<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation V106I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 33
Patients 47
Isolates 52
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_21132113 AZT, DDINoneD67N, T69TADN, K70KR, T215F, K219Q K20R, T39A, A98S, V106I, V118VI, K122Q, I135IV, I178L, F214L, L228H, V245T, K277R, T286A, E297K, G333E, M357T, G359S, K366R, A376T, T386I, K390R, A400T, K431T, K451R, L452LS, D460N, R461K, V467VI, H483Y, L486LFB
 ACTG320_23352335 DDC, AZT, DDINoneM41L, L210W, T215D E6D, K43N, V106I, V118I, D123E, D177E, H208Y, R211K, K223Q, L228R, V245K, T286A, A288T, I329V, K350R, M357T, K390R, A400T, L469F, T470TNSYB
 ACTG320_27572757 AZT, DDINoneM41L, D67N, T69D, K70KR, L210W, T215Y V35I, E44D, V60I, R83K, V106I, V118I, D177G, G196GE, T200AE, H208Y, R211K, D218E, V245E, A272P, K281KR, E297K, R356K, M357T, K366R, K390KR, A400T, F416Y, V435I, D460N, V467IB
Winters (1997)143P6143P6W88AF013437DDINoneL74V V106I, D123E, I135T, S162W, D177EB
Cabana (1999)Cab-aA0AF102331AZT, D4TNoneM41L, D67N, L210W, T215Y K43E, E44D, V106I, V118I, K122E, D177N, I178M, G196EB
  A11AF102332AZT, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y K43E, E44D, V106I, V118I, K122E, D177N, G196EB
Murphy (1999)ACTG347_0073073_RT_w22 AZT, 3TCNone  V106I, D121C, K122E, S162T, I178L, T200A, R211K, V245I, D250TB
Venturi (1999)GV-11Vent11BAF169062AZTNoneD67N, K70R, T215S, K219Q G51A, T69N, V106I, D123E, I135IT, Y144Y*, F214LB
  Vent11W24AF169063AZT, DDINoneD67N, K70R, T215S, K219Q K43R, T69N, V106I, V118M, D123E, I135T, Y144*, F214LB
Bacheler (2000)LB4-P112P112-0 AZT, 3TCNoneM184V V106I, D123E, D177E, T200I, R211KB
Baxter (2000)GART-G64GART-64 NRTI, 3TC, DDINoneM184V T69N, R83K, V106I, K126N, S162A, E248DB
 GART-NG77GART-77 NRTI, AZT, 3TCNoneM41L, D67N, K70R, L210W, T215Y, K219E K22R, V106I, K122E, I135V, S162Y, H208Y, R211K, L228R, V245EKB
Rousseau (2000)MNR1MNR1AJ405947AZT, DDI, D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219R K32N, V35I, E44D, V106I, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454RB
Albrecht (2001)ACTG364_60076007 DDC, AZT, 3TCNoneM41L, T69D, M184V, L210W, T215Y V21I, E40F, K43E, K49R, V106I, G196GE, E203K, H208Y, R211K, K223E, L228R, Q278QH, I293VB
Eshleman (2001)A068AF357669AF357669AZT, DDINoneM41L, D67N, T69D, V75T, L210W, T215Y, K219KQ K20R, K64H, V106I, D123E, I142V, D177E, I178L, E203K, Q207E, R211K, K223KE, Q278QH, K281KR, T286A, E297KB
Gonzales (2001)CA1294CA3222AY030512D4T, AZT, 3TCNoneK70R, M184MV I31IV, V106I, K122E, I135T, S162Y, F214L, A272P, K281RB
 CA1626CA4609AY030714AZT, DDI, 3TCNoneD67N, K70R, M184V, K219Q K20R, V35T, V60I, V106I, D123E, I135V, S162C, K166R, I178L, Q197QE, F214L, D218E, A272P, K277R, I293VB
 CA2260CA8188AY030846DDC, AZT, D4T, 3TCNoneM184V, L210W, T215Y K11R, K49R, S68G, R83K, K101Q, V106I, I135IT, K166R, R211K, A272P, K277RB
 CA4584CA11212AY031381DDC, AZT, D4T, 3TCNoneM41L, D67S, K70R, M184V, L210W, T215Y, K219E T39A, T69N, V106I, K122E, I178IM, E203D, H208Y, Q278H, A304GB
 CA5114CA12403AY031682AZT, D4T, DDINone  V106I, V118I, I135T, T165I, K173E, T200A, F214L, V245L, A272P, K281R, T286AB
 CA5697CA14462AY032099AZT, 3TC, D4T, ABCNoneK65KR, L74LV, M184V V106I, S162C, K173R, Q174R, R211K, F214L, K263KN, N265ND, A272PB
 CA5954CA14718AY032202D4T, 3TC, DDINoneM41L, D67DN, L210W, T215Y V35M, T39A, K43Q, S68SG, V106I, V118I, K122E, D123E, I135IT, I142V, D177E, I178M, G196GE, R211K, V245VIM, A272P, T290TA, I293VB
Katzenstein (2001)ACTG302_35853585RT_bl AZT, DDINoneD67N, T69D, K70R, V75T, K219Q K102R, K104R, V106I, D123E, S162Y, K173KE, A272S, I293VB
Perez (2001)EP-1934EP-1934AF320521NRTINoneM41L, D67N, T69D, M184V, L210W, T215Y V106I, V118I, S162C, E169D, K173N, Q174K, I178L, Q207E, H208F, R211KB
 EP-2141EP-2141AF320526NRTINoneM41L, D67N, T69D, L210W, T215Y K43E, I63*, K64R, V106I, V118I, S162D, R211K, V245VMB
Brindeiro (2002)TVSP19TVSP19AY145815AZT, 3TC, D4TNoneM41L, A62V, M184V, T215FA98GV106I, K122E, I135T, F214L, K249Q, A272P, K277R, E297A, V317AB
Cuevas (2002)CU97CU97AF425478AZT, 3TCNoneD67N, K70R K49R, V106I, D123E, E169D, I178L, T200A, E204K, Q207E, R211K, F214LB
Naugler (2002)WES-11HIV11BLAF422708AZTNoneM41L, L210W, T215S V35L, V60G, A62P, V106I, I202V, R211KB
  HIV11ESAF422733AZT, DDINoneM41L, L210W, T215SK103NV35L, E42V, V60G, A62P, L100V, V106I, I202V, R211KB
Tural (2002)9728097280 AZT, D4T, DDINoneD67N, K70R, K219Q K20R, T39A, V60I, K64Y, V106I, D123E, I135T, N136S, I178M, D218E, L228HB
 880724880724 D4TNone  V35I, S68G, V106I, I135T, S162C, G196E, T200A, E203G, Q207N, R211KB
Venturi (2002)GV-12GV-12.1AF517264D4T, 3TCNoneM41L, D67N, T69D, L210W, T215D E44D, V106I, V118I, K122E, D123E, I135IT, Q207EK, H208HY, R211KB
Gonzales (2003)CA1450CA12419AY305945AZT, DDI, DDC, 3TC, D4T, ABCNone  V35I, V106I, K122E, I135T, F214LB
Gonzales (2003)CA1626CA8198AF514111AZT, DDI, 3TCNoneD67N, K70R, M184V, K219Q K20R, W24WC, V35T, V60I, V106I, D123E, I135IV, S162C, K166R, I178L, Q197E, F214L, D218E, A272P, K277RB
Saah (2003)AS-27AS-27 AZT, 3TCNoneM41L, M184V V106I, I135T, K166R, K173E, Q207E, F214LB
Shafer (2003)A384_07350735b D4T, DDINone  V106I, V245MB
Gulick (2004)RG127RG127w20 ABC, AZT, 3TCNoneM184V V106I, K122KE, A158S, I178M, T200A, R211G, V245LB
Garcia-Bujalance (2005)GBS_35GBS_35AY872370DDC, AZT, D4T, 3TCNoneK70R, M184V, K219Q K49Q, V106I, V118I, K122E, F124Y, I135T, I178M, T200TA, F214L, L228H, P236TB
Non-B Workgroup (2005)PL4987492578 AZT, 3TCNoneM184V E28EK, V106I, I178ILM, R211G, F214L, V245AT, A272P, T286A, E297A, V317A, Q334LB
Ochoa de Echaguen (2005)B-1204B-1024AY833594AZT, DDI, D4T, ABCNoneK65R K49R, V60VG, S68G, R83K, V106I, D123E, D177E, I178V, T200A, I293V, E297AB
Rhee (2005)CA1450CA9438AY800953AZT, DDI, DDC, 3TC, D4TNone  V35I, V106I, K122E, I135T, F214L, I293V, E297TB
 CA3888CA34583AY801184D4T, DDINoneD67N, K70E, V75T K11A, V35T, D86E, V106I, I135V, I142V, G196E, Q197K, Q207E, A272P, I293V, E297V, G333E, Q334H, M357I, A376T, T386I, V435E, D460N, R461K, L469I, L491S, L517I, S519N, Q520K, K527N, A534TB
 CA9919CA24501AY8021913TC, D4TNone  E6D, V106I, D123DE, I135T, D177E, T200TR, I202IV, R211K, F214L, I293VB
 CA14684CA35136AY802407D4T, 3TC, AZT, DDINone  V35I, K102Q, V106I, K122E, D123N, I132V, I135T, E169D, F214L, H221HY, A272P, K287KEB
 CA17694CA41631AY802545D4T, 3TCNoneM41L, A62V, D67G, M184V, L210W, T215Y, K219RV108IK20R, K43Q, E44D, K102S, V106I, T107A, V118I, K122E, Q174E, G196E, H208Y, R211K, K223Q, L228H, E297K, K350EB
Riddler (2008)RG91109RG91109w32 AZT, 3TCNone  K65KE, V106I, I178M, R211K, P243S, A272P, G335C, M357T, A360I, A376T, K390RB
Rosen-Zvi (2008)5000p50-1 AZT, 3TC, D4T, DDI, ABCNone Y181CT39A, S68G, V90I, V106I, I135T, T165I, Q174QR, R211G, H221Y, A272P, K277R, L283I, I293V, P294Q, I309LB
Rhee (2009)CA16540CA39270FJ983438AZT, 3TCNoneM184V E6D, A98AS, V106I, V118I, K122E, I135IT, I142IV, Q207E, R211K, F214L, V276I, I293VB
von Wyl (2010)47969104796910GQ848134AZT, DDINone  V106I, D123E, S162A, R211K, V245M, R284K, T286A, I293V, T296TS, E297K, I329L, M357I, T369A, A376V, K390R, K395R, E399DB
Melo (2012)0744SV0744SVJF804814NRTINone  K49R, K103E, V106I, D123E, I135T, S162C, T200A, A272P, K281R, T286A, E297K, M357T, A376T, T386I, T403V, V435E, L452K, S468P, H483Y, K527R, V548I, A554TB
 0632SV0632SVJF804810NRTINone  V35T, T39A, V106I, D123E, I178L, T200A, F214*, A272P, K277R, I293V, M357T, A376T, T386I, T403I, N447S, L452Q, A554SB
Grossman (2014)424424KC213665ABC, DDINone  K101R, V106I, D123N, I135T, I142V, T165I, I178L, F214LB