<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K103R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 35
Patients 81
Isolates 98
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP16JIDP16W104AF021300AZT, DDINoneL210W, T215Y R83K, K102Q, K103R, S162Y, Q207X, R211K, V241A, V245MB
Hammer (1997)ACTG320_10571057 AZT, DDINoneD67N, T69TADN, K70R, T215TFIS, K219Q V35R, T39A, K103R, R211RK, F214L, K277R, T286TA, I293V, E297K, S322T, Y342F, R356RK, A360T, A376T, K390R, A400T, D460N, R461K, L469IB
 ACTG320_11031103 AZT, D4TNoneK70R, T215Y K64R, T69S, K103R, Q197E, V245K, S251I, K277R, T286A, Q334E, P345L, A360T, K390R, A400T, T403S, L452LI, D460N, R461K, H483XB
 ACTG320_113113 AZT, DDI, DDCNoneM41L, D67N, K70R, L210LW, T215Y V60I, K82KR, K102Q, K103R, V118VI, I135T, S162C, G196GE, R211K, A272P, K277R, T286TA, I293IV, E297EQ, K366R, A400T, T403M, E404D, V466A, S468P, L491PB
 ACTG320_11891189 AZT, DDCNoneD67N, K70R, T215F, K219Q K103R, V118I, K122KE, I135T, A158S, S162G, I202V, F214L, A272P, K281R, E297K, A371AV, A376S, T377M, K390R, A400T, P421PL, V435A, N447NS, K454RB
 ACTG320_20722072 AZTNoneM41L, T215Y W88C, K102KQ, K103R, K122E, I202V, Q207DE, V245E, A288S, I293V, D324E, M357T, A360AV, K390R, V435P, A437AV, A446AS, E449ED, S468PB
 ACTG320_25182518 AZT, DDINoneD67N, K70R, T215F, K219Q V35M, K103R, K104KN, K122E, D123E, I135V, S162C, D218E, V245VIM, E248D, T286A, A288S, I293IV, E297K, G359GS, A371V, A376T, K390R, E399D, A400T, A446S, K454R, D460S, H483Y, Q487XB
 ACTG320_25192519 AZTNoneT215Y E6D, V60I, R83K, K103R, G196E, I202V, A272P, T286A, F346Y, M357S, R358RK, K366R, K390R, T403M, R448K, L452S, S468T, L469I, T470AB
 ACTG320_25712571 AZT, D4TNoneD67N, K70R, K219Q T39TA, V60I, T69N, K82KR, K103R, I135AT, G196E, F214L, K277R, V317A, G335S, G359S, I375V, A376S, S379C, K390R, V435A, G436EB
 ACTG320_27382738 DDC, AZTNoneM41L, L210W, T215Y V35M, K43E, E44A, K103R, V118VI, K122E, D123N, I135V, I178M, Q197K, T200A, H208HY, R211K, L228LH, A288AS, I341V, R358RK, A360AV, A371AV, A400AT, D460N, S468PB
 ACTG320_27442744 AZT, DDINoneM41L, D67N, K70R, L210LW, T215F, K219Q T39TA, V60I, K102Q, K103R, D123E, S162Y, E203ED, H208HY, R211RK, K277R, Q278H, A288S, I293V, E297A, F346Y, G359S, A371AT, T377L, K390R, A400T, L452IM, V466A, V467I, S468P, K476QB
 ACTG320_29492949 AZTNoneD67A, K70R, K219Q T69N, K103R, K104N, S162A, F214L, T286A, R356RK, A360V, A400I, E432D, V435E, V458I, D460NB
 ACTG320_369369 AZT, D4T, DDINoneD67N, T69D, K70R, T215Y, K219Q K20R, K103R, K277R, T286A, P294S, I329V, R356K, R358RK, T369A, A376S, K390R, K395R, D460N, Q464R, K465NB
 ACTG320_767767 AZT, DDI, DDC, 3TC, D4TNoneD67N, K70KR, T215IV, K219QA98GK20R, V35M, K103R, K122KE, D123DE, Q174E, D177E, F214L, V245I, A272ST, I293V, E312N, R356K, A360T, A376T, V381VI, H483Y, G490GEB
Orlandi (1998)PO-Pt17Orl17-W224AF056670AZTNoneD67N, K70R, K219Q T39A, T69N, K103R, D123E, K166R, Q207A, R211K, F214LB
  Orl17-W228AF056671AZTNoneD67N, K70R, K219Q T39A, T69N, K103R, D123E, K166R, Q207A, R211K, F214LB
Cabana (1999)Cab-jJ0AF102361D4T, 3TCNoneD67N, K70I, M184V, T215Y, K219Q N54Y, D76Y, K82T, K103R, K122E, I135T, R211KB
Milazzo (1999)Mil-COMilazzoCO0AF153377AZTNoneD67N, T69D, K70R, T215F, K219Q V90I, K103R, D123E, I135T, S162N, V179I, Q207X, F214LB
Zolopa (1999)CA1138CA2577AF088090AZT, D4T, 3TCNoneK70R, M184V E6K, K103R, K122E, I135L, D192X, Q197X, Q207E, R211KB
Albrecht (2000)ACTG303_46204620RT_bl AZT, DDINone  K49R, I50IV, K103R, G196E, R211K, F214L, V276I, I293V, E297A, E300E*B
Bacheler (2000)LB3-P18P18-0 NRTINone  V35I, K103R, V118I, K122E, D123E, D177E, G196E, F214LB
 LB3-P25P25-0 NRTINoneA62V, V75I K20R, R83K, K103R, G196E, T200A, R211KB
 LB3-P36P36-0 NRTINone  R83K, K103R, R211KB
Balotta (2000)CB-167CB-167AF252029AZT, D4T, 3TC, DDINoneD67N, K70R, M184V, T215F, K219Q T69N, K103R, V118I, D121N, D123E, I142V, T200A, F214LB
 CB-219CB-219AF252073DDC, AZT, D4T, 3TC, DDINoneM41L, D67N, T69D, K70R, M184V, T215F, K219Q P9X, V35L, T39A, K49R, K103R, S105ST, K122E, R172RK, R211K, D218E, I244VB
Baxter (2000)GART-G136GART-136 NRTI, 3TC, D4TNoneK70R, M184V K49KR, K103R, T200I, F214LB
Demeter (2000)260Pt14260Pt14BCAF090475AZTNoneD67N, K70R, K219Q T69TN, K103R, Q174X, G196E, Q207R, F214LB
Shulman (2000)CA1277CA4391AY802653AZT, D4T, DDI, DDC, 3TCNoneD67N, K70R, M184V, K219Q V60I, K103R, K104KN, I135L, S162A, T200A, Q207E, F214L, D218DE, A272P, K277R, A288SB
Venturi (2000)V2000-14V2000-14PAF158769AZT, DDI, D4T, 3TCNoneD67N, K70R, M184V, K219Q V60I, T69N, K103R, D113E, I159R, N175K, G196E, Q197K, Q207E, R211K, F214L, D218EB
Albrecht (2001)ACTG364_12031203 AZT, DDC, 3TCNoneM41L, M184V, T215Y R83K, K103R, R211RK, V245E, E248DB
 ACTG364_48074807 AZT, DDC, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215F, K219Q K20R, V35VL, E36EQ, T39A, K43KE, K103R, V118I, K122KE, I135V, S162D, F214L, L228H, K277RB
 ACTG364_55615561 AZT, DDI, 3TCNoneM184V K49R, I50V, S68N, K103R, K166R, G196E, R211K, F214L, K275KR, V276I, I293V, E297AVB
Delgado (2001)ED_V74ED_V74AY016983AZT, 3TCNone  E6K, K103R, K122E, D123N, G196E, I244VB
Eshleman (2001)A084AF357685AF357685AZT, DDINoneM184V K20R, K103R, Q174E, F214L, A272S, K277R, L283I, I293V, E312K, D324EB
Fitzgibbon (2001)JF-2JF2-BAF444172AZT, 3TCNoneM41L, D67N, L210W, T215Y V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245EB
  JF2-M4AF444173AZT, 3TC, D4TNoneM41L, M184V, L210W, T215Y V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245EB
 JF-6JF6-BAF444179AZT, DDINoneD67N, K70R, T215F, K219Q V35M, K103R, K122E, D123E, A158S, N175Y, T200EB
 JF-8JF8-B9AF444183AZT, DDINoneK70R, T215F, K219Q K22N, K103R, K122E, I135T, R211K, F214LB
  JF8-M10AF444184AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, T215F, K219Q V35M, Y56S, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228HB
  JF8-M14AF444185AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, T215F, K219Q K20R, V35M, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228HB
Gonzales (2001)CA1277CA3066AY030498AZT, D4T, DDI, DDC, 3TCNoneD67N, K70R, M184V, K219Q V60I, K103R, K104N, S162A, T200A, Q207E, F214L, A272P, K277R, A288SB
 CH001546KGXN7145AY030663DDI, AZT, 3TCNoneD67N, T69D, K70R, T215F, K219Q K20R, K102R, K103R, K104R, I132IT, V179I, G196E, T200A, A272S, T286AB
 CA1799CA4834AY030717D4T, 3TCNoneD67N, K70R, M184V, K219Q E6D, K20R, T69N, K103R, K122E, T200I, R211K, F214L, K311KR, R356K, A360V, A376T, A400T, L452LS, T470A, H483Y, G490GE, L491LS, K527KN, A554NB
 CA1809CA4854AY030724AZT, 3TC, D4TNoneD67N, K70R, M184V, T215V, K219Q K43KE, T69N, K103R, V118I, I135L, G196E, R211K, F214LB
 CA1847CA4954AY030752DDI, AZTNoneM41L, D67N, T69D, K70R, L74V, T215F, K219Q A33AG, V60I, K103R, V118I, K122E, I135T, I159L, K166T, E194EA, I202IT, H208HY, F214L, D218DEB
 CA1860CA4982AY030764AZT, 3TC, D4T, DDINoneM41L, D67N, T69D, K70R, T215F, K219QA98GK20R, V35E, T39A, V60I, K103R, V118I, K122E, I135K, F214L, L228H, I293V, E297K, T386I, K390R, A400T, A437V, V458I, Q509Y, K527N, A554TB
 CA2205CA7988AY030827D4T, 3TCNoneM41ML, M184V V35M, K102Q, K103R, K122E, Q174KR, T200I, I202V, V245M, A272SB
 CA2321CA8419AY030865AZT, 3TC, D4TNoneA62V, M184VV179DV35T, K103R, I135T, Q174E, R211K, T215X, K259KR, N265NT, A272SB
 CA3935CA9143AY030934D4T, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219Q K20R, V21VI, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V, A304GB
 CA4291CA10476AY031157DDC, AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, V75M, T215F, K219Q K20R, Q23X, V60I, K103R, V118I, I135T, G196E, R211G, F214LB
 CA4330CA10521AY031194AZT, DDI, 3TCNoneM41L, D67N, T69D, K70R, M184V, T215S, K219Q D17DG, K20R, P25PA, V35L, V60I, K103R, V118I, K122E, S134SC, K173E, Q207E, F214L, L228H, K277R, A288T, I293V, E297KB
 CA4738CA11604AY031400AZT, DDINoneD67N, K70R, K219Q K64Y, K103R, K173R, V245L, T286A, E291EGB
 CA4828CA11743AY031487AZT, 3TCNoneM184VV179DE6EA, T27TA, I31L, V90I, K103R, T200I, R211K, F214L, L228H, V245K, I293VB
 CA4874CA11971AY0315143TC, DDI, DDC, D4TNoneM41L, D67N, K70R, M184V, T215F, K219Q K20R, T69N, W88C, K103R, D123E, I135IV, G196E, E203D, F214L, A272P, I293VB
 CA5006CA12277AY031581AZT, 3TC, D4T, DDINoneD67N, K70R, T215I, K219Q V60I, T69N, K102KQ, K103R, K122KE, F130FL, I135T, S162C, F214FL, D218E, A272PB
 CA5033CA12307AY031604AZT, DDC, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215F, K219Q V35L, T39A, R83K, K103R, K122E, I135T, S162C, G196E, T200TA, E203ED, D218E, A272P, K277R, I293V, E297AB
 CA5155CA12450AY031721AZT, DDI, 3TCNoneM184VV179DV60I, R72RG, K103R, I142V, A158S, F214L, V245K, A272S, K277R, I293VB
 CA5483CA24824AY032022AZT, 3TCNoneM184V R83K, K103R, A129AV, I135X, E138EV, R143RI, T200A, R211K, V245K, T286A, A304GB
Katzenstein (2001)ACTG302_26572657RT_bl DDINoneL74V, L210W K103R, K122P, F171FY, I178M, G196E, R211RK, F214LB
Perez (2001)EP-1738EP-1738AF320533NRTINoneD67N, T69D, K70R, T215F, K219Q K43Q, V60I, K103R, K122E, Q207E, R211K, L228H, V245KB
Shulman (2001)302-260859260859 AZTNoneD67N, T69D, K70R, K219Q T39A, K103R, T200K, I202V, Q207E, R211K, F214L, A272PB
 302-140750140750 AZTNoneD67N, K70R, K219Q T39TA, S48T, K103R, K122E, D123N, I135T, T165I, Q197E, T200I, R211RK, F214L, L228LH, A272AP, K277R, I293V, E297A, A304GB
Ait-Khaled (2002)MAK-17551755161AJ426012AZT, 3TCNoneM184V K20R, I31L, V35I, L100X, K103R, I135A, I178M, V179IB
  1755481AJ425919AZT, 3TC, ABC, D4TNoneM184V K20R, V35IR, K103R, I135AT, I178M, V179IB
 MAK-17001700481AJ425986ABC, AZT, 3TCNoneL74V, M184V K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211KB
Cho (2002)KKS99KKS12AF282150AZTNoneD67N, K70R, K219Q T69N, K103R, K122E, T200I, I202VB
 PBK01PBK403AF407373DDINone  K103R, K122E, I142V, D177E, I178M, T200A, Q207E, K223EB
Gonzales (2003)CA1138CA3735AF514019AZT, D4T, 3TC, DDINoneK70R, M184V E6K, K103R, K122E, I135L, Q207E, R211K, V245E, K281KE, T286A, E297KB
 CA3935CA12327AF514162D4T, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219Q K20R, V21I, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, L149LP, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293VB
Gulick (2004)RG263RG263w22 ABC, AZT, 3TCNone  E53Q, T69TN, K102Q, K103R, V118I, K122E, T200E, E204EQ, Q207E, R211K, F214L, V245TB
 RG285RG285w24 ABC, AZT, 3TCNoneM184V I50IV, T69TI, K103R, K122P, I135T, I142A, T200TA, R211K, F214LB
 RG365RG365w135 ABC, AZT, 3TC, DDI, TDFNoneM41L, M184V, T215Y M16MV, V21I, A98S, K102Q, K103R, K122E, I142X, T200I, R211S, Q278H, K281R, I293VB
Kuritzkes (2004)KDR_pat77A0089AY527906D4T, 3TCNoneK70KR K103R, K122KE, T139TI, R211K, F214L, K223KRB
  A0090AY527907D4T, 3TCNoneK70R, M184V K103R, R211K, F214LB
 KDR_pat113A0135AY527952AZT, 3TCNoneD67N, K70R, M184V, K219Q V60I, T69N, K103R, F214L, P243TB
  A0136AY527953AZT, 3TCNoneD67N, K70R, M184V, K219Q V60I, T69N, K103R, I135IT, F214L, P243TB
Machado (2004)con25con25AY313434AZT, DDINoneM41L, D67N, L210W, T215Y K43E, V60I, K102Q, K103R, V118I, D121Y, K122E, G196EB
 con60con60AY313446AZT, DDINoneM41L, D67N, K70R, T215Y K103R, D123E, D177E, T200AB
 cs130cs130AY313414AZT, DDINoneD67N, K70R, T215F, K219Q K103R, V118I, I135T, E169D, G196E, Q207E, F214LB
Gallant (2005)JEG06JEG06_w12DQ199579ABC, TDF, 3TCNoneM184V T27S, V60I, R83K, K101Q, K103R, K122KE, D123E, I178M, V179I, T200A, V245E, I293VB
Rhee (2005)JVM-PT14JVMPT14 AZTNoneK70R K103R, E203KB
 CA1277CA9946AY800837AZT, D4T, DDI, DDC, 3TCNoneD67N, K70R, M184V, K219Q V60I, K103R, I135L, S162A, T200A, Q207E, F214L, K249KR, A272PB
 CA2205CA9398AY801149D4T, 3TCNoneM41L, M184V V35M, K102Q, K103R, K122E, P150PL, Q174KR, T200I, I202V, V245M, A272S, L283I, T286A, A288AS, I293VB
 CA4828CA34731AY801422AZT, 3TCNoneM184V, T215FV179DI31L, S68SG, K103R, T200TI, R211K, F214L, V245K, I293VB
 CA5483CA24822AY801589AZT, 3TCNoneM184V R83K, K103R, T200A, R211K, K220KI, V245K, E248EK, S251SN, L260VB
 CA7971CA34609AY801875AZT, 3TCNoneA62AV, M184V E6EG, R83K, K103R, D123E, S162C, D177E, T200A, P243S, V245E, A272P, K281R, T286A, V292I, I293V, M357T, R358RK, T369V, A376T, T386S, E399D, A400T, Y405H, A446S, D460N, R461K, S468T, H483Y, Q509I, Q520R, Q524E, A554NB
 CA9823CA24160AY802130AZT, DDCNoneT69ADSY, K70R, T215TFIS, K219KQ K20R, K102R, K103R, K173S, I195IL, R211RK, F214L, L228HR, T286A, I293IV, E297QB
  CA34855AY802131AZT, DDCNoneT69ADSY, K70R, T215TFIS, K219KQ K20R, K102R, K103R, K173S, I195IL, Q207QE, R211RK, F214L, L228HR, T286TA, I293IV, E297QB
 CA9881CA24385AY802161AZT, 3TC, D4T, DDINoneD67N, K70R, K219Q T39A, K64N, T69N, K103R, K122E, I135L, F214LB
  CA34472AY802162AZT, 3TC, D4T, DDINoneD67N, K70R, T215TI, K219Q T39A, K64HN, S68Y, T69S, K103R, K122KE, I135L, F214L, A272P, T286A, V317A, D324E, G333E, Q334H, D364E, D460N, T477A, I482IV, H483Y, S515T, L517I, K527NB
Rhee (2006)CA7877CA19917 AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, T215F, K219Q E6D, T39TA, V60I, K103R, V118I, K122E, F124FL, T131TRS, I142IM, Q197K, T200E, E203D, Q207D, F214L, K223Q, L228LH, Q242K, V245M, A272P, V276T, L283I, A288T, I293V, E297AB
Rios (2007)CH95MR_CH95.1EF193996AZT, 3TCNone  V35I, D76A, F77Y, K103R, G112A, S134A, I142V, D177E, F214L, F227S, V245EB
Riddler (2008)RG17932RG17932w48 AZT, 3TCNone  K20R, K49KR, K103R, D123E, S162C, Q174E, T200A, V245VEKM, A272S, K277R, L283I, A288T, I293V, E297A, E312K, G335D, R356K, G359S, A360TB
Rosen-Zvi (2008)5200p52-1 AZT, DDC, D4T, DDI, ABC, 3TCNoneD67N, K70R, V75T, K219Q V35I, K43Q, K64Y, K102KR, K103R, V118I, L210F, F214L, D218DE, L228H, K277R, T286A, A288T, I293VB
Rhee (2009)CA4340CA37830FJ983168AZT, 3TCNoneM184V P4PS, E6X, K103R, K122E, I142V, T200A, Q207E, R211K, F214L, I293V, P294AB
 CA35657CA79852FJ983563D4T, 3TC, TDF, DDINoneD67N, K70R, K219Q P4T, K11R, M16MV, K20R, V35L, V60I, K64R, K82KR, K103R, K122E, D123DN, I135IV, G196E, Q197K, R211K, F214L, L228LH, A272P, K277KR, T286A, E297QB
Grossman (2014)492492KF135087AZT, 3TCNone  R83RK, K103R, K122P, I135T, I142L, T165I, T200I, R211K, F214LB
  492KF135088AZT, 3TCNone  I37L, K103R, K122P, I135T, I142L, T165I, D177DH, D186DN, T200I, R211K, F214LB