<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation Y318F
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 58
Isolates 62
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_11171117 AZT, DDIDLVD67N, K70R, T215F, K219QK103N, Y318FV60I, R83K, V90I, K102Q, D123E, S162Y, Q174Q*, G196E, D324DE, R356RK, K390R, A400T, T419TI, G436GE, L452LS, D460N, V467I, H483YB
 ACTG320_15881588 AZT, DDIDLVL74LVV179VD, Y181YC, Y318FT69TN, R83K, S162C, I178L, H221HY, K281R, T286TA, K390R, A400L, V435VA, L452V, D460N, R461K, S468TB
 ACTG320_24292429 AZT, DDIDLVK70R, K219QK103N, Y318FK104N, V118I, K122E, T200A, F214L, L228LR, V245E, A272P, I293V, Q334Y, R356RK, A360T, K366R, A400T, R461RK, L469IB
 ACTG320_36713671 AZT, DDIDLVL210LW, T215DK103N, Y318FK20R, V35VI, K122E, I135T, S162C, E203D, R211K, E224ED, A272P, K277R, L283I, I293V, Q334DE, R356K, G359S, A371AV, T377MV, K390R, A400T, T403A, K451R, L452S, S468PB
 ACTG320_533533 AZT, DDIDLVM41ML, D67DE, T215YK103N, Y318FK20R, K64R, T69S, I293V, Q334L, A371V, I375V, K390R, A400X, N447NS, S468P, H483XB
 ACTG320_548548 AZT, DDIDLVD67N, K70R, L74V, K219QY181C, Y318FK11R, K104N, K122E, D123N, E169D, D177E, I202IV, F227FY, D250DN, A272P, K277RB
Gonzales (2001)CA2092CA7730AY030799AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219QK103N, Y318FT39A, E44ED, V60I, K122E, I142V, D177E, I178M, I195L, G196E, E203D, H208Y, R211Q, D218E, A272P, L283I, V317A, Q334L, R356K, G359S, A371V, K390R, A400T, R461K, L469I, Q480E, E529ED, A554SB
Brindeiro (2002)TVGG28TVGG28AY145795AZT, 3TC, D4TNNRTID67N, K70R, M184V, T215F, K219EP236L, Y318FV118I, D121H, K122E, I135T, F214L, N265I, Q278R, T286P, K287R, I293V, E297K, E312A, Y319IB
Margot (2002)MM-2877366692877366691 NRTINNRTIM41L, T69D, V75M, M184V, L210W, T215YK103N, Y318FE6EK, T39A, E44D, K64H, V118I, G196E, Q207E, R211K, L228R, I293V, V317A, R356K, M357L, A360V, T369A, I375VB
Gomez-Carrillo (2004)119106119106AY365962NRTINNRTID67N, K70R, T215I, K219QA98G, K103N, Y181YC, K238KN, Y318FV35ILM, V60I, K64R, I135T, I195T, G196E, D237DE, T286A, A288S, E297A, G359S, A360T, A400TB
 122995122995AY366018NRTINNRTIM184V, N348IK103N, Y318FI135T, I142V, G196E, I202IV, Q207H, R211K, A272P, R284K, I293V, E297Q, A376S, T386TA, K390R, Q394LB
Rhee (2005)CA6585CA48122AY801682AZT, 3TC, D4T, DDI, ABC, TDFNVP, EFV, DLVM41L, D67N, T69D, M184V, L210W, T215YA98G, Y188L, Y318FS3A, V35I, T39A, K43Q, E44D, V118I, K122E, I135T, V179I, G196E, T200A, E203K, Q207E, H208F, R211K, H221L, K223Q, V245E, A272P, T286A, I293V, E297R, G333DB
Baxter (2006)12-21372137-31022DQ879122NRTINNRTIM41L, D67N, K70R, M184I, T215Y, K219EK103N, V108I, Y318FS68G, K102Q, V118I, K122E, I135T, I178IM, T200A, Q207E, R211K, L228H, V245K, I293V, S322ST, M357T, R358K, V365I, E399GB
  2137-40728DQ879121NRTINNRTIM41L, D67N, K70R, L74LI, M184V, T215Y, K219EK103N, V108I, Y318FS68G, K102Q, V118I, K122E, T200A, Q207E, R211K, L228H, V245K, I293V, M357T, R358K, G359GS, V365I, T386I, E399GB
 12-19981998-40316DQ879119NRTINNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219QK101P, K103N, Y318FP4S, K20R, V60I, T69N, K122E, D177E, I178L, G196E, Q207H, R211K, D218E, A272P, I293V, P294Q, E297S, R356K, I375V, T386IB
 12-11961196-30912DQ879103NRTINNRTIK65R, D67N, T69D, K70R, V75I, F116Y, Q151M, K219QG190A, Y318FA33V, V60I, K102Y, V118I, K122E, D123E, I142V, S162Y, Q174K, N175Y, I178M, I180V, G196E, F214L, L228H, V245E, I293V, E297K, K331KR, Q334L, F346Y, M357T, G359S, V365I, T386I, I393IM, A400TB
 48-14381438-30513DQ877828NRTINNRTID67N, T69D, K70R, L74V, M184V, K219QK103N, Y318FV35L, D123E, I135T, D177E, I178M, F214L, P294T, S322T, I329V, M357T, A400LB
 48-31283128-30415DQ878036NRTINNRTIM41L, L74V, Y115F, M184V, L210W, T215DK101H, V108I, Y181C, G190A, Y318FV35I, T39A, V106I, V118I, K122E, I135T, R211K, A272AP, I293V, Q334P, A355S, M357V, G359S, A376S, K390R, A400TB
  3128-31125DQ878038NRTINNRTIM41L, L74V, Y115F, M184V, L210W, T215DK101H, V108I, Y181C, G190A, Y318FP1L, V35I, T39A, V106I, V118I, K122E, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R, A400TB
  3128-40708DQ878037NRTINNRTIM41L, L74V, Y115F, M184V, L210W, T215YK101H, V108I, Y181C, G190A, Y318FV35I, T39A, V106I, V118I, K122E, D123DN, I135T, Q174K, R211K, A272P, I293V, Q334P, A355S, M357V, G359S, A376S, K390R, A400TB
 48-31613161-30416DQ878070NRTINNRTIM41L, D67N, L210W, T215Y, K219KNY188L, Y318FV35VI, K43KN, E44D, V60I, K101KQ, V118I, D121H, K122E, D123S, I135V, K173KR, D177E, V179IL, Q207E, R211K, A272P, K275R, K277R, T286A, A288T, I293V, E297A, Q334N, G335GD, A360T, A371V, I375V, A400TB
 48-31943194-30512DQ878104NRTINNRTIM41L, D67N, T215Y, K219NK103N, Y318FT39A, K66R, V118I, I142V, S162C, T200A, L210S, R211E, D218E, L228R, S251H, A272P, T286A, V292VI, I293V, E297K, Q334L, M357T, R358K, K390R, A400TB
 48-40054005-30317DQ878239NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219RK103N, V108I, Y318FK20R, T39A, E44D, V60I, V118I, D121Y, K122E, I142V, I195IT, T200E, E203K, Q207E, H208FY, R211K, H221Y, T286A, E297Q, R356RK, G359S, A371V, I375IVB
 48-40714071-30218DQ878300NRTINNRTIM41L, V75L, F77L, M184V, L210W, T215YK103S, G190A, Y318FV35M, E40F, K43E, K49KR, V118I, K122E, I135T, Q207E, L228H, Q242H, V245E, K277R, R284K, T286A, I293V, E297K, A376S, S379C, K390R, A400TB
 48-41294129-30314DQ878359NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219RK103N, V108I, Y318FK20R, T39A, E44D, V60I, V118I, D121Y, K122E, I142V, I195IT, T200E, E203K, Q207E, H208FY, R211K, H221Y, T286A, E297Q, R356RK, G359S, A371V, I375IVB
 48-41794179-30428DQ878413NRTINNRTIM41L, A62AV, D67N, M184V, L210W, T215Y, K219NY188L, Y318FE6DN, T39A, K43E, E44D, K102KQ, V106I, V118I, K122E, D123DN, S162Y, V179I, V189I, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, E291D, I326IL, Q334LV, R356K, M357R, G359S, T369V, T377M, K390RB
 48-42674267-30624DQ878499NRTINNRTIM41L, D67N, K70R, L74I, V75M, M184V, T215Y, K219QK101P, G190A, Y318FE6N, V35I, K43Q, E44D, K73M, I94L, V118I, K122E, D123E, I159L, S162D, D177E, I178M, V179I, E203G, Q207E, H208Y, L210Y, R211K, D218E, L228H, Q242H, V245K, I293V, R358K, I375V, A376S, T386I, K390R, K395R, E399DB
  4267-40518DQ878500NRTINNRTIM41L, D67N, K70R, L74I, V75M, M184V, T215Y, K219QK101P, G190A, Y318FE6N, V35I, K43Q, E44D, K73M, I94L, V118I, K122E, D123E, I159L, S162D, D177E, I178M, V179I, E203G, Q207E, H208Y, L210Y, R211K, D218E, L228H, Q242H, V245K, I293V, R358K, I375V, A376S, T386I, K390R, K395R, E399DB
 48-43924392-30722DQ878532NRTINNRTIM41L, D67N, T69D, V75M, M184V, L210W, T215Y, K219RA98G, K103S, G190A, Y318FK43Q, E44D, V60I, V118I, D123E, I135V, I142V, S162Y, G196E, T200A, E203D, H208Y, R211K, W212C, L228H, V245Q, I293V, E297EK, Q334E, G359S, K390R, E399D, A400TB
 48-60046004-30219DQ878600NRTINNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K103KN, V108I, Y318FI2V, E6D, V35M, E44D, I50V, K64H, T69N, S117A, V118I, K122KE, D123E, I135IT, S162A, G196E, F214L, D218E, F227Y, L228H, Q242H, V245T, A272P, K277R, T286A, A288S, I293V, M357T, S379C, K385R, K390R, A400TB
 48-60616061-30723DQ878659NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219RK103N, V108I, Y318FT39TA, K43Q, E44D, V60I, V118I, K122E, I135T, E203K, Q207E, R211K, K223Q, V245E, A272P, I293IV, E297K, I329V, G335S, G359S, A371V, K390R, E399D, A400TB
 48-60986098-30611DQ878693NRTINNRTIM41L, D67N, L74LIV, V75M, M184I, L210W, T215D, K219RL100LI, K101PT, K103N, Y318FP1L, V35I, K43Q, E44D, V90I, V118I, K122E, I135T, I178IM, E194EQ, G196E, R211K, D218E, V245IM, A272P, A288S, I293V, E297KR, K311R, M357T, I375V, T386I, A400TB
 48-60996099-30618DQ878694NRTINNRTIM41L, L74I, M184V, L210W, T215YK103N, V108I, Y318FK20R, V35M, K43N, S68G, D123E, I135T, S162SN, D177E, R211K, V245E, A272P, K281R, I293V, E297K, Q334N, M357T, G359S, K366R, T369V, E370D, A371V, I375IV, A376S, T377I, A400TB
 48-61066106-30618DQ878698NRTINNRTIM41L, D67N, M184V, L210W, T215YK103N, Y318FE6D, V60VI, K122KE, I135T, K166R, G196E, R211K, A272P, K277R, E297R, R356K, M357V, A360T, A400TB
 48-62486248-30929DQ878807NRTINNRTIM41L, M184V, T215YK103N, Y318FK20R, T39A, I142V, S162AG, T165L, T200A, Q207E, R211K, K277R, L283I, I293V, E297A, S322T, D324DE, I329L, V365I, T369V, T386I, A400TB
 48-62726272-30910DQ878825NRTINNRTIM41L, A62V, V75I, L210W, T215Y, K219KN, N348NIK103N, M230L, L234I, Y318FV90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394L, A400TB
 48-63626362-30929DQ878877NRTINNRTID67N, K70R, T215TI, K219Q, N348ITK103N, Y318FK104KT, D123E, I135T, T165IM, G196E, T200Q, I202V, A272P, K277R, I293V, K311R, Q334D, G335C, R356K, M357K, K390R, A400VB
 48-72027202-30808DQ879027NRTINNRTIM41L, A62V, L74V, M184V, T215FK103N, Y318FV35I, K43Q, W88C, D123E, I135T, D177E, R211K, F214L, I329V, A371V, K390R, E399DB
 48-80778077-30818DQ879087NRTINNRTIM41L, D67N, M184V, L210W, T215YK103N, Y318FE44D, A98S, D123E, I135IL, E138Q, K166R, D177E, I178IL, G196E, T200A, E203D, Q207K, R211A, A272P, I293V, I326V, I329V, G335S, K347Q, A371V, A376S, T386I, K390R, A400TB
Rosen-Zvi (2008)1802p18-1 AZT, DDI, 3TCNVPD67N, K70R, M184V, K219QK103N, Y318FV60VI, K102Q, I135T, S162A, V245K, E312QB
 2201p22-1 AZT, DDI, DDC, 3TC, D4T, ABCDLV, EFVM41L, D67N, T69D, L74V, M184V, L210W, T215YL100I, K103N, Y318FE29K, K43Q, E44D, N57Y, R83K, V111I, K122E, I142V, D177G, G196E, E203Q, Q207D, H208Y, R211K, Q278E, I293V, E297KB
Dau (2010)06093A06093AGU581703NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NK103N, V108I, Y318FP4S, E28K, K32E, E40F, K43E, K49R, V118I, K122E, E169D, G196K, Q197E, T200A, E203V, Q207E, H208Y, R211K, V245Q, A272P, V292I, E297K, V317A, S322A, Q334L, K350KR, M357V, R358K, V365I, A371V, T397TIB
 06682A06682AGU581765NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215YL100I, K103N, Y318FP9Q, K20R, V35I, K43N, E44D, V118I, I135T, S162Y, D177E, Q207E, E224D, K277R, R284K, A288S, I293V, E297K, M357I, R358K, K366R, K395R, E399D, A400TB
 06860A06860AGU581792NRTINNRTID67N, T69D, T215F, K219QY318FI2V, K103R, V118I, K122E, D123E, K166R, F214L, K277R, R284K, P294S, E297R, M357I, R358K, V365I, A376T, T377L, T386A, K390R, E399D, A400TB
 07155A07155AGU581821NRTINNRTIM41L, L74I, M184V, L210W, T215YK103N, Y318FV35T, T39A, K43Q, S68G, A98S, D121C, K122E, I135T, S162A, D177E, T200A, R211RK, L228Q, A272P, K277R, T286A, E297Q, I329V, Q334QR, G335GD, R356RK, G359S, A371VB
 07319A07319AGU581838NRTINNRTIM41L, V75L, F77FL, L210W, T215YK103N, Y318FT39K, K43E, K122E, I135M, E138Q, Q174QK, T200A, Q207E, H208HY, R211RK, Q278H, A288S, I293V, E297A, D324DE, M357T, A360AV, T386I, K390R, A400TB
 07342A07342AGU581839NRTINNRTIM41L, D67N, T69D, K70R, V75M, M184V, L210W, T215Y, K219QK103NS, Y318FE28EKQ, T39E, E44ED, V60I, A98AS, K101KQ, V118I, K122E, D123E, I135T, S162SDGN, Q174K, N175Y, D177DN, G196E, Q197QE, R211K, D218E, L228H, Q242H, A272P, L283LI, P345L, G359S, A371V, S379C, K390R, A400TB
 07426A07426AGU581845NRTINNRTIM41L, D67N, L210W, T215Y, K219KRY188L, Y318FE44D, V60I, V118I, K122KE, D123DE, D177E, V189I, G196GE, T200K, E203EK, Q207D, H208HY, R211K, E297A, Q334C, K390R, E399D, A400TB
 08255A08255AGU581902NRTINNRTIM41ML, V75L, F77L, M184V, L210W, T215CYK103N, Y318FP4PS, V35VL, T39K, K43E, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, M357T, T386I, K390R, A400TB
 09065A09065AGU581957NRTINNRTIM41L, V75L, F77L, M184V, L210W, T215YK103N, Y318FV35VL, T39K, K43E, V118VI, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, D324DE, N348NT, M357T, T386I, K390R, A400TB
 09756A09756AGU581981NRTINNRTIM41L, V75L, F77L, M184V, L210W, T215Y, N348ITK103N, Y318FV35VL, T39K, K43E, V118I, K122E, I135M, E138Q, Q174QK, V179VI, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, E312EG, D324E, M357T, A360AV, T386I, K390R, A400TB
 10025A10025AGU581992NRTINNRTIM41L, D67N, L74I, M184V, L210W, T215Y, K219NV108VI, Y181YC, Y318FK43Q, E44D, V118I, K122E, D177E, I178IM, G196E, E203K, Q207E, R211K, D218DE, K223Q, L228LH, A272P, K277R, Q278H, I293V, E297EK, D324E, M357T, G359S, A371V, S379G, T386I, K390R, K395R, E399D, A400TB
 11025A11025AGU582029NRTINNRTIM41L, D67N, V75LM, F77L, M184V, L210W, T215YK103N, Y318FV35L, T39K, E40F, K43E, V118I, K122E, I135M, E138Q, T200TAEK, Q207DE, R211K, Q278H, A288S, I293V, E297A, D324DE, N348T, M357T, T386I, K390R, A400TB
Jones (2012)132615132615JN669513NRTINNRTIK70R, M184V, T215F, K219EK103N, M230L, L234I, Y318FV35T, K49R, V60I, T69N, R83K, K101Q, T139K, L228H, V245E, L283I, I293V, E297A, Q334L, R356K, M357L, G359S, A371V, A376T, T386A, K390RB
 135587135587JN669547NRTINNRTIM41L, L74IV, M184V, L210W, T215Y, N348IK103N, Y318FK20R, T39A, K43E, K122Q, D123DH, R211K, V245K, S251I, A272P, I293V, P294Q, R356K, M357R, R358G, G359S, A360T, K366R, A371I, I375V, A376S, T386I, K388R, A400TB
 145636145636JN669661NRTINNRTIM41L, M184V, T215YK103N, Y318FD121Y, K122E, D123E, I135T, S162H, D177E, I202V, A272P, Q334H, G335S, R358K, G359S, K366R, T369V, A371V, I375V, A376S, T377I, S379C, K390R, A400TB
 154985154985JN669829NRTINNRTIM41L, T215YK103N, Y318FV35E, T39A, V90I, K122E, I135T, T139K, I142V, I202V, D237DE, I293V, M357T, A376T, T386A, K395R, E399D, A400TB
 157897157897JN669902NRTINNRTIM41L, T69~, L210W, T215YY318FE28EA, T39A, E44D, S68G, A98S, K102Q, V118I, I135T, K166R, D177N, I202V, R211K, Y271F, A272P, L283I, I293V, P294T, E297K, I329V, Q334E, Y342F, G359S, T386I, K390R, A400TB
Kouri (2012)CU738-10CU738-10JQ585414NRTINNRTIM184V, T215FK103N, Y318FV8VI, K20R, V35VI, K49R, S68SG, V118I, D123E, I135KT, E169D, D177E, I178L, Q207E, R211K, F214L, V245K, A288S, D324E, I329LB
 CU1234-09CU1234-09JQ585281NRTINNRTID67N, K70R, M184V, T215F, K219E, N348IG190A, Y318FP1H, V35T, T39A, S48T, E53D, T69N, A98S, K122E, D123G, I135V, R211K, V245K, A272P, K277R, E297K, K311Q, I329V, Q334LB
Melikian (2012)CA4323CA59233GQ211136AZT, DDI, DDC, D4T, ABC, 3TC, TDFDLV, EFVM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219DK103N, L234I, Y318FV35I, T39A, K43E, K64R, V118I, K122E, G196E, T200A, E203K, Q207E, D218E, F227Y, L228H, T286A, I293V, S322A, G335DB
Theys (2013)136352136352 AZT, 3TCEFVM184VK103N, V108I, Y318FK20R, K122E, I135T, G196E, D237E, V245IT, E248D, A272P, E297AB