Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	E138A
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	37
Patients	71
Isolates	75

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1994)	JIDP27	JIDP27W0	AF021284	AZT	None			R83K, E138A, K166R, G196E, W239C, V241X	B
Ruiz (1996)	JCS-C1	C1B	Z99298	AZT, DDI	None	M41L, D67N, K70R, T215Y		K20R, V35T, V60I, A98S, K104N, E138A, E169D, I178M, H208Y, R211K	B
		C1W24	Z99299	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y		K20R, V35T, V60I, E138A, I178M, E203K, H208Y, R211K	B
Hammer (1997)	ACTG320_135	135		AZT	None	D67N, K70R, T215TI, K219Q		K104KN, T107TP, K122E, E138A, A158S, E169D, T200TA, I202V, F214L, I293V, A371AV, A376V, A400T, L452LI, V467VI, S468P, H483X	B
	ACTG320_2523	2523		AZT	None	D67N, K70R, T215F, K219Q		K20R, E138A, K166KR, G196GE, I202V, R211K, P243Q, V245VEKM, A272P, K277R, T286A, D324DE, M357T, A371V, A376T, K390R, A400T, T403L, A446S, K454KR, H483Y	B
	ACTG320_2797	2797		AZT	None	D67N, K70R, T215Y, K219Q		K20R, T69N, V118I, I135T, E138A, K166KR, R211K, F214L, P243T, K277R, T286A, E291D, P294ST, E297K, Q334E, T369TA, A376T, K390R, A400T, T403A, L452LI, D460N, S468A, L469I, H483Y	B
	ACTG320_3703	3703		DDC, AZT	None	M41L, D67DN, L210W, T215Y		K20R, K43KN, E44ED, V60VI, V118VI, D123DE, E138A, K173Q, G196K, H208HY, R211K, A272P, K281R, V292I, E297K, K311R, S322T, M357T, A360AV, A376AS, T377S, V381I, A400T, D460N	B
	ACTG320_3706	3706		AZT, DDC, DDI	None	M41L, L210W, T215Y		E44ED, K122E, I135V, E138A, I142T, S162C, T200E, R211K, L228HR, A272P, K277R, L283I, I293V, F346Y, G359GS, A371AV, V435E, D460N, S468T, L469I, T470A	B
	ACTG320_857	857		AZT, DDI	None	M41L, T215Y		E53D, K64KR, A98AS, K104KN, K122KE, E138A, T286A, A288S, K311R, Q334E, M357S, T369TA, A376T, E399D, A400T, T403S, V435VA, F440FY, A446AS, Q480X	B
	ACTG320_96	96		AZT, DDC, DDI	None	M41L, L74V, L210LW, T215Y		V60VI, E138A, S162C, T200E, E248D, I293V, I326V, A360T, T403L, V435A, G436E, N447S, V458I, H483Y	B
Winters (1997)	143P19	143P19W80	AF013433	DDI	None			K122E, E138A, K166R, T200I	B
Milazzo (1999)	Mil-SA	MilazzoSA1	AF153396	AZT, 3TC	None	M41ML, D67N, K70R, M184V, K219Q		K20R, K32N, S68SC, T107TS, D123E, I135T, E138A, E203D, E204ED, F214L	B
Pellegrin (1999)	IP-38	IP38-M12		D4T, DDI	None	T215Y	K101E	R83K, E138A, S162C, V179I, R211K	B
Bacheler (2000)	LB3-P76	P76-0		NRTI	None			K49R, I50V, V60I, R83K, E138A, S162C, V179I, G196E	B
	LB3-P98	P98-0		NRTI	None	K70R		D123E, E138A, I178M, V179I	B
Balotta (2000)	CB-148	CB-148	AF252013	DDC, AZT, D4T, 3TC, DDI	None	M41L, D67N, M184V, L210W, T215Y	K101E	E44D, A98S, V118I, K122KE, E138A, T139E, I142T, K166KR, Q174E, D177G, T200A, Q207K, H208Y, R211K, K223KQ, V245E	B
	CB-181	CB-181	AF251950	DDC, AZT, D4T, 3TC, DDI	None	D67N, K70R, M184V, T215F, K219Q	K101E	K20R, A98S, D123E, I135T, E138A, K166R, G196E	B
	CB-187	CB-187	AF252038	D4T, 3TC, DDC, AZT, DDI	None	M41L, A62V, L210W, T215Y		T27TA, K43Q, E44D, K49R, V118I, K122E, E138A, S162C, Q174N, I178F, H208Y, R211K, L228H	B
	CB-240	CB-240	AF252046	DDC, AZT, D4T, 3TC, DDI	None	M41L, T215TNSY		W24WG, K101KQ, K102KQ, D123E, E138A, I142IV, G196E, T200TA	B
	CB-245	CB-245	AF252027	AZT, D4T, 3TC, DDI	None	D67N, K70R, M184V, T215F, K219Q		K20R, T69X, E138A, K173E, I178M, V179I, G196E	B
Baxter (2000)	GART-G40	GART-40		NRTI, AZT, 3TC	None	D67N, K70R, M184V, K219Q		K20R, E138A, I178IM, R211K	B
	GART-G80	GART-80		NRTI, AZT, 3TC	None	M184V		K20R, V35I, R83K, A98S, K122KE, I135V, E138A, V245E	B
	GART-NG98	GART-98		NRTI, 3TC, D4T	None	D67DN, K70R, M184V		K20KR, A98AS, K122KE, I135IV, E138A, T165I, F214L, E248D, K249Q, A272P	B
Coakley (2000)	EC19	EC19F		D4T, DDI	None			K101Q, K122E, I135T, E138A, I202V, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468P	B
Rousseau (2000)	MNR5	MNR4062	AJ405950	AZT, DDI, DDC, D4T, 3TC	None	M41L, D67N, T69D, L210W, T215Y		K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, E138A, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436E	B
Albrecht (2001)	ACTG364_1652	1652		AZT, 3TC	None	M184V		K20KR, R83K, E138A, I142V, A272P, A288T	B
Delgado (2001)	ED_V72	ED_V72	AY016981	AZT	None			V60I, S68G, K122E, E138A, A158AS, T165TI, I178M, G196E	B
	ED_V80	ED_V80	AY016989	AZT, 3TC	None		K101E	E138A, I142T, V179I	B
	ED_V81	ED_V81	AY016990	AZT, 3TC	None		K101E	E138A, I142T, V179I	B
Eshleman (2001)	A004	AF357608	AF357608	AZT, DDI	None	D67N, K70R, T215TA, K219Q		V35M, T39A, V60VI, K64KN, T69N, R83K, E138A, T165I, I178M, I202IV, F214FL, D218DE, A272P, T286A, V317A	B
	A085	AF357686	AF357686	AZT, DDI	None	M41L, L210W, T215Y		T39A, V60I, R83K, D123E, E138A, I178L, A272P, K281R, T286A, E297K, D320E	B
Gonzales (2001)	CA3990	CA9242	AY030989	AZT, D4T, DDI	None	M41L, L210W, T215Y		V35VI, K43EQ, R83K, K102Q, V118VI, D123DE, E138A, D177E, R211K, E233D	B
	CA5377	CA13103	AY031932	D4T, 3TC	None	M184V		V60I, R83K, A98S, E138A, T200A, Q207D, R211K, K249Q, D250E	B
	CA5482	CA13507	AY032021	AZT, 3TC	None	M184V		K20R, K49R, S68G, A98S, I135V, E138A, K166R, V245E, D250E, A272P, K277R, L283I, R284K, I293V, E297A, E302E*	B
	CA5719	CA14138	AY032111	D4T, 3TC	None	M184V		K102Q, K122KE, D123E, I135T, E138A, T139IM, I142V, S162C, D177E, V179I, T200I, V245M	B
	CA6798	CA16844	AY032531	AZT, 3TC, D4T	None	M184V		K122E, E138A, I142V, K173KR, A272P, K277R, K281KE, A288AT, L289LR, V292I, I293V, T296S, E297A	B
Katzenstein (2001)	ACTG302_3142	3142RT_f1		AZT, DDI, 3TC	None	K70R, M184MV, K219KQ		K20R, T39TA, T69TN, R83RK, K102Q, K104KN, I135T, E138A, K166KR, T200TA, R211RK, F214FL, I293V	B
Servais (2001)	JS18	JS97095	AJ401769	AZT, 3TC	None	M41L, T215Y		K122E, E138A, T200A, F214W	B
		JS97439	AJ401787	AZT, 3TC	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y		K43Q, E44D, V60I, K102R, V118I, K122E, I135M, E138A, I142V, T200A, R211K, F214W	B
Ait-Khaled (2002)	MAK-1686	1686161	AJ425899	AZT, 3TC	None	M184V		E138A, I142T, T200A	B
Papa (2002)	AP-15	AP-15	AF315765	D4T, DDI	None	M41L, K70N, V75A		S68G, R83K, K122E, E138A, A158AS, S162AD, I202IV	B
Tural (2002)	880806	880806		AZT, DDI, 3TC, D4T	None	M41L, M184V, L210W, T215Y		K43N, K49R, R83K, K122E, I135V, E138A, S162N, E169K, K173E, I178L, G196E, Q207E, R211K, L234P, D237H	B
Venturi (2002)	GV-2	GV-2.1	AF517254	AZT, 3TC	None			V35I, R83K, D123E, E138A, D177E, T200A, R211G	B
	GV-8	GV-8.1	AF517260	DDC, AZT	None			E6ED, K20KR, V118VI, D123E, E138A, K166R, K173KT, G196E, F214L	B
Shafer (2003)	A384_1956	1956b	EF548643	D4T, DDI	None			K49R, S68G, I135T, E138A, T139E, G196E, R211G, P243T	B
	A384_5929	5929b	EF549350	AZT, 3TC	None	M184V		V35I, R83K, K122E, E138A, K173N, V179I, A272P, K277R, T286A, P294Q, E297R	B
	A384_3210	3210b	EF548383	AZT, 3TC	None	D67N, K70R, M184V, T215TFIS, K219Q		E6D, K20R, V35T, E42EA, K122E, E138A, T200K, Q207N, R211RK, A272G, I293V	B
Dumans (2004)	235	235	AY390139	AZT, DDI	None	D67N, L210W, T215Y		K49R, K122E, D123N, I135T, E138A, I142T, E169D, I202V	B
Kuritzkes (2004)	KDR_pat128	A0154	AY527971	AZT, 3TC	None	M184MV		D123E, E138A, I178L, T200TI, I202V, E204EG, R211RK, F214L	B
		DRK_A0155	AY527972	AZT, 3TC	None			R83RK, D123E, E138A, I178L, T200TI, I202V, E204EGKR, R211RK, F214L	B
	KDR_pat143	A0179	AY527996	D4T, 3TC	None	M41ML, M184V, T215C		S68SDGN, A98S, E138A, I142IT, S162A, T200A	B
	KDR_pat214	A0286	AY528103	AZT, 3TC	None	M184V		E138A, I142V, Q174L, D186DY, L193M, T200A, R211G	B
Machado (2004)	cs160	cs160	AY313394	AZT, DDI, 3TC	None	M41L, D67E, V75M, F77L, M184V, L210W, T215Y		T39A, E44D, S68G, V118I, D123E, I135T, E138A, I142T, Q197L, R211K	B
	con15	con15	AY313430	AZT, DDI	None	T215S		K64R, K122T, I135T, E138A, I142V, D177E, I178V, G196R, T200A	B
Delaunay (2005)	DC_TON08002	08002w12	DQ286521	ABC, TDF, 3TC	None	K65R, M184V		E138A, I142T, I202V, R211K	B
Holguin (2005)	SP_SK2	SP_SK2	AF466719	AZT, 3TC	None	L210W, T215S		V60I, R83K, I94V, A98S, I135V, E138A	B
Non-B Workgroup (2005)	IL503	IL503		AZT, 3TC	None	M184V		T69S, A98S, E138A, I142IV, V179I, R211K, K223I, V245E	B
	TH_575	TH_575		AZT, DDI	None	M41L, D67N, T69D, K70R, T215F, K219Q	V179D	V35L, V60I, K102E, K122E, I135V, E138A, T139A, D177E, I202V, V245K	B
Rhee (2005)	CA5719	CA42644	AY801604	D4T, 3TC	None	M41L, M184V, T215F		K102Q, D123E, I135T, E138A, T139M, I142V, S162C, D177E, V179I, T200I, V245MT, T286A, P294PQ	B
	CA7988	CA20078	AY801884	AZT, 3TC, D4T, DDI	None	D67N, K70R, K219Q		K20R, V35M, T39AE, N54NK, V60I, K64H, T69N, I135T, E138A, I202V, F214L, L228H, T286A, I293V	B
	CA9682	CA23687	AY802060	D4T, 3TC	None	M41L, D67N, M184V, T215F, K219Q	K101E	V60I, I135T, E138A, R211K, D218E, K277KR, T286A, E297K	B
	CA14249	CA41369	AY802284	D4T, 3TC	None	M184V		K20KR, R83K, F87FS, I135IL, E138A, I159IV, T200A, R211K, A272P, K277R, I293V, E297K	B
Santos (2006)	012	012PR_RT	AY275721	AZT, 3TC	None			K122E, D123S, E138A, T200A, R211K	B
Rios (2007)	CH71	MR_CH71.1	EF193966	AZT, 3TC	None		V179D	L12X, V35I, T39A, E138A, G141A, R211A, F214L, V245T	B
von Wyl (2007)	95	662081	EF449985	NRTI	None	M184V		K104R, K122P, E138A, I142T, A158S, S162C, V179I, T200A, R211K	B
	152	1482529	EF449806	NRTI	None	M184MV		V35T, V60I, R83K, I135T, E138A, P150S, N175K	B
Riddler (2008)	RG13636	RG13636w35		D4T, 3TC	None			T27S, V35I, V60I, K64R, R83K, K122E, I135T, E138A, S162Y, Q207D, R211K, I244V, A272P, K277R, T286A, E297K, Q334E, F346Y, M357V, K366R, K390R	B
	RG95549	RG95549w29		TDF, 3TC	None			K49R, E53EDHQ, K122E, E138A, S162C, K173Q, G196E, T200A, E204G, F214L, A272P, I293V, V317A, I326V, F346Y, M357T, A376S, Q394L	B
Rosen-Zvi (2008)	81	02p81-1		AZT, DDI, D4T	None			R83K, K122E, I135V, E138A, S162T, D177E, G196E, T200I, I202V, R211G, V245I, D250E, A272P, K277R, A288S, E297K, S322T, Q334D	B
Rhee (2009)	CA8468	CA21241	FJ983302	D4T, 3TC	None	A62AV, M184V		A98AS, K122E, I132IV, E138A, G196E, Q207D, D250E, K277R, T286A, A288Q, P294Q, E297R	B
	CA9985	CA24774	FJ983342	D4T, 3TC	None	M184V		K20R, V35IT, T69TA, R83K, K122E, I135V, E138A, K166R, Q197L, I202IV, F214FL, V245E, E248D, D250DN, A272P, V276I, L283LI, A288S	B
	CA37887	CA84416	FJ983565	D4T, 3TC	None	M184V, T215Y		K20R, S68T, K122E, D123DN, I135T, E138A, T165I, R172K, Q174QK, I178L, I195L, T200A, I202IV, V245T, D250E, A272P, K277R, T286A, A288S, P294T, E297A	B
von Wyl (2010)	4796717	4796717	GQ848130	AZT, 3TC, D4T	None	M184V, N348I		A98S, K101KQ, K102KQ, K122E, D123DN, E138A, I142V, S162C, R211RK, A272S, T286A, K311R, D324E, R358K, G359GS, T377R, K385R	B
	6504	6504	GU301079	3TC	None	M184V		K20KR, V35I, E138A, T165I, I202IV, A272AP, K277R, L283I, T286A, P294S, R356K, A376T, V381I, K390R, L469I, T470N, H483Y, G490GE, Q524E, K527KN, A534AS	B
Melikian (2012)	CA26324	CA61104	GQ211618	AZT, 3TC, D4T, TDF	None	K70G, M184V		K43KN, E138A, I142T, S162C, K173KE, I178IM, L210LF, R211K, F214L, V245T, V261VG, A272P, V292I	B

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