<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation E138Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 59
Isolates 75
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gonzales (2001)CA1287CA3159AY030507AZT, 3TCNVPM184VK103ND123E, I135L, E138Q, I142T, S156X, Q174E, L228LP, L234X, D250SB
 CA6353CA15839AY032312AZT, 3TCNVPM184VK103NE138Q, I142V, R211K, T286AB
 CA6602CA16456AY032508Unknown, ABCUnknown, EFVA62V, L74V, M184V, T215FYL100I, K103NK122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211K, L228H, I257L, Q269X, K277R, T286A, A288S, I293GV, T296S, E297RB
Gonzales (2003)CA3999CA9256AY030997AZT, DDC, DDI, 3TC, D4TDLVM41L, D67N, T69D, L210W, T215YK103NK43N, E44D, A98S, V118I, K122E, I135V, E138Q, S162C, G196E, E203K, Q207E, H208Y, R211KB
Gomez-Carrillo (2004)9706497064AY365540NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215YK103NT, Y181CK20R, E28K, K32E, E44D, V60I, K64R, T107TP, V118I, K122E, I135T, E138Q, G196Q, T200A, I202V, Q207E, E224D, K277R, T286A, T290TP, I293V, P294PT, E297K, E300A, E312ED, G359S, A371V, K390RB
Montes (2004)MB_patNAV02_NAV727AJ577961AZT, 3TCNVPM41L, M184V, T215YK103NV35L, I37L, K122E, I135T, E138Q, I142T, V179I, I180V, K220EB
Rhee (2005)CA2204CA20158AY801145AZT, DDI, D4T, 3TC, ABCNVPM41L, D67N, M184V, L210W, T215YK103KNK13N, V35M, K43Q, E44D, D86S, K101KQ, V118I, E138Q, S162D, G196E, R211K, Q278H, T286A, I293V, E297RB
  CA24294AY801146AZT, DDI, D4T, 3TC, ABCNVPM41L, D67N, L210W, T215YK103NK13N, V35M, K43Q, D86S, V118I, E138Q, S162D, G196E, R211K, Q278H, T286A, I293V, E297KB
  CA34577AY802693AZT, DDI, D4T, 3TC, ABC, TDFNVPM41L, D67N, M184V, L210W, T215Y, N348IK103NK13N, V35M, K43Q, E44D, D86N, V118I, Y127YC, E138Q, S162D, G196D, R211K, Q278H, T286A, I293V, E297R, K366R, S379G, K385KR, T386I, A400T, G436E, N447NS, D460N, V467I, L491S, S519ST, Q524E, A554TB
  CA38109AY801147AZT, DDI, D4T, 3TC, ABC, TDFNVP, EFVM41L, D67N, L74I, M184V, L210W, T215YK101P, K103N, G190AK13N, V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, H221Y, Q278H, T286A, I293V, E297RB
  CA48186AY801148AZT, DDI, D4T, 3TC, ABC, TDFNVP, EFVM41L, D67N, L74I, M184V, L210W, T215YK101P, K103N, G190AK13N, V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, H221DY, Q278H, T286A, I293V, E297RB
 SWC-3636P3636-1388 D4T, AZT, 3TCNVPM41L, D67N, M184V, L210W, T215YK103NT39A, V118I, I135T, E138Q, S162C, G196EB
 CA6602CA24264AY801687Unknown, ABC, TDFUnknown, EFVA62V, L74V, M184V, T215FL100I, K103ND86E, K122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211K, L228H, I257L, K277R, T286A, A288S, I293V, T296S, E297RB
  CA38093AY801688Unknown, ABC, TDFUnknown, EFVA62V, T215YK103NK122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211KB
  CA42706AY801689Unknown, ABC, TDFUnknown, EFVA62V, T215YK103NW88WS, K122E, I135IT, E138Q, S162C, E169D, I178L, T200A, R211K, L228R, I244IV, D250E, I257L, K277R, T286A, A288S, I293V, T296S, E297R, L301I, I329L, G333EB
 CA8028CA20151AY801912D4T, 3TC, DDINVPM41L, D67N, T215YK101E, G190AE6D, K43E, D123E, I135T, E138Q, D177E, V179I, T200I, I202V, I257LB
  CA34853AY801913D4T, 3TC, DDINVPM41L, D67N, T215YK101E, G190AE6D, K43E, E44D, V118I, D123E, I135T, E138Q, D177E, V179I, T200I, L210S, I257L, I293VB
 CA9878CA24369AY802160Unknown, D4TUnknown, DLVA62V, K70RK103NV35VI, T69N, E138Q, I142MB
 CA14672CA35106AY802404AZT, 3TC, D4T, DDIEFV, NVPM41L, M184V, L210W, T215YK103ND121H, I135T, E138Q, I142V, T200TA, R211K, A272AP, K277R, E297KB
Baxter (2006)12-12811281-30424DQ879378NRTINNRTIM41L, D67N, L210W, T215Y, K219RK103NT39A, V60I, T69TN, L120L*W, K122E, I135M, E138Q, Q174K, N175Y, V189VL, G196E, K201IV, R211K, V245VEB
 12-40044004-30128DQ880388NRTINNRTIM41L, A62V, D67DN, V75I, L210W, T215YK103NT39A, E44ED, S68SG, A98AS, K101Q, V118VI, K122E, D123S, E138Q, I142T, S162ST, R172RK, I178L, Q207E, R211KB
 12-18661866-30506DQ879823NRTINNRTIM41L, L74LI, M184V, L210W, T215Y, K219NK101P, G190GAE40F, K43E, S68G, K102R, L109I, K122E, E138Q, V179I, T200A, L228HQB
 12-13531353-30711DQ879429NRTINNRTIM41L, K65R, V75I, F77L, F116Y, Q151MV179D, G190AS68G, V90I, K103R, V106L, V118I, I135L, E138Q, T165I, R172K, F214LB
 12-13551355-30527DQ879431NRTINNRTIM41L, D67N, K70R, T215F, K219QV179DT39A, K64H, T69N, K103R, E138Q, S162C, G196E, T200A, E203K, Q207E, R211I, V245KB
 12-13871387-30521DQ879457NRTINNRTIM41L, D67N, K70R, M184V, T215V, K219QK103N, V179E, P225HV118I, L120*, K122E, D123DN, E138Q, T200A, Q207E, R211K, F214L, L228HB
 12-11991199-30225DQ879305NRTINNRTIA62V, T69S_SS, V75VL, M184V, T215YK103N, V108IK122E, D123N, I135T, E138Q, I159IK, K173R, Q207E, L210S, R211KB
 12-31113111-30515DQ880334NRTINNRTIM41L, A62V, D67E, T69T_QA, L210W, T215YY181CK43E, S68G, V118I, K122E, E138Q, R211N, E224D, L228HB
 12-17171717-30424DQ879708NRTINNRTIM41L, D67G, T69TADN, L74V, L210W, T215Y, K219RL100I, K103N, P225H, K238TK43Q, E44D, V118VI, K122E, I135T, E138Q, S162C, R172RK, T200TA, I202V, Q207QE, R211KB
 12-17681768-30522DQ879755NRTINNRTIK65R, K70R, V75M, F77L, Q151M, T215DK103N, V108IP52T, S68G, A98S, K122E, I135V, E138Q, A158S, S162A, R172K, G196E, H221YB
 48-10051005-30909DQ877744NRTINNRTIM41L, D67N, L74LI, M184V, L210W, T215Y, K219E, N348IV108I, Y181C, F227LV35I, T39S, E40FV, K43E, D86DE, K101Q, E138Q, G196E, H221Y, L228R, V292I, I293V, I326IV, R356K, K390RB
  1005-40615DQ877743NRTINNRTIM41L, D67N, L74LI, M184V, L210W, T215Y, K219E, N348IV108I, Y181C, F227LV35M, T39S, E40F, K43E, K101Q, E138Q, G196E, H221Y, L228R, V292I, I293V, I326IV, R356K, R358RK, K390RB
 48-30173017-30530DQ877927NRTINNRTIM41L, L74V, M184V, T215YK103N, Y181CK20R, K122E, I135V, E138Q, S162C, T200A, L228H, L283I, I293V, S322A, D324DE, G359S, A371VB
 48-31253125-30410DQ878033NRTINNRTIM41L, D67N, M184V, L210W, T215YK101KE, G190AK43N, V60I, V106I, V118I, D123E, I135V, E138Q, D177DE, V179I, G196E, R211K, I293V, V317A, Q334IL, M357MT, V365I, E370A, T386I, E399DB
 48-31453145-30429DQ878056NRTINNRTIM41L, D67N, M184V, L210W, T215YK101P, K103ST27S, V35T, K43N, V60I, V90I, V118I, K122E, D123N, I135T, E138Q, N175Y, T200K, K201I, R211K, A272AP, T286A, E297A, D324E, I329L, A360ATB
 48-40224022-30326DQ878256NRTINNRTIM41L, D67N, V75L, M184V, L210W, T215YK101E, G190AS3C, K43E, E44A, K122E, E138Q, I142V, S162C, I167V, I178L, H208F, R211K, D237E, V245K, T286TA, E297R, I326V, Q334E, R356K, R358K, S379C, K390RB
 48-42254225-30617DQ878460NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NK103NE44D, V118I, K122E, D123N, E138Q, D177N, V179I, I195L, G196E, Q207QH, H208Y, R211K, W212M, V245K, T286V, I293V, E297K, V317A, Q334L, M357T, A360V, T377LB
 48-60216021-30331DQ878620NRTINNRTIM41L, D67N, L74V, L210W, T215Y, K219RK101P, Y188L, Y318YFV35M, T39A, K43E, E44ED, V60VI, A98S, K102Q, K104KR, V118I, K122P, D123E, I135T, E138Q, R172K, Q207E, D218E, D250E, A272P, K277KR, Q278H, T286P, A288S, I293V, E297K, K311R, M357TB
 48-92709270-30918DQ880863NRTINNRTIM41L, D67N, K70KQ, V75M, M184V, L210W, T215YK103NT39TA, E40F, K43E, K122E, D123E, I135T, E138Q, S162C, I167V, I178L, G196E, Q207E, H208Y, R211K, D237EB
 48-80778077-30818DQ879087NRTINNRTIM41L, D67N, M184V, L210W, T215YK103N, Y318FE44D, A98S, D123E, I135IL, E138Q, K166R, D177E, I178IL, G196E, T200A, E203D, Q207K, R211A, A272P, I293V, I326V, I329V, G335S, K347Q, A371V, A376S, T386I, K390RB
Rosen-Zvi (2008)1701p17-3 AZT, 3TC, DDC, D4T, DDINVPD67S, L74V, L210W, T215YK103N, Y181CK20R, V35M, T69S, K122KE, I135M, E138Q, S162A, V179I, R211K, K277R, Q278E, T286A, E297KB
 6199p61-1 AZT, DDC, 3TC, D4TDLVM41L, D67N, L74V, M184V, T215YL100I, K103ND123E, E138Q, I142V, D177E, I178L, Q207E, L210S, I293V, P294Q, E297KB
  00p61-2 AZT, DDC, 3TC, D4T, DDIDLVD67N, T215YK103NT39A, K43E, E44D, V118I, D123E, E138Q, I142V, R172K, D177E, I178L, Q207E, L210S, I293V, P294Q, E297KB
  00p61-3 AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, M184V, T215YK103NT39A, K43E, E44D, V118I, D123E, E138Q, I142V, P170PT, D177E, I178L, E203ED, Q207E, L210S, C280CY, I293V, P294Q, E297KB
  01p61-4 AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, M184V, T215YK103NT39A, K43EG, E44D, V118VI, D123E, E138Q, I142V, D177E, I178L, Q207E, L210S, I293V, P294Q, E297KB
  02p61-5 AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, M184V, T215YK103NT27S, T39A, K43E, E44D, V60VI, D123E, E138Q, I142V, D177E, I178L, E203ED, Q207E, L210S, I293V, P294Q, E297KB
  07p61-6 AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, M184V, T215Y, K219RK103SK20R, T27S, E29K, T39A, K43E, E44D, V60I, V108VA, D123E, E138Q, I142V, D177E, I178L, V179I, E203D, Q207E, L210S, L228H, I293V, P294Q, E297KB
  07p61-7 AZT, DDC, 3TC, D4T, DDIDLVM41L, D67N, M184V, T215Y, K219RK103NSK20KR, T27S, T39A, K43E, E44D, V60I, V118I, K122KR, D123E, E138Q, I142V, D177E, I178L, V179I, Q207E, L210S, L228H, I293V, P294Q, E297KB
Cardoso (2009)3110BRGO3110FJ638450NRTINNRTIM184VY181CI31L, V35L, T39A, E44D, K102KR, V111I, K122E, D123N, I135T, E138Q, S162C, I178L, V179IB
Kagan (2009)33 NRTINNRTID67H, K70R, L74I, M184V, T215F, K219QK101P, K103TK43Q, V60I, T69N, K122E, I135T, E138Q, D177G, I178M, V179I, G196E, F214L, L228H, Q242L, V245E, A272T, K277R, I293V, Q334H, G335D, R356K, G359S, V365I, A376T, T386M, A400TB
Dau (2010)05604A05604AGU581677NRTINNRTI K103N, P225HK20R, V35I, E40D, E138Q, T200A, F214L, P243S, V245E, D250E, T286TA, V317A, M357T, A376T, T377I, Q394L, E399DB
 07105A07105AGU581817NRTINNRTIM184V V35T, V60I, R83K, D123E, I135V, E138Q, V179I, T200A, V245E, E248D, A272P, M357T, S379G, K385R, T386IB
 07319A07319AGU581838NRTINNRTIM41L, V75L, F77FL, L210W, T215YK103N, Y318FT39K, K43E, K122E, I135M, E138Q, Q174QK, T200A, Q207E, H208HY, R211RK, Q278H, A288S, I293V, E297A, D324DE, M357T, A360AV, T386I, K390RB
 08255A08255AGU581902NRTINNRTIM41ML, V75L, F77L, M184V, L210W, T215CYK103N, Y318FP4PS, V35VL, T39K, K43E, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, M357T, T386I, K390RB
 09065A09065AGU581957NRTINNRTIM41L, V75L, F77L, M184V, L210W, T215YK103N, Y318FV35VL, T39K, K43E, V118VI, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, D324DE, N348NT, M357T, T386I, K390RB
 09756A09756AGU581981NRTINNRTIM41L, V75L, F77L, M184V, L210W, T215Y, N348ITK103N, Y318FV35VL, T39K, K43E, V118I, K122E, I135M, E138Q, Q174QK, V179VI, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, E312EG, D324E, M357T, A360AV, T386I, K390RB
 11025A11025AGU582029NRTINNRTIM41L, D67N, V75LM, F77L, M184V, L210W, T215YK103N, Y318FV35L, T39K, E40F, K43E, V118I, K122E, I135M, E138Q, T200TAEK, Q207DE, R211K, Q278H, A288S, I293V, E297A, D324DE, N348T, M357T, T386I, K390RB
Jones (2012)142526142526JN669617NRTINNRTIM41L, M184V, L210W, T215Y, N348NIK103NI135M, E138Q, I178M, G196E, R211T, V245M, A272P, K277R, I293V, E297K, A304E, F346Y, A360V, E370EG, A376S, T386I, K390RB
 150599150599JN669751NRTINNRTIA62V, M184V, T215YK103NM16MI, K22K*NY, V90I, V111VG, D121H, K122E, I135T, E138Q, N147NK, S162A, Q174H, N175NH, I178M, G196E, T200A, Q207H, R211E, V245M, A272P, K277R, A288AT, I293V, E297V, Q334I, Y339YH, A360V, D364DG, A376S, T386I, K390R, E396EKB
 156893156893JN669876NRTINNRTIM41L, D67N, L74V, L210W, T215D, K219RL100I, K103NT39A, E44D, S48T, V60I, V118I, K122E, E138Q, I202V, Q207G, R211K, V245R, S251I, A272P, K277R, E291D, I329V, Q334Y, A376S, T386IB
 163140163140JN670054NRTINNRTIM41L, A62V, D67HN, K70R, V75T, M184V, L210LW, T215F, K219EA98AG, K103N, Y181CT69TN, D121H, K122E, E138Q, T200A, R211K, L228H, I293V, D324E, G359S, T369A, I375V, K390R, T397I, E399EKB
 173308173308JN670323NRTINNRTID67N, K70R, M184V, T215F, K219QK103ND123E, E138Q, S162C, T200I, R211K, D218E, V245M, A272P, K277R, E297K, Q334D, R356K, M357T, A360T, A371AV, I375V, A376S, T377RB
 182466182466JN670613NRTINNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219QL100LI, K103N, V108VI, K238NV8VI, K122E, E138Q, G196S, R211Q, D218E, S322T, I329L, M357T, A360V, A376S, K390R, A400SB
 190266190266JN670791NRTINNRTIM41L, V75VIM, M184V, T215FK103N, V108VIK43KE, E138Q, Q174K, D177G, G196E, T200TA, R211K, T286TA, V292I, I293V, E297AV, A304E, I326V, T369V, A376S, S379C, K388R, K390RB
 190411190411JN670797NRTINNRTIM41L, L210W, T215Y, N348IG190AV21VI, V35T, K43Q, F87FS, W88R, V118I, D123E, E138Q, K173D, Q174K, A272P, I293V, P294T, E297R, V317G, G359S, A360T, K366R, A376T, T377L, T386V, E399DB
Kouri (2012)CU881-10CU881-10JQ585418NRTINNRTID67G, K70R, M184V, K219QK103N, P225HS68G, A98S, K122E, I135IL, E138Q, S162CY, K173KT, D177E, G196GE, T200A, R211K, L228H, V245E, D250E, A272P, A288T, V292I, I293V, E297A, K311KR, I329VB
 CU329-10CU329-10JQ585384NRTINNRTIM184VK103N, K238PTV35VI, K43KQ, K122E, I135T, E138Q, S162C, D177E, T200A, R211K, V245Q, E248D, A272P, K277R, I293V, P294PS, E297ATB
 CU1492-10CU1492-10JQ585430NRTINNRTIM184VK103N, K238TV35I, K43Q, K122E, I135T, E138Q, S162C, D177E, T200A, R211K, V245Q, E248D, A272P, K277R, I293V, E297TB
 CU181-11CU181-11JQ585481NRTINNRTIA62AV, M184V, T215YK101E, Y181YC, G190AK122E, I135IT, E138Q, S162C, D177E, V179VL, Q197QK, R211K, V245Q, E248D, A272P, K277R, E297A, E312EGB
Melikian (2012)CA6602CA84188GQ213089Unknown, ABC, TDFUnknown, EFVA62V, K70N, T215Y V35I, A98S, K122E, D123DN, E138Q, S162C, E169D, I178L, T200A, I202IV, R211K, L228R, I257L, A272P, K277R, T286A, A288S, I293V, T296S, E297RB
Theys (2013)3342433424KC220896NRTI, TDFNNRTIM184V, T215CK103NK49R, V60I, R83K, E138Q, I142V, A158S, R211KB
 2551025510KC220355NRTI, TDFNNRTIM41L, L210W, T215YA98G, K101E, G190AK49R, E53D, K102N, K122E, E138Q, K166R, Q174H, V179I, R211KB
 2596425964KC220385NRTI, TDFNNRTI  E53D, R83RK, A98S, K101R, D123E, E138Q, K166R, V179I, T200A, R211KB
 2744827448KC220499NRTI, TDFNNRTIM41L, D67N, K70R, L210LW, T215F, K219QK101E, G190AE53ED, V60I, K122E, E138Q, K166R, K173N, V179I, R211K, D218DEB
 5311953119KC221570NRTI, TDFNNRTI K101E, G190AR83K, K122KR, E138Q, R211KB
 2451024510KC220263NRTI, TDFNNRTID67N, K70R, M184V, T215E, K219QK101E, Y181CT69S, V118I, K122E, E138Q, T139A, D177E, F214L, L228HB