Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	V106M
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	17
Patients	47
Isolates	57

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Gonzales (2001)	CA6839	CA16903	AY032571	AZT, 3TC, D4T, DDI	EFV	M41L, D67N, T215Y	V106M, V179E	K122E, I135V, D177N, I178M, T200A, Q207E, V245T, E248D, V261VG, N265ND, Q269QE, I270IL, A272P, I274IV, K277R	B
Tural (2002)	50331	50331		DDC, AZT, 3TC, D4T, DDI	NVP	K65R, K70R, V75I, F77L, F116Y, Q151M	V106M, G190A, F227L	E42K, S68N, V118I, K122E, F124S, R125G, I135T, K166R, K173E, F214L	B
Gonzales (2003)	CA1446	CA24292	AY305912	AZT, 3TC, DDI, D4T, ABC	NVP, EFV	M41L, D67N, L74I, V75VA, M184V, L210W, T215Y	K103N, V106M	K20R, V35M, E44D, K102KR, K122E, E169D, T200A, H208Y, R211K, K223Q, L228Q, I293V	B
Gulick (2004)	RG162	RG162w70		ABC, D4T, 3TC	EFV	L74LV, Y115F, M184V	K103N, V106M	R83K, K102KR, D113N, D123N, I135V, K166R, K173KN, D177E, I202V, R211K, H235L	B
	RG205	RG205w35		ABC, AZT, 3TC, DDI	EFV	L74I, M184V	V106M, V179D, F227FL	I37X, I142T, Q207A, R211K, D237DN, V245VIM	B
		RG205w39		ABC, AZT, 3TC, DDI	EFV	L74I, M184V	V106M, V179D, F227FL	I142T, Q207A, R211K	B
	RG419	RG419w152		ABC, AZT, 3TC	EFV		K103N, V106M	I135IL, S162Y, E169ED, K173T, Q174K, V179I, G196E, R211RK, P243H, V245E	B
Machado (2004)	CS183	CS183	AY569969	AZT, DDI, 3TC	EFV	D67N, K70R, T215F, K219Q	K103N, V106M	T69N, I135T, S162C, F171Y, I178L, T200A	B
Rhee (2005)	CA1446	CA12465	AY800945	AZT, 3TC, DDI, D4T, ABC	NVP, EFV	M41L, D67N, L74I, M184MV, L210W, T215Y, K219KN	K103N, V106M	K20R, V35IM, E44D, R83K, K102KR, K122KE, E169D, T200A, H208Y, R211K, L228Q, I293V	B
		CA38107	AY800946	AZT, 3TC, DDI, D4T, ABC, TDF	NVP, EFV	M41L, D67N, L74I, M184V, L210W, T215Y, K219R	K103N, V106M	K20R, V35M, E44ED, V111I, K122E, E169D, V179I, T200A, H208Y, R211K, K223Q, L228Q, I293V	B
	CA1542	CA35222	AY801027	AZT, 3TC, D4T, DDI	EFV	M41ML, D67N, K70R, T215FY, K219Q	K103N, V106M	A98S, I178L	B
	CA4791	CA37923	AY801408	AZT, 3TC, D4T, DDI	EFV		K103N, V106M	K122E, I142V, Q174H, T200A, I202V, Q207E, L210F, R211K, A272P	B
	CA5063	CA20230	AY801473	AZT, DDC, D4T, 3TC, Unknown	Unknown, NVP	M41L, K70R, M184V	V106M, G190A	M16ML, T69N, I142V, K166R, E169D, V179I, F214L, L228H	B
	CA5153	CA42584	AY801498	DDI, AZT, D4T, 3TC, ABC	EFV	M41L, D67N, T69D, K70R, T215F, K219Q	K103N, V106M	V60I, V118I, I135T, Q174H, V179VI, T200A, Q207R, R211E, F214L, L228R, I293V, I329IL, E344EG, Y354H, K366KR, T369TA, A376T, T386TS, K390R, A400T, T403TA, E404D, V435A, A437IV, D460N, R461K, H483HY, L491S, S519SN, K540KT, A554ADNT, K558R	B
	CA6814	CA34281	AY801705	D4T, 3TC, ABC	NVP	L74V, Y115F, Q151M, M184V	K103S, V106M	K102R, D177E, I178M, T200E, R211Q, F214FL, V245VE, A272P, I293V	B
	CA6839	CA35230	AY801710	AZT, 3TC, D4T, DDI, ABC	EFV, DLV	M41L, D67N, T215CY	V106M, V179E	K122E, I135V, D177N, I178M, T200A, Q207E, V245T, E248D, A272P, K277R, E291D, E297K	B
		CA37844	AY801711	AZT, 3TC, D4T, DDI, ABC, TDF	EFV, DLV	M41L, D67N, M184V, T215Y	V106M, V179E	K122E, I135V, D177N, I178M, V189VI, T200A, Q207E, V245T, E248D, A272P, K277R, E291D, E297K	B
	CA14650	CA35065	AY802395	3TC, DDI	EFV	M184V	V106M, V179D	D123E, I178M, A272P, T286A, V292I	B
Weber (2005)	WJ_pat7152	7152_W36	AY736117	3TC, D4T	EFV	K65R, T69~, K70R	V106M, V179D	K20R, V35L, K43S, I50V, R83K, D121H, K122E, E169D, D177E, F214L, E248D, A272P, K277R, T286A	B
	WJ_pat7101	7101_W12	AY736109	TDF, 3TC	EFV	D67N, M184V	V106M, V179D	E6D, D123E, I178L, G196E, T200I, F214L, V245T, K249Q, K275R, V276I, I293V, P294Q	B
		7101_W24	AY736110	TDF, 3TC	EFV	A62AV, K65KR, M184V	V106M, V179D	E6D, V21VD, S68SN, D123E, I178L, E194EK, G196E, T200I, R211RK, F214L, V245T, K249Q, K275R, V276I, I293V, P294Q	B
Baxter (2006)	12-4002	4002-30124	DQ880386	NRTI	NNRTI	M41L, D67G, L74V, Y115YF, M184V, T215TI, K219N	V106M, V179D, G190GA	S68G, K103R, V118I, I135T, T165I, Q207E, R211RK, F214L, D237N	B
	12-2223	2223-30805	DQ880112	NRTI	NNRTI	M41L, D67G, K70R, L74I, V75M, M184V, T215F, K219Q	K101E, V106M, Y181V, G190A	K64R, T69N, V118I, K122E, I135V, T139A, Q174N, I202IV, F214L, L228H, Q242E, V245K	B
	48-1411	1411-30312	DQ877806	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219Q	V106M, Y181C, G190A, F227FL	K20R, K32KT, T39A, E44ED, V60I, K101Q, K122E, I135T, Q174E, I202V, K223T, A272P, E297K, V317A, Q334L, K347KE, G359S, K390R, E399D	B
	48-4178	4178-30627	DQ878412	NRTI	NNRTI	M41L, D67N, K70R, L74I, V75A, M184V, T215F, K219Q	V106M, G190GA, F227L	T7TP, P9S, I37IL, T39E, E44D, T69N, I94L, V118I, D121DH, D123E, I135T, S162A, D177E, V179VI, T200S, E203ED, Q207E, H208Y, R211K, F214L, D218E, K249Q, A272P, A288S, E297K, Q334P, G335S, M357T, G359S, A371V, T386I	B
Margot (2006)	7152	7152W48		D4T, 3TC	EFV	K65R, K70R	V106M, V179D	L34LI, V35L, K43KSRN, I50V, R83K, D121HY, E169D, D177E, E248D, T286A, R358K, T369TA, E399G	B
		7152W48		D4T, 3TC	EFV	A62AV, M184V, N348NI	V106M, V179D	V35L, K43KSRN, I50V, R83K, D121HY, E169D, D177E, E248D, T286A, R358K, T369TA, E399G, A400AT	B
	7655	7655W48		D4T, 3TC	EFV		K103N, V106M	V35I, D123E, I135V, D177E, R206K, Q207E, P294S, E297K, V317A, G333E, Q334L, R356K, K390R	B
	7827	7827W48		D4T, 3TC	EFV	M184V	V106M, V179D	K20R, K103KR, V118I, I135M, T200A, Q207E, V245I, T286A, I293V, T338S, H361HP, K366R, K390R, A400AT	B
		7827W96		D4T, 3TC	EFV		V106M, V179D	V118VI, T200A, Q207E, T286A, I293V, T338S, K366R, K390R	B
Riddler (2008)	43021	21512Db	HM056537	TDF, 3TC	EFV	M184V	V106M, V179D	I142V, K173Q, Q174K, P243T, V245E, A272P, V292I, M357T, T377L, S379G, K390R, A400S, E404D, V435I, R448K, D460N, R461K, S519N, A554S	B
	RG48284	RG48284w32		AZT, 3TC	EFV		V106M, E138EK	V35I, R83K, D123E, I135T, I178L, G196E, R211G, I244V, V245K, A272P, K281R, T286A, E297K, V317A, I329V, G333E, F346Y, M357T, K390R, E399D	B
Cardoso (2009)	3153	BRGO3153	FJ638466	NRTI	NNRTI	M41L, M184V, T215Y	K103N, V106M	K20R, K30R, E44D, D121H, K122E, D123E, D177E, I178L, R211T	B
Luo (2009)	xs.1386	05HBxs.1386	FJ375088	NRTI	NNRTI	A62V, K65R, D67N, V75T	V106M, V179D, G190A	K101Q, D113G, I135V, S162C, M164V, T200A, L210F, A272P, K277R, Q278E, L283I, Q334L	B
Rhee (2009)	CA27769	CA64194	FJ983547	TDF, DDI	EFV	L74LIV, M184V	V106M, V179VD, G190A	I135IT, K173E, I178L, E204EK, Q207E, F214L, D237DN, V245K, D250E	B
Dau (2010)	07714A	07714A	GU581863	NRTI	NNRTI	K65R, Y115F	V106M, V179D, Y181C	T39A, W88S, K173E, Q174K, E204Q, Q207E, R211K, F214L, A272P, T286P, V292I, I293V, E297A, K311R, I326V, G333GE, Q334L, M357T, K385R, K390R, Q394N	B
	08561A	08561A	GU581923	NRTI	NNRTI	L74V	K103N, V106M, F227L	K20KR, V21I, V60I, R211K, V245K, E297KR, I329V, R356K, K366R, T377Q, K390R, E399D	B
	09895A	09895A	GU581990	NRTI	NNRTI	M41L, D67N, K70R, T215Y	K103N, V106M	K20R, K122E, R211Q	B
Hachiya (2011)	CL-ACC	CL-1 ACC311	AB506802	D4T, DDI, TDF	EFV	A62V, V75I, F116Y, Q151M	V106M, V179D	S68G, V90I, K101Q, K122E, D123S, I135T, R172K, K173S, Q174K, T200K, I202V, R211K, F214L, A272P, K277R, I293V, A376T, T386I, K390R, A400T, T403I, S468P, K527N, A554N, K558R	B
		CL-2 ACC334	AB506803	D4T, DDI, TDF	EFV	A62V, K70Q, V75I, F116Y, Q151M	V106M, V108I, V179D	S68G, V90I, K101Q, K102R, K122E, D123S, I135T, R172K, K173S, Q174K, T200K, I202V, R211K, F214L, A272P, K277R, I293V, A376T, T386I, K390R, A400T, T403I, S468P, K527N, A554N, K558R	B
Jones (2012)	129903	129903	JN669475	NRTI	NNRTI	M41L, D67N, M184V, L210W, T215Y, K219N	V106M, G190A	T39A, K43E, E44A, K64R, K101Q, V118I, I202V, R211RK, V245T, V292I, I293V, E297R, I341V, A360T, A376V, T386I, K390R	B
	135338	135338	JN669541	NRTI	NNRTI	A62V, K70Q, V75I, F77L, Y115F, F116Y, Q151M, M184V	V106M, V179D, G190A	T7I, T58N, S68R, K103R, V118I, D121C, K122E, I135T, E138A, T165I, Q174K, D177E, G196GE, Q197LP, I202V, F214L, V245M, A272P, T286P, I293V, P294T, K311KR, Q334L, T338S, E370D, T386I, E399D	B
	139475	139475	JN669577	NRTI	NNRTI	M41L, D67N, L210W, T215Y, K219R	K103N, V106M	E44D, K102R, K122E, D123E, I135T, V179I, G196E, T286P, V292I, I293V, E297K, S322T, N348T, G359S, A371T, K388R, E399D	B
	142746	142746	JN669624	NRTI	NNRTI	A62V, K70Q, V75I, F77L, Y115F, F116Y, Q151M, M184V	V106M, V179D, G190A	T7I, T58N, S68R, K103R, V118I, D121C, K122E, I135T, E138A, T165I, Q174K, D177E, G196E, Q197L, I202V, F214L, V245M, A272P, T286P, I293V, P294T, K311KR, Q334L, T338S, E370D, T386I, E399D	B
	150626	150626	JN669752	NRTI	NNRTI	D67N, K70R, K219Q	V106M, Y181C, G190A	V35T, T39A, E40D, V60I, T69N, K122E, S156SP, E169D, V179VI, T200A, I202V, E203K, Q207E, H221Y, E248EG, D250E, A272P, K281R, T286P, E297K, V317A, R358K, A376S, T386I, K388KR, K390R, Q394L, E399D	B
	154224	154224	JN669814	NRTI	NNRTI	A62V, K65KR, D67DN, K70KR, V75T, K219KHNQ	K103N, V106M, Y181YC, G190GA	K20R, S68G, K102KR, I135T, F214L, V245E, A288T, V292I, I293V, E297R, I329L, Q334C, M357T, V372VIM, T386TI	B
	158443	158443	JN669921	NRTI	NNRTI	L74V, Y115F	K103N, V106M	V35VI, V60I, R211K, E224EK, V245K, A272P, T286A, E297T, I326V, I329L, G335D, M357T, R358K, A360T	B
	160464	160464	JN669978	NRTI	NNRTI	M41L, D67N, T69D, L74V, L210W, T215Y	V106M, F227L, M230L	V35I, T39K, K43E, E44D, D76DN, V118I, D121H, K122E, I135T, P140T, S162D, K166R, I178L, E203D, H208Y, R211K, W212C, H221Y, A272P, L283I, R284K, I293V, I326V, K350R, R356K, G359A, T386I, K390R	B
	175531	175531	JN670363	NRTI	NNRTI	A62AV, D67N, K70R, V75T, M184V, K219Q, N348I	K103N, V106M	V35M, K102R, I135V, D177E, F214L, A272P, I293V, E297K, K311KR, I329IV, Q334Y, I341F, K390R, Q394L, E399D	B
	177288	177288	JN670432	NRTI	NNRTI	M41L, T69D, L210W, T215Y, K219R	V106M, V108I, V179E, F227L	P4S, K43Q, V60VI, W88C, V118I, K122E, T139K, S162H, D177E, T200A, E203K, H208Y, R211K, K223E, E224ED, L228HR, A272P, A288S, E297R, S322L, I329L, G335S, G359S, A371V, A376C, T377IV, T386I, K390R, E399D	B
	178223	178223	JN670476	NRTI	NNRTI	A62V, M184V, T215TFIS, N348I	V106M, V179E	V35T, I135R, F214L, A272P, K277R, R284RK, T286A, I293V, E297Q, R358RK, E370G, A376T, K390R, Q394QL	B
	182465	182465	JN670612	NRTI	NNRTI	Y115YF, M184V	V106M, V179D, F227FL	V35T, T39L, V60I, T69N, K122E, I135T, T200A, A272P, T286V, E291D, E297KT, M357T, A376T, T386TA, K390R, Q394L, E399D	B
	194482	194482	JN670937	NRTI	NNRTI	D67N, K70R, M184V, K219Q, N348NI	V106M, G190A	K101KQ, V108VL, E169D, V179VI, T200R, I202V, Q207H, R211K, F214L, A272P, R284RK, I293V, E297T, K311R, D324DE, Q334L, I341IF, M357I, A360T, D364DE, K374KR, A376T, T377K, T386I, K390R, W398CY	B
	199006	199006	JN671145	NRTI	NNRTI	M41ML, D67DN, L74LV, K219KR	V106M, V179D, F227FL	V35T, V60I, K104KR, S105SA, K122KE, D123DE, I135V, I142V, I178L, F214L, A272P, T286A, E297K, G333E, Q334H, K390R, Q394L, E399D	B
	199028	199028	JN671149	NRTI	NNRTI	M41L, D67DN, K70KR, M184V, T215E	V106M, F227FL	K122E, I135M, T139TR, A158S, T200E, I202V, E203K, Q207E, E248D, T286A, A288T, E297A, I382L, K390R	B
	203233	203233	JN671304	NRTI	NNRTI		V106M, V179D, F227L	K122E, I135T, V245K, T286A, I293V, E297T, Q334E, M357T, A376S, S379G, T386I, K390R	B
Melikian (2012)	CA1446	CA87356		AZT, 3TC, DDI, D4T, ABC, TDF, FTC	NVP, EFV	M41L, D67N, L74I, M184V, L210W, T215Y, K219R	K103N, V106M	K20R, V35M, E44ED, K64KR, V111I, E169D, Q174QR, V179I, T200A, I202IV, H208Y, R211K, K223Q, L228Q	B

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