Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	V108I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	15
Patients	18
Isolates	27

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP22	JIDP22W104	AF021316	AZT, DDI	None	M41L, D67N, L210W, T215Y	A98G, V108I	E44D, V60I, R83K, V118I, R211K, V245E	B
Albrecht (2000)	ACTG303_3553	3553RT_f1		AZT, DDI, 3TC	None	M41L, D67N, K70R, V75M, M184V, T215F, K219W	V108I	K20R, V35M, T39A, V60I, T69TA, L109I, V118I, K122E, I135T, S162D, K166R, T200TI, I202V, D218E, V245Q, A272P, E291D	B
Coakley (2000)	EC34	EC3452w		D4T, DDI	None	F116Y, Q151M	V108I	V60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, Q367P, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519N	B
Falloon (2000)	JF10	JF10-(-)1w	AF227723	AZT, DDI, DDC, D4T, 3TC, PFA	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E, F214X	B
		JF10-12w	AF227724	AZT, DDI, DDC, D4T, 3TC, PFA, ABC	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E	B
Gonzales (2001)	CA1467	CA3912	AY030602	AZT, 3TC, DDC, D4T	None	M41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215Y	V108I	R83K, D123E, K166R, D177E, I202V, A272P, I293V	B
	CA1502	CA4301	AY030628	AZT, DDI	None	D67N, K70R, T215F, K219Q	V108I	K20R, V35M, V60I, K64R, K101R, K122P, I135T, D177E, I178L, A272P, K277R, I293V, E298EQ, A299AS	B
	CA1595	CA4544	AY030693	D4T, 3TC	None	M41L, D67N, T69D, V75M, M184V, L210W, T215Y	V108I	V35VI, T39A, K43Q, E44D, T107A, L109V, V118I, K122E, D123E, S162C, I178L, V179I, V189I, G196E, H208Y, R211K, V245VE, A272P, E297Q	B
	CA5258	CA12854	AY031815	D4T, 3TC	None	K70KR	V108I	T69S, D121C, K122E, K166KR, D177E, I178IL, T200TA, Q207E, R211K, A272P	B
	CA5531	CA13666	AY032041	D4T, 3TC	None	K70R, M184V, T215E	V108I	K20R, D123E, Y127YF, S134ST, I135IS, Q174R, D177E, E194K, G196E, R211K, E248GS, A272P, A299AG	B
	CA5949	CA14712	AY032198	NRTI, AZT, 3TC	None	K70KR, M184V	V108I	V35I, D121C, K122E, K166R, D177E, G196E, Q207E, R211K, L228N, V245M, N265NT, A272P, K277R, I293V	B
Papa (2002)	AP_GR49	AP_GR49	AY046881	D4T, DDI, AZT, 3TC	None	M41L, D67N, L74LV, L210W, T215Y, K219R	V108I	K43E, E44D, L109I, V118VI, K122Q, D123DE, I178L, V189I, G196E, I202T, H208HY, R211K, E224D	B
Venturi (2002)	GV-5	GV-5.1	AF517257	DDC, AZT	None		V108I	V35M, R83K, K122P, D123E, D177E, I178L, G196E, T200I	B
Gonzales (2003)	CA1502	CA9366	AY351711	AZT, DDI, D4T, 3TC	None	D67N, K70R, M184V, T215F, K219Q	V108I	K20R, V35M, V60I, K64R, T69TN, K101RS, K122P, I135T, D177E, I178L, A272P, K277R	B
Gonzales (2003)		CA16468	AY305932	AZT, DDI, D4T, 3TC	None	D67N, K70R, M184V, T215F, K219Q	V108I	K20R, V35M, V60I, K64R, K101RS, K122P, I135T, K166KQ, D177E, I178L, D218DE, Q269QHY, Y271Y, A272P, K277R	B
Gonzales (2003)	CA3871	CA10950	AF514155	DDI, DDC, AZT, 3TC, D4T	None	M41L, D67N, T69D, M184V, L210W, T215Y, K219R	V108I	V35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, H208Y, R211K, H221Y, A272P, I293IL, G335S, M357MT, E370EK, A371V, I375V, A400T, E404D, V435E, K451R, D460N, S468P, H483HY, L491LQ, S519N, K530KR	B
Shafer (2003)	A384_0967	0967b	EF548167	AZT, 3TC	None		V108I	I37X, K101R, D123E, N137NS, S162N, K173KR, D177DE, I178IM, R211G	B
Gulick (2004)	RG12	RG12w140		ABC, AZT, 3TC, TDF	None	D67N, K70R, V75T, M184V	V108I	K30R, D123E, I142V, T165L, D177E, R211Q, K277R, K281R, T286A	B
Garcia-Bujalance (2005)	GBS_36	GBS_36	AY872371	AZT, DDC, D4T, 3TC, DDI	None	A62AV, K70R, M184V	V108I	T69N, K122R, D123E, D177E, I178L	B
Rhee (2005)	CA1502	CA4378	AY801001	AZT, DDI	None	D67N, K70R, T215F, K219Q	V108I	K20R, V35M, V60I, K64R, K101R, K122P, I135T, I178L, R211G, Q258QP, A272P, K275KN, K277R, C280CR, L289LF, I293V	B
		CA12340	AY801002	AZT, DDI, D4T, 3TC	None	D67N, K70R, M184V, T215F, K219Q	V108I	K20R, V35M, V60I, K64R, K101S, K122P, I135T, D177E, I178L	B
		CA23764	AY801003	AZT, DDI, D4T, 3TC	None	D67N, K70R, M184V, T215F, K219Q	V108I	K20R, V35M, V60I, K64KR, T69TN, K101RS, K122P, I135T, K166Q, D177E, I178L, D218DE, A272P, K277R, T286TA, I293IV	B
	CA5258	CA24818	AY801528	D4T, 3TC, AZT	None	K70R, M184V	V108I	T69S, D121C, K122E, S162SN, K166R, D177E, I178L, T200A, Q207E, R211RK, A272P, K277R, E297K	B
		CA34266	AY801529	D4T, 3TC, AZT	None	K70R, M184V	V108I	T69S, D121C, K122E, K166R, D177E, I178IL, T200A, Q207E, R211RK, A272P, K277R, E297K	B
		CA48136	AY801530	D4T, 3TC, AZT, TDF	None		V108I	T69S, D121C, K122E, K173KQ, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, E297K	B
	CA17694	CA41631	AY802545	D4T, 3TC	None	M41L, A62V, D67G, M184V, L210W, T215Y, K219R	V108I	K20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350E	B
Riddler (2008)	RG83898	RG83898w31		AZT, 3TC	None		V108I	V35I, H96L, A98S, K122KR, D123DEKN, K166R, D177E, I178L, R211K, F214FL, E248D, A272P, K275R, K277Q, E297K, K366R, K390R	B

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