, V245K, I293V, S322ST, M357T, R358K, V365I, E399G	B
		2137-40728	DQ879121	NRTI	NNRTI	M41L, D67N, K70R, L74LI, M184V, T215Y, K219E	K103N, V108I, Y318F	S68G, K102Q, V118I, K122E, T200A, Q207E, R211K, L228H, V245K, I293V, M357T, R358K, G359GS, V365I, T386I, E399G	B
	12-1998	1998-40316	DQ879119	NRTI	NNRTI	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	K101P, K103N, Y318F	P4S, K20R, V60I, T69N, K122E, D177E, I178L, G196E, Q207H, R211K, D218E, A272P, I293V, P294Q, E297S, R356K, I375V, T386I	B
	12-1196	1196-30912	DQ879103	NRTI	NNRTI	K65R, D67N, T69D, K70R, V75I, F116Y, Q151M, K219Q	G190A, Y318F	A33V, V60I, K102Y, V118I, K122E, D123E, I142V, S162Y, Q174K, N175Y, I178M, I180V, G196E, F214L, L228H, V245E, I293V, E297K, K331KR, Q334L, F346Y, M357T, G359S, V365I, T386I, I393IM	B
	48-1438	1438-30513	DQ877828	NRTI	NNRTI	D67N, T69D, K70R, L74V, M184V, K219Q	K103N, Y318F	V35L, D123E, I135T, D177E, I178M, F214L, P294T, S322T, I329V, M357T	B
	48-3128	3128-30415	DQ878036	NRTI	NNRTI	M41L, L74V, Y115F, M184V, L210W, T215D	K101H, V108I, Y181C, G190A, Y318F	V35I, T39A, V106I, V118I, K122E, I135T, R211K, A272AP, I293V, Q334P, A355S, M357V, G359S, A376S, K390R	B
		3128-31125	DQ878038	NRTI	NNRTI	M41L, L74V, Y115F, M184V, L210W, T215D	K101H, V108I, Y181C, G190A, Y318F	V35I, T39A, V106I, V118I, K122E, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R	B
		3128-40708	DQ878037	NRTI	NNRTI	M41L, L74V, Y115F, M184V, L210W, T215Y	K101H, V108I, Y181C, G190A, Y318F	V35I, T39A, V106I, V118I, K122E, D123DN, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R	B
	48-3161	3161-30416	DQ878070	NRTI	NNRTI	M41L, D67N, L210W, T215Y, K219KN	Y188L, Y318F	V35VI, K43KN, E44D, V60I, K101KQ, V118I, D121H, K122E, D123S, I135V, K173KR, D177E, V179IL, Q207E, R211K, A272P, K275R, K277R, T286A, A288T, I293V, E297A, Q334N, G335GD, A360T, A371V, I375V	B
	48-3194	3194-30512	DQ878104	NRTI	NNRTI	M41L, D67N, T215Y, K219N	K103N, Y318F	T39A, K66R, V118I, I142V, S162C, T200A, L210S, R211E, D218E, L228R, S251H, A272P, T286A, V292VI, I293V, E297K, Q334L, M357T, R358K, K390R	B
	48-4005	4005-30317	DQ878239	NRTI	NNRTI	M41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219R	K103N, V108I, Y318F	K20R, T39A, E44D, V60I, V118I, D121Y, K122E, I142V, I195IT, T200E, E203K, Q207E, H208FY, R211K, H221Y, T286A, E297Q, R356RK, G359S, A371V, I375IV	B
	48-4071	4071-30218	DQ878300	NRTI	NNRTI	M41L, V75L, F77L, M184V, L210W, T215Y	K103S, G190A, Y318F	V35M, E40F, K43E, K49KR, V118I, K122E, I135T, Q207E, L228H, Q242H, V245E, K277R, R284K, T286A, I293V, E297K, A376S, S379C, K390R	B
	48-4129	4129-30314	DQ878359	NRTI	NNRTI	M41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219R	K103N, V108I, Y318F	K20R, T39A, E44D, V60I, V118I, D121Y, K122E, I142V, I195IT, T200E, E203K, Q207E, H208FY, R211K, H221Y, T286A, E297Q, R356RK, G359S, A371V, I375IV	B
	48-4179	4179-30428	DQ878413	NRTI	NNRTI	M41L, A62AV, D67N, M184V, L210W, T215Y, K219N	Y188L, Y318F	E6DN, T39A, K43E, E44D, K102KQ, V106I, V118I, K122E, D123DN, S162Y, V179I, V189I, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, E291D, I326IL, Q334LV, R356K, M357R, G359S, T369V, T377M, K390R	B
	48-4267	4267-30624	DQ878499	NRTI	NNRTI	M41L, D67N, K70R, L74I, V75M, M184V, T215Y, K219Q	K101P, G190A, Y318F	E6N, V35I, K43Q, E44D, K73M, I94L, V118I, K122E, D123E, I159L, S162D, D177E, I178M, V179I, E203G, Q207E, H208Y, L210Y, R211K, D218E, L228H, Q242H, V245K, I293V, R358K, I375V, A376S, T386I, K390R, K395R, E399D	B
		4267-40518	DQ878500	NRTI	NNRTI	M41L, D67N, K70R, L74I, V75M, M184V, T215Y, K219Q	K101P, G190A, Y318F	E6N, V35I, K43Q, E44D, K73M, I94L, V118I, K122E, D123E, I159L, S162D, D177E, I178M, V179I, E203G, Q207E, H208Y, L210Y, R211K, D218E, L228H, Q242H, V245K, I293V, R358K, I375V, A376S, T386I, K390R, K395R, E399D	B
	48-4392	4392-30722	DQ878532	NRTI	NNRTI	M41L, D67N, T69D, V75M, M184V, L210W, T215Y, K219R	A98G, K103S, G190A, Y318F	K43Q, E44D, V60I, V118I, D123E, I135V, I142V, S162Y, G196E, T200A, E203D, H208Y, R211K, W212C, L228H, V245Q, I293V, E297EK, Q334E, G359S, K390R, E399D	B
	48-6004	6004-30219	DQ878600	NRTI	NNRTI	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	A98G, K103KN, V108I, Y318F	I2V, E6D, V35M, E44D, I50V, K64H, T69N, S117A, V118I, K122KE, D123E, I135IT, S162A, G196E, F214L, D218E, F227Y, L228H, Q242H, V245T, A272P, K277R, T286A, A288S, I293V, M357T, S379C, K385R, K390R	B
	48-6061	6061-30723	DQ878659	NRTI	NNRTI	M41L, D67N, V75M, M184V, L210W, T215Y, K219R	K103N, V108I, Y318F	T39TA, K43Q, E44D, V60I, V118I, K122E, I135T, E203K, Q207E, R211K, K223Q, V245E, A272P, I293IV, E297K, I329V, G335S, G359S, A371V, K390R, E399D	B
	48-6098	6098-30611	DQ878693	NRTI	NNRTI	M41L, D67N, L74LIV, V75M, M184I, L210W, T215D, K219R	L100LI, K101PT, K103N, Y318F	V35I, K43Q, E44D, V90I, V118I, K122E, I135T, I178IM, E194EQ, G196E, R211K, D218E, V245IM, A272P, A288S, I293V, E297KR, K311R, M357T, I375V, T386I	B
	48-6099	6099-30618	DQ878694	NRTI	NNRTI	M41L, L74I, M184V, L210W, T215Y	K103N, V108I, Y318F	K20R, V35M, K43N, S68G, D123E, I135T, S162SN, D177E, R211K, V245E, A272P, K281R, I293V, E297K, Q334N, M357T, G359S, K366R, T369V, E370D, A371V, I375IV, A376S, T377I	B
	48-6106	6106-30618	DQ878698	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y	K103N, Y318F	E6D, V60VI, K122KE, I135T, K166R, G196E, R211K, A272P, K277R, E297R, R356K, M357V, A360T	B
	48-6248	6248-30929	DQ878807	NRTI	NNRTI	M41L, M184V, T215Y	K103N, Y318F	K20R, T39A, I142V, S162AG, T165L, T200A, Q207E, R211K, K277R, L283I, I293V, E297A, S322T, D324DE, I329L, V365I, T369V, T386I	B
	48-6272	6272-30910	DQ878825	NRTI	NNRTI	M41L, A62V, V75I, L210W, T215Y, K219KN, N348NI	K103N, M230L, L234I, Y318F	V90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394L	B
	48-6362	6362-30929	DQ878877	NRTI	NNRTI	D67N, K70R, T215TI, K219Q, N348IT	K103N, Y318F	K104KT, D123E, I135T, T165IM, G196E, T200Q, I202V, A272P, K277R, I293V, K311R, Q334D, G335C, R356K, M357K, K390R	B
	48-7202	7202-30808	DQ879027	NRTI	NNRTI	M41L, A62V, L74V, M184V, T215F	K103N, Y318F	V35I, K43Q, W88C, D123E, I135T, D177E, R211K, F214L, I329V, A371V, K390R, E399D	B
	48-8077	8077-30818	DQ879087	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y	K103N, Y318F	E44D, A98S, D123E, I135IL, E138Q, K166R, D177E, I178IL, G196E, T200A, E203D, Q207K, R211A, A272P, I293V, I326V, I329V, G335S, K347Q, A371V, A376S, T386I, K390R	B
Rosen-Zvi (2008)	18	02p18-1		AZT, DDI, 3TC	NVP	D67N, K70R, M184V, K219Q	K103N, Y318F	V60VI, K102Q, I135T, S162A, V245K, E312Q	B
	22	01p22-1		AZT, DDI, DDC, 3TC, D4T, ABC	DLV, EFV	M41L, D67N, T69D, L74V, M184V, L210W, T215Y	L100I, K103N, Y318F	E29K, K43Q, E44D, N57Y, R83K, V111I, K122E, I142V, D177G, G196E, E203Q, Q207D, H208Y, R211K, Q278E, I293V, E297K	B
Dau (2010)	06093A	06093A	GU581703	NRTI	NNRTI	M41L, D67N, V75M, M184V, L210W, T215Y, K219N	K103N, V108I, Y318F	P4S, E28K, K32E, E40F, K43E, K49R, V118I, K122E, E169D, G196K, Q197E, T200A, E203V, Q207E, H208Y, R211K, V245Q, A272P, V292I, E297K, V317A, S322A, Q334L, K350KR, M357V, R358K, V365I, A371V, T397TI	B
	06682A	06682A	GU581765	NRTI	NNRTI	M41L, D67N, T69D, L74V, M184V, L210W, T215Y	L100I, K103N, Y318F	P9Q, K20R, V35I, K43N, E44D, V118I, I135T, S162Y, D177E, Q207E, E224D, K277R, R284K, A288S, I293V, E297K, M357I, R358K, K366R, K395R, E399D	B
	06860A	06860A	GU581792	NRTI	NNRTI	D67N, T69D, T215F, K219Q	Y318F	I2V, K103R, V118I, K122E, D123E, K166R, F214L, K277R, R284K, P294S, E297R, M357I, R358K, V365I, A376T, T377L, T386A, K390R, E399D	B
	07155A	07155A	GU581821	NRTI	NNRTI	M41L, L74I, M184V, L210W, T215Y	K103N, Y318F	V35T, T39A, K43Q, S68G, A98S, D121C, K122E, I135T, S162A, D177E, T200A, R211RK, L228Q, A272P, K277R, T286A, E297Q, I329V, Q334QR, G335GD, R356RK, G359S, A371V	B
	07319A	07319A	GU581838	NRTI	NNRTI	M41L, V75L, F77FL, L210W, T215Y	K103N, Y318F	T39K, K43E, K122E, I135M, E138Q, Q174QK, T200A, Q207E, H208HY, R211RK, Q278H, A288S, I293V, E297A, D324DE, M357T, A360AV, T386I, K390R	B
	07342A	07342A	GU581839	NRTI	NNRTI	M41L, D67N, T69D, K70R, V75M, M184V, L210W, T215Y, K219Q	K103NS, Y318F	E28EKQ, T39E, E44ED, V60I, A98AS, K101KQ, V118I, K122E, D123E, I135T, S162SDGN, Q174K, N175Y, D177DN, G196E, Q197QE, R211K, D218E, L228H, Q242H, A272P, L283LI, P345L, G359S, A371V, S379C, K390R	B
	07426A	07426A	GU581845	NRTI	NNRTI	M41L, D67N, L210W, T215Y, K219KR	Y188L, Y318F	E44D, V60I, V118I, K122KE, D123DE, D177E, V189I, G196GE, T200K, E203EK, Q207D, H208HY, R211K, E297A, Q334C, K390R, E399D	B
	08255A	08255A	GU581902	NRTI	NNRTI	M41ML, V75L, F77L, M184V, L210W, T215CY	K103N, Y318F	P4PS, V35VL, T39K, K43E, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, M357T, T386I, K390R	B
	09065A	09065A	GU581957	NRTI	NNRTI	M41L, V75L, F77L, M184V, L210W, T215Y	K103N, Y318F	V35VL, T39K, K43E, V118VI, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, D324DE, N348NT, M357T, T386I, K390R	B
	09756A	09756A	GU581981	NRTI	NNRTI	M41L, V75L, F77L, M184V, L210W, T215Y, N348IT	K103N, Y318F	V35VL, T39K, K43E, V118I, K122E, I135M, E138Q, Q174QK, V179VI, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, E312EG, D324E, M357T, A360AV, T386I, K390R	B
	10025A	10025A	GU581992	NRTI	NNRTI	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	V108VI, Y181YC, Y318F	K43Q, E44D, V118I, K122E, D177E, I178IM, G196E, E203K, Q207E, R211K, D218DE, K223Q, L228LH, A272P, K277R, Q278H, I293V, E297EK, D324E, M357T, G359S, A371V, S379G, T386I, K390R, K395R, E399D	B
	11025A	11025A	GU582029	NRTI	NNRTI	M41L, D67N, V75LM, F77L, M184V, L210W, T215Y	K103N, Y318F	V35L, T39K, E40F, K43E, V118I, K122E, I135M, E138Q, T200TAEK, Q207DE, R211K, Q278H, A288S, I293V, E297A, D324DE, N348T, M357T, T386I, K390R	B
Jones (2012)	132615	132615	JN669513	NRTI	NNRTI	K70R, M184V, T215F, K219E	K103N, M230L, L234I, Y318F	V35T, K49R, V60I, T69N, R83K, K101Q, T139K, L228H, V245E, L283I, I293V, E297A, Q334L, R356K, M357L, G359S, A371V, A376T, T386A, K390R	B
	135587	135587	JN669547	NRTI	NNRTI	M41L, L74IV, M184V, L210W, T215Y, N348I	K103N, Y318F	K20R, T39A, K43E, K122Q, D123DH, R211K, V245K, S251I, A272P, I293V, P294Q, R356K, M357R, R358G, G359S, A360T, K366R, A371I, I375V, A376S, T386I, K388R	B
	145636	145636	JN669661	NRTI	NNRTI	M41L, M184V, T215Y	K103N, Y318F	D121Y, K122E, D123E, I135T, S162H, D177E, I202V, A272P, Q334H, G335S, R358K, G359S, K366R, T369V, A371V, I375V, A376S, T377I, S379C, K390R	B
	154985	154985	JN669829	NRTI	NNRTI	M41L, T215Y	K103N, Y318F	V35E, T39A, V90I, K122E, I135T, T139K, I142V, I202V, D237DE, I293V, M357T, A376T, T386A, K395R, E399D	B
	157897	157897	JN669902	NRTI	NNRTI	M41L, L210W, T215Y	Y318F	E28EA, T39A, E44D, S68G, T69d, A98S, K102Q, V118I, I135T, K166R, D177N, I202V, R211K, Y271F, A272P, L283I, I293V, P294T, E297K, I329V, Q334E, Y342F, G359S, T386I, K390R	B
	178038	178038	JN670468	NRTI	NNRTI	M41L, D67N, T69D, M184V, L210W, T215Y	K103N, V179F, Y181C, G190A, Y318F	S3G, E28K, K32E, V35M, K43E, E44A, K101R, V111I, K122E, I135V, T139K, I167V, T200A, E203D, H208Y, R211T, L228H, V245E, A272P, L283I, R284K, I293V, E297K, E300D, M357T, A376S, T386I, K390R, Q394L, E399D	B
	179227	179227	JN670505	NRTI	NNRTI	M41L, L74I, M184V, T215Y	K103N, V108I, Y318F	V35K, T39L, E44D, V90I, A98S, I135L, S162H, D177G, T200A, E203D, L210S, H221Y, A272P, K281KR, L283I, T286P, I293V, E297K, R356K, M357T, G359GS, A376S, K385R, K390R, Q394L, E399D	B
	183735	183735	JN670659	NRTI	NNRTI	M41ML, M184V, T215Y	K103N, Y318F	K20R, S68SG, I135L, T200TA, A272P, K281R, R284RK, T286TA, P294S, E297K, L310LI, V365I, A376CST, E399D	B
	190546	190546	JN670800	NRTI	NNRTI	D67N, K70R, M184V, K219Q, N348I	K103N, P225PH, K238T, Y318F	V35T, T39K, K43E, K49R, V60I, I135V, T200A, A272P, K277R, T286A, A288S, E291D, E297K, A376T, K390R, Q394L, E399D	B
	198714	198714	JN671133	NRTI	NNRTI	M184V	A98AG, K103N, K238T, Y318F	V35T, D123E, T200A, F214L, V245K, A272P, I293V, P294A, E297R, I329L, G333E, M357T, R358K, A376S, T386I, Q394L, E399D	B
	205495	205495	JN671363	NRTI	NNRTI	M41L, V75M, F77L, M184V, L210W, T215Y	A98G, V108I, G190A, Y318F	V35T, E44D, V118I, K122E, D123E, S162C, T200A, E203D, H221Y, L228H, A272P, K281R, T286A, E297K, D324E, R356RK, M357T, G359S, Q394L, E399D	B
Melikian (2012)	CA4323	CA59233	GQ211136	AZT, DDI, DDC, D4T, ABC, 3TC, TDF	DLV, EFV	M41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219D	K103N, L234I, Y318F	V35I, T39A, K43E, K64R, V118I, K122E, G196E, T200A, E203K, Q207E, D218E, F227Y, L228H, T286A, I293V, S322A, G335D	B

Reverse Transcriptase Inhibitors

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