<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation Y181V
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 53
Isolates 56
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_12131213 AZT, DDINVPM41L, L74V, L210W, T215YA98G, Y181VV35M, T39A, K43E, E44A, R83K, K102Q, V118I, D123E, I195L, G196GE, E203K, H208HY, R211K, K223E, L228H, A272P, T286A, E297K, D324E, Q334L, G335S, R356RK, G359S, K366R, A371V, A376T, K390R, A400T, V435I, K451R, V458I, R461RKB
Dumans (2004)233233AY390129AZT, DDI, 3TC, D4TNVP, EFVM41L, D67N, L74V, M184V, L210W, T215YA98G, K101E, V108I, Y181V, G190AK43Q, E44D, V118I, D123E, I135T, E203K, Q207E, H208Y, R211K, K223QB
Gomez-Carrillo (2004)115855115855AY365925NRTINNRTID67N, T69D, K70R, F116Y, Q151M, T215V, K219Q, N348IK101E, V108I, Y181V, G190AV35T, T39TA, V60VI, W88C, K122E, I167V, L210F, D237N, V245K, A272P, T286A, E291ED, E297KR, I329L, T386I, Q394L, E399D, A400TB
 119804119804AY365974NRTINNRTID67N, K70R, Q151M, T215F, K219E, N348IV108I, Y181VK20R, V35T, V60I, T69N, K102Q, L109I, D123E, I135V, S162W, D218E, L228H, A272P, E297Q, M357T, A376T, Q394L, E399D, A400TB
Rhee (2005)CA1455CA7736AY800960AZT, DDI, D4T, DDC, ABCNVP, EFVM41L, D67G, K70R, L74V, T215Y, K219EK101E, Y181V, G190AE28A, V60I, S68G, K122E, I135T, I178MB
  CA17361AY800961AZT, DDI, D4T, DDC, ABCNVP, EFVM41L, D67G, K70R, L74V, M184V, L210W, T215Y, K219EK101E, Y181V, G190AE28A, V60I, S68G, K103KR, V106I, L109I, V118I, K122E, I135T, I178M, D218E, Q242K, A299AGB
 SWC-39273927-1960 AZT, NRTI, 3TC, D4TNVPM41L, M184V, L210W, T215Y, K219NY181VK32K*EQ, E44D, V118I, D123E, I135T, V179I, E203K, Q207E, H208Y, R211K, K223Q, L228R, Q269QH, A272PB
 CA5735CA24332AY801606AZT, D4T, 3TCNVPK70R, T215FK101E, Y181VT27S, E28K, K32E, V60I, T69N, R83K, V179I, T200A, Q207D, L228R, V245E, T286A, E297KB
  CA34844AY801607AZT, D4T, 3TCNVPM41ML, T69DN, K70KR, M184V, T215FK101E, Y181VK20KR, T27S, E28K, K32E, V60I, R83K, V179I, T200A, Q207D, L228R, V245E, T286A, E297KB
 CA7074CA17408AY801756D4T, 3TC, AZT, DDINVPM41L, L210W, T215YY181VT39A, S68G, I135T, K166R, T200A, R211K, Q278H, T286A, A288S, I293V, E297KB
 CA14547CA34914AY802377AZT, DDC, 3TC, D4T, DDI, ABC, TDFNVP, EFVM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219RA98G, K101E, V108I, Y181V, G190AT39A, E44D, V106I, V118I, I159L, V179I, E203K, H208Y, R211D, K223Q, A272P, K277R, I293V, E297K, I329V, M357MT, V365I, A400T, W410WC, V435A, T450S, L452V, D460N, R461K, S468T, Q509QH, Q524E, A554SB
  CA38275AY802378AZT, DDC, 3TC, D4T, DDI, ABC, TDFNVP, EFVM41L, D67N, T69D, L74V, M184MV, L210W, T215Y, K219RA98G, K101E, V108I, Y181V, G190AT39A, E44D, V106I, V118I, I159L, V179IM, E203K, H208Y, R211D, K223Q, A272P, K277R, I293V, E297KB
Baxter (2006)12-14281428-30313DQ879488NRTINNRTID67N, K70R, T215I, K219EY181VK65KE, T69N, K122E, S162A, Q207E, R211K, L228HR, P243S, V245EB
 12-20832083-30609DQ880004NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219NK101E, Y181VT39A, E40V, K43E, V118I, K122P, S162C, S163G, I178IM, V179I, R211K, D218EB
 12-20482048-30819DQ879977NRTINNRTIK65KR, L74LV, T215TNSYY181VS68SN, K122E, D123E, I135T, S162C, Q174K, T200I, R211K, F214FL, E224EDB
 12-21502150-30818DQ880057NRTINNRTIM41L, D67*EKQ, T69G, K70R, L74V, M184V, L210W, T215FY, K219EV108I, Y181VT39A, E40D, V60I, K66X, K102E, V118VI, K122E, I135T, T139TA, S162CY, V179I, T200TA, D218E, H221HY, L228H, Q242HB
 12-22232223-30805DQ880112NRTINNRTIM41L, D67G, K70R, L74I, V75M, M184V, T215F, K219QK101E, V106M, Y181V, G190AK64R, T69N, V118I, K122E, I135V, T139A, Q174N, I202IV, F214L, L228H, Q242E, V245KB
 12-17931793-30609DQ879776NRTINNRTID67N, K70KR, L74I, M184V, T215F, K219QY181VK101Q, S162SC, E169D, Q174N, R211S, L228HB
 12-17381738-30617DQ879728NRTINNRTIM41L, D67N, T69D, V75M, M184V, L210W, T215F, K219QV108I, Y181VT39E, E44D, V60I, A98S, V111VL, V118I, K122E, I132IK, I142V, S162D, E169K, K173E, V179I, I195IL, G196E, T200A, E203V, Q207E, R211K, D218E, F227FY, L228K, V245EB
 48-11111111-30630DQ880552NRTINNRTIM41L, A62V, K65KR, D67N, K70KR, V75I, F116Y, Q151M, T215F, K219QY181VG112GA, K122E, S162A, P170L, D177E, T200TI, I202IV, R211RS, D218E, L228HB
 48-11031103-30708DQ880545NRTINNRTID67NY, K70R, Q151M, T215F, K219EK103N, V108I, Y181VV60I, T69N, W88S, K101Q, K102Q, L109I, D123E, I135V, S162W, I202V, F214FL, D218E, L228HB
 48-31533153-30416DQ878064NRTINNRTIM41L, D67N, T69D, L210W, T215Y, K219RV108VI, Y181VT39E, E44D, V60I, V118I, K122E, I135L, V179I, R211RQ, H221Y, V245T, K277R, Q278E, T286A, I293V, E297K, V317VA, I329V, Q334L, G335GS, G359S, A371V, A376S, T386I, Q394L, A400TB
 48-41244124-30318DQ878355NRTINNRTIM41L, D67N, M184V, T215Y, K219Q, N348IK103N, Y181V, Y188LM16V, V35M, T39A, V118VI, K122KE, I135V, G196E, E203A, L210LS, D218E, L228H, A272P, K277R, T286A, E297AT, S322T, Q334P, G335NS, R356K, K366R, A376T, E399EDB
 48-41294129-30318DQ878360NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219NY181VK43E, E44A, V118I, K122KE, N137H, I142V, K166R, V179I, T200M, E203K, Q207D, H208Y, R211K, K223E, L228LH, A272P, K277R, K281R, I293IV, E297K, S322T, I326V, G333E, Q334N, G335C, M357V, G359S, V365I, A371V, A400TB
 48-60446044-30507DQ878643NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219NY181VV35M, T39A, E40F, K43E, T69N, K122E, T200A, V245Q, T286A, A288S, E297A, Q334L, A371V, A376V, E399D, A400TB
 48-71667166-30611DQ879003NRTINNRTIM41L, D67N, T69D, M184V, L210W, T215Y, K219NY181VP4S, K20R, T39TA, K43E, E44A, V118I, K122KE, D123DE, I135IV, I178M, V179I, H208HY, R211K, L228H, A272P, K277R, I293V, Q334E, M357T, A376T, T386A, A400TB
 48-90279027-30825DQ880666NRTINNRTID67N, K70R, M184V, T215F, K219EY181V, G190ST69H, K102Q, K122E, D123E, I135T, S162C, V245KB
 48-90369036-30825DQ880674NRTINNRTIM41L, D67N, V75M, L210W, T215Y, K219NA98G, Y181V, G190A, F227LK43Q, E44D, K49R, V60I, V106VI, V111I, K122E, D123DE, I135IV, S162D, S163T, M164I, I167V, E169D, I178F, V179I, T200A, E203K, H208Y, R211K, K223EB
 48-92819281-30925DQ880872NRTINNRTIM41L, D67N, T69D, L74V, M184MV, L210W, T215Y, K219KRA98G, K101HQ, V108VI, Y181V, G190A, F227LK43E, E44A, V118I, K122E, D123DN, I135T, P140T, S162D, S163G, K166KR, V179VI, G196E, T200TIM, E203K, R211K, H221HY, K223Q, L228H, V245MB
Waleria-Aleixo (2008)08RJ06059908RJ060599FJ591759NRTINNRTIM41L, D67G, L74V, M184V, L210W, T215Y, K219NK103N, Y181V, G190AK20R, S68G, V106I, V118I, K122E, I135T, T165I, R172K, R211K, F214L, H221Y, A272P, K277R, E291D, I293V, E297AB
 RES295RES295FJ591989NRTINNRTIK65R, F116YY181VT27TI, T39TA, S68G, T84TI, D123E, I135T, R143RK, Q151W, S162C, G196GR, I202V, R211K, V245EB
 08RJ06052208RJ060522FJ591714NRTINNRTIM41L, L210W, T215YY181VV35VI, K43Q, E44D, V60VI, V118I, K122E, I135T, I178M, V179I, R211K, L228H, Q242H, A288S, I293VB
Dau (2010)07444A07444AGU581847NRTINNRTIM41L, D67N, T69D, K70R, L74V, T215F, K219W, N348IY181V, G190EK11KR, V35VI, T39TA, K101T, V118VI, K122E, E138A, S162CY, R172RK, H208HY, L210LS, L228H, V245MR, R284K, A288S, I293V, E298A, E312A, I326V, Q334E, M357T, V365VI, A376T, T386A, K390KRB
 07893A07893AGU581880NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NV179VD, Y181V, Y188LV35VI, K43KR, E44D, A98S, K101Q, K103KR, L109I, V118I, K122E, D123E, I135V, S162SN, K173KR, V189I, I202IV, H208Y, D218E, A272S, L283I, T286A, I293V, R356RK, R358K, G359S, A371V, I375IV, K390RB
Aulicino (2011)ARL908RABARL908RABFJ525820NRTINNRTIM41L, D67N, T69D, M184V, L210W, T215Y, K219NV108I, Y181VP4PAST, T27A, E28K, K32E, V35M, T39K, E40F, K43E, W88C, L109I, D123E, S162D, K166R, D177E, V179L, G196E, I202V, H208Y, R211KB
 ARM53NBEARM53NBEFJ525823NRTINNRTIM184VY181VK49R, K101Q, K122E, E169D, D177N, V179I, T200A, F214LB
 1015-O234HMN1015-O234HMNHQ158187NRTINNRTID67N, K70R, L74I, M184V, T215F, K219QY181VK20R, V35I, V60I, K101Q, D123E, F171Y, D177E, V189I, F214FLB
Jones (2012)151726151726JN669766NRTINNRTID67N, T69D, Y115F, F116Y, Q151M, M184V, T215V, K219Q, N348IK101E, V108VI, Y181V, G190AV35T, T39A, V60I, W88C, K122E, I167V, H208HP, L210F, L228H, D237N, V245K, A272P, T286A, E291D, E297R, I329L, T386I, Q394L, E399D, A400TB
 158342158342JN669913NRTINNRTIT69G_XG, T215YK101E, Y181V, G190SK20R, V35I, K64R, S68SC, K122E, I135L, E169D, Q197K, T200A, L228R, A272S, T286A, E297K, I326V, I329V, R356K, G359S, A371V, T386I, A400TB
 159357159357JN669951NRTINNRTIV75LK103N, V108I, Y181VK101Q, I135T, K173T, T200A, F214FL, H221Y, V245T, A272P, K277R, I293V, E297T, V314I, Q334L, R356K, A376T, T386I, K390RB
 165035165035JN670092NRTINNRTIM41L, M184V, L210W, T215YY181VK43HQ, K49R, E79E*, D177E, Q207E, R211K, A272P, V276I, K281R, L283I, I293V, E297K, E300ED, R356K, A376S, F389FV, K390R, Q394L, T397IB
 183117183117JN670638NRTINNRTIM184VY181VV35M, T39A, K49KR, R83K, K166R, K173KR, Q207G, R211K, A272P, P294T, E297Q, D324E, I329V, Q334D, A376S, T377TA, S379C, Q394L, E399D, A400TB
 183614183614JN670654NRTINNRTIM41L, D67N, L210W, T215YY181VV35T, T39A, K49R, V60I, R83K, D123E, I135V, D177E, I178L, Q197K, T200S, A272P, T286A, E297Q, R356K, A376S, K390R, Q394L, E399D, A400TB
 184478184478JN670679NRTINNRTIM41L, L74V, M184V, L210W, T215Y, N348IK103N, Y181VV35T, V60I, V118I, D123E, K166R, V179VI, T200A, R211K, D250E, A272P, K277R, K281KR, I293V, P294A, E297K, R356K, G359S, S379G, K390R, A400TB
 195201195201JN670970NRTINNRTIM41L, D67G, T69D, L210W, T215Y, K219RK103S, Y181VK20R, V35M, T39A, K43Q, E44D, S68T, V90I, V106I, V111I, V118I, K122KE, E138G, I159IL, S162SG, K166RS, I178IL, G196E, T200TA, E203V, Q207D, H208Y, R211K, W212M, D218E, K223PQ, L228H, A272P, K277R, T286A, V292I, I293V, E297R, D324E, I326V, Q334L, G335S, M357T, T386IV, K390RB
 198930198930JN671141NRTINNRTIM184V, T215CYY181VV35I, K43E, K64R, K101Q, K122Q, I135V, D177E, I178IV, V179I, G196E, Q197K, R211K, F214L, L228H, I293V, E297K, K311R, D324E, Q334E, G359SB
 201835201835JN671237NRTINNRTIV75LK103N, V108I, Y181VE79ED, K101Q, I135T, K173T, Q174QK, T200A, H221Y, V245T, A272P, K277R, I293V, E297AT, E312EG, V314I, Q334L, R356K, T386TI, K390RB
 204424204424JN671341NRTINNRTIM41L, L74V, M184V, L210LW, T215Y, N348IY181VV35T, K122E, K166R, G196E, R211RK, A272P, K277R, T286A, E297K, T369TA, I375V, Q394L, E399D, A400TB
Kouri (2012)CU1337-09CU1337-09JQ585293NRTINNRTIM41L, D67N, M184I, L210W, T215Y, K219RY181V, K238TE28A, T39A, K43E, E44D, V118I, D123E, S162H, D177E, V179I, T200I, D218E, K249Q, T286A, A288S, I293V, P294A, E297K, K311RB
Melikian (2012)CA22109CA51129GQ208431NRTI, ABC, TDF, DDINNRTI, NVPM41L, L74V, T215YY181VK20R, K32KQ, E53ED, P59PS, I135T, Q145QR, R211K, K249RB
Theys (2013)2830628306KC220569TDF, FTCNVPA62AV, K65R, M184VK101KE, Y181VS48T, K104Q, K122P, D123E, I135T, I142IV, I178M, R211SB
 5436954369KC221626NRTI, TDFNNRTID67N, K70R, M184V, T215F, K219QK103N, Y181VV60I, T69N, D123E, E138A, I142V, G196E, F214FL, D218E, L228HB
 2774427744KC220522NRTI, TDFNNRTIM41L, T215YA98G, Y181VE44ED, D86E, D123E, V179I, G196E, T200TA, E203DB
 2774127741KC220521NRTI, TDFNNRTID67N, K70R, M184V, T215F, K219QK103N, Y181VV60I, T69N, D123E, E138A, I142V, G196E, F214FL, D218E, L228HB
Theys (2013)60866086KY386679TDF, FTCNVPM184VY181VV21VI, V35I, V60I, V90VI, K122E, I135T, S162A, K173Q, P176Q, T200A, E203K, Q207E, V245Q, E248D, V292I, I293V, I326VB
Rhee (2017)222092222092KY373201TDF, 3TCNVPA62V, K65R, Y115F, M184VY181VV35T, T39K, V60I, D110DN, D121H, K122E, D177E, I178M, T200A, Q207A, R211S, V245Q, D250EB