<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V179D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 22
Patients 28
Isolates 32
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_30093009 AZTNone V179DD121H, K122E, I135L, S162C, T200TA, R211K, P243PT, V245Q, A272S, T286A, V292VI, I293IV, I329V, F346H, T386I, K390R, E399ED, A400T, V435VA, D460N, D488XB
Pellegrin (1999)IP-29IP29-M6 D4T, DDINone V179DI50IV, R83K, K122KE, S162C, E169D, D177DE, I178L, R211RK, P243X, E248EVB
 IP-12IP12-M6 D4T, DDINoneV75ATV179DT39A, T69A, K73KQ, R83K, S162C, Y232CB
Venturi (1999)GV-8Vent8BAF169056AZTNoneK70RV179DD123E, I135T, R211K, F214LB
  Vent8W24AF169057AZT, DDINoneK70R, T215F, K219QV179DS68X, K82X, V118X, R211K, F214LB
Balotta (2000)CB-192CB-192AF251989DDC, AZT, D4T, 3TC, DDINoneD67N, K70R, M184V, K219QV179DE6D, K13KE, P14PT, K104N, D123E, I135T, S162N, E169D, G196E, T200E, E203K, Q207E, F214LB
Coakley (2000)EC26EC26F D4T, DDINoneV75TV179DD123E, D177E, V245M, A272S, K277R, I293V, G333E, Q334H, T338S, M357I, T377L, A400T, T470N, K512I, E516K, V548IB
Rousseau (2000)MNR7MNR4292AJ405952AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, T69D, M184V, L210W, T215YV179DK43Q, E44D, V111I, K122E, D123E, I142V, T165I, I178M, G196E, T200K, Q207A, R211K, A272P, V276I, L283I, A288T, V292I, I293V, T338S, R356K, A360T, T369A, A376I, T386M, K390R, K395R, E399D, T403M, W410V, V435IB
 MNR12MNR4575AJ405957AZT, DDI, 3TC, D4TNoneM41L, D67N, L210W, T215YV179DP4S, E28K, K32E, E44D, K49R, D123E, I135T, I178M, T200K, E203D, R211K, A272P, V276I, L283I, V292I, I293V, R356K, A376V, T386I, K395R, E399D, T403L, W410VB
Albrecht (2001)ACTG364_48044804 AZT, DDI, 3TCNoneD67N, K70R, M184V, K219QV179DK122E, D123N, T200E, E204Q, Q207D, R211K, F214L, V245K, K249Q, A272G, K277R, I293VB
Eshleman (2001)A100AF357701AF357701AZT, DDINone V179DK20R, V35I, K104R, D123E, T200A, Q207E, F214L, V245E, D250E, A272P, K277R, L283I, I293V, P313TB
Gonzales (2001)CA2321CA8419AY030865AZT, 3TC, D4TNoneA62V, M184VV179DV35T, K103R, I135T, Q174E, R211K, T215X, K259KR, N265NT, A272SB
 CA4828CA11743AY031487AZT, 3TCNoneM184VV179DE6EA, T27TA, I31L, V90I, K103R, T200I, R211K, F214L, L228H, V245K, I293VB
 CA5155CA12450AY031721AZT, DDI, 3TCNoneM184VV179DV60I, R72RG, K103R, I142V, A158S, F214L, V245K, A272S, K277R, I293VB
 CA5242CA12837AY031799AZT, 3TC, D4T, DDINoneM184MV, N348IV179DV118I, K122E, I135T, I142IV, T200A, F214L, K277R, I293V, A299AG, I326T, R356K, T386I, K431KR, E432ED, R463RK, V466VA, T477TA, Q480QH, E492A, K527N, A554S, I556IV, K558KRB
 CA5307CA13016AY031863D4T, 3TCNone V179DV35I, K73KI, R83K, V90I, D123E, I132IM, I135IV, E138EV, K166R, P176PT, Q197E, R211K, A272S, T286A, A304GB
Papa (2002)AP-35AP-35AF315778DDC, AZTNoneK219QV179DI135T, I202V, R211K, F214L, L228RB
Gonzales (2003)CA5242CA23663AY305921AZT, 3TC, D4T, DDINoneF116Y, Q151M, N348IV179DV35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554SB
Roge (2003)ea1ea1-FAY222051ABC, D4T, DDINoneK65R, K219RV179DS68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214LB
Gulick (2004)RG218RG218w32 ABC, AZT, 3TC, D4TNoneM184VV179DK43Q, K102E, K104KR, G196E, F214LB
 RG301RG301w102 ABC, AZT, 3TC, TDFNone V179DS48T, K49R, V60I, K122P, Q207E, R211K, V245QB
Gallant (2005)JEG32JEG32_w12DQ199605ABC, TDF, 3TCNoneM184VV179DT39A, R83RK, V106VI, K122E, I135V, S162C, G196GE, T200A, R211G, E248D, A272P, A288S, E297KB
Mo (2005)82658265_d1 NRTINoneM184VV179DE28EK, D123E, I135IM, K166R, T200I, I202V, R211K, A272P, Q278E, L283I, E298AB
Non-B Workgroup (2005)TH_575TH_575 AZT, DDINoneM41L, D67N, T69D, K70R, T215F, K219QV179DV35L, V60I, K102E, K122E, I135V, E138A, T139A, D177E, I202V, V245KB
Rhee (2005)CA4828CA34731AY801422AZT, 3TCNoneM184V, T215FV179DI31L, S68SG, K103R, T200TI, R211K, F214L, V245K, I293VB
 CA5242CA16447AY801521AZT, 3TC, D4T, DDINoneQ151MV179DV35I, V118I, K122E, I135T, I142V, T200A, F214L, K277R, I293X, L301LVB
Rios (2007)CH71MR_CH71.1EF193966AZT, 3TCNone V179DL12X, V35I, T39A, E138A, G141A, R211A, F214L, V245TB
Dumans (2009)RENA101RENA101FJ405038AZT, 3TCNoneM184VV179DS48T, E79D, K102R, K122E, T139M, F214L, P243S, V245K, A272P, K281R, T286A, E297K, D324E, Q334EB
Rhee (2009)CA7998CA60854FJ983258ABC, AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EE138K, V179DK20R, V35VI, V60I, K64HN, K122P, I135V, I142V, R211A, V245K, A272P, K277R, L283I, I293V, G335S, Y339W, R356KB
El Annaz (2012)40014001.RTJN185294AZT, 3TCNoneM184VV179DM16V, K20Q, V21D, V35T, S48T, K122E, T139K, K166R, R206K, F214LB
Mollan (2012)MK192MK192w30 ABC, 3TCNone V179DK20R, V118I, K122E, I135T, R211RK, F214L, A272P, V276I, K277R, I293V, T296TAB
 MK21MK21w126 ABC, 3TCNone V179DK20R, V118I, K122E, I135R, R211K, F214LB