Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	V179D
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	20
Patients	25
Isolates	29

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_3009	3009		AZT	None		V179D	D121H, K122E, I135L, S162C, T200TA, R211K, P243PT, V245Q, A272S, T286A, V292VI, I293IV, I329V, F346H, T386I, K390R, E399ED, A400T, V435VA, D460N, D488X	B
Pellegrin (1999)	IP-29	IP29-M6		D4T, DDI	None		V179D	I50IV, R83K, K122KE, S162C, E169D, D177DE, I178L, R211RK, P243X, E248EV	B
	IP-12	IP12-M6		D4T, DDI	None	V75AT	V179D	T39A, T69A, K73KQ, R83K, S162C, Y232C	B
Venturi (1999)	GV-8	Vent8B	AF169056	AZT	None	K70R	V179D	D123E, I135T, R211K, F214L	B
		Vent8W24	AF169057	AZT, DDI	None	K70R, T215F, K219Q	V179D	S68X, K82X, V118X, R211K, F214L	B
Balotta (2000)	CB-192	CB-192	AF251989	DDC, AZT, D4T, 3TC, DDI	None	D67N, K70R, M184V, K219Q	V179D	E6D, K13KE, P14PT, K104N, D123E, I135T, S162N, E169D, G196E, T200E, E203K, Q207E, F214L	B
Coakley (2000)	EC26	EC26F		D4T, DDI	None	V75T	V179D	D123E, D177E, V245M, A272S, K277R, I293V, G333E, Q334H, T338S, M357I, T377L, A400T, T470N, K512I, E516K, V548I	B
Rousseau (2000)	MNR7	MNR4292	AJ405952	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67N, T69D, M184V, L210W, T215Y	V179D	K43Q, E44D, V111I, K122E, D123E, I142V, T165I, I178M, G196E, T200K, Q207A, R211K, A272P, V276I, L283I, A288T, V292I, I293V, T338S, R356K, A360T, T369A, A376I, T386M, K390R, K395R, E399D, T403M, W410V, V435I	B
	MNR12	MNR4575	AJ405957	AZT, DDI, 3TC, D4T	None	M41L, D67N, L210W, T215Y	V179D	P4S, E28K, K32E, E44D, K49R, D123E, I135T, I178M, T200K, E203D, R211K, A272P, V276I, L283I, V292I, I293V, R356K, A376V, T386I, K395R, E399D, T403L, W410V	B
Albrecht (2001)	ACTG364_4804	4804		AZT, DDI, 3TC	None	D67N, K70R, M184V, K219Q	V179D	K122E, D123N, T200E, E204Q, Q207D, R211K, F214L, V245K, K249Q, A272G, K277R, I293V	B
Eshleman (2001)	A100	AF357701	AF357701	AZT, DDI	None		V179D	K20R, V35I, K104R, D123E, T200A, Q207E, F214L, V245E, D250E, A272P, K277R, L283I, I293V, P313T	B
Gonzales (2001)	CA2321	CA8419	AY030865	AZT, 3TC, D4T	None	A62V, M184V	V179D	V35T, K103R, I135T, Q174E, R211K, T215X, K259KR, N265NT, A272S	B
	CA4828	CA11743	AY031487	AZT, 3TC	None	M184V	V179D	E6EA, T27TA, I31L, V90I, K103R, T200I, R211K, F214L, L228H, V245K, I293V	B
	CA5155	CA12450	AY031721	AZT, DDI, 3TC	None	M184V	V179D	V60I, R72RG, K103R, I142V, A158S, F214L, V245K, A272S, K277R, I293V	B
	CA5242	CA12837	AY031799	AZT, 3TC, D4T, DDI	None	M184MV, N348I	V179D	V118I, K122E, I135T, I142IV, T200A, F214L, K277R, I293V, A299AG, I326T, R356K, T386I, K431KR, E432ED, R463RK, V466VA, T477TA, Q480QH, E492A, K527N, A554S, I556IV, K558KR	B
	CA5307	CA13016	AY031863	D4T, 3TC	None		V179D	V35I, K73KI, R83K, V90I, D123E, I132IM, I135IV, E138EV, K166R, P176PT, Q197E, R211K, A272S, T286A, A304G	B
Papa (2002)	AP-35	AP-35	AF315778	DDC, AZT	None	K219Q	V179D	I135T, I202V, R211K, F214L, L228R	B
Gonzales (2003)	CA5242	CA23663	AY305921	AZT, 3TC, D4T, DDI	None	F116Y, Q151M, N348I	V179D	V35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554S	B
Roge (2003)	ea1	ea1-F	AY222051	ABC, D4T, DDI	None	K65R, K219R	V179D	S68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214L	B
Gulick (2004)	RG218	RG218w32		ABC, AZT, 3TC, D4T	None	M184V	V179D	K43Q, K102E, K104KR, G196E, F214L	B
	RG301	RG301w102		ABC, AZT, 3TC, TDF	None		V179D	S48T, K49R, V60I, K122P, Q207E, R211K, V245Q	B
Gallant (2005)	JEG32	JEG32_w12	DQ199605	ABC, TDF, 3TC	None	M184V	V179D	T39A, R83RK, V106VI, K122E, I135V, S162C, G196GE, T200A, R211G, E248D, A272P, A288S, E297K	B
Mo (2005)	8265	8265_d1		NRTI	None	M184V	V179D	E28EK, D123E, I135IM, K166R, T200I, I202V, R211K, A272P, Q278E, L283I, E298A	B
Non-B Workgroup (2005)	TH_575	TH_575		AZT, DDI	None	M41L, D67N, T69D, K70R, T215F, K219Q	V179D	V35L, V60I, K102E, K122E, I135V, E138A, T139A, D177E, I202V, V245K	B
Rhee (2005)	CA4828	CA34731	AY801422	AZT, 3TC	None	M184V, T215F	V179D	I31L, S68SG, K103R, T200TI, R211K, F214L, V245K, I293V	B
	CA5242	CA16447	AY801521	AZT, 3TC, D4T, DDI	None	Q151M	V179D	V35I, V118I, K122E, I135T, I142V, T200A, F214L, K277R, I293X, L301LV	B
Rios (2007)	CH71	MR_CH71.1	EF193966	AZT, 3TC	None		V179D	L12X, V35I, T39A, E138A, G141A, R211A, F214L, V245T	B
Dumans (2009)	RENA101	RENA101	FJ405038	AZT, 3TC	None	M184V	V179D	S48T, E79D, K102R, K122E, T139M, F214L, P243S, V245K, A272P, K281R, T286A, E297K, D324E, Q334E	B
Rhee (2009)	CA7998	CA60854	FJ983258	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215F, K219E	E138K, V179D	K20R, V35VI, V60I, K64HN, K122P, I135V, I142V, R211A, V245K, A272P, K277R, L283I, I293V, G335S, Y339W, R356K	B

Reverse Transcriptase Inhibitors

Database

Resources

Team