Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	E138Q
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	11
Patients	52
Isolates	68

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Gonzales (2001)	CA1287	CA3159	AY030507	AZT, 3TC	NVP	M184V	K103N	D123E, I135L, E138Q, I142T, S156X, Q174E, L228LP, L234X, D250S	B
	CA6353	CA15839	AY032312	AZT, 3TC	NVP	M184V	K103N	E138Q, I142V, R211K, T286A	B
	CA6602	CA16456	AY032508	Unknown, ABC	Unknown, EFV	A62V, L74V, M184V, T215FY	L100I, K103N	K122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211K, L228H, I257L, Q269X, K277R, T286A, A288S, I293GV, T296S, E297R	B
Gonzales (2003)	CA3999	CA9256	AY030997	AZT, DDC, DDI, 3TC, D4T	DLV	M41L, D67N, T69D, L210W, T215Y	K103N	K43N, E44D, A98S, V118I, K122E, I135V, E138Q, S162C, G196E, E203K, Q207E, H208Y, R211K	B
Montes (2004)	MB_patNAV	02_NAV727	AJ577961	AZT, 3TC	NVP	M41L, M184V, T215Y	K103N	V35L, I37L, K122E, I135T, E138Q, I142T, V179I, I180V, K220E	B
Rhee (2005)	CA2204	CA20158	AY801145	AZT, DDI, D4T, 3TC, ABC	NVP	M41L, D67N, M184V, L210W, T215Y	K103KN	K13N, V35M, K43Q, E44D, D86S, K101KQ, V118I, E138Q, S162D, G196E, R211K, Q278H, T286A, I293V, E297R	B
		CA24294	AY801146	AZT, DDI, D4T, 3TC, ABC	NVP	M41L, D67N, L210W, T215Y	K103N	K13N, V35M, K43Q, D86S, V118I, E138Q, S162D, G196E, R211K, Q278H, T286A, I293V, E297K	B
		CA34577	AY802693	AZT, DDI, D4T, 3TC, ABC, TDF	NVP	M41L, D67N, M184V, L210W, T215Y, N348I	K103N	K13N, V35M, K43Q, E44D, D86N, V118I, Y127YC, E138Q, S162D, G196D, R211K, Q278H, T286A, I293V, E297R, K366R, S379G, K385KR, T386I, A400T, G436E, N447NS, D460N, V467I, L491S, S519ST, Q524E, A554T	B
		CA38109	AY801147	AZT, DDI, D4T, 3TC, ABC, TDF	NVP, EFV	M41L, D67N, L74I, M184V, L210W, T215Y	K101P, K103N, G190A	K13N, V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, H221Y, Q278H, T286A, I293V, E297R	B
		CA48186	AY801148	AZT, DDI, D4T, 3TC, ABC, TDF	NVP, EFV	M41L, D67N, L74I, M184V, L210W, T215Y	K101P, K103N, G190A	K13N, V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, H221DY, Q278H, T286A, I293V, E297R	B
	SWC-3636	P3636-1388		D4T, AZT, 3TC	NVP	M41L, D67N, M184V, L210W, T215Y	K103N	T39A, V118I, I135T, E138Q, S162C, G196E	B
	CA6602	CA24264	AY801687	Unknown, ABC, TDF	Unknown, EFV	A62V, L74V, M184V, T215F	L100I, K103N	D86E, K122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211K, L228H, I257L, K277R, T286A, A288S, I293V, T296S, E297R	B
		CA38093	AY801688	Unknown, ABC, TDF	Unknown, EFV	A62V, T215Y	K103N	K122E, I135T, E138Q, S162C, E169D, I178L, T200A, R211K	B
		CA42706	AY801689	Unknown, ABC, TDF	Unknown, EFV	A62V, T215Y	K103N	W88WS, K122E, I135IT, E138Q, S162C, E169D, I178L, T200A, R211K, L228R, I244IV, D250E, I257L, K277R, T286A, A288S, I293V, T296S, E297R, L301I, I329L, G333E	B
	CA8028	CA20151	AY801912	D4T, 3TC, DDI	NVP	M41L, D67N, T215Y	K101E, G190A	E6D, K43E, D123E, I135T, E138Q, D177E, V179I, T200I, I202V, I257L	B
		CA34853	AY801913	D4T, 3TC, DDI	NVP	M41L, D67N, T215Y	K101E, G190A	E6D, K43E, E44D, V118I, D123E, I135T, E138Q, D177E, V179I, T200I, L210S, I257L, I293V	B
	CA9878	CA24369	AY802160	Unknown, D4T	Unknown, DLV	A62V, K70R	K103N	V35VI, T69N, E138Q, I142M	B
	CA14672	CA35106	AY802404	AZT, 3TC, D4T, DDI	EFV, NVP	M41L, M184V, L210W, T215Y	K103N	D121H, I135T, E138Q, I142V, T200TA, R211K, A272AP, K277R, E297K	B
Baxter (2006)	12-1281	1281-30424	DQ879378	NRTI	NNRTI	M41L, D67N, L210W, T215Y, K219R	K103N	T39A, V60I, T69TN, L120L*W, K122E, I135M, E138Q, Q174K, N175Y, V189VL, G196E, K201IV, R211K, V245VE	B
	12-4004	4004-30128	DQ880388	NRTI	NNRTI	M41L, A62V, D67DN, V75I, L210W, T215Y	K103N	T39A, E44ED, S68SG, A98AS, K101Q, V118VI, K122E, D123S, E138Q, I142T, S162ST, R172RK, I178L, Q207E, R211K	B
	12-1866	1866-30506	DQ879823	NRTI	NNRTI	M41L, L74LI, M184V, L210W, T215Y, K219N	K101P, G190GA	E40F, K43E, S68G, K102R, L109I, K122E, E138Q, V179I, T200A, L228HQ	B
	12-1353	1353-30711	DQ879429	NRTI	NNRTI	M41L, K65R, V75I, F77L, F116Y, Q151M	V179D, G190A	S68G, V90I, K103R, V106L, V118I, I135L, E138Q, T165I, R172K, F214L	B
	12-1355	1355-30527	DQ879431	NRTI	NNRTI	M41L, D67N, K70R, T215F, K219Q	V179D	T39A, K64H, T69N, K103R, E138Q, S162C, G196E, T200A, E203K, Q207E, R211I, V245K	B
	12-1387	1387-30521	DQ879457	NRTI	NNRTI	M41L, D67N, K70R, M184V, T215V, K219Q	K103N, V179E, P225H	V118I, L120*, K122E, D123DN, E138Q, T200A, Q207E, R211K, F214L, L228H	B
	12-1199	1199-30225	DQ879305	NRTI	NNRTI	A62V, T69S_SS, V75VL, M184V, T215Y	K103N, V108I	K122E, D123N, I135T, E138Q, I159IK, K173R, Q207E, L210S, R211K	B
	12-3111	3111-30515	DQ880334	NRTI	NNRTI	M41L, A62V, D67E, T69T_QA, L210W, T215Y	Y181C	K43E, S68G, V118I, K122E, E138Q, R211N, E224D, L228H	B
	12-1717	1717-30424	DQ879708	NRTI	NNRTI	M41L, D67G, T69TADN, L74V, L210W, T215Y, K219R	L100I, K103N, P225H, K238T	K43Q, E44D, V118VI, K122E, I135T, E138Q, S162C, R172RK, T200TA, I202V, Q207QE, R211K	B
	12-1768	1768-30522	DQ879755	NRTI	NNRTI	K65R, K70R, V75M, F77L, Q151M, T215D	K103N, V108I	P52T, S68G, A98S, K122E, I135V, E138Q, A158S, S162A, R172K, G196E, H221Y	B
	48-1005	1005-30909	DQ877744	NRTI	NNRTI	M41L, D67N, L74LI, M184V, L210W, T215Y, K219E, N348I	V108I, Y181C, F227L	V35I, T39S, E40FV, K43E, D86DE, K101Q, E138Q, G196E, H221Y, L228R, V292I, I293V, I326IV, R356K, K390R	B
		1005-40615	DQ877743	NRTI	NNRTI	M41L, D67N, L74LI, M184V, L210W, T215Y, K219E, N348I	V108I, Y181C, F227L	V35M, T39S, E40F, K43E, K101Q, E138Q, G196E, H221Y, L228R, V292I, I293V, I326IV, R356K, R358RK, K390R	B
	48-3017	3017-30530	DQ877927	NRTI	NNRTI	M41L, L74V, M184V, T215Y	K103N, Y181C	K20R, K122E, I135V, E138Q, S162C, T200A, L228H, L283I, I293V, S322A, D324DE, G359S, A371V	B
	48-3125	3125-30410	DQ878033	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y	K101KE, G190A	K43N, V60I, V106I, V118I, D123E, I135V, E138Q, D177DE, V179I, G196E, R211K, I293V, V317A, Q334IL, M357MT, V365I, E370A, T386I, E399D	B
	48-3145	3145-30429	DQ878056	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y	K101P, K103S	T27S, V35T, K43N, V60I, V90I, V118I, K122E, D123N, I135T, E138Q, N175Y, T200K, K201I, R211K, A272AP, T286A, E297A, D324E, I329L, A360AT	B
	48-4022	4022-30326	DQ878256	NRTI	NNRTI	M41L, D67N, V75L, M184V, L210W, T215Y	K101E, G190A	S3C, K43E, E44A, K122E, E138Q, I142V, S162C, I167V, I178L, H208F, R211K, D237E, V245K, T286TA, E297R, I326V, Q334E, R356K, R358K, S379C, K390R	B
	48-4225	4225-30617	DQ878460	NRTI	NNRTI	M41L, D67N, V75M, M184V, L210W, T215Y, K219N	K103N	E44D, V118I, K122E, D123N, E138Q, D177N, V179I, I195L, G196E, Q207QH, H208Y, R211K, W212M, V245K, T286V, I293V, E297K, V317A, Q334L, M357T, A360V, T377L	B
	48-6021	6021-30331	DQ878620	NRTI	NNRTI	M41L, D67N, L74V, L210W, T215Y, K219R	K101P, Y188L, Y318YF	V35M, T39A, K43E, E44ED, V60VI, A98S, K102Q, K104KR, V118I, K122P, D123E, I135T, E138Q, R172K, Q207E, D218E, D250E, A272P, K277KR, Q278H, T286P, A288S, I293V, E297K, K311R, M357T	B
	48-9270	9270-30918	DQ880863	NRTI	NNRTI	M41L, D67N, K70KQ, V75M, M184V, L210W, T215Y	K103N	T39TA, E40F, K43E, K122E, D123E, I135T, E138Q, S162C, I167V, I178L, G196E, Q207E, H208Y, R211K, D237E	B
	48-8077	8077-30818	DQ879087	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y	K103N, Y318F	E44D, A98S, D123E, I135IL, E138Q, K166R, D177E, I178IL, G196E, T200A, E203D, Q207K, R211A, A272P, I293V, I326V, I329V, G335S, K347Q, A371V, A376S, T386I, K390R	B
Rosen-Zvi (2008)	17	01p17-3		AZT, 3TC, DDC, D4T, DDI	NVP	D67S, L74V, L210W, T215Y	K103N, Y181C	K20R, V35M, T69S, K122KE, I135M, E138Q, S162A, V179I, R211K, K277R, Q278E, T286A, E297K	B
	61	99p61-1		AZT, DDC, 3TC, D4T	DLV	M41L, D67N, L74V, M184V, T215Y	L100I, K103N	D123E, E138Q, I142V, D177E, I178L, Q207E, L210S, I293V, P294Q, E297K	B
		00p61-2		AZT, DDC, 3TC, D4T, DDI	DLV	D67N, T215Y	K103N	T39A, K43E, E44D, V118I, D123E, E138Q, I142V, R172K, D177E, I178L, Q207E, L210S, I293V, P294Q, E297K	B
		00p61-3		AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, M184V, T215Y	K103N	T39A, K43E, E44D, V118I, D123E, E138Q, I142V, P170PT, D177E, I178L, E203ED, Q207E, L210S, C280CY, I293V, P294Q, E297K	B
		01p61-4		AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, M184V, T215Y	K103N	T39A, K43EG, E44D, V118VI, D123E, E138Q, I142V, D177E, I178L, Q207E, L210S, I293V, P294Q, E297K	B
		02p61-5		AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, M184V, T215Y	K103N	T27S, T39A, K43E, E44D, V60VI, D123E, E138Q, I142V, D177E, I178L, E203ED, Q207E, L210S, I293V, P294Q, E297K	B
		07p61-6		AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, M184V, T215Y, K219R	K103S	K20R, T27S, E29K, T39A, K43E, E44D, V60I, V108VA, D123E, E138Q, I142V, D177E, I178L, V179I, E203D, Q207E, L210S, L228H, I293V, P294Q, E297K	B
		07p61-7		AZT, DDC, 3TC, D4T, DDI	DLV	M41L, D67N, M184V, T215Y, K219R	K103NS	K20KR, T27S, T39A, K43E, E44D, V60I, V118I, K122KR, D123E, E138Q, I142V, D177E, I178L, V179I, Q207E, L210S, L228H, I293V, P294Q, E297K	B
Cardoso (2009)	3110	BRGO3110	FJ638450	NRTI	NNRTI	M184V	Y181C	I31L, V35L, T39A, E44D, K102KR, V111I, K122E, D123N, I135T, E138Q, S162C, I178L, V179I	B
Kagan (2009)	3	3		NRTI	NNRTI	D67H, K70R, L74I, M184V, T215F, K219Q	K101P, K103T	K43Q, V60I, T69N, K122E, I135T, E138Q, D177G, I178M, V179I, G196E, F214L, L228H, Q242L, V245E, A272T, K277R, I293V, Q334H, G335D, R356K, G359S, V365I, A376T, T386M, A400T	B
Dau (2010)	05604A	05604A	GU581677	NRTI	NNRTI		K103N, P225H	K20R, V35I, E40D, E138Q, T200A, F214L, P243S, V245E, D250E, T286TA, V317A, M357T, A376T, T377I, Q394L, E399D	B
	07105A	07105A	GU581817	NRTI	NNRTI	M184V		V35T, V60I, R83K, D123E, I135V, E138Q, V179I, T200A, V245E, E248D, A272P, M357T, S379G, K385R, T386I	B
	07319A	07319A	GU581838	NRTI	NNRTI	M41L, V75L, F77FL, L210W, T215Y	K103N, Y318F	T39K, K43E, K122E, I135M, E138Q, Q174QK, T200A, Q207E, H208HY, R211RK, Q278H, A288S, I293V, E297A, D324DE, M357T, A360AV, T386I, K390R	B
	08255A	08255A	GU581902	NRTI	NNRTI	M41ML, V75L, F77L, M184V, L210W, T215CY	K103N, Y318F	P4PS, V35VL, T39K, K43E, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, M357T, T386I, K390R	B
	09065A	09065A	GU581957	NRTI	NNRTI	M41L, V75L, F77L, M184V, L210W, T215Y	K103N, Y318F	V35VL, T39K, K43E, V118VI, K122E, I135M, E138Q, Q174QK, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, D324DE, N348NT, M357T, T386I, K390R	B
	09756A	09756A	GU581981	NRTI	NNRTI	M41L, V75L, F77L, M184V, L210W, T215Y, N348IT	K103N, Y318F	V35VL, T39K, K43E, V118I, K122E, I135M, E138Q, Q174QK, V179VI, T200TAEK, Q207E, R211RK, Q278H, A288S, I293V, E297A, E312EG, D324E, M357T, A360AV, T386I, K390R	B
	11025A	11025A	GU582029	NRTI	NNRTI	M41L, D67N, V75LM, F77L, M184V, L210W, T215Y	K103N, Y318F	V35L, T39K, E40F, K43E, V118I, K122E, I135M, E138Q, T200TAEK, Q207DE, R211K, Q278H, A288S, I293V, E297A, D324DE, N348T, M357T, T386I, K390R	B
Jones (2012)	142526	142526	JN669617	NRTI	NNRTI	M41L, M184V, L210W, T215Y, N348NI	K103N	I135M, E138Q, I178M, G196E, R211T, V245M, A272P, K277R, I293V, E297K, A304E, F346Y, A360V, E370EG, A376S, T386I, K390R	B
	150599	150599	JN669751	NRTI	NNRTI	A62V, M184V, T215Y	K103N	M16MI, K22K*NY, V90I, V111VG, D121H, K122E, I135T, E138Q, N147NK, S162A, Q174H, N175NH, I178M, G196E, T200A, Q207H, R211E, V245M, A272P, K277R, A288AT, I293V, E297V, Q334I, Y339YH, A360V, D364DG, A376S, T386I, K390R, E396EK	B
	155819	155819	JN669846	NRTI	NNRTI	M184V	K103N	V35T, V60I, A98S, K102Q, K122E, D123K, S134SR, I135V, E138Q, K166R, Q197K, I202V, R211K, I244IM, A272P, L283I, I293V, E297K, A327V, Y342F, R356K, K388R, K390R, Q394L, K395R, E399D	B
	156893	156893	JN669876	NRTI	NNRTI	M41L, D67N, L74V, L210W, T215D, K219R	L100I, K103N	T39A, E44D, S48T, V60I, V118I, K122E, E138Q, I202V, Q207G, R211K, V245R, S251I, A272P, K277R, E291D, I329V, Q334Y, A376S, T386I	B
	163140	163140	JN670054	NRTI	NNRTI	M41L, A62V, D67HN, K70R, V75T, M184V, L210LW, T215F, K219E	A98AG, K103N, Y181C	T69TN, D121H, K122E, E138Q, T200A, R211K, L228H, I293V, D324E, G359S, T369A, I375V, K390R, T397I, E399EK	B
	173308	173308	JN670323	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219Q	K103N	D123E, E138Q, S162C, T200I, R211K, D218E, V245M, A272P, K277R, E297K, Q334D, R356K, M357T, A360T, A371AV, I375V, A376S, T377R	B
	182466	182466	JN670613	NRTI	NNRTI	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	L100LI, K103N, V108VI, K238N	V8VI, K122E, E138Q, G196S, R211Q, D218E, S322T, I329L, M357T, A360V, A376S, K390R, A400S	B
	188365	188365	JN670754	NRTI	NNRTI	M41L, L74V, L210W, T215Y	L100I, K103N	V35LQ, E36D, K43Q, K104R, V118I, D123E, E138Q, K166R, R211K, L228R, A272P, L283I, P294A, E297K, I329V, K350R, R356K, K366R, T397I, E399D	B
	190266	190266	JN670791	NRTI	NNRTI	M41L, V75VIM, M184V, T215F	K103N, V108VI	K43KE, E138Q, Q174K, D177G, G196E, T200TA, R211K, T286TA, V292I, I293V, E297AV, A304E, I326V, T369V, A376S, S379C, K388R, K390R	B
	190411	190411	JN670797	NRTI	NNRTI	M41L, L210W, T215Y, N348I	G190A	V21VI, V35T, K43Q, F87FS, W88R, V118I, D123E, E138Q, K173D, Q174K, A272P, I293V, P294T, E297R, V317G, G359S, A360T, K366R, A376T, T377L, T386V, E399D	B
	193627	193627	JN670905	NRTI	NNRTI	M184V	K103N	V60VI, K102Q, D121H, K122E, D123G, I135T, E138Q, S162A, I178M, V179I, V241VI, V245M, I257IL, A272P, I293V, P294PS, M357T, A376T, T386I	B
	198168	198168	JN671107	NRTI	NNRTI	K70R, M184V, N348I	K103N, Y318YF	K20KR, V35T, V60I, D123E, I135V, E138Q, I142V, S162ST, I178L, Q197K, T200S, S251T, A272P, K277R, E297K, Q340QH, A360AG, A376S, K390R, Q394L, E399D	B
Melikian (2012)	CA6602	CA84188	GQ213089	Unknown, ABC, TDF	Unknown, EFV	A62V, K70N, T215Y		V35I, A98S, K122E, D123DN, E138Q, S162C, E169D, I178L, T200A, I202IV, R211K, L228R, I257L, A272P, K277R, T286A, A288S, I293V, T296S, E297R	B

Reverse Transcriptase Inhibitors

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