<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K101R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 20
Patients 33
Isolates 40
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_18541854 AZT, DDCNoneM41ML, T215Y K101R, K122E, K166KR, G196E, A272P, K277R, Q278H, E291D, K350R, R356RK, A360T, K366R, A376T, K390R, A400T, D460N, R461KB
Venturi (1999)GV-10Vent10BAF169060AZTNoneD67N, K70R, K219Q K49R, A98S, K101R, D123E, I135T, D177EB
  Vent10W24AF169061AZT, DDINoneD67N, K70R, K219Q K49R, A98S, K101R, D123E, I135TB
 GV-39Vent39BAF169118AZTNoneD67N, K70R, K219Q K49R, A98S, K101R, D123E, I135T, S162X, D177E, T215XB
  Vent39W24AF169119AZT, 3TCNoneD67N, K70R, T215F, K219Q K49R, A98S, K101R, D123E, I135T, S162X, D177E, M184XB
Baxter (2000)GART-G143GART-143 NRTI, AZT, 3TCNoneM41L, M184V, L210W, T215Y K43E, K101R, K122E, I135V, K166R, R211K, I244V, V245K, E248D, D250DEB
Albrecht (2001)ACTG364_306306 AZT, DDINoneM41L, D67DN, L210W, T215Y V35I, K43Q, E44ED, R83K, A98S, K101R, K104KN, V118I, I135T, K166R, E203ED, R211K, K277RB
 ACTG364_60136013 DDC, AZTNoneD67N, K70R, K219KQ K20KR, I50V, K101R, K104N, I202IV, V245R, A272P, K277R, I293VB
Gonzales (2001)CA1502CA4301AY030628AZT, DDINoneD67N, K70R, T215F, K219QV108IK20R, V35M, V60I, K64R, K101R, K122P, I135T, D177E, I178L, A272P, K277R, I293V, E298EQ, A299ASB
 CA5136CA12429AY031702AZT, 3TCNoneM184V K20R, K101R, K122E, T139K, I195M, Q197K, T200TA, V245EB
 CA6462CA15979AY032413DDC, AZT, 3TC, D4TNoneD67N, K70R, M184V, K219Q, N348NI K101R, K102Q, K122KE, D123DN, I135L, I142IT, K166R, Q207H, R211K, L228LH, A272P, K275R, Q278H, T286A, I293IL, E300EG, V317VA, Q334P, P345A, G359S, V365VI, K366R, A371V, A376V, A400T, T403S, L452LS, D460N, S468T, D471DA, H483Y, L491S, K512R, S519N, V531I, K550R, A554T, K558RB
Katzenstein (2001)ACTG302_33003300RT_bl AZT, DDINoneM41L, D67N, K70R, T215Y K11R, V35I, K43KE, S48T, D76DE, R83K, V90I, K101R, K102KE, S134R, N137NDGS, S162H, K166R, K173KI, G196E, A272P, V276VA, K277R, K281KR, K287KN, A288AS, I293IV, E297RB
Tural (2002)881218881218 AZT, DDI, D4TNoneM41L, D67N, K70R, T215Y, K219Q V60I, K101R, K122E, I135M, V245LB
Saah (2003)AS-4AS-4 AZT, DDI, D4T, 3TCNoneM41L, M184V, T215Y K101R, I135T, K166R, R211KB
Shafer (2003)A384_09670967bEF548167AZT, 3TCNone V108II37X, K101R, D123E, N137NS, S162N, K173KR, D177DE, I178IM, R211GB
Gulick (2004)RG469RG469w100 ABC, AZT, 3TCNoneY115F, M184VK103NT39S, V90VI, K101R, K122E, D123N, I142V, S162A, E169D, Q174K, G196E, Q207E, R211K, L228R, V245QB
Kuritzkes (2004)KDR_pat246A0341AY528158AZT, 3TCNoneM184V R83K, K101R, I135T, S162C, E169D, R211RSB
  A0342AY528159AZT, 3TCNoneM184V R83K, K101R, I135T, S162SC, E169D, R211RSB
  A0343AY528160AZT, 3TCNoneM184V R83K, K101R, I135T, E169D, R211RSB
Mo (2005)90199019_d1 NRTINone  V60I, T69TN, K101R, K122E, I135T, S162SN, T200TI, V245M, A272P, A288SB
Rhee (2005)CA1502CA4378AY801001AZT, DDINoneD67N, K70R, T215F, K219QV108IK20R, V35M, V60I, K64R, K101R, K122P, I135T, I178L, R211G, Q258QP, A272P, K275KN, K277R, C280CR, L289LF, I293VB
 SWC-46034603-93 AZT, DDCNoneM41L, M184V, T215Y K101R, I135T, A272PB
  4603-1579 AZT, DDCNoneM41L, L210W, T215Y K101R, I135T, I142X, A272PB
 ASRU006ASRU006 AZT, DDI, D4T, 3TCNoneD67N, M184V K101R, T128S, I135T, S162CB
 CA7898CA19954AY801825D4T, 3TC, ABCNone  R83K, K101R, K122P, K166KR, I178L, R211RK, V245EB
 CA7932CA19999AY802710DDC, AZT, 3TC, D4TNoneM184V K101R, I135R, Q174H, G196GR, R211RK, T286A, T296S, E297K, A299AGB
  CA23551AY801851DDC, AZT, 3TC, D4TNoneM184MV K101R, I135R, Q174H, T200TA, Q207QAEP, R211RK, T286A, T296S, E297KB
 CA8049CA20183AY801927AZT, 3TC, D4T, DDINoneD67N, K70R V35L, R83K, K101R, D177E, I178M, G196E, T200A, E204N, R211K, V245E, A272PB
Rios (2007)CH32MR_CH32.1EF193921AZT, DDINoneM41L, D67N, L210W, T215Y K32Q, V35I, K43N, E44D, K46N, K101R, D123E, I135L, G196E, R211K, A272P, K277RB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
von Wyl (2007)127496581EF449789NRTINoneM184V I31V, K43R, I47M, E53D, Y56C, N57K, T58S, K101R, S162C, K201TB
 5498411EF449925NRTINoneM184V K49R, V60I, K101R, E169D, D177E, R211KB
 1167207936EF449823NRTINoneD67N V35I, K46Q, K101R, D123E, Q174K, Q207E, R211KB
 1037289674EF449837NRTINoneD67N V35I, K46Q, K101R, D123E, Q174K, Q207E, R211KB
 1254798867EF449986NRTINoneM184V R83K, K101R, D123E, K166R, I178MB
Rosen-Zvi (2008)403p4-1 AZT, 3TC, D4T, ABCNone  K101R, I142V, A158S, R211K, D218N, V245T, K277R, T286A, E297K, V317T, I329V, Q332RB
von Wyl (2010)17656951765695GQ848112AZT, DDI, 3TCNoneD67N, T69DN, K70R, M184V, K219KQ K20KR, V21VI, V35T, V60I, K101R, K103KR, I135IATV, E138ED, K166R, T200A, Q207QH, F214FL, E248D, D250DN, Q269QH, A272S, A288AT, I293V, K347Q, R356K, G359S, A360T, A376AT, K390RB
 47961374796137GQ848125AZT, 3TCNoneM184V, N348I V35M, T39TA, K49KR, V60VI, R83K, K101R, D123DE, I135T, E169D, D250N, A272P, I293V, E297A, T338TS, P345Q, M357I, R358K, G359S, K366R, I375V, T386IB
Mollan (2012)MK19MK19w25 TDF, FTCNone  V35R, K101R, D123E, S162CB
Grossman (2014)424424KC213665ABC, DDINone  K101R, V106I, D123N, I135T, I142V, T165I, I178L, F214LB