Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K101Q
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	21
Patients	33
Isolates	34

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1994)	143U206	143206_W40		AZT, DDI	None	M41L, T215F		T27X, V35I, R83K, K101Q, D123E, I135T, S162C, R211K	B
Shafer (1995)	JIDP7	JIDP7W104	AF021305	AZT, DDI	None	D67N, K70R, T215F, K219Q		V35I, K101Q, K104KN, K122E, I135V, R211K	B
Hammer (1997)	ACTG320_119	119		AZT, DDI	None	M41L, D67N, L210W, T215Y		K43Q, V90I, K101Q, V118I, K122E, I135R, G196GE, Q197L, I202IV, R211K, V245M, D250E, V292VI, I293V, V317T, R356K, G359S, A371AV, T377M, S379G, K390R, V467VI, S468P, H483HY	B
	ACTG320_1280	1280		AZT, DDC	None			K101Q, K122E, S162C, V179VI, I195IL, Q207QKPT, L210LM, R211K, V245M, A272P, K277R, I293V	B
	ACTG320_2777	2777		AZT	None	T69TADN, K70R		V60VI, R83K, K101Q, K122KE, D123E, S162C, D177E, T200TI, E203D, R211K, A272P, K277R, I293IV, A360AV, K366KR, A400T, E404D, V417I, N418S, D460N, V467I, L469I	B
Cabana (1999)	Cab-e	E37	AF102344	DDC, AZT, 3TC, D4T	None	M41L, D67N, M184V, L210W, T215Y		E44D, K101Q, V118I, K122E, Q174R, N175Y, G196E, Q207E, R211K	B
Bacheler (2000)	LB4-P148	P148-0		AZT, 3TC	None	M184V		R83K, K101Q, S162A, F214L	B
Baxter (2000)	GART-NG36	GART-36		NRTI, 3TC, D4T	None	M41ML, D67N, K70KR, M184V, T215Y, K219KE		K20KR, V60I, R83K, K101Q, G196E, V245E	B
	GART-G124	GART-124		NRTI, 3TC, D4T	None	K70KR, M184V, K219Q		K11E, K32I, V35I, E40V, R83RK, K101Q, T200A, R211K, V245M, E248D	B
Coakley (2000)	EC19	EC19F		D4T, DDI	None			K101Q, K122E, I135T, E138A, I202V, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468P	B
Parkin (2000)	SD-5	SD-5_44	AF294551	NRTI, AZT, 3TC, ABC, D4T	None	M184V		K20R, K101Q, K122E, I142V, T165I, K277R, A288S, I293V	B
Albrecht (2001)	ACTG364_5102	5102		DDI, AZT, 3TC	None	V75T, M184V, K219KR		I37L, K49KR, K101Q, R143R*, S162D, K166R, T200I, Q207E, R211K, F214L, H221HY, K277R	B
Gonzales (2001)	CA1267	CA3042	AY030493	NRTI, 3TC, D4T, ADV	None	M41L, D67N, M184V, T215Y		K20R, V60I, K101Q, K104N, I135T, S162C, T200A	B
	CA1507	CA4315	AY030632	DDI, 3TC, D4T, DDC	None	M184V		E6D, K32KN, T39TA, A98S, K101Q, D123E, I135R, D177E, V179I, V245E, I293V	B
	CA2260	CA8188	AY030846	DDC, AZT, 3TC, D4T	None	M184V, L210W, T215Y		K11R, K49R, S68G, R83K, K101Q, V106I, I135IT, K166R, R211K, A272P, K277R	B
	CA5058	CA12338	AY031628	AZT, DDC, D4T, 3TC	None	M41L, M184V, T215Y		T39A, R83K, K101Q, D123E, S162CF, V179I, E204Q, R211K, D250E, A272P, T286A, E297R, A304G	B
	CA5998	CA14776	AY032243	AZT, D4T, 3TC	None	D67N, K70R, M184V, T215Y, K219Q		K101Q, K122E, T131TP, E169D, D177E, V179VI, G196E, T200A, E203ED, Q207E, H208HY, F214L, V245T, E248V, A272P, K281KE, R284K, I293V	B
Ait-Khaled (2002)	MAK-1700	1700481	AJ425986	ABC, AZT, 3TC	None	L74V, M184V		K20R, V35I, K64KR, D86S, K101Q, K103R, I135K, K173E, Q174R, R211K	B
Papa (2002)	AP-12	AP-12	AF315748	AZT, 3TC, D4T, DDI	None	D67N, K70R, M184V, T215FY, K219Q		K101Q, K122E, K166R, G196E	B
Monno (2003)	ML_pt9	ML1030_1	AY267788	AZT, DDI, 3TC, D4T, ABC	None	M41L, D67N, M184MV, L210W, T215Y		E40X, R83K, K101Q, K104R, V118I, D123E, E203K, Q207E, H208HY, R211K, A272P, T286P, E297R, E312Q	B
Shafer (2003)	A384_1768	1768b	EF548788	AZT, 3TC	None	M184V		K101Q, D123E, E138EA, D177E, V179I, V245M	B
Dumans (2004)	197	197	AY390154	AZT, DDI, D4T, 3TC	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q	E138K	K49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214L	B
	198	198	AY390118	AZT, DDI, 3TC, D4T	None	M41L, V75M, M184V, L210W, T215Y		K101Q, V118I, K122E	B
Gulick (2004)	RG201	RG201w65		ABC, AZT, 3TC	None	M184V		T7A, K101Q, G196E, S251I	B
Machado (2004)	cs131	cs131	AY313415	DDI, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y		K43Q, E44D, K101Q, V118I, K166R, E169D, T200I, R211K	B
Gallant (2005)	JEG06	JEG06_w12	DQ199579	ABC, TDF, 3TC	None	M184V		T27S, V60I, R83K, K101Q, K103R, K122KE, D123E, I178M, V179I, T200A, V245E, I293V	B
Garcia-Bujalance (2005)	GBS_12	GBS_12	AY872347	ABC, AZT, 3TC	None	M41L, M184V, L210W, T215Y, K219KN		E44D, K101Q, V118VI, D177G, T200TA, E203K, Q207QE, H208HY, R211K	B
Rhee (2005)	CA8435	CA21191	AY802011	AZT, 3TC	None	M41L, M184V, T215Y		K101Q, K103KR, S162T, A272P, K277R, I293V	B
	CA14156	CA34268	AY802242	AZT, 3TC, D4T	None	M184V		E28K, K32E, K101Q, G196KR, R211K, V245E, D250E, T286V	B
	CA16425	CA39011	AY802511	ABC, AZT, 3TC	None	T215D		K32N, V35IT, K101Q, D123E, I135R, I142AV, S162C, E169AT, K173E, P176PS, D177DE, I178ILM, I202IMV, A272P, T286TA	B
	CA18428	CA43004	AY802567	AZT, 3TC	None	D67N, K70R, M184V		E28K, K32E, V35I, F77FS, R83K, K101Q, K122E, I135V, V245K, K281R, I293V, E297EK	B
Riddler (2008)	RG59374	RG59374w48		D4T, 3TC	None			V35L, V60VI, K101Q, K104R, K122E, D123A, I142IV, I178IM, T200A, Q207E, I244IV, V245VAMT, E248ED, A272P, E297K, M357MT, A376T	B
	RG83604	RG83604w8		AZT, 3TC	None			V35I, R83RK, K101Q, K104R, S162Y, E169D, V179I, R211T, W229WR, L234LV, A272P, T286A, K311R, A376S, K390R	B
		RG83604w19		AZT, 3TC	None			V35I, R83RK, K101Q, K104R, S162Y, E169D, V179I, R211T, A272P, T286A, K311R, A376S, K390R	B

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