<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V108I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 16
Patients 20
Isolates 29
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP22JIDP22W104AF021316AZT, DDINoneM41L, D67N, L210W, T215YA98G, V108IE44D, V60I, R83K, V118I, R211K, V245EB
Albrecht (2000)ACTG303_35533553RT_f1 AZT, DDI, 3TCNoneM41L, D67N, K70R, V75M, M184V, T215F, K219WV108IK20R, V35M, T39A, V60I, T69TA, L109I, V118I, K122E, I135T, S162D, K166R, T200TI, I202V, D218E, V245Q, A272P, E291DB
Coakley (2000)EC34EC3452w D4T, DDINoneF116Y, Q151MV108IV60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, Q367P, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519NB
Falloon (2000)JF10JF10-(-)1wAF227723AZT, DDI, DDC, D4T, 3TC, PFANoneM41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219RV108IV118I, K122E, I178M, G196E, E203K, R211E, F214XB
  JF10-12wAF227724AZT, DDI, DDC, D4T, 3TC, PFA, ABCNoneM41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219RV108IV118I, K122E, I178M, G196E, E203K, R211EB
Gonzales (2001)CA1467CA3912AY030602AZT, 3TC, DDC, D4TNoneM41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215YV108IR83K, D123E, K166R, D177E, I202V, A272P, I293VB
 CA1502CA4301AY030628AZT, DDINoneD67N, K70R, T215F, K219QV108IK20R, V35M, V60I, K64R, K101R, K122P, I135T, D177E, I178L, A272P, K277R, I293V, E298EQ, A299ASB
 CA1595CA4544AY030693D4T, 3TCNoneM41L, D67N, T69D, V75M, M184V, L210W, T215YV108IV35VI, T39A, K43Q, E44D, T107A, L109V, V118I, K122E, D123E, S162C, I178L, V179I, V189I, G196E, H208Y, R211K, V245VE, A272P, E297QB
 CA5258CA12854AY031815D4T, 3TCNoneK70KRV108IT69S, D121C, K122E, K166KR, D177E, I178IL, T200TA, Q207E, R211K, A272PB
 CA5531CA13666AY032041D4T, 3TCNoneK70R, M184V, T215EV108IK20R, D123E, Y127YF, S134ST, I135IS, Q174R, D177E, E194K, G196E, R211K, E248GS, A272P, A299AGB
 CA5949CA14712AY032198NRTI, AZT, 3TCNoneK70KR, M184VV108IV35I, D121C, K122E, K166R, D177E, G196E, Q207E, R211K, L228N, V245M, N265NT, A272P, K277R, I293VB
Papa (2002)AP_GR49AP_GR49AY046881D4T, DDI, AZT, 3TCNoneM41L, D67N, L74LV, L210W, T215Y, K219RV108IK43E, E44D, L109I, V118VI, K122Q, D123DE, I178L, V189I, G196E, I202T, H208HY, R211K, E224DB
Venturi (2002)GV-5GV-5.1AF517257DDC, AZTNone V108IV35M, R83K, K122P, D123E, D177E, I178L, G196E, T200IB
Gonzales (2003)CA1502CA9366AY351711AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, T215F, K219QV108IK20R, V35M, V60I, K64R, T69TN, K101RS, K122P, I135T, D177E, I178L, A272P, K277RB
Gonzales (2003) CA16468AY305932AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, T215F, K219QV108IK20R, V35M, V60I, K64R, K101RS, K122P, I135T, K166KQ, D177E, I178L, D218DE, Q269Q*HY, Y271Y*, A272P, K277RB
Gonzales (2003)CA3871CA10950AF514155DDI, DDC, AZT, 3TC, D4TNoneM41L, D67N, T69D, M184V, L210W, T215Y, K219RV108IV35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, H208Y, R211K, H221Y, A272P, I293IL, G335S, M357MT, E370EK, A371V, I375V, A400T, E404D, V435E, K451R, D460N, S468P, H483HY, L491LQ, S519N, K530KRB
Shafer (2003)A384_09670967bEF548167AZT, 3TCNone V108II37X, K101R, D123E, N137NS, S162N, K173KR, D177DE, I178IM, R211GB
Gulick (2004)RG12RG12w140 ABC, AZT, 3TC, TDFNoneD67N, K70R, V75T, M184VV108IK30R, D123E, I142V, T165L, D177E, R211Q, K277R, K281R, T286AB
Garcia-Bujalance (2005)GBS_36GBS_36AY872371AZT, DDC, D4T, 3TC, DDINoneA62AV, K70R, M184VV108IT69N, K122R, D123E, D177E, I178LB
Rhee (2005)CA1502CA4378AY801001AZT, DDINoneD67N, K70R, T215F, K219QV108IK20R, V35M, V60I, K64R, K101R, K122P, I135T, I178L, R211G, Q258QP, A272P, K275KN, K277R, C280CR, L289LF, I293VB
  CA12340AY801002AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, T215F, K219QV108IK20R, V35M, V60I, K64R, K101S, K122P, I135T, D177E, I178LB
  CA23764AY801003AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, T215F, K219QV108IK20R, V35M, V60I, K64KR, T69TN, K101RS, K122P, I135T, K166Q, D177E, I178L, D218DE, A272P, K277R, T286TA, I293IVB
 CA5258CA24818AY801528D4T, 3TC, AZTNoneK70R, M184VV108IT69S, D121C, K122E, S162SN, K166R, D177E, I178L, T200A, Q207E, R211RK, A272P, K277R, E297KB
  CA34266AY801529D4T, 3TC, AZTNoneK70R, M184VV108IT69S, D121C, K122E, K166R, D177E, I178IL, T200A, Q207E, R211RK, A272P, K277R, E297KB
  CA48136AY801530D4T, 3TC, AZT, TDFNone V108IT69S, D121C, K122E, K173KQ, D177E, I178L, T200A, Q207E, R211K, A272P, K277R, E297KB
 CA17694CA41631AY802545D4T, 3TCNoneM41L, A62V, D67G, M184V, L210W, T215Y, K219RV108IK20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350EB
Riddler (2008)RG83898RG83898w31 AZT, 3TCNone V108IV35I, H96L, A98S, K122KR, D123DEKN, K166R, D177E, I178L, R211K, F214FL, E248D, A272P, K275R, K277Q, E297K, K366R, K390RB
Grossman (2014)3333 3TC, DDI, D4TNoneM41L, D67N, T69D, V75M, M184I, L210W, T215Y, K219RV108II37L, E44D, V60I, V118I, K122E, Q174K, N175Y, V179VI, G196E, T200R, E203V, Q207E, R211A, D218E, L228V, Q242LB
 815815 D4T, 3TCNone V108IK122E, D123E, I135T, T200I, F214L, P243LB