<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation M230L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 22
Patients 61
Isolates 73
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_18171817 AZT, DDCDLVM41L, D67N, L210W, T215Y, K219NK103N, M230LK22R, V35VL, K43KN, E44D, K64KHNQ, W88C, V90VI, V118VI, I178L, T200A, E203ED, H208Y, R211K, H221HY, K277R, T286A, E297A, S322T, D324E, A376T, T386I, Q394L, D460N, R461K, L469I, H483LB
 ACTG320_27592759 AZTDLVT215YK103N, M230LV35I, R83K, K122E, I135T, S162C, E169D, I178L, R211K, A272P, K277R, I293V, Q334E, M357T, K366R, E404D, N447S, D460N, H483Q, D488XB
Huang (2000)Huang-Pt1Huang-Pt1 NRTI, ABCNVPM41L, L74I, M184V, L210W, T215YY181C, M230LK102Q, S162C, R211K, L228R, K277R, I293V, T296SB
 Huang-Pt2Huang-Pt2 NRTI, AZT, 3TCEFVM184VK103N, M230LK49R, K122E, S162C, E169D, I178M, I195T, T200A, R211K, V245M, D250E, K275Q, V276I, T286A, I293V, P294TB
 Huang-Pt3Huang-Pt3 NRTI, ABC, D4TEFVD67N, L210W, T215YK101E, K103N, G190S, M230L, K238TD86E, K102X, V118I, K122P, A158S, Q174X, D177E, R211K, F214L, H221YB
Parkin (2000)SD-14SD-14_8AF294535NRTI, 3TC, DDI, ABCNVPM41L, L74I, M184V, L210W, T215YY181C, M230LD177E, H208Y, R211K, L228R, T286A, T296S, E297KB
  SD-14_16AF294536NRTI, 3TC, DDI, ABCNVPM41L, L74I, M184V, L210W, T215YY181C, M230LD177E, H208Y, R211K, L228R, T286A, T296S, E297KB
Shulman (2000)CA1433CA10463AY802663AZT, DDC, D4T, DDI, ADV, 3TCEFVM41L, M184V, L210W, T215YK103N, M230LA98S, V118I, D121Y, K122E, Q207E, R211K, I293VB
Gonzales (2001)CA2100CA7750AY030807AZT, DDC, D4T, 3TCDLVM41L, D67G, L74I, M184V, T215YL100I, V179D, M230LV35I, K103R, K122E, I202V, Q207QH, R211K, T240KB
 CA4068CA9336AY031063AZT, DDC, DDI, D4T, 3TCNVPM41L, D67N, K70R, L74V, V75M, M184V, L210W, T215Y, K219QK103T, M230L, K238TT39A, V60I, L109M, V118I, K122E, I142V, L187M, E203K, Q207E, H208Y, R211K, D218E, L228H, K277R, T286AB
 CA4408CA10616AY031264AZT, DDI, DDC, D4T, 3TC, ABCEFVM41L, L210W, T215YK103N, M230LT39A, S68G, K122E, I135T, D177E, Q207K, R211K, D237E, A288S, I293VB
 CA6467CA15984AY032418AZT, DDI, D4T, 3TCNVPD67N, T69D, K70R, T215I, K219QK103N, M230LV35I, K122P, D123E, I135T, D177E, T200A, L228H, K277R, L283LI, T286TP, I293V, E297QB
 CA6807CA16858AY032540AZT, DDI, 3TC, D4TEFVL210CW, T215Y, K219EV179D, M230LK13X, K22KN, V106L, V118I, D123E, I135T, S162C, Q174E, H208Y, R211K, K223Q, L228R, K281KR, I293VB
Kempf (2001)DK-34946338_d113 RTI, NRTIRTI, NVPM184V, T215YK103N, M230LA98S, K122E, S134SN, D177E, Q207E, R211K, L228LH, D250E, A272P, I274VB
  6338_d225 RTI, NRTIRTI, NVPM184V, T215YK103N, M230LA98S, V118VI, K122E, D177E, Q207E, R211K, L228H, D250E, A272P, I274VB
  6338_d336 RTI, NRTIRTI, NVPM41ML, M184V, T215YK103N, M230LA98S, V118VI, K122E, D177E, Q207E, R211K, L228H, D250E, A272P, I274VB
Margot (2002)MM-2331365782331365781 NRTINNRTIM184VV179D, M230L, K238TK103KR, L109M, I142V, S162C, Q174H, T200A, Q207E, R211K, V245E, I274IV, V292I, E297RK, K311R, D324P, Q334Y, Y342F, R358K, A360TB
 MM-2252366762252366761 NRTINNRTID67T, K70R, T215F, K219EK103N, Y181C, M230L, K238NK20R, T69N, I135T, S162A, L228R, A288S, I293V, V317A, S322T, M357T, A360VB
 MM-2248364952248364951 NRTINNRTIM41L, L74V, M184V, T215YK103N, P225H, M230LV21I, V35M, T39A, K223KR, W229L, V245E, I293V, E297K, D324E, A360V, K366R, K390RB
Gonzales (2003)CA1433CA14562AY305959AZT, DDC, D4T, DDI, ADV, 3TC, ABCEFVM41L, L74V, M184V, L210W, T215YK103N, V108I, M230LA98S, V118VI, D121HY, K122E, Q207E, R211K, K277KR, I293VB
Gonzales (2003)CA1590CA20013AF514102DDC, AZT, D4T, 3TC, DDI, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219NY181C, M230LE44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, A272P, A299AGB
 CA4334CA14487AF514188AZT, D4T, 3TC, DDI, ADV, ABCDLV, EFVM41L, D67DN, L74V, M184MV, L210W, T215Y, K219NV179D, M230LT39E, R83K, K103R, K122E, S162C, K173KR, I178IM, G196GE, E203D, H208HY, R211K, V245Q, T286A, V292IB
Shafer (2003)A384_08620862bEF548483AZT, 3TCEFVM184IK103N, M230LK122E, D123E, I178L, R211K, V245MB
 A384_04850485c D4T, DDI, 3TC, AZTEFVD67N, M184VL100I, M230LR211K, H221HFLYB
  0485dEF548919D4T, DDI, 3TC, AZTEFVD67N, M184VL100I, M230LI37X, R211K, H221HFLYB
 A384_07850785bEF549041D4T, DDIEFV K103N, M230LK49R, V60I, R83K, D123E, V245KB
Gomez-Carrillo (2004)103118103118AY365666NRTINNRTIM41L, D67N, M184V, L210W, T215C, K219NK101E, G190A, M230LV35I, T39A, K43N, E44D, K46R, K102R, V106I, V118I, K122E, I142T, K173S, Q174K, G196E, D237DE, A272P, T286A, A288P, E297A, K311R, I326V, G333D, K350KR, G359S, A371VB
Gulick (2004)RG114RG114w136 AZT, 3TCEFVM184VM230LK103G, V106VI, I135T, P140PT, T200A, Q207E, R211K, H221Y, V245KB
 RG343RG343w68 ABC, AZT, 3TCEFVM184VK103N, M230LK49R, I135V, S162C, Q207E, R211GB
Non-B Workgroup (2005)TH_432TH_432 D4T, DDIEFVM41L, D67N, T69D, L210W, T215YK103N, M230LV35L, T39S, E44D, K64H, V118I, D123E, I178M, T200A, V245EB
Rhee (2005)CA1579CA11981AY801041DDC, AZT, 3TC, D4T, DDIDLV, NVPM41L, M184V, L210W, T215YM230L, K238KNK20R, K122E, E138G, D177E, I178L, R211K, H221HY, V245M, K281KE, I293V, V317A, I329V, Q334L, G359S, A371V, I375IV, A376S, T386I, K390KR, A400T, T403M, A446S, V467I, L491S, S519N, A554STB
  CA24547AY801042DDC, AZT, 3TC, D4T, DDIDLV, NVPM41L, L210W, T215YF227L, M230LK20R, K122E, E138G, D177E, I178L, R211K, H221Y, V245M, I293VB
  CA48132AY801043DDC, AZT, 3TC, D4T, DDI, ABC, TDFDLV, NVPM41L, L74LV, M184V, L210W, T215YF227L, M230LK20R, K43KE, S48SL, K122E, I135IV, E138G, D177E, I178L, R211K, H221C, L228R, V245MB
 CA1590CA42642AY801053DDC, AZT, D4T, 3TC, DDI, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219NY181C, M230LE44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, D237DE, A272P, K275KRB
 CA2100CA9235AY801131AZT, DDC, D4T, 3TC, UnknownDLV, UnknownM41L, D67G, L74I, M184V, T215Y, K219KNL100I, V179D, M230LV35I, K103R, K122E, I202V, R211K, T240K, V276VI, I329V, Q334E, A371V, K390R, K395R, E399D, A400S, S468PB
 CA5349CA23671AY801554AZT, Unknown, D4T, 3TC, ABCUnknown, EFVD67N, K70R, L74I, M184V, T215I, K219QK103N, M230LK20R, A98S, Q197E, Q207E, R211K, F214L, V245K, D250E, T286A, I293V, D324E, I329L, M357V, T369I, A376C, K390R, T403I, E404D, V435I, E449D, L452S, K512RB
 CA7115CA23768AY801789Unknown, 3TCUnknown, EFVM41L, L74V, M184V, L210W, T215FV108I, G190A, F227L, M230LK43N, K49R, V60I, R83K, V90I, V118I, S162D, K166R, T200A, A272P, E297KR, Q334H, G335S, G359S, A371IV, A376AT, V381I, T386TS, A400T, T403M, D460N, Q487E, L491S, S519N, K530KRB
 CA14290CA34497AY802290D4T, 3TCNVPM184IVK103N, M230LE6D, L109LS, D123E, I135T, S162A, T200I, E204Q, Q207E, F214L, I244V, I293VB
  CA41373AY802291D4T, 3TC, TDFNVPK65R, K70T, M184VK103N, F227L, M230LE6D, S68G, D123DE, I135T, S162A, I178IM, T200I, E204Q, Q207E, F214L, L228HR, I244V, I293VB
 CA14363CA34608AY802317AZT, 3TCEFVM184VK103N, P225H, M230LV35VI, P119PA, E138EG, S162C, I178M, T200A, V245E, A272P, K277R, K281RB
 CA16248CA38645AY802465TDF, AZT, 3TCEFVM184VK103N, M230LE6EG, V60I, R83K, V90I, T165L, T200A, F214L, K277R, L283I, R284K, V292I, I293V, E297EKB
 CA17677CA41597AY802540AZT, DDI, ABC, TDF, 3TCDLV, EFVD67N, K70R, L74I, M184V, T215F, K219QA98AG, K103N, V108VI, M230LE169D, T200A, Q207E, R211K, D218E, D237DEB
Baxter (2006)12-18031803-30515DQ879780NRTINNRTIM41L, D67N, K70R, L74V, V75T, L210LW, T215F, K219EL100I, K103N, M230LT39A, K102R, P140PT, I142T, E169D, V179VI, G196GE, T200A, I202V, D218DE, L228H, Q242QHB
 12-13831383-30507DQ879454NRTINNRTIM41L, D67N, K70S, L74V, M184V, L210W, T215Y, K219QV179D, M230LT39A, E40F, K43E, K103R, K104KR, V111I, D123E, S162SA, I167V, G196E, Q207E, H208HY, R211K, V245MB
 12-11071107-30617DQ879220NRTINNRTIM41L, V75M, M184V, L210W, T215FK103N, M230LK43E, D123E, I135T, N137H, S162C, K166R, D177E, G196E, T200A, E204Q, Q207E, R211K, L228RB
 12-11701170-30305DQ879282NRTINNRTIM41L, L74V, M184V, L210W, T215YK103N, V108I, M230LE44D, S68G, K122P, I135V, K166R, D177E, T200TA, R211K, V245AB
 12-21492149-30813DQ880056NRTINNRTIM41L, D67G, L74V, M184V, L210W, T215Y, K219NK101E, Y181C, G190A, M230LE44D, K64Y, S68ST, A98S, V118I, K122E, E138A, Q174HN, H208Y, R211K, W212M, D218E, L228LHB
 48-31053105-30418DQ878011NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103N, F227L, M230LK43E, E44A, V60I, K64R, V111I, V118I, K122P, I135L, D177E, I178L, H208Y, K238S, V245E, K277R, Q278H, T286A, I293V, E297K, A355AT, M357MT, S379G, T386I, K390RB
 48-61836183-30721DQ878755NRTINNRTIT69DN, T215YK103N, M230LK102Q, E138A, I202IV, Q207A, R211K, F214L, A272S, L283I, I293V, R356K, G359GS, A371V, A376S, S379G, T386I, K390R, A400ATB
 48-62726272-30910DQ878825NRTINNRTIM41L, A62V, V75I, L210W, T215Y, K219KN, N348NIK103N, M230L, L234I, Y318FV90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394LB
 48-90769076-30902DQ880702NRTINNRTIM41L, D67N, L74V, M184MV, L210W, T215Y, K219NK103N, M230L, L234IT39A, K43E, E44A, K64H, V106I, V111I, V118I, D121DH, K122E, S162D, G196E, T200A, H208HY, R211K, L228H, V245RB
Tee (2006)MYKL162004MYKL1620AY960896AZT, 3TCNVPM184V, T215YK103N, M230LV21G, T27P, V90I, S162C, T200A, R211KB
Riddler (2008)RG74133RG74133w19 NoneEFV M230L, K238TA62AP, D123E, D177E, V189I, R211K, V245Q, A272P, K281R, L283I, I293V, E297K, I329V, I341V, E370D, A371V, A376VB
 RG8559RG8559w17 NoneEFV K103N, M230LK20R, T39A, K46Q, S68G, T69N, D123E, I135T, E138A, S162C, D177E, G196E, R211G, A272P, K277R, V317A, S322T, M357T, I375V, V381IB
Rhee (2009)CA1590CA57674FJ983146DDC, AZT, D4T, 3TC, DDI, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219NK101KE, Y181C, M230LE44D, V60I, K66R, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, D237DE, A272P, T286PB
Dau (2010)06694A06694AGU581769NRTINNRTIM41L, L74V, M184V, T215YK103N, V108I, M230LT39A, K122E, S162C, E169D, Q174QR, D177E, I178M, Q207E, R211K, A272P, T286A, Q334IN, M357T, T377Q, T386IB
 08559A08559AGU581921NRTINNRTIM41L, L74V, M184V, L210W, T215YK103N, V108I, M230L, K238NV35E, T39A, K64R, K122KE, I135K, F160Y, H221HY, S251I, A272P, I293V, E297AITV, S322T, I329V, T377QB
Jones (2012)132615132615JN669513NRTINNRTIK70R, M184V, T215F, K219EK103N, M230L, L234I, Y318FV35T, K49R, V60I, T69N, R83K, K101Q, T139K, L228H, V245E, L283I, I293V, E297A, Q334L, R356K, M357L, G359S, A371V, A376T, T386A, K390RB
 134854134854JN669536NRTINNRTID67N, M184V, L210W, T215Y, K219QV179D, M230L, K238NV60I, A98S, K103R, I195T, R211K, A272P, T286A, V317A, I326V, I329V, G333E, Q334NB
 153844153844JN669807NRTINNRTIM184V, N348IK103N, P225PH, M230LS68G, K122E, P150PS, K166R, D177E, G196E, E203D, R206RS, R211K, V245M, K277R, Q278E, T286A, I293V, E297T, K311R, G333E, T377R, K388KR, E396DB
 160464160464JN669978NRTINNRTIM41L, D67N, T69D, L74V, L210W, T215YV106M, F227L, M230LV35I, T39K, K43E, E44D, D76DN, V118I, D121H, K122E, I135T, P140T, S162D, K166R, I178L, E203D, H208Y, R211K, W212C, H221Y, A272P, L283I, R284K, I293V, I326V, K350R, R356K, G359A, T386I, K390RB
 168874168874JN670186NRTINNRTID67N, M184V, T215Y, K219EK103N, V108I, M230L, K238TE44ED, V60VI, S68SG, V118VI, D123E, I135T, I178M, G196E, E203AG, Q207K, L210G, R211A, L228LH, V245M, E248D, A272P, K277KR, T286TN, I293V, E297K, A304E, Q334L, A360T, V365I, A376S, T386I, K390RB
 178450178450JN670485NRTINNRTIM184VK103N, M230LE6K, S48E, V90I, D177E, I178L, R211K, E224A, V245M, A272P, K277R, T286A, I293V, E297T, I326V, Q334E, M357R, I375V, I380L, V381I, T386I, K390RB
 178917178917JN670492NRTINNRTIM184V, T215FK103N, M230LV35VAIT, K101KQ, V106I, V118I, K122E, I132IL, I135T, K166R, K173N, Q174R, G196E, Q197K, T200I, I202V, R211K, A272P, I293V, Q334E, P345T, M357T, K366KR, T386I, E399EKB
 183421183421JN670646NRTINNRTIM184V, T215YK103N, M230LD121Y, K122E, I135T, S162C, T200E, E203D, R211K, A272P, K311R, I326V, G333E, T377I, K390R, E399EDB
 199317199317JN671162NRTINNRTIA62AV, V75VI, M184V, T215TFISK103N, M230LV35I, S48E, D123E, I135IT, D177E, T200A, R211K, V245M, A272P, Q334E, E344D, M357T, A360T, K390R, Q394LB
Melikian (2012)CA1467CA57664GQ210616AZT, 3TC, DDC, D4T, ABC, Unknown, TDFEFV, Unknown, NVPM41L, A62V, D67N, T69D, V75I, F116Y, Q151M, L210W, T215YK103N, V108I, M230LR83K, D123E, K166R, D177E, I202V, A272P, I293V, E297KB
 CA1590CA68617GQ212337DDC, AZT, D4T, 3TC, DDI, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219NK101E, Y181C, M230LE44D, V60I, K66R, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, A272P, T286TPB
 CA4825CA162236 AZT, 3TC, ABC, TDF, DDI, DDCNVP, ETRK65KR, L74LVK103N, Y181C, F227C, M230LK20R, V35I, K122E, T200A, R211K, V245Q, I293V, E297AB
 CA22088CA64070GQ211906D4T, 3TC, TDF, DDI, ABCNVP, EFVK65RK103N, Y181C, M230LV35VI, S68N, T69S, V90I, K101KR, V106I, D177E, V179VL, Q207KR, R211Q, H221Y, A272P, V292I, I293V, P294S, E297KB
Mollan (2012)MK22MK22w29 TDF, FTCEFVK65R, V75L, M184VK103N, M230LD123E, I142T, T165I, D177N, I202V, R211T, V245Q, A272P, V276I, K277R, T286A, E297KB
 MK239MK239w33 ABC, 3TCEFVK70E, V75IV179D, G190A, M230LK11R, I50V, R83K, V106I, V118I, D123E, A158S, S163C, T200A, F214L, A272S, K277R, K281R, A288S, I293V, E297KB
 MK2MK2w65 TDF, FTCEFVM184IK103N, M230L, L234LIV35I, T39E, D121Y, K122E, I135R, S162C, D177E, R211Q, Y232YH, T286AB