<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation E138A
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 41
Patients 74
Isolates 80
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1994)JIDP27JIDP27W0AF021284AZTNone  R83K, E138A, K166R, G196E, W239C, V241VAEGB
Shafer (1995) JIDP27W104AF021311AZT, DDINone  E28E*KQ, R83K, K122E, E138A, M164MI, K166KR, G196E, W239C, V241VAEGB
Ruiz (1996)JCS-C1C1BZ99298AZT, DDINoneM41L, D67N, K70R, T215Y K20R, V35T, V60I, A98S, K104N, E138A, E169D, I178M, H208Y, R211KB
  C1W24Z99299AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y K20R, V35T, V60I, E138A, I178M, E203K, H208Y, R211KB
Hammer (1997)ACTG320_135135 AZTNoneD67N, K70R, T215TI, K219Q K104KN, T107TP, K122E, E138A, A158S, E169D, T200TA, I202V, F214L, I293V, A371AV, A376V, A400T, L452LI, V467VI, S468P, H483*YB
 ACTG320_25232523 AZTNoneD67N, K70R, T215F, K219Q K20R, E138A, K166KR, G196GE, I202V, R211K, P243Q, V245VEKM, A272P, K277R, T286A, D324DE, M357T, A371V, A376T, K390R, A400T, T403L, A446S, K454KR, H483YB
 ACTG320_27972797 AZTNoneD67N, K70R, T215Y, K219Q K20R, T69N, V118I, I135T, E138A, K166KR, R211K, F214L, P243T, K277R, T286A, E291D, P294ST, E297K, Q334E, T369TA, A376T, K390R, A400T, T403A, L452LI, D460N, S468A, L469I, H483YB
 ACTG320_37033703 DDC, AZTNoneM41L, D67DN, L210W, T215Y K20R, K43KN, E44ED, V60VI, V118VI, D123DE, E138A, K173Q, G196K, H208HY, R211K, A272P, K281R, V292I, E297K, K311R, S322T, M357T, A360AV, A376AS, T377S, V381I, A400T, D460NB
 ACTG320_37063706 AZT, DDC, DDINoneM41L, L210W, T215Y E44ED, K122E, I135V, E138A, I142T, S162C, T200E, R211K, L228HR, A272P, K277R, L283I, I293V, F346Y, G359GS, A371AV, V435E, D460N, S468T, L469I, T470AB
 ACTG320_857857 AZT, DDINoneM41L, T215Y E53D, K64KR, A98AS, K104KN, K122KE, E138A, T286A, A288S, K311R, Q334E, M357S, T369TA, A376T, E399D, A400T, T403S, V435VA, F440FY, A446AS, Q480QHB
 ACTG320_9696 AZT, DDC, DDINoneM41L, L74V, L210LW, T215Y V60VI, E138A, S162C, T200E, E248D, I293V, I326V, A360T, T403L, V435A, G436E, N447S, V458I, H483YB
Winters (1997)143P19143P19W80AF013433DDINone  K122E, E138A, K166R, T200IB
Masquelier (1999)DRO-17DRO17BAJ239260DDC, AZT, DDINoneM41L, L210W, T215Y V35I, K49KR, R83K, D123E, I135T, E138A, P140Q, K173Q, V179VI, I202VB
Milazzo (1999)Mil-SAMilazzoSA0AF153395AZTNoneK70R, T215Y, K219Q K20R, K32N, E42EG, E44G, G45GR, K65E, R78G, R83G, D123E, I135T, E138A, G196GE, E204D, F214LB
  MilazzoSA1AF153396AZT, 3TCNoneM41ML, D67N, K70R, M184V, K219Q K20R, K32N, S68SC, T107TS, D123E, I135T, E138A, E203D, E204ED, F214LB
Pellegrin (1999)IP-38IP38-M12 D4T, DDINoneT215YK101ER83K, E138A, S162C, V179I, R211KB
Bacheler (2000)LB3-P76P76-0 NRTINone  K49R, I50V, V60I, R83K, E138A, S162C, V179I, G196EB
 LB3-P98P98-0 NRTINoneK70R D123E, E138A, I178M, V179IB
Balotta (2000)CB-148CB-148AF252013DDC, AZT, D4T, 3TC, DDINoneM41L, D67N, M184V, L210W, T215YK101EE44D, A98S, V118I, K122KE, E138A, T139E, I142T, K166KR, Q174E, D177G, T200A, Q207K, H208Y, R211K, K223KQ, V245EB
 CB-181CB-181AF251950DDC, AZT, D4T, 3TC, DDINoneD67N, K70R, M184V, T215F, K219QK101EK20R, A98S, D123E, I135T, E138A, K166R, G196EB
 CB-187CB-187AF252038D4T, 3TC, DDC, AZT, DDINoneM41L, A62V, L210W, T215Y T27TA, K43Q, E44D, K49R, V118I, K122E, E138A, S162C, Q174N, I178F, H208Y, R211K, L228HB
 CB-240CB-240AF252046DDC, AZT, D4T, 3TC, DDINoneM41L, T215TNSY W24WG, K101KQ, K102KQ, D123E, E138A, I142IV, G196E, T200TAB
 CB-245CB-245AF252027AZT, D4T, 3TC, DDINoneD67N, T69TADN, K70R, M184V, T215F, K219Q K20R, E138A, K173E, I178M, V179I, G196EB
Baxter (2000)GART-G40GART-40 NRTI, AZT, 3TCNoneD67N, K70R, M184V, K219Q K20R, E138A, I178IM, R211KB
 GART-G80GART-80 NRTI, AZT, 3TCNoneM184V K20R, V35I, R83K, A98S, K122KE, I135V, E138A, V245EB
 GART-NG98GART-98 NRTI, 3TC, D4TNoneD67DN, K70R, M184V K20KR, A98AS, K122KE, I135IV, E138A, T165I, F214L, E248D, K249Q, A272PB
Coakley (2000)EC19EC19F D4T, DDINone  K101Q, K122E, I135T, E138A, I202V, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468PB
Rousseau (2000)MNR5MNR4062AJ405950AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, T69D, L210W, T215Y K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, E138A, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436EB
Albrecht (2001)ACTG364_16521652 AZT, 3TCNoneM184V K20KR, R83K, E138A, I142V, A272P, A288TB
Delgado (2001)ED_V72ED_V72AY016981AZTNone  V60I, S68G, K122E, E138A, A158AS, T165TI, I178M, G196EB
 ED_V80ED_V80AY016989AZT, 3TCNone K101EE138A, I142T, V179IB
 ED_V81ED_V81AY016990AZT, 3TCNone K101EE138A, I142T, V179IB
Eshleman (2001)A004AF357608AF357608AZT, DDINoneD67N, K70R, T215TA, K219Q V35M, T39A, V60VI, K64KN, T69N, R83K, E138A, T165I, I178M, I202IV, F214FL, D218DE, A272P, T286A, V317AB
 A085AF357686AF357686AZT, DDINoneM41L, L210W, T215Y T39A, V60I, R83K, D123E, E138A, I178L, A272P, K281R, T286A, E297K, D320EB
Gonzales (2001)CA3990CA9242AY030989AZT, D4T, DDINoneM41L, L210W, T215Y V35VI, K43EQ, R83K, K102Q, V118VI, D123DE, E138A, D177E, R211K, E233DB
 CA5377CA13103AY031932D4T, 3TCNoneM184V V60I, R83K, A98S, E138A, T200A, Q207D, R211K, K249Q, D250EB
 CA5482CA13507AY032021AZT, 3TCNoneM184V K20R, K49R, S68G, A98S, I135V, E138A, K166R, V245E, D250E, A272P, K277R, L283I, R284K, I293V, E297A, E302E*B
 CA5719CA14138AY032111D4T, 3TCNoneM184V K102Q, K122KE, D123E, I135T, E138A, T139IM, I142V, S162C, D177E, V179I, T200I, V245MB
 CA6798CA16844AY032531AZT, 3TC, D4TNoneM184V K122E, E138A, I142V, K173KR, A272P, K277R, K281KE, A288AT, L289LR, V292I, I293V, T296S, E297AB
Katzenstein (2001)ACTG302_31423142RT_f1 AZT, DDI, 3TCNoneK70R, M184MV, K219KQ K20R, T39TA, T69TN, R83RK, K102Q, K104KN, I135T, E138A, K166KR, T200TA, R211RK, F214FL, I293VB
Servais (2001)JS18JS97095AJ401769AZT, 3TCNoneM41L, T215Y K122E, E138A, T200A, F214WB
  JS97439AJ401787AZT, 3TCNoneM41L, D67N, T69D, V75M, M184V, L210W, T215Y K43Q, E44D, V60I, K102R, V118I, K122E, I135M, E138A, I142V, T200A, R211K, F214WB
Ait-Khaled (2002)MAK-16861686161AJ425899AZT, 3TCNoneM184V E138A, I142T, T200AB
Brindeiro (2002)TVSP4TVSP4AY145816AZT, DDI, D4T, 3TCNoneM184V L80LF, E138A, G196E, T200I, Q207D, R211K, V245Q, E248N, A272P, I293V, L310IB
Papa (2002)AP-15AP-15AF315765D4T, DDINoneM41L, K70N, V75A S68G, R83K, K122E, E138A, A158AS, S162AD, I202IVB
Tural (2002)880806880806 AZT, DDI, 3TC, D4TNoneM41L, M184V, L210W, T215Y K43N, K49R, R83K, K122E, I135V, E138A, S162N, E169K, K173E, I178L, G196E, Q207E, R211K, L234P, D237HB
Venturi (2002)GV-2GV-2.1AF517254AZT, 3TCNone  V35I, R83K, D123E, E138A, D177E, T200A, R211GB
 GV-8GV-8.1AF517260DDC, AZTNone  E6ED, K20KR, V118VI, D123E, E138A, K166R, K173KT, G196E, F214LB
Shafer (2003)A384_19561956bEF548643D4T, DDINone  K49R, S68G, I135T, E138A, T139E, G196E, R211G, P243TB
 A384_59295929bEF549350AZT, 3TCNoneM184V V35I, R83K, K122E, E138A, K173N, V179I, A272P, K277R, T286A, P294Q, E297RB
 A384_32103210bEF548383AZT, 3TCNoneD67N, K70R, M184V, T215TFIS, K219Q E6D, K20R, V35T, E42EA, K122E, E138A, T200K, Q207N, R211RK, A272G, I293VB
Dumans (2004)235235AY390139AZT, DDINoneD67N, L210W, T215Y K49R, K122E, D123N, I135T, E138A, I142T, E169D, I202VB
Kuritzkes (2004)KDR_pat128A0154AY527971AZT, 3TCNoneM184MV D123E, E138A, I178L, T200TI, I202V, E204EG, R211RK, F214LB
  DRK_A0155AY527972AZT, 3TCNone  R83RK, D123E, E138A, I178L, T200TI, I202V, E204EGKR, R211RK, F214LB
 KDR_pat143A0179AY527996D4T, 3TCNoneM41ML, M184V, T215C S68SDGN, A98S, E138A, I142IT, S162A, T200AB
 KDR_pat214A0286AY528103AZT, 3TCNoneM184V E138A, I142V, Q174L, D186DY, L193M, T200A, R211GB
Machado (2004)cs160cs160AY313394AZT, DDI, 3TCNoneM41L, D67E, V75M, F77L, M184V, L210W, T215Y T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211KB
 con15con15AY313430AZT, DDINoneT215S K64R, K122T, I135T, E138A, I142V, D177E, I178V, G196R, T200AB
Delaunay (2005)DC_TON0800208002w12DQ286521ABC, TDF, 3TCNoneK65R, M184V E138A, I142T, I202V, R211KB
Holguin (2005)SP_SK2SP_SK2AF466719AZT, 3TCNoneL210W, T215S V60I, R83K, I94V, A98S, I135V, E138AB
Non-B Workgroup (2005)IL503IL503 AZT, 3TCNoneM184V T69S, A98S, E138A, I142IV, V179I, R211K, K223I, V245EB
 TH_575TH_575 AZT, DDINoneM41L, D67N, T69D, K70R, T215F, K219QV179DV35L, V60I, K102E, K122E, I135V, E138A, T139A, D177E, I202V, V245KB
Rhee (2005)CA5719CA42644AY801604D4T, 3TCNoneM41L, M184V, T215F K102Q, D123E, I135T, E138A, T139M, I142V, S162C, D177E, V179I, T200I, V245MT, T286A, P294PQB
 CA7988CA20078AY801884AZT, 3TC, D4T, DDINoneD67N, K70R, K219Q K20R, V35M, T39AE, N54NK, V60I, K64H, T69N, I135T, E138A, I202V, F214L, L228H, T286A, I293VB
 CA9682CA23687AY802060D4T, 3TCNoneM41L, D67N, M184V, T215F, K219QK101EV60I, I135T, E138A, R211K, D218E, K277KR, T286A, E297KB
 CA14249CA41369AY802284D4T, 3TCNoneM184V K20KR, R83K, F87FS, I135IL, E138A, I159IV, T200A, R211K, A272P, K277R, I293V, E297KB
Santos (2006)012012PR_RTAY275721AZT, 3TCNone  K122E, D123S, E138A, T200A, R211KB
Rios (2007)CH71MR_CH71.1EF193966AZT, 3TCNone V179DL12LIV, V35I, T39A, E138A, G141A, R211A, F214L, V245TB
von Wyl (2007)95662081EF449985NRTINoneM184V K104R, K122P, E138A, I142T, A158S, S162C, V179I, T200A, R211KB
 1521482529EF449806NRTINoneM184MV V35T, V60I, R83K, I135T, E138A, P150S, N175KB
Riddler (2008)RG13636RG13636w35 D4T, 3TCNone  T27S, V35I, V60I, K64R, R83K, K122E, I135T, E138A, S162Y, Q207D, R211K, I244V, A272P, K277R, T286A, E297K, Q334E, F346Y, M357V, K366R, K390RB
 RG95549RG95549w29 TDF, 3TCNone  K49R, E53EDHQ, K122E, E138A, S162C, K173Q, G196E, T200A, E204G, F214L, A272P, I293V, V317A, I326V, F346Y, M357T, A376S, Q394LB
Rosen-Zvi (2008)8102p81-1 AZT, DDI, D4TNone  R83K, K122E, I135V, E138A, S162T, D177E, G196E, T200I, I202V, R211G, V245I, D250E, A272P, K277R, A288S, E297K, S322T, Q334DB
Rhee (2009)CA8468CA21241FJ983302D4T, 3TCNoneA62AV, M184V A98AS, K122E, I132IV, E138A, G196E, Q207D, D250E, K277R, T286A, A288Q, P294Q, E297RB
 CA9985CA24774FJ983342D4T, 3TCNoneM184V K20R, V35IT, T69TA, R83K, K122E, I135V, E138A, K166R, Q197L, I202IV, F214FL, V245E, E248D, D250DN, A272P, V276I, L283LI, A288SB
 CA37887CA84416FJ983565D4T, 3TCNoneM184V, T215Y K20R, S68T, K122E, D123DN, I135T, E138A, T165I, R172K, Q174QK, I178L, I195L, T200A, I202IV, V245T, D250E, A272P, K277R, T286A, A288S, P294T, E297AB
von Wyl (2010)47967174796717GQ848130AZT, 3TC, D4TNoneM184V, N348I A98S, K101KQ, K102KQ, K122E, D123DN, E138A, I142V, S162C, R211RK, A272S, T286A, K311R, D324E, R358K, G359GS, T377R, K385RB
 65046504GU3010793TCNoneM184V K20KR, V35I, E138A, T165I, I202IV, A272AP, K277R, L283I, T286A, P294S, R356K, A376T, V381I, K390R, L469I, T470N, H483Y, G490GE, Q524E, K527KN, A534ASB
Melikian (2012)CA26324CA61104GQ211618AZT, 3TC, D4T, TDFNoneK70G, M184V K43KN, E138A, I142T, S162C, K173KE, I178IM, L210LF, R211K, F214L, V245T, V261VG, A272P, V292IB
Mollan (2012)MK170MK170w41 TDF, FTCNone  V21VI, K43R, K49R, I50V, V60I, K101Q, V118VI, I135L, E138A, T165I, Q174C, V179I, G196E, I202V, I244V, K277R, A288SB