<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K101Q
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 24
Patients 37
Isolates 38
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1994)143U206143206_W40 AZT, DDINoneM41L, T215F T27X, V35I, R83K, K101Q, D123E, I135T, S162C, R211KB
Shafer (1995)JIDP7JIDP7W104AF021305AZT, DDINoneD67N, K70R, T215F, K219Q V35I, K101Q, K104KN, K122E, I135V, R211KB
Hammer (1997)ACTG320_119119 AZT, DDINoneM41L, D67N, L210W, T215Y K43Q, V90I, K101Q, V118I, K122E, I135R, G196GE, Q197L, I202IV, R211K, V245M, D250E, V292VI, I293V, V317T, R356K, G359S, A371AV, T377M, S379G, K390R, V467VI, S468P, H483HYB
 ACTG320_12801280 AZT, DDCNone  K101Q, K122E, S162C, V179VI, I195IL, Q207QKPT, L210LM, R211K, V245M, A272P, K277R, I293VB
 ACTG320_27772777 AZTNoneT69TADN, K70R V60VI, R83K, K101Q, K122KE, D123E, S162C, D177E, T200TI, E203D, R211K, A272P, K277R, I293IV, A360AV, K366KR, A400T, E404D, V417I, N418S, D460N, V467I, L469IB
Cabana (1999)Cab-eE37AF102344DDC, AZT, 3TC, D4TNoneM41L, D67N, M184V, L210W, T215Y E44D, K101Q, V118I, K122E, Q174R, N175Y, G196E, Q207E, R211KB
Bacheler (2000)LB4-P148P148-0 AZT, 3TCNoneM184V R83K, K101Q, S162A, F214LB
Baxter (2000)GART-NG36GART-36 NRTI, 3TC, D4TNoneM41ML, D67N, K70KR, M184V, T215Y, K219KE K20KR, V60I, R83K, K101Q, G196E, V245EB
 GART-G124GART-124 NRTI, 3TC, D4TNoneK70KR, M184V, K219Q K11E, K32I, V35I, E40V, R83RK, K101Q, T200A, R211K, V245M, E248DB
Coakley (2000)EC19EC19F D4T, DDINone  K101Q, K122E, I135T, E138A, I202V, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468PB
Parkin (2000)SD-5SD-5_44AF294551NRTI, AZT, 3TC, ABC, D4TNoneM184V K20R, K101Q, K122E, I142V, T165I, K277R, A288S, I293VB
Albrecht (2001)ACTG364_51025102 DDI, AZT, 3TCNoneV75T, M184V, K219KR I37L, K49KR, K101Q, R143R*, S162D, K166R, T200I, Q207E, R211K, F214L, H221HY, K277RB
Gonzales (2001)CA1267CA3042AY030493NRTI, 3TC, D4T, ADVNoneM41L, D67N, M184V, T215Y K20R, V60I, K101Q, K104N, I135T, S162C, T200AB
 CA1507CA4315AY030632DDI, 3TC, D4T, DDCNoneM184V E6D, K32KN, T39TA, A98S, K101Q, D123E, I135R, D177E, V179I, V245E, I293VB
 CA2260CA8188AY030846DDC, AZT, D4T, 3TCNoneM184V, L210W, T215Y K11R, K49R, S68G, R83K, K101Q, V106I, I135IT, K166R, R211K, A272P, K277RB
 CA5058CA12338AY031628AZT, DDC, D4T, 3TCNoneM41L, M184V, T215Y T39A, R83K, K101Q, D123E, S162CF, V179I, E204Q, R211K, D250E, A272P, T286A, E297R, A304GB
 CA5998CA14776AY032243AZT, D4T, 3TCNoneD67N, K70R, M184V, T215Y, K219Q K101Q, K122E, T131TP, E169D, D177E, V179VI, G196E, T200A, E203ED, Q207E, H208HY, F214L, V245T, E248V, A272P, K281KE, R284K, I293VB
Ait-Khaled (2002)MAK-17001700481AJ425986ABC, AZT, 3TCNoneL74V, M184V K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211KB
Papa (2002)AP-12AP-12AF315748AZT, 3TC, D4T, DDINoneD67N, K70R, M184V, T215FY, K219Q K101Q, K122E, K166R, G196EB
Monno (2003)ML_pt9ML1030_1AY267788AZT, DDI, 3TC, D4T, ABCNoneM41L, D67N, M184MV, L210W, T215Y E40X, R83K, K101Q, K104R, V118I, D123E, E203K, Q207E, H208HY, R211K, A272P, T286P, E297R, E312QB
Shafer (2003)A384_17681768bEF548788AZT, 3TCNoneM184V K101Q, D123E, E138EA, D177E, V179I, V245MB
Dumans (2004)197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
 198198AY390118AZT, DDI, 3TC, D4TNoneM41L, V75M, M184V, L210W, T215Y K101Q, V118I, K122EB
Gulick (2004)RG201RG201w65 ABC, AZT, 3TCNoneM184V T7A, K101Q, G196E, S251IB
Machado (2004)cs131cs131AY313415DDI, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y K43Q, E44D, K101Q, V118I, K166R, E169D, T200I, R211KB
Richard (2004)RN_Pat15RNJLT15CAY556798ABC, D4T, 3TCNoneL74I K32I, V60I, S68C, K73T, N81H, K82M, E89A, K101Q, K122E, D177E, I178LB
Gallant (2005)JEG06JEG06_w12DQ199579ABC, TDF, 3TCNoneM184V T27S, V60I, R83K, K101Q, K103R, K122KE, D123E, I178M, V179I, T200A, V245E, I293VB
Garcia-Bujalance (2005)GBS_12GBS_12AY872347ABC, AZT, 3TCNoneM41L, M184V, L210W, T215Y, K219KN E44D, K101Q, V118VI, D177G, T200TA, E203K, Q207QE, H208HY, R211KB
Rhee (2005)CA8435CA21191AY802011AZT, 3TCNoneM41L, M184V, T215Y K101Q, K103KR, S162T, A272P, K277R, I293VB
 CA14156CA34268AY802242AZT, 3TC, D4TNoneM184V E28K, K32E, K101Q, G196KR, R211K, V245E, D250E, T286VB
 CA16425CA39011AY802511ABC, AZT, 3TCNoneT215D K32N, V35IT, K101Q, D123E, I135R, I142AV, S162C, E169AT, K173E, P176PS, D177DE, I178ILM, I202IMV, A272P, T286TAB
 CA18428CA43004AY802567AZT, 3TCNoneD67N, K70R, M184V E28K, K32E, V35I, F77FS, R83K, K101Q, K122E, I135V, V245K, K281R, I293V, E297EKB
Riddler (2008)RG59374RG59374w48 D4T, 3TCNone  V35L, V60VI, K101Q, K104R, K122E, D123A, I142IV, I178IM, T200A, Q207E, I244IV, V245VAMT, E248ED, A272P, E297K, M357MT, A376TB
 RG83604RG83604w8 AZT, 3TCNone  V35I, R83RK, K101Q, K104R, S162Y, E169D, V179I, R211T, W229WR, L234LV, A272P, T286A, K311R, A376S, K390RB
  RG83604w19 AZT, 3TCNone  V35I, R83RK, K101Q, K104R, S162Y, E169D, V179I, R211T, A272P, T286A, K311R, A376S, K390RB
Mollan (2012)MK170MK170w41 TDF, FTCNone  V21VI, K43R, K49R, I50V, V60I, K101Q, V118VI, I135L, E138A, T165I, Q174C, V179I, G196E, I202V, I244V, K277R, A288SB
 MK98MK98w98 ABC, 3TCNoneM184MV E6D, V35VL, K82KR, A98S, K101Q, K102Q, K104R, S162C, K173R, Q174K, R211K, K249Q, A272P, K277KR, T286A, I293VB
Kim (2013)Tx14281KC1208743TC, DDINone K103NK101Q, D121H, K122E, I135R, T200I, V245A, L246I, I293V, E297G, E312Q, S322AB