Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K103N
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	13
Patients	18
Isolates	19

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_3671	3671		AZT, DDI	None	L210LW, T215D	K103N, Y318F	K20R, V35VI, K122E, I135T, S162C, E203D, R211K, E224ED, A272P, K277R, L283I, I293V, Q334DE, R356K, G359S, A371AV, T377MV, K390R, A400T, T403A, K451R, L452S, S468P	B
Baxter (2000)	GART-G140	GART-140		NRTI, AZT, 3TC	None	M41L, M184V, L210W, T215Y	K103N	V35T, K49R, A98AS, K102R, K122E, E169D, D177E, I178M, Q207E, R211K, A272P	B
Eshleman (2001)	A067	AF357668	AF357668	AZT, DDI	None	M41L, T215Y	K103N	K20R, K102R, K122E, Q278H, T286A	B
Gonzales (2001)	CA2103	CA7758	AY030810	AZT, DDI, DDC, D4T, 3TC	None	M41L, A62V, D67N, L74I, M184V, L210W, T215F, K219Q	K103N	V35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228H	B
	CA3886	CA9078	AY030891	AZT, 3TC	None	M184V	K103N	I135V, S162C, I178L, R211K, L234LH, P243PH	B
Naugler (2002)	WES-11	HIV11ES	AF422733	AZT, DDI	None	M41L, L210W, T215S	K103N	V35L, E42V, V60G, A62P, L100V, V106I, I202V, R211K	B
Shafer (2003)	A384_3104	3104b	EF548272	D4T, DDI	None		K103N	T39S, R83K, K122E, S162C, S163T, Q207E, E248ED, A272P, T286A, I293IL, E297T	B
	A384_2436	2436b		AZT, 3TC	None		K103N	S48T, E79D, I178L, R211K, V245K	B
	A384_1744	1744b	EF548751	AZT, 3TC	None		K101E, K103N	D123E, I142V, T200E, Q207G, V245K	B
Dumans (2004)	260	260	AY390162	AZT, DDI	None	M41L, L210W, T215S	K103N	V118I, D121Y, K122E, D123E, I135T, S162C, D177E, G196E, Q207H, R211K	B
Gulick (2004)	RG444	RG444w90		ABC, AZT, 3TC, DDI	None		K103N	R83K, K166R, I178L, R211K	B
	RG469	RG469w100		ABC, AZT, 3TC	None	Y115F, M184V	K103N	T39S, V90VI, K101R, K122E, D123N, I142V, S162A, E169D, Q174K, G196E, Q207E, R211K, L228R, V245Q	B
Montes (2004)	MB_patCAS	00_CASE717	AJ577859	DDC, AZT, 3TC, D4T, DDI, ABC	None	M41L, D67N, T69D, L74V, L210W, T215Y	K103N	E6D, T39K, K43E, E44D, V60I, V118I, K122P, D123E, I135T, S162N, K173T, D177E, G196D, E203K, Q207E, H208Y, R211K, K223Q	B
Gallant (2005)	JEG33	JEG33_w12	DQ199606	ABC, TDF, 3TC	None		K103N	Q23Q*, T69A, R83K, D121C, K122E, S162C, D177E, A272P, K277R	B
Dumans (2009)	RENA686	RENA686	FJ405043	AZT, 3TC	None	D67G, K70R, M184V, T215F, K219E	K103N	K20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334D	B
	117PR	117PR	FJ405058	AZT, 3TC, D4T, DDI	None		K103N	K20R, K122E, Q174H, D177N, Q197E, I202V, D256A	B
Rhee (2009)	CA9699	CA23740	FJ983316	AZT, 3TC	None	D67N, M184V, K219Q	K103N	K11KR, K20R, V35I, V60I, I135T, S162A, K166R, R172RK, Q207E, R211K, K277R, I293V	B
	CA22110	CA51131	FJ983497	AZT, 3TC	None	M41L, M184V, T215Y	K103N	K20R, K122E, T200A, R211K	B
Melikian (2012)		CA95213	GQ213522	AZT, 3TC, TDF, DDI	None	M41L, L210W, T215Y	K103N	K20R, V60VI, V118VI, K122E, D123DG, V179VI, T200A, R211K, I270IF	B

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