<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V106M
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 48
Isolates 57
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gonzales (2001)CA6839CA16903AY032571AZT, 3TC, D4T, DDIEFVM41L, D67N, T215YV106M, V179EK122E, I135V, D177N, I178M, T200A, Q207E, V245T, E248D, V261VG, N265ND, Q269QE, I270IL, A272P, I274IV, K277RB
Tural (2002)5033150331 DDC, AZT, 3TC, D4T, DDINVPK65R, K70R, V75I, F77L, F116Y, Q151MV106M, G190A, F227LE42K, S68N, V118I, K122E, F124S, R125G, I135T, K166R, K173E, F214LB
Gonzales (2003)CA1446CA24292AY305912AZT, 3TC, DDI, D4T, ABCNVP, EFVM41L, D67N, L74I, V75VA, M184V, L210W, T215YK103N, V106MK20R, V35M, E44D, K102KR, K122E, E169D, T200A, H208Y, R211K, K223Q, L228Q, I293VB
Gomez-Carrillo (2004)9193891938AY365472NRTINNRTIM184VV106M, V179DV35L, S48T, K103KR, D123E, I135IV, K166R, I178L, R211K, F214L, D237DN, V245T, A272P, K277R, I293V, E297K, I329L, Y342F, M357V, A360T, T386I, K390KRB
 107857107857AY365776NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219DE, N348IK103N, V106M, V108IK11Q, V60I, D121C, K122E, I142V, D177E, I178L, T200A, E203D, Q207E, H208Y, R211K, H221HY, L228H, V245T, K275KR, K277R, Q278H, A288S, I293V, I341IF, M357T, A360T, T386I, K390RB
Gulick (2004)RG162RG162w70 ABC, D4T, 3TCEFVL74LV, Y115F, M184VK103N, V106MR83K, K102KR, D113N, D123N, I135V, K166R, K173KN, D177E, I202V, R211K, H235LB
 RG205RG205w35 ABC, AZT, 3TC, DDIEFVL74I, M184VV106M, V179D, F227FLI37X, I142T, Q207A, R211K, D237DN, V245VIMB
  RG205w39 ABC, AZT, 3TC, DDIEFVL74I, M184VV106M, V179D, F227FLI142T, Q207A, R211KB
 RG419RG419w152 ABC, AZT, 3TCEFV K103N, V106MI135IL, S162Y, E169ED, K173T, Q174K, V179I, G196E, R211RK, P243H, V245EB
Machado (2004)CS183CS183AY569969AZT, DDI, 3TCEFVD67N, K70R, T215F, K219QK103N, V106MT69N, I135T, S162C, F171Y, I178L, T200AB
Rhee (2005)CA1446CA12465AY800945AZT, 3TC, DDI, D4T, ABCNVP, EFVM41L, D67N, L74I, M184MV, L210W, T215Y, K219KNK103N, V106MK20R, V35IM, E44D, R83K, K102KR, K122KE, E169D, T200A, H208Y, R211K, L228Q, I293VB
  CA38107AY800946AZT, 3TC, DDI, D4T, ABC, TDFNVP, EFVM41L, D67N, L74I, M184V, L210W, T215Y, K219RK103N, V106MK20R, V35M, E44ED, V111I, K122E, E169D, V179I, T200A, H208Y, R211K, K223Q, L228Q, I293VB
 CA1542CA35222AY801027AZT, 3TC, D4T, DDIEFVM41ML, D67N, K70R, T215FY, K219QK103N, V106MA98S, I178LB
 CA4791CA37923AY801408AZT, 3TC, D4T, DDIEFV K103N, V106MK122E, I142V, Q174H, T200A, I202V, Q207E, L210F, R211K, A272PB
 CA5063CA20230AY801473AZT, DDC, D4T, 3TC, UnknownUnknown, NVPM41L, K70R, M184VV106M, G190AM16ML, T69N, I142V, K166R, E169D, V179I, F214L, L228HB
 CA5153CA42584AY801498DDI, AZT, D4T, 3TC, ABCEFVM41L, D67N, T69D, K70R, T215F, K219QK103N, V106MV60I, V118I, I135T, Q174H, V179VI, T200A, Q207R, R211E, F214L, L228R, I293V, I329IL, E344EG, Y354H, K366KR, T369TA, A376T, T386TS, K390R, A400T, T403TA, E404D, V435A, A437IV, D460N, R461K, H483HY, L491S, S519SN, K540KT, A554ADNT, K558RB
 CA6814CA34281AY801705D4T, 3TC, ABCNVPL74V, Y115F, Q151M, M184VK103S, V106MK102R, D177E, I178M, T200E, R211Q, F214FL, V245VE, A272P, I293VB
 CA6839CA35230AY801710AZT, 3TC, D4T, DDI, ABCEFV, DLVM41L, D67N, T215CYV106M, V179EK122E, I135V, D177N, I178M, T200A, Q207E, V245T, E248D, A272P, K277R, E291D, E297KB
  CA37844AY801711AZT, 3TC, D4T, DDI, ABC, TDFEFV, DLVM41L, D67N, M184V, T215YV106M, V179EK122E, I135V, D177N, I178M, V189VI, T200A, Q207E, V245T, E248D, A272P, K277R, E291D, E297KB
 CA14650CA35065AY8023953TC, DDIEFVM184VV106M, V179DD123E, I178M, A272P, T286A, V292IB
Weber (2005)WJ_pat71527152_W36AY7361173TC, D4TEFVK65R, T69~, K70RV106M, V179DK20R, V35L, K43S, I50V, R83K, D121H, K122E, E169D, D177E, F214L, E248D, A272P, K277R, T286AB
 WJ_pat71017101_W12AY736109TDF, 3TCEFVD67N, M184VV106M, V179DE6D, D123E, I178L, G196E, T200I, F214L, V245T, K249Q, K275R, V276I, I293V, P294QB
  7101_W24AY736110TDF, 3TCEFVA62AV, K65KR, M184VV106M, V179DE6D, V21VD, S68SN, D123E, I178L, E194EK, G196E, T200I, R211RK, F214L, V245T, K249Q, K275R, V276I, I293V, P294QB
Baxter (2006)12-40024002-30124DQ880386NRTINNRTIM41L, D67G, L74V, Y115YF, M184V, T215TI, K219NV106M, V179D, G190GAS68G, K103R, V118I, I135T, T165I, Q207E, R211RK, F214L, D237NB
 12-22232223-30805DQ880112NRTINNRTIM41L, D67G, K70R, L74I, V75M, M184V, T215F, K219QK101E, V106M, Y181V, G190AK64R, T69N, V118I, K122E, I135V, T139A, Q174N, I202IV, F214L, L228H, Q242E, V245KB
 48-14111411-30312DQ877806NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219QV106M, Y181C, G190A, F227FLK20R, K32KT, T39A, E44ED, V60I, K101Q, K122E, I135T, Q174E, I202V, K223T, A272P, E297K, V317A, Q334L, K347KE, G359S, K390R, E399DB
 48-41784178-30627DQ878412NRTINNRTIM41L, D67N, K70R, L74I, V75A, M184V, T215F, K219QV106M, G190GA, F227LT7TP, P9S, I37IL, T39E, E44D, T69N, I94L, V118I, D121DH, D123E, I135T, S162A, D177E, V179VI, T200S, E203ED, Q207E, H208Y, R211K, F214L, D218E, K249Q, A272P, A288S, E297K, Q334P, G335S, M357T, G359S, A371V, T386IB
Margot (2006)71527152W48 D4T, 3TCEFVK65R, K70RV106M, V179DL34LI, V35L, K43KSRN, I50V, R83K, D121HY, E169D, D177E, E248D, T286A, R358K, T369TA, E399GB
  7152W48 D4T, 3TCEFVA62AV, M184V, N348NIV106M, V179DV35L, K43KSRN, I50V, R83K, D121HY, E169D, D177E, E248D, T286A, R358K, T369TA, E399G, A400ATB
 76557655W48 D4T, 3TCEFV K103N, V106MV35I, D123E, I135V, D177E, R206K, Q207E, P294S, E297K, V317A, G333E, Q334L, R356K, K390RB
 78277827W48 D4T, 3TCEFVM184VV106M, V179DK20R, K103KR, V118I, I135M, T200A, Q207E, V245I, T286A, I293V, T338S, H361HP, K366R, K390R, A400ATB
  7827W96 D4T, 3TCEFV V106M, V179DV118VI, T200A, Q207E, T286A, I293V, T338S, K366R, K390RB
Riddler (2008)4302121512DbHM056537TDF, 3TCEFVM184VV106M, V179DI142V, K173Q, Q174K, P243T, V245E, A272P, V292I, M357T, T377L, S379G, K390R, A400S, E404D, V435I, R448K, D460N, R461K, S519N, A554SB
 RG48284RG48284w32 AZT, 3TCEFV V106M, E138EKV35I, R83K, D123E, I135T, I178L, G196E, R211G, I244V, V245K, A272P, K281R, T286A, E297K, V317A, I329V, G333E, F346Y, M357T, K390R, E399DB
Cardoso (2009)3153BRGO3153FJ638466NRTINNRTIM41L, M184V, T215YK103N, V106MK20R, K30R, E44D, D121H, K122E, D123E, D177E, I178L, R211TB
Luo (2009)xs.138605HBxs.1386FJ375088NRTINNRTIA62V, K65R, D67N, V75TV106M, V179D, G190AK101Q, D113G, I135V, S162C, M164V, T200A, L210F, A272P, K277R, Q278E, L283I, Q334LB
Rhee (2009)CA27769CA64194FJ983547TDF, DDIEFVL74LIV, M184VV106M, V179VD, G190AI135IT, K173E, I178L, E204EK, Q207E, F214L, D237DN, V245K, D250EB
Dau (2010)07714A07714AGU581863NRTINNRTIK65R, Y115FV106M, V179D, Y181CT39A, W88S, K173E, Q174K, E204Q, Q207E, R211K, F214L, A272P, T286P, V292I, I293V, E297A, K311R, I326V, G333GE, Q334L, M357T, K385R, K390R, Q394NB
 08561A08561AGU581923NRTINNRTIL74VK103N, V106M, F227LK20KR, V21I, V60I, R211K, V245K, E297KR, I329V, R356K, K366R, T377Q, K390R, E399DB
 09895A09895AGU581990NRTINNRTIM41L, D67N, K70R, T215YK103N, V106MK20R, K122E, R211QB
Aulicino (2011)ARN571EAEARN571EAEFJ525863NRTINNRTIK70R, M184VK103N, V106MV35R, T39A, I142T, D177E, V179I, E194T, G196E, F214LB
 3005-M993MNY3005-M993MNYHQ158168NRTINNRTI K103N, V106MV35T, V60I, K122E, D123S, I135V, D177E, I178LB
Jones (2012)129903129903JN669475NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219NV106M, G190AT39A, K43E, E44A, K64R, K101Q, V118I, I202V, R211RK, V245T, V292I, I293V, E297R, I341V, A360T, A376V, T386I, K390RB
 135338135338JN669541NRTINNRTIA62V, K70Q, V75I, F77L, Y115F, F116Y, Q151M, M184VV106M, V179D, G190AT7I, T58N, S68R, K103R, V118I, D121C, K122E, I135T, E138A, T165I, Q174K, D177E, G196GE, Q197LP, I202V, F214L, V245M, A272P, T286P, I293V, P294T, K311KR, Q334L, T338S, E370D, T386I, E399DB
 139475139475JN669577NRTINNRTIM41L, D67N, L210W, T215Y, K219RK103N, V106ME44D, K102R, K122E, D123E, I135T, V179I, G196E, T286P, V292I, I293V, E297K, S322T, N348T, G359S, A371T, K388R, E399DB
 142746142746JN669624NRTINNRTIA62V, K70Q, V75I, F77L, Y115F, F116Y, Q151M, M184VV106M, V179D, G190AT7I, T58N, S68R, K103R, V118I, D121C, K122E, I135T, E138A, T165I, Q174K, D177E, G196E, Q197L, I202V, F214L, V245M, A272P, T286P, I293V, P294T, K311KR, Q334L, T338S, E370D, T386I, E399DB
 154224154224JN669814NRTINNRTIA62V, K65KR, D67DN, K70KR, V75T, K219KHNQK103N, V106M, Y181YC, G190GAK20R, S68G, K102KR, I135T, F214L, V245E, A288T, V292I, I293V, E297R, I329L, Q334C, M357T, V372VIM, T386TIB
 158443158443JN669921NRTINNRTIL74V, Y115FK103N, V106MV35VI, V60I, R211K, E224EK, V245K, A272P, T286A, E297T, I326V, I329L, G335D, M357T, R358K, A360TB
 160464160464JN669978NRTINNRTIM41L, D67N, T69D, L74V, L210W, T215YV106M, F227L, M230LV35I, T39K, K43E, E44D, D76DN, V118I, D121H, K122E, I135T, P140T, S162D, K166R, I178L, E203D, H208Y, R211K, W212C, H221Y, A272P, L283I, R284K, I293V, I326V, K350R, R356K, G359A, T386I, K390RB
 177288177288JN670432NRTINNRTIM41L, T69D, L210W, T215Y, K219RV106M, V108I, V179E, F227LP4S, K43Q, V60VI, W88C, V118I, K122E, T139K, S162H, D177E, T200A, E203K, H208Y, R211K, K223E, E224ED, L228HR, A272P, A288S, E297R, S322L, I329L, G335S, G359S, A371V, A376C, T377IV, T386I, K390R, E399DB
 194482194482JN670937NRTINNRTID67N, K70R, M184V, K219Q, N348NIV106M, G190AK101KQ, V108VL, E169D, V179VI, T200R, I202V, Q207H, R211K, F214L, A272P, R284RK, I293V, E297T, K311R, D324DE, Q334L, I341IF, M357I, A360T, D364DE, K374KR, A376T, T377K, T386I, K390R, W398CYB
 203233203233JN671304NRTINNRTI V106M, V179D, F227LK122E, I135T, V245K, T286A, I293V, E297T, Q334E, M357T, A376S, S379G, T386I, K390RB
Melikian (2012)CA1446CA87356 AZT, 3TC, DDI, D4T, ABC, TDF, FTCNVP, EFVM41L, D67N, L74I, M184V, L210W, T215Y, K219RK103N, V106MK20R, V35M, E44ED, K64KR, V111I, E169D, Q174QR, V179I, T200A, I202IV, H208Y, R211K, K223Q, L228QB
Mollan (2012)MK115MK115w60 TDF, FTCEFVK65RV106M, Y188CK32N, V35I, K102E, T200I, Q207E, V245M, D250E, A272PB
 MK159MK159w18 ABC, 3TCEFVM184VV106M, V179DP4PS, E6EK, K20KR, K103KR, V118I, I142M, Q207E, F214L, V245M, A272P, K277R, T286A, E297EK, K311RB
 MK216MK216w18 ABC, 3TCEFVY115YF, M184VV106M, V179DK103KR, I142T, T200A, V245T, E248D, I293V, P294AB
 MK258MK258w17 ABC, 3TCEFVL74LI, M184VV106M, V179DV35T, D123E, R211K, F214L, V245M, I293V, E297AB