Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	M230L
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	25
Patients	64
Isolates	76

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_1817	1817		AZT, DDC	DLV	M41L, D67N, L210W, T215Y, K219N	K103N, M230L	K22R, V35VL, K43KN, E44D, K64KHNQ, W88C, V90VI, V118VI, I178L, T200A, E203ED, H208Y, R211K, H221HY, K277R, T286A, E297A, S322T, D324E, A376T, T386I, Q394L, D460N, R461K, L469I, H483L	B
	ACTG320_2759	2759		AZT	DLV	T215Y	K103N, M230L	V35I, R83K, K122E, I135T, S162C, E169D, I178L, R211K, A272P, K277R, I293V, Q334E, M357T, K366R, E404D, N447S, D460N, H483Q, D488X	B
Huang (2000)	Huang-Pt1	Huang-Pt1		NRTI, ABC	NVP	M41L, L74I, M184V, L210W, T215Y	Y181C, M230L	K102Q, S162C, R211K, L228R, K277R, I293V, T296S	B
	Huang-Pt2	Huang-Pt2		NRTI, AZT, 3TC	EFV	M184V	K103N, M230L	K49R, K122E, S162C, E169D, I178M, I195T, T200A, R211K, V245M, D250E, K275Q, V276I, T286A, I293V, P294T	B
	Huang-Pt3	Huang-Pt3		NRTI, ABC, D4T	EFV	D67N, L210W, T215Y	K101E, K103N, G190S, M230L, K238T	D86E, K102X, V118I, K122P, A158S, Q174X, D177E, R211K, F214L, H221Y	B
Parkin (2000)	SD-14	SD-14_8	AF294535	NRTI, 3TC, DDI, ABC	NVP	M41L, L74I, M184V, L210W, T215Y	Y181C, M230L	D177E, H208Y, R211K, L228R, T286A, T296S, E297K	B
		SD-14_16	AF294536	NRTI, 3TC, DDI, ABC	NVP	M41L, L74I, M184V, L210W, T215Y	Y181C, M230L	D177E, H208Y, R211K, L228R, T286A, T296S, E297K	B
Shulman (2000)	CA1433	CA10463	AY802663	AZT, DDC, D4T, DDI, ADV, 3TC	EFV	M41L, M184V, L210W, T215Y	K103N, M230L	A98S, V118I, D121Y, K122E, Q207E, R211K, I293V	B
Gonzales (2001)	CA2100	CA7750	AY030807	AZT, DDC, D4T, 3TC	DLV	M41L, D67G, L74I, M184V, T215Y	L100I, V179D, M230L	V35I, K103R, K122E, I202V, Q207QH, R211K, T240K	B
	CA4068	CA9336	AY031063	AZT, DDC, DDI, D4T, 3TC	NVP	M41L, D67N, K70R, L74V, V75M, M184V, L210W, T215Y, K219Q	K103T, M230L, K238T	T39A, V60I, L109M, V118I, K122E, I142V, L187M, E203K, Q207E, H208Y, R211K, D218E, L228H, K277R, T286A	B
	CA4408	CA10616	AY031264	AZT, DDI, DDC, D4T, 3TC, ABC	EFV	M41L, L210W, T215Y	K103N, M230L	T39A, S68G, K122E, I135T, D177E, Q207K, R211K, D237E, A288S, I293V	B
	CA6467	CA15984	AY032418	AZT, DDI, D4T, 3TC	NVP	D67N, T69D, K70R, T215I, K219Q	K103N, M230L	V35I, K122P, D123E, I135T, D177E, T200A, L228H, K277R, L283LI, T286TP, I293V, E297Q	B
	CA6807	CA16858	AY032540	AZT, DDI, 3TC, D4T	EFV	L210CW, T215Y, K219E	V179D, M230L	K13X, K22KN, V106L, V118I, D123E, I135T, S162C, Q174E, H208Y, R211K, K223Q, L228R, K281KR, I293V	B
Kempf (2001)	DK-3494	6338_d113		RTI, NRTI	RTI, NVP	M184V, T215Y	K103N, M230L	A98S, K122E, S134SN, D177E, Q207E, R211K, L228LH, D250E, A272P, I274V	B
		6338_d225		RTI, NRTI	RTI, NVP	M184V, T215Y	K103N, M230L	A98S, V118VI, K122E, D177E, Q207E, R211K, L228H, D250E, A272P, I274V	B
		6338_d336		RTI, NRTI	RTI, NVP	M41ML, M184V, T215Y	K103N, M230L	A98S, V118VI, K122E, D177E, Q207E, R211K, L228H, D250E, A272P, I274V	B
Margot (2002)	MM-233136578	2331365781		NRTI	NNRTI	M184V	V179D, M230L, K238T	K103KR, L109M, I142V, S162C, Q174H, T200A, Q207E, R211K, V245E, I274IV, V292I, E297RK, K311R, D324P, Q334Y, Y342F, R358K, A360T	B
	MM-225236676	2252366761		NRTI	NNRTI	D67T, K70R, T215F, K219E	K103N, Y181C, M230L, K238N	K20R, T69N, I135T, S162A, L228R, A288S, I293V, V317A, S322T, M357T, A360V	B
	MM-224836495	2248364951		NRTI	NNRTI	M41L, L74V, M184V, T215Y	K103N, P225H, M230L	V21I, V35M, T39A, K223KR, W229L, V245E, I293V, E297K, D324E, A360V, K366R, K390R	B
Gonzales (2003)	CA1433	CA14562	AY305959	AZT, DDC, D4T, DDI, ADV, 3TC, ABC	EFV	M41L, L74V, M184V, L210W, T215Y	K103N, V108I, M230L	A98S, V118VI, D121HY, K122E, Q207E, R211K, K277KR, I293V	B
Gonzales (2003)	CA1590	CA20013	AF514102	DDC, AZT, D4T, 3TC, DDI, ABC	NVP	M41L, D67N, T69D, L74V, L210W, T215Y, K219N	Y181C, M230L	E44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, A272P, A299AG	B
	CA4334	CA14487	AF514188	AZT, D4T, 3TC, DDI, ADV, ABC	DLV, EFV	M41L, D67DN, L74V, M184MV, L210W, T215Y, K219N	V179D, M230L	T39E, R83K, K103R, K122E, S162C, K173KR, I178IM, G196GE, E203D, H208HY, R211K, V245Q, T286A, V292I	B
Shafer (2003)	A384_0862	0862b	EF548483	AZT, 3TC	EFV	M184I	K103N, M230L	K122E, D123E, I178L, R211K, V245M	B
	A384_0485	0485c		D4T, DDI, 3TC, AZT	EFV	D67N, M184V	L100I, M230L	R211K, H221HFLY	B
		0485d	EF548919	D4T, DDI, 3TC, AZT	EFV	D67N, M184V	L100I, M230L	I37X, R211K, H221HFLY	B
	A384_0785	0785b	EF549041	D4T, DDI	EFV		K103N, M230L	K49R, V60I, R83K, D123E, V245K	B
Gomez-Carrillo (2004)	103118	103118	AY365666	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215C, K219N	K101E, G190A, M230L	V35I, T39A, K43N, E44D, K46R, K102R, V106I, V118I, K122E, I142T, K173S, Q174K, G196E, D237DE, A272P, T286A, A288P, E297A, K311R, I326V, G333D, K350KR, G359S, A371V	B
Gulick (2004)	RG114	RG114w136		AZT, 3TC	EFV	M184V	M230L	K103G, V106VI, I135T, P140PT, T200A, Q207E, R211K, H221Y, V245K	B
	RG343	RG343w68		ABC, AZT, 3TC	EFV	M184V	K103N, M230L	K49R, I135V, S162C, Q207E, R211G	B
Non-B Workgroup (2005)	TH_432	TH_432		D4T, DDI	EFV	M41L, D67N, T69D, L210W, T215Y	K103N, M230L	V35L, T39S, E44D, K64H, V118I, D123E, I178M, T200A, V245E	B
Rhee (2005)	CA1579	CA11981	AY801041	DDC, AZT, 3TC, D4T, DDI	DLV, NVP	M41L, M184V, L210W, T215Y	M230L, K238KN	K20R, K122E, E138G, D177E, I178L, R211K, H221HY, V245M, K281KE, I293V, V317A, I329V, Q334L, G359S, A371V, I375IV, A376S, T386I, K390KR, A400T, T403M, A446S, V467I, L491S, S519N, A554ST	B
		CA24547	AY801042	DDC, AZT, 3TC, D4T, DDI	DLV, NVP	M41L, L210W, T215Y	F227L, M230L	K20R, K122E, E138G, D177E, I178L, R211K, H221Y, V245M, I293V	B
		CA48132	AY801043	DDC, AZT, 3TC, D4T, DDI, ABC, TDF	DLV, NVP	M41L, L74LV, M184V, L210W, T215Y	F227L, M230L	K20R, K43KE, S48SL, K122E, I135IV, E138G, D177E, I178L, R211K, H221C, L228R, V245M	B
	CA1590	CA42642	AY801053	DDC, AZT, D4T, 3TC, DDI, ABC	NVP	M41L, D67N, T69D, L74V, L210W, T215Y, K219N	Y181C, M230L	E44D, V60I, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, D237DE, A272P, K275KR	B
	CA2100	CA9235	AY801131	AZT, DDC, D4T, 3TC, Unknown	DLV, Unknown	M41L, D67G, L74I, M184V, T215Y, K219KN	L100I, V179D, M230L	V35I, K103R, K122E, I202V, R211K, T240K, V276VI, I329V, Q334E, A371V, K390R, K395R, E399D, A400S, S468P	B
	CA5349	CA23671	AY801554	AZT, Unknown, D4T, 3TC, ABC	Unknown, EFV	D67N, K70R, L74I, M184V, T215I, K219Q	K103N, M230L	K20R, A98S, Q197E, Q207E, R211K, F214L, V245K, D250E, T286A, I293V, D324E, I329L, M357V, T369I, A376C, K390R, T403I, E404D, V435I, E449D, L452S, K512R	B
	CA7115	CA23768	AY801789	Unknown, 3TC	Unknown, EFV	M41L, L74V, M184V, L210W, T215F	V108I, G190A, F227L, M230L	K43N, K49R, V60I, R83K, V90I, V118I, S162D, K166R, T200A, A272P, E297KR, Q334H, G335S, G359S, A371IV, A376AT, V381I, T386TS, A400T, T403M, D460N, Q487E, L491S, S519N, K530KR	B
	CA14290	CA34497	AY802290	D4T, 3TC	NVP	M184IV	K103N, M230L	E6D, L109LS, D123E, I135T, S162A, T200I, E204Q, Q207E, F214L, I244V, I293V	B
		CA41373	AY802291	D4T, 3TC, TDF	NVP	K65R, K70T, M184V	K103N, F227L, M230L	E6D, S68G, D123DE, I135T, S162A, I178IM, T200I, E204Q, Q207E, F214L, L228HR, I244V, I293V	B
	CA14363	CA34608	AY802317	AZT, 3TC	EFV	M184V	K103N, P225H, M230L	V35VI, P119PA, E138EG, S162C, I178M, T200A, V245E, A272P, K277R, K281R	B
	CA16248	CA38645	AY802465	TDF, AZT, 3TC	EFV	M184V	K103N, M230L	E6EG, V60I, R83K, V90I, T165L, T200A, F214L, K277R, L283I, R284K, V292I, I293V, E297EK	B
	CA17677	CA41597	AY802540	AZT, DDI, ABC, TDF, 3TC	DLV, EFV	D67N, K70R, L74I, M184V, T215F, K219Q	A98AG, K103N, V108VI, M230L	E169D, T200A, Q207E, R211K, D218E, D237DE	B
Baxter (2006)	12-1803	1803-30515	DQ879780	NRTI	NNRTI	M41L, D67N, K70R, L74V, V75T, L210LW, T215F, K219E	L100I, K103N, M230L	T39A, K102R, P140PT, I142T, E169D, V179VI, G196GE, T200A, I202V, D218DE, L228H, Q242QH	B
	12-1383	1383-30507	DQ879454	NRTI	NNRTI	M41L, D67N, K70S, L74V, M184V, L210W, T215Y, K219Q	V179D, M230L	T39A, E40F, K43E, K103R, K104KR, V111I, D123E, S162SA, I167V, G196E, Q207E, H208HY, R211K, V245M	B
	12-1107	1107-30617	DQ879220	NRTI	NNRTI	M41L, V75M, M184V, L210W, T215F	K103N, M230L	K43E, D123E, I135T, N137H, S162C, K166R, D177E, G196E, T200A, E204Q, Q207E, R211K, L228R	B
	12-1170	1170-30305	DQ879282	NRTI	NNRTI	M41L, L74V, M184V, L210W, T215Y	K103N, V108I, M230L	E44D, S68G, K122P, I135V, K166R, D177E, T200TA, R211K, V245A	B
	12-2149	2149-30813	DQ880056	NRTI	NNRTI	M41L, D67G, L74V, M184V, L210W, T215Y, K219N	K101E, Y181C, G190A, M230L	E44D, K64Y, S68ST, A98S, V118I, K122E, E138A, Q174HN, H208Y, R211K, W212M, D218E, L228LH	B
	48-3105	3105-30418	DQ878011	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219N	K103N, F227L, M230L	K43E, E44A, V60I, K64R, V111I, V118I, K122P, I135L, D177E, I178L, H208Y, K238S, V245E, K277R, Q278H, T286A, I293V, E297K, A355AT, M357MT, S379G, T386I, K390R	B
	48-6183	6183-30721	DQ878755	NRTI	NNRTI	T69DN, T215Y	K103N, M230L	K102Q, E138A, I202IV, Q207A, R211K, F214L, A272S, L283I, I293V, R356K, G359GS, A371V, A376S, S379G, T386I, K390R, A400AT	B
	48-6272	6272-30910	DQ878825	NRTI	NNRTI	M41L, A62V, V75I, L210W, T215Y, K219KN, N348NI	K103N, M230L, L234I, Y318F	V90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394L	B
	48-9076	9076-30902	DQ880702	NRTI	NNRTI	M41L, D67N, L74V, M184MV, L210W, T215Y, K219N	K103N, M230L, L234I	T39A, K43E, E44A, K64H, V106I, V111I, V118I, D121DH, K122E, S162D, G196E, T200A, H208HY, R211K, L228H, V245R	B
Tee (2006)	MYKL1620	04MYKL1620	AY960896	AZT, 3TC	NVP	M184V, T215Y	K103N, M230L	V21G, T27P, V90I, S162C, T200A, R211K	B
Riddler (2008)	RG74133	RG74133w19		None	EFV		M230L, K238T	A62AP, D123E, D177E, V189I, R211K, V245Q, A272P, K281R, L283I, I293V, E297K, I329V, I341V, E370D, A371V, A376V	B
	RG8559	RG8559w17		None	EFV		K103N, M230L	K20R, T39A, K46Q, S68G, T69N, D123E, I135T, E138A, S162C, D177E, G196E, R211G, A272P, K277R, V317A, S322T, M357T, I375V, V381I	B
Rhee (2009)	CA1590	CA57674	FJ983146	DDC, AZT, D4T, 3TC, DDI, ABC	NVP	M41L, D67N, T69D, L74V, L210W, T215Y, K219N	K101KE, Y181C, M230L	E44D, V60I, K66R, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, D237DE, A272P, T286P	B
Dau (2010)	06694A	06694A	GU581769	NRTI	NNRTI	M41L, L74V, M184V, T215Y	K103N, V108I, M230L	T39A, K122E, S162C, E169D, Q174QR, D177E, I178M, Q207E, R211K, A272P, T286A, Q334IN, M357T, T377Q, T386I	B
	08559A	08559A	GU581921	NRTI	NNRTI	M41L, L74V, M184V, L210W, T215Y	K103N, V108I, M230L, K238N	V35E, T39A, K64R, K122KE, I135K, F160Y, H221HY, S251I, A272P, I293V, E297AITV, S322T, I329V, T377Q	B
Dvali (2012)	R143	R143	FJ426625	AZT, 3TC	EFV	M184V, T215Y	K103N, M230L	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, V60VI, K102Q, D123E, I135T, R211S	B
Fourati (2012)	10120884	10120884	JQ395816	NRTI	NNRTI		M230L	K49R, R83K, D123E, E169D, D177E, D192N, G196E, Q207E, R211K, K223M	B
Jones (2012)	132615	132615	JN669513	NRTI	NNRTI	K70R, M184V, T215F, K219E	K103N, M230L, L234I, Y318F	V35T, K49R, V60I, T69N, R83K, K101Q, T139K, L228H, V245E, L283I, I293V, E297A, Q334L, R356K, M357L, G359S, A371V, A376T, T386A, K390R	B
	134854	134854	JN669536	NRTI	NNRTI	D67N, M184V, L210W, T215Y, K219Q	V179D, M230L, K238N	V60I, A98S, K103R, I195T, R211K, A272P, T286A, V317A, I326V, I329V, G333E, Q334N	B
	153844	153844	JN669807	NRTI	NNRTI	M184V, N348I	K103N, P225PH, M230L	S68G, K122E, P150PS, K166R, D177E, G196E, E203D, R206RS, R211K, V245M, K277R, Q278E, T286A, I293V, E297T, K311R, G333E, T377R, K388KR, E396D	B
	160464	160464	JN669978	NRTI	NNRTI	M41L, D67N, T69D, L74V, L210W, T215Y	V106M, F227L, M230L	V35I, T39K, K43E, E44D, D76DN, V118I, D121H, K122E, I135T, P140T, S162D, K166R, I178L, E203D, H208Y, R211K, W212C, H221Y, A272P, L283I, R284K, I293V, I326V, K350R, R356K, G359A, T386I, K390R	B
	168874	168874	JN670186	NRTI	NNRTI	D67N, M184V, T215Y, K219E	K103N, V108I, M230L, K238T	E44ED, V60VI, S68SG, V118VI, D123E, I135T, I178M, G196E, E203AG, Q207K, L210G, R211A, L228LH, V245M, E248D, A272P, K277KR, T286TN, I293V, E297K, A304E, Q334L, A360T, V365I, A376S, T386I, K390R	B
	178450	178450	JN670485	NRTI	NNRTI	M184V	K103N, M230L	E6K, S48E, V90I, D177E, I178L, R211K, E224A, V245M, A272P, K277R, T286A, I293V, E297T, I326V, Q334E, M357R, I375V, I380L, V381I, T386I, K390R	B
	178917	178917	JN670492	NRTI	NNRTI	M184V, T215F	K103N, M230L	V35VAIT, K101KQ, V106I, V118I, K122E, I132IL, I135T, K166R, K173N, Q174R, G196E, Q197K, T200I, I202V, R211K, A272P, I293V, Q334E, P345T, M357T, K366KR, T386I, E399EK	B
	183421	183421	JN670646	NRTI	NNRTI	M184V, T215Y	K103N, M230L	D121Y, K122E, I135T, S162C, T200E, E203D, R211K, A272P, K311R, I326V, G333E, T377I, K390R, E399ED	B
	199317	199317	JN671162	NRTI	NNRTI	A62AV, V75VI, M184V, T215TFIS	K103N, M230L	V35I, S48E, D123E, I135IT, D177E, T200A, R211K, V245M, A272P, Q334E, E344D, M357T, A360T, K390R, Q394L	B
Melikian (2012)	CA1467	CA57664	GQ210616	AZT, 3TC, DDC, D4T, ABC, Unknown, TDF	EFV, Unknown, NVP	M41L, A62V, D67N, T69D, V75I, F116Y, Q151M, L210W, T215Y	K103N, V108I, M230L	R83K, D123E, K166R, D177E, I202V, A272P, I293V, E297K	B
	CA1590	CA68617	GQ212337	DDC, AZT, D4T, 3TC, DDI, ABC	NVP	M41L, D67N, T69D, L74V, L210W, T215Y, K219N	K101E, Y181C, M230L	E44D, V60I, K66R, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, A272P, T286TP	B
	CA4825	CA162236		AZT, 3TC, ABC, TDF, DDI, DDC	NVP, ETR	K65KR, L74LV	K103N, Y181C, F227C, M230L	K20R, V35I, K122E, T200A, R211K, V245Q, I293V, E297A	B
	CA22088	CA64070	GQ211906	D4T, 3TC, TDF, DDI, ABC	NVP, EFV	K65R	K103N, Y181C, M230L	V35VI, S68N, T69S, V90I, K101KR, V106I, D177E, V179VL, Q207KR, R211Q, H221Y, A272P, V292I, I293V, P294S, E297K	B
Mollan (2012)	MK22	MK22w29		TDF, FTC	EFV	K65R, V75L, M184V	K103N, M230L	D123E, I142T, T165I, D177N, I202V, R211T, V245Q, A272P, V276I, K277R, T286A, E297K	B
	MK239	MK239w33		ABC, 3TC	EFV	K70E, V75I	V179D, G190A, M230L	K11R, I50V, R83K, V106I, V118I, D123E, A158S, S163C, T200A, F214L, A272S, K277R, K281R, A288S, I293V, E297K	B
	MK2	MK2w65		TDF, FTC	EFV	M184I	K103N, M230L, L234LI	V35I, T39E, D121Y, K122E, I135R, S162C, D177E, R211Q, Y232YH, T286A	B
Porter (2014)	STaR6	STaR6_WK40		TDF, FTC	RPV	D67G, M184I, K219E	K101E, Y181C, M230L	V35I, A98S, K122E, D123G, T200A, V245E, K277R, I293V, P294A, E297K	B

Reverse Transcriptase Inhibitors

Database

Resources

Team