Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K103R
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	34
Patients	80
Isolates	96

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP16	JIDP16W104	AF021300	AZT, DDI	None	L210W, T215Y		R83K, K102Q, K103R, S162Y, Q207X, R211K, V241A, V245M	B
Hammer (1997)	ACTG320_1057	1057		AZT, DDI	None	D67N, T69TADN, K70R, T215TFIS, K219Q		V35R, T39A, K103R, R211RK, F214L, K277R, T286TA, I293V, E297K, S322T, Y342F, R356RK, A360T, A376T, K390R, A400T, D460N, R461K, L469I	B
	ACTG320_1103	1103		AZT, D4T	None	K70R, T215Y		K64R, T69S, K103R, Q197E, V245K, S251I, K277R, T286A, Q334E, P345L, A360T, K390R, A400T, T403S, L452LI, D460N, R461K, H483X	B
	ACTG320_113	113		AZT, DDI, DDC	None	M41L, D67N, K70R, L210LW, T215Y		V60I, K82KR, K102Q, K103R, V118VI, I135T, S162C, G196GE, R211K, A272P, K277R, T286TA, I293IV, E297EQ, K366R, A400T, T403M, E404D, V466A, S468P, L491P	B
	ACTG320_1189	1189		AZT, DDC	None	D67N, K70R, T215F, K219Q		K103R, V118I, K122KE, I135T, A158S, S162G, I202V, F214L, A272P, K281R, E297K, A371AV, A376S, T377M, K390R, A400T, P421PL, V435A, N447NS, K454R	B
	ACTG320_2072	2072		AZT	None	M41L, T215Y		W88C, K102KQ, K103R, K122E, I202V, Q207DE, V245E, A288S, I293V, D324E, M357T, A360AV, K390R, V435P, A437AV, A446AS, E449ED, S468P	B
	ACTG320_2518	2518		AZT, DDI	None	D67N, K70R, T215F, K219Q		V35M, K103R, K104KN, K122E, D123E, I135V, S162C, D218E, V245VIM, E248D, T286A, A288S, I293IV, E297K, G359GS, A371V, A376T, K390R, E399D, A400T, A446S, K454R, D460S, H483Y, Q487X	B
	ACTG320_2519	2519		AZT	None	T215Y		E6D, V60I, R83K, K103R, G196E, I202V, A272P, T286A, F346Y, M357S, R358RK, K366R, K390R, T403M, R448K, L452S, S468T, L469I, T470A	B
	ACTG320_2571	2571		AZT, D4T	None	D67N, K70R, K219Q		T39TA, V60I, T69N, K82KR, K103R, I135AT, G196E, F214L, K277R, V317A, G335S, G359S, I375V, A376S, S379C, K390R, V435A, G436E	B
	ACTG320_2738	2738		DDC, AZT	None	M41L, L210W, T215Y		V35M, K43E, E44A, K103R, V118VI, K122E, D123N, I135V, I178M, Q197K, T200A, H208HY, R211K, L228LH, A288AS, I341V, R358RK, A360AV, A371AV, A400AT, D460N, S468P	B
	ACTG320_2744	2744		AZT, DDI	None	M41L, D67N, K70R, L210LW, T215F, K219Q		T39TA, V60I, K102Q, K103R, D123E, S162Y, E203ED, H208HY, R211RK, K277R, Q278H, A288S, I293V, E297A, F346Y, G359S, A371AT, T377L, K390R, A400T, L452IM, V466A, V467I, S468P, K476Q	B
	ACTG320_2949	2949		AZT	None	D67A, K70R, K219Q		T69N, K103R, K104N, S162A, F214L, T286A, R356RK, A360V, A400I, E432D, V435E, V458I, D460N	B
	ACTG320_369	369		AZT, D4T, DDI	None	D67N, T69D, K70R, T215Y, K219Q		K20R, K103R, K277R, T286A, P294S, I329V, R356K, R358RK, T369A, A376S, K390R, K395R, D460N, Q464R, K465N	B
	ACTG320_767	767		AZT, DDI, DDC, 3TC, D4T	None	D67N, K70KR, T215IV, K219Q	A98G	K20R, V35M, K103R, K122KE, D123DE, Q174E, D177E, F214L, V245I, A272ST, I293V, E312N, R356K, A360T, A376T, V381VI, H483Y, G490GE	B
Orlandi (1998)	PO-Pt17	Orl17-W224	AF056670	AZT	None	D67N, K70R, K219Q		T39A, T69N, K103R, D123E, K166R, Q207A, R211K, F214L	B
		Orl17-W228	AF056671	AZT	None	D67N, K70R, K219Q		T39A, T69N, K103R, D123E, K166R, Q207A, R211K, F214L	B
Cabana (1999)	Cab-j	J0	AF102361	D4T, 3TC	None	D67N, K70I, M184V, T215Y, K219Q		N54Y, D76Y, K82T, K103R, K122E, I135T, R211K	B
Milazzo (1999)	Mil-CO	MilazzoCO0	AF153377	AZT	None	D67N, T69D, K70R, T215F, K219Q		V90I, K103R, D123E, I135T, S162N, V179I, Q207X, F214L	B
Zolopa (1999)	CA1138	CA2577	AF088090	AZT, D4T, 3TC	None	K70R, M184V		E6K, K103R, K122E, I135L, D192X, Q197X, Q207E, R211K	B
Albrecht (2000)	ACTG303_4620	4620RT_bl		AZT, DDI	None			K49R, I50IV, K103R, G196E, R211K, F214L, V276I, I293V, E297A, E300E*	B
Bacheler (2000)	LB3-P18	P18-0		NRTI	None			V35I, K103R, V118I, K122E, D123E, D177E, G196E, F214L	B
	LB3-P25	P25-0		NRTI	None	A62V, V75I		K20R, R83K, K103R, G196E, T200A, R211K	B
	LB3-P36	P36-0		NRTI	None			R83K, K103R, R211K	B
Balotta (2000)	CB-167	CB-167	AF252029	AZT, D4T, 3TC, DDI	None	D67N, K70R, M184V, T215F, K219Q		T69N, K103R, V118I, D121N, D123E, I142V, T200A, F214L	B
	CB-219	CB-219	AF252073	DDC, AZT, D4T, 3TC, DDI	None	M41L, D67N, T69D, K70R, M184V, T215F, K219Q		P9X, V35L, T39A, K49R, K103R, S105ST, K122E, R172RK, R211K, D218E, I244V	B
Baxter (2000)	GART-G136	GART-136		NRTI, 3TC, D4T	None	K70R, M184V		K49KR, K103R, T200I, F214L	B
Demeter (2000)	260Pt14	260Pt14BC	AF090475	AZT	None	D67N, K70R, K219Q		T69TN, K103R, Q174X, G196E, Q207R, F214L	B
Shulman (2000)	CA1277	CA4391	AY802653	AZT, D4T, DDI, DDC, 3TC	None	D67N, K70R, M184V, K219Q		V60I, K103R, K104KN, I135L, S162A, T200A, Q207E, F214L, D218DE, A272P, K277R, A288S	B
Venturi (2000)	V2000-14	V2000-14P	AF158769	AZT, DDI, D4T, 3TC	None	D67N, K70R, M184V, K219Q		V60I, T69N, K103R, D113E, I159R, N175K, G196E, Q197K, Q207E, R211K, F214L, D218E	B
Albrecht (2001)	ACTG364_1203	1203		AZT, DDC, 3TC	None	M41L, M184V, T215Y		R83K, K103R, R211RK, V245E, E248D	B
	ACTG364_4807	4807		AZT, DDC, 3TC	None	M41L, D67N, T69D, K70R, M184V, T215F, K219Q		K20R, V35VL, E36EQ, T39A, K43KE, K103R, V118I, K122KE, I135V, S162D, F214L, L228H, K277R	B
	ACTG364_5561	5561		AZT, DDI, 3TC	None	M184V		K49R, I50V, S68N, K103R, K166R, G196E, R211K, F214L, K275KR, V276I, I293V, E297AV	B
Delgado (2001)	ED_V74	ED_V74	AY016983	AZT, 3TC	None			E6K, K103R, K122E, D123N, G196E, I244V	B
Eshleman (2001)	A084	AF357685	AF357685	AZT, DDI	None	M184V		K20R, K103R, Q174E, F214L, A272S, K277R, L283I, I293V, E312K, D324E	B
Fitzgibbon (2001)	JF-2	JF2-B	AF444172	AZT, 3TC	None	M41L, D67N, L210W, T215Y		V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245E	B
		JF2-M4	AF444173	AZT, 3TC, D4T	None	M41L, M184V, L210W, T215Y		V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245E	B
	JF-6	JF6-B	AF444179	AZT, DDI	None	D67N, K70R, T215F, K219Q		V35M, K103R, K122E, D123E, A158S, N175Y, T200E	B
	JF-8	JF8-B9	AF444183	AZT, DDI	None	K70R, T215F, K219Q		K22N, K103R, K122E, I135T, R211K, F214L	B
		JF8-M10	AF444184	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, T215F, K219Q		V35M, Y56S, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228H	B
		JF8-M14	AF444185	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, T215F, K219Q		K20R, V35M, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228H	B
Gonzales (2001)	CA1277	CA3066	AY030498	AZT, D4T, DDI, DDC, 3TC	None	D67N, K70R, M184V, K219Q		V60I, K103R, K104N, S162A, T200A, Q207E, F214L, A272P, K277R, A288S	B
	CH001546	KGXN7145	AY030663	DDI, AZT, 3TC	None	D67N, T69D, K70R, T215F, K219Q		K20R, K102R, K103R, K104R, I132IT, V179I, G196E, T200A, A272S, T286A	B
	CA1799	CA4834	AY030717	D4T, 3TC	None	D67N, K70R, M184V, K219Q		E6D, K20R, T69N, K103R, K122E, T200I, R211K, F214L, K311KR, R356K, A360V, A376T, A400T, L452LS, T470A, H483Y, G490GE, L491LS, K527KN, A554N	B
	CA1809	CA4854	AY030724	AZT, 3TC, D4T	None	D67N, K70R, M184V, T215V, K219Q		K43KE, T69N, K103R, V118I, I135L, G196E, R211K, F214L	B
	CA1847	CA4954	AY030752	DDI, AZT	None	M41L, D67N, T69D, K70R, L74V, T215F, K219Q		A33AG, V60I, K103R, V118I, K122E, I135T, I159L, K166T, E194EA, I202IT, H208HY, F214L, D218DE	B
	CA1860	CA4982	AY030764	AZT, 3TC, D4T, DDI	None	M41L, D67N, T69D, K70R, T215F, K219Q	A98G	K20R, V35E, T39A, V60I, K103R, V118I, K122E, I135K, F214L, L228H, I293V, E297K, T386I, K390R, A400T, A437V, V458I, Q509Y, K527N, A554T	B
	CA2205	CA7988	AY030827	D4T, 3TC	None	M41ML, M184V		V35M, K102Q, K103R, K122E, Q174KR, T200I, I202V, V245M, A272S	B
	CA2321	CA8419	AY030865	AZT, 3TC, D4T	None	A62V, M184V	V179D	V35T, K103R, I135T, Q174E, R211K, T215X, K259KR, N265NT, A272S	B
	CA3935	CA9143	AY030934	D4T, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219Q		K20R, V21VI, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V, A304G	B
	CA4291	CA10476	AY031157	DDC, AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, V75M, T215F, K219Q		K20R, Q23X, V60I, K103R, V118I, I135T, G196E, R211G, F214L	B
	CA4330	CA10521	AY031194	AZT, DDI, 3TC	None	M41L, D67N, T69D, K70R, M184V, T215S, K219Q		D17DG, K20R, P25PA, V35L, V60I, K103R, V118I, K122E, S134SC, K173E, Q207E, F214L, L228H, K277R, A288T, I293V, E297K	B
	CA4738	CA11604	AY031400	AZT, DDI	None	D67N, K70R, K219Q		K64Y, K103R, K173R, V245L, T286A, E291EG	B
	CA4828	CA11743	AY031487	AZT, 3TC	None	M184V	V179D	E6EA, T27TA, I31L, V90I, K103R, T200I, R211K, F214L, L228H, V245K, I293V	B
	CA4874	CA11971	AY031514	3TC, DDI, DDC, D4T	None	M41L, D67N, K70R, M184V, T215F, K219Q		K20R, T69N, W88C, K103R, D123E, I135IV, G196E, E203D, F214L, A272P, I293V	B
	CA5006	CA12277	AY031581	AZT, 3TC, D4T, DDI	None	D67N, K70R, T215I, K219Q		V60I, T69N, K102KQ, K103R, K122KE, F130FL, I135T, S162C, F214FL, D218E, A272P	B
	CA5033	CA12307	AY031604	AZT, DDC, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215F, K219Q		V35L, T39A, R83K, K103R, K122E, I135T, S162C, G196E, T200TA, E203ED, D218E, A272P, K277R, I293V, E297A	B
	CA5155	CA12450	AY031721	AZT, DDI, 3TC	None	M184V	V179D	V60I, R72RG, K103R, I142V, A158S, F214L, V245K, A272S, K277R, I293V	B
	CA5483	CA24824	AY032022	AZT, 3TC	None	M184V		R83K, K103R, A129AV, I135X, E138EV, R143RI, T200A, R211K, V245K, T286A, A304G	B
Katzenstein (2001)	ACTG302_2657	2657RT_bl		DDI	None	L74V, L210W		K103R, K122P, F171FY, I178M, G196E, R211RK, F214L	B
Perez (2001)	EP-1738	EP-1738	AF320533	NRTI	None	D67N, T69D, K70R, T215F, K219Q		K43Q, V60I, K103R, K122E, Q207E, R211K, L228H, V245K	B
Shulman (2001)	302-260859	260859		AZT	None	D67N, T69D, K70R, K219Q		T39A, K103R, T200K, I202V, Q207E, R211K, F214L, A272P	B
	302-140750	140750		AZT	None	D67N, K70R, K219Q		T39TA, S48T, K103R, K122E, D123N, I135T, T165I, Q197E, T200I, R211RK, F214L, L228LH, A272AP, K277R, I293V, E297A, A304G	B
Ait-Khaled (2002)	MAK-1755	1755161	AJ426012	AZT, 3TC	None	M184V		K20R, I31L, V35I, L100X, K103R, I135A, I178M, V179I	B
		1755481	AJ425919	AZT, 3TC, ABC, D4T	None	M184V		K20R, V35IR, K103R, I135AT, I178M, V179I	B
	MAK-1700	1700481	AJ425986	ABC, AZT, 3TC	None	L74V, M184V		K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211K	B
Cho (2002)	KKS	99KKS12	AF282150	AZT	None	D67N, K70R, K219Q		T69N, K103R, K122E, T200I, I202V	B
	PBK	01PBK403	AF407373	DDI	None			K103R, K122E, I142V, D177E, I178M, T200A, Q207E, K223E	B
Gonzales (2003)	CA1138	CA3735	AF514019	AZT, D4T, 3TC, DDI	None	K70R, M184V		E6K, K103R, K122E, I135L, Q207E, R211K, V245E, K281KE, T286A, E297K	B
	CA3935	CA12327	AF514162	D4T, 3TC	None	M41L, D67N, V75M, M184V, L210W, T215Y, K219Q		K20R, V21I, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, L149LP, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V	B
Gulick (2004)	RG263	RG263w22		ABC, AZT, 3TC	None			E53Q, T69TN, K102Q, K103R, V118I, K122E, T200E, E204EQ, Q207E, R211K, F214L, V245T	B
	RG285	RG285w24		ABC, AZT, 3TC	None	M184V		I50IV, T69TI, K103R, K122P, I135T, I142A, T200TA, R211K, F214L	B
	RG365	RG365w135		ABC, AZT, 3TC, DDI, TDF	None	M41L, M184V, T215Y		M16MV, V21I, A98S, K102Q, K103R, K122E, I142X, T200I, R211S, Q278H, K281R, I293V	B
Kuritzkes (2004)	KDR_pat77	A0089	AY527906	D4T, 3TC	None	K70KR		K103R, K122KE, T139TI, R211K, F214L, K223KR	B
		A0090	AY527907	D4T, 3TC	None	K70R, M184V		K103R, R211K, F214L	B
	KDR_pat113	A0135	AY527952	AZT, 3TC	None	D67N, K70R, M184V, K219Q		V60I, T69N, K103R, F214L, P243T	B
		A0136	AY527953	AZT, 3TC	None	D67N, K70R, M184V, K219Q		V60I, T69N, K103R, I135IT, F214L, P243T	B
Machado (2004)	con25	con25	AY313434	AZT, DDI	None	M41L, D67N, L210W, T215Y		K43E, V60I, K102Q, K103R, V118I, D121Y, K122E, G196E	B
	con60	con60	AY313446	AZT, DDI	None	M41L, D67N, K70R, T215Y		K103R, D123E, D177E, T200A	B
	cs130	cs130	AY313414	AZT, DDI	None	D67N, K70R, T215F, K219Q		K103R, V118I, I135T, E169D, G196E, Q207E, F214L	B
Gallant (2005)	JEG06	JEG06_w12	DQ199579	ABC, TDF, 3TC	None	M184V		T27S, V60I, R83K, K101Q, K103R, K122KE, D123E, I178M, V179I, T200A, V245E, I293V	B
Rhee (2005)	JVM-PT14	JVMPT14		AZT	None	K70R		K103R, E203K	B
	CA1277	CA9946	AY800837	AZT, D4T, DDI, DDC, 3TC	None	D67N, K70R, M184V, K219Q		V60I, K103R, I135L, S162A, T200A, Q207E, F214L, K249KR, A272P	B
	CA2205	CA9398	AY801149	D4T, 3TC	None	M41L, M184V		V35M, K102Q, K103R, K122E, P150PL, Q174KR, T200I, I202V, V245M, A272S, L283I, T286A, A288AS, I293V	B
	CA4828	CA34731	AY801422	AZT, 3TC	None	M184V, T215F	V179D	I31L, S68SG, K103R, T200TI, R211K, F214L, V245K, I293V	B
	CA5483	CA24822	AY801589	AZT, 3TC	None	M184V		R83K, K103R, T200A, R211K, K220KI, V245K, E248EK, S251SN, L260V	B
	CA7971	CA34609	AY801875	AZT, 3TC	None	A62AV, M184V		E6EG, R83K, K103R, D123E, S162C, D177E, T200A, P243S, V245E, A272P, K281R, T286A, V292I, I293V, M357T, R358RK, T369V, A376T, T386S, E399D, A400T, Y405H, A446S, D460N, R461K, S468T, H483Y, Q509I, Q520R, Q524E, A554N	B
	CA9823	CA24160	AY802130	AZT, DDC	None	T69ADSY, K70R, T215TFIS, K219KQ		K20R, K102R, K103R, K173S, I195IL, R211RK, F214L, L228HR, T286A, I293IV, E297Q	B
		CA34855	AY802131	AZT, DDC	None	T69ADSY, K70R, T215TFIS, K219KQ		K20R, K102R, K103R, K173S, I195IL, Q207QE, R211RK, F214L, L228HR, T286TA, I293IV, E297Q	B
	CA9881	CA24385	AY802161	AZT, 3TC, D4T, DDI	None	D67N, K70R, K219Q		T39A, K64N, T69N, K103R, K122E, I135L, F214L	B
		CA34472	AY802162	AZT, 3TC, D4T, DDI	None	D67N, T69S_X, K70R, T215TI, K219Q		T39A, K64HN, S68Y, K103R, K122KE, I135L, F214L, A272P, T286A	B
Rhee (2006)	CA7877	CA19917		AZT, 3TC, D4T, DDI	None	M41L, D67N, K70R, T215F, K219Q		E6D, T39TA, V60I, K103R, V118I, K122E, F124FL, T131TRS, I142IM, Q197K, T200E, E203D, Q207D, F214L, K223Q, L228LH, Q242K, V245M, A272P, V276T, L283I, A288T, I293V, E297A	B
Rios (2007)	CH95	MR_CH95.1	EF193996	AZT, 3TC	None			V35I, D76A, F77Y, K103R, G112A, S134A, I142V, D177E, F214L, F227S, V245E	B
Riddler (2008)	RG17932	RG17932w48		AZT, 3TC	None			K20R, K49KR, K103R, D123E, S162C, Q174E, T200A, V245VEKM, A272S, K277R, L283I, A288T, I293V, E297A, E312K, G335D, R356K, G359S, A360T	B
Rosen-Zvi (2008)	52	00p52-1		AZT, DDC, D4T, DDI, ABC, 3TC	None	D67N, K70R, V75T, K219Q		V35I, K43Q, K64Y, K102KR, K103R, V118I, L210F, F214L, D218DE, L228H, K277R, T286A, A288T, I293V	B
Rhee (2009)	CA4340	CA37830	FJ983168	AZT, 3TC	None	M184V		P4PS, E6X, K103R, K122E, I142V, T200A, Q207E, R211K, F214L, I293V, P294A	B
	CA35657	CA79852	FJ983563	D4T, 3TC, TDF, DDI	None	D67N, K70R, K219Q		P4T, K11R, M16MV, K20R, V35L, V60I, K64R, K82KR, K103R, K122E, D123DN, I135IV, G196E, Q197K, R211K, F214L, L228LH, A272P, K277KR, T286A, E297Q	B

Reverse Transcriptase Inhibitors

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