<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation A98S
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 32
Isolates 32
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Weber (2005)M36781M36781-2AY714403D4T, DDI, Unknown, AZT, 3TC, TDFNVP, Unknown, EFVM41L, V75I, M184V, T215FK103NV35T, V90I, A98S, K122E, D123N, I132L, I135T, S162H, K173A, D177E, T200A, Q207A, R211N, V245M, K281R, E291D, I293V, P294T, E298G, E312N, S322AA
 M55405M55405AY6775643TC, D4TNVPM184VK101E, G190AP4S, K11T, K20R, V21I, V35T, T39K, S68G, V90I, A98S, K122E, D123N, T165I, K166R, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, E297EA, E312DYA
Nyombi (2008)TBK032TBK032EU251734NoneNVP  V35T, T39TR, A98S, K104R, K122E, D123G, K173R, D177E, V179I, I202V, Q207A, V245Q, E248D, A272P, K275Q, K277R, K281R, E291D, I293V, V317A, G335D, F346Y, R356K, M357I, G359T, K366R, A376T, T377LA
Hamers (2012)CP076307653CP076307653JQ480188AZT, 3TCEFVM184VY181CV21I, K32E, V35T, T39K, A98S, K122E, D123S, I135R, K173A, D177E, V179I, I195V, T200E, I202V, Q207A, R211S, V245Q, E248D, A272G, K281R, T286A, E291D, V292I, I293V, E312DA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Acharya (2014)DGP035DGP035KJ185205TDF, 3TCEFVM41L, K70R, M184V, L210W, T215Y, K219EY181IK20R, V35T, E44D, V60I, I94L, A98S, L109I, D121H, K122E, D123S, I135T, S162D, K166R, K173A, Q174K, D177E, V179I, Q197K, T200A, Q207A, R211N, D218E, L228H, V245T, D250E, A272P, R284K, T286A, V292I, I293VA
Aghokeng (2014)CM-3-175CM-3-175KC350358NRTINNRTIM184VK101HQ, V106VA, G190A, P225PHE6K, K11T, E28K, K32E, V35T, T39L, S48T, K49KR, V60VI, A98S, K122E, D123N, I135IT, S162SADY, K173S, Q174K, V179I, T200TA, I202V, Q207A, R211K, F214FL, P243A, V245Q, A272P, V276I, E291D, V292VI, I293V, P294T, S322T, G335DA
Crawford (2014)SN-031169SN-031169KF781844AZT, 3TCNVPM41L, T69S_XS, V75M, F77FL, M184V, L210W, T215FK101E, V108I, G190AT39E, V60I, K64KR, D86E, W88C, I94IL, A98S, D121Y, K122E, E138A, K173A, Q174K, D177E, V179I, G196E, Q207D, R211K, L228H, V245QA
Meini (2015)118170118170KM438309AZT, 3TCNVPD67N, K70R, M184V, T215I, K219EY181CK11T, V21I, V35T, T39G, E40V, T69N, A98S, K101R, K122E, D123S, I142V, K173L, Q174K, D177E, V179I, T200A, I202V, Q207AE, R211S, D218EA
 109266109266KM438248D4T, DDIEFVM41L, D67N, K70R, T215FL100I, K103NL34I, V35T, T39TA, K49R, V60I, V90VI, A98S, V118I, T139K, K173LS, V179I, T200A, Q207A, R211S, V245KA
Boillot (2016)VIR26VIR26KT315991AZT, 3TCEFV  K11Q, V35T, K49R, V60VM, A98S, K122E, D123G, I135T, I142V, T165I, K173A, Q174QK, D177E, I178IM, V179I, T200A, Q207A, R211S, V245Q, E248DA
Ndahimana Jd Riedel (2016)20342034KT982524NRTINNRTID67N, K70R, T215Y, K219EK101N, K103N, K238TK11T, E28A, V35T, A98S, K122E, D123N, I135T, S162A, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, V245M, D250E, Q278H, E291D, I293V, P294T, E312D, M357K, R358K, G359S, A360T, K366R, T369TI, E370D, A371V, I375V, A376S, T377M, K390R, E399D, A400TA
Steegen (2016)GFKZB161GFKZB161KU128052TDF, 3TC, FTCEFVA62AV, K70E, L74LI, M184V, K219RK103N, P225HE6K, K20KR, K22KR, V35T, A98S, K122E, I135T, I142V, K173S, V189I, T200TA, I202V, Q207KNRS, R211K, L228R, D237DE, V245Q, E248D, A272P, V276I, L283I, T286A, E291D, I293V, P294T, E297KR, E312D, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376V, T386A, E399ED, A400TA
Chaplin (2017)NJIH0241NJIH0241MF622792NRTINNRTI  I5IV, K11T, K20R, V35T, T39N, S48L, A98S, D121H, K122E, D123DG, K173S, Q197QH, T200A, Q207A, I244IV, V245X, E248ED, D250DE, T286X, E291D, I293V, E312T, G333EA
Kekitiinwa (2017)28168_29428168_294KY237804NRTINNRTIL74V, Y115F, M184V, K219KNY181CK20R, V21I, V35T, T39A, E40D, K49R, P59PS, V60VI, A98S, K101KR, D123NS, T131TI, I135T, K173S, Q174K, I178L, V179I, T200TA, Q207A, R211RS, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, P294T, E302EDA
Kityo (2017)8351283512KY062066NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215YK101E, V106A, F227LK43E, V60I, A98S, L109I, V111I, V118I, K122E, D123N, E138A, K173S, V179VI, V189VM, T200A, I202V, Q207A, H208Y, R211K, H221YA
 8304683046KY061605NRTINNRTIM184V, T215YK103N, P225H, K238TA98S, K101Q, K122E, D123DN, K173L, Q174K, N175Y, T200A, Q207AA
 8356383563KY062117NRTINNRTID67N, K70R, M184V, T215F, K219EG190A, F227LT69N, A98S, L109I, K122E, D123N, I142V, K173S, D177E, V179T, T200A, I202V, Q207A, R211N, D218E, L228HA
 8328683286KY061841NRTINNRTID67N, K70R, M184V, T215Y, K219EQK103N, P225H, K238TV60I, H96HL, A98S, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211SA
 8291582915KY061479NRTINNRTID67N, K70R, M184V, T215F, K219EK101E, K103NV60I, A98S, K122E, D123N, I135T, S162A, K173S, Q174K, T200A, I202V, Q207S, D237DHA
 8327983279KY061834NRTINNRTIM41L, M184V, L210W, T215YK103NE44D, V60I, S68SG, A98S, K122E, D123N, I135T, K173L, D177E, G196E, I202V, Q207A, H221YA
 8344783447KY062001NRTINNRTIK65R, M184V, K219EV108VI, Y181CV60I, S68G, A98S, K101KQ, K102R, K122E, D123N, I135T, K173S, Q174R, D177E, V179I, T200AE, I202V, Q207A, R211S, F214FLA
 8302583025KY061585NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219EK103N, P225HYV60I, T69TN, A98S, K102R, K122E, D123S, I135T, K173ST, Q174K, D177E, T200AE, Q207A, R211N, D218DEA
 6604866048KY061415NRTINNRTIM41L, L74LI, V75M, M184V, L210W, T215YV106AK43N, K64R, K82KR, V90I, A98S, V118I, K122E, D123S, E138A, S162H, K166KQ, K173IL, Q174QK, V179I, G196E, Q207A, R211K, Y232HA
 6606466064KY061426NRTINNRTIM41L, D67G, T69D, L74I, M184V, L210W, T215YV108I, Y181CE44ED, K49R, V60I, A98S, V118I, K122E, D123NS, I135T, S162D, K173S, Q174K, D177E, I178IM, V179I, T200E, I202V, E203EK, Q207A, R211N, H221YA
 8328983289KY061844NRTINNRTIM41L, M184V, L210W, T215YK103NK43KQ, E44ED, V60I, A98S, V118VI, K122E, D123N, I135M, E138Q, K173L, D177G, Q197E, T200A, Q207A, R211KA
 8326983269KY061824NRTINNRTID67N, K70R, M184V, K219QK103N, P225HV60I, T69N, A98S, D121H, K122E, D123S, K173S, Q174K, D177E, Q197E, T200A, Q207A, K238QA
 8320483204KY061760NRTINNRTIM41L, D67N, M184V, T215YK103NE44D, S48T, A98S, V111I, K122E, D123S, I135T, K173S, D177E, G196GE, T200A, E203K, Q207E, H208HY, L210S, K223QA
 8352683526KY062080NRTINNRTID67N, K70R, M184V, T215F, K219EY188LK49R, V60I, K64R, T69N, A98S, I135T, K173A, D177E, V179I, T200A, Q207A, R211RK, E224D, L228HA
 8306183061KY061620NRTINNRTIK70R, M184V, K219QG190AT69TS, A98S, K101X, K122E, D123S, K173S, V179I, I195L, G196E, Q207A, R211S, F214L, L228HA
Rhee (2017)KE14492KE14492KY364313TDF, 3TCNVPK65R, Y115F, M184VY181CK20R, V35T, T39K, K43E, V60I, A98S, K102Q, D121Y, K122E, K166R, F171Y, K173L, Q174K, V179I, T200A, Q207A, R211S, H221Y, V245Q, D250EA
 1111011110KY358855TDF, 3TCNVPM184IY181CV35T, T39K, K43E, V60I, A98S, K122E, D123S, I135R, K166R, K173I, Q174K, D177E, I202V, Q207E, R211K, Y232IA