<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation A98G
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 24
Patients 99
Isolates 100
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patBES01_BES703AJ577739AZT, DDI, 3TC, D4T, ABCEFVD67N, K70R, M184V, K219QA98G, K103NV35T, T39A, K46Q, V60I, T69N, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
  02_BES706AJ577740AZT, DDI, 3TC, D4T, ABCEFVD67N, K70R, T215I, K219QA98G, K103NK11T, V35P, K46Q, V60I, T69N, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
Chantratita (2005)NP159NP159DQ130774NRTINNRTIM41L, D67N, K70R, L210W, T215F, K219QA98GT39K, K43E, V60I, K102R, K122E, D123S, E138A, S162A, K173I, Q174K, I178M, T200A, I202V, Q207A, R211S, V245EA
Non-B Workgroup (2005)UK4280UK4280AY901826AZT, 3TCNVPM184VA98G, K101E, G190AK11T, K20R, V35T, E42K, K122E, D123S, I135T, E138A, K173S, Q174K, D177G, V179I, I202V, Q207D, R211S, F214LA
Weber (2005)F51354F51354AY677539AZT, 3TC, DDC, D4T, DDINVP, EFVD67DN, K70KR, L74LV, T215FA98G, K103N, Y181CK11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312GA
 F87084F87084AY677580D4T, 3TC, AZTNVPM41L, M184V, T215YA98G, G190AP14A, V35T, T39A, E44ED, V90I, K122E, D123S, I135T, S162Y, K173L, Q174K, D177E, V179I, T200A, Q207E, R211S, V245E, D250E, A272G, I274IV, E291D, V292I, I293V, E312D, Y318X, Y319XA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Steegen (2009)BV141BV141-2EU8721433TC, D4TNVPM184VA98G, K103NV35T, T39A, K49R, V60I, K122E, D123G, S134R, I135T, K173A, Q174K, D177E, T200A, Q207E, R211KA
Moussa (2010)2511-CP001021HM117952D4T, 3TCNVPM184V, T215FA98G, K101E, Y181C, G190AE28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245KA
Ndembi (2010)DT3736_05_P13736GQ409623AZT, 3TCNVPD67N, M184VA98G, K103NV35T, V60I, D121H, K122E, I135T, I142V, K173A, Q174K, D177E, I178L, T200A, Q207EA
Towler (2010)9509635-DHM037900D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, G190AE6S, V35T, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, E203K, Q207E, R211RS, V245Q, D250E, A272T, T286A, E291D, V292I, I293V, E312D, S322A, A327VA
Charpentier (2011)6CP001071 D4T, 3TCNVPM184VA98G, K103KN, G190GA, K238KTK11AT, V35T, T39N, V60VI, D121H, K122E, I135T, I142IV, K173AS, Q174K, D177E, T200A, Q207A, R211NS, F214L, V245Q, E248DN, D250DE, S251SC, T286A, A288S, E291D, I293V, L295M, E297EGKR, E312DA
 121CP001724 D4T, 3TCNVPA62V, V75I, F116Y, Q151M, M184VA98G, Y181CI31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324EA
 219CP001004 D4T, 3TCNVPM41L, D67DN, L74LI, M184V, L210LW, T215FYA98G, K101E, G190AG45GR, L109I, V118VI, D121H, K122E, D123S, I142IT, S162D, E169EK, K173AT, Q174K, D177E, V179I, G196GS, I202IV, E203EK, Q207ADE, H208HY, R211RKNS, H221HYA
Charpentier (2011)CR-26CR-26FJ688232AZT, 3TCNNRTIM41ML, M184V, T215TNSYA98G, K103NT27S, V35T, T39R, K43E, S68G, D121Y, K122E, D123G, I135T, K173A, Q174K, D177E, G196E, T200A, Q207A, R211S, V245Q, D250E, A272P, G285GR, T286A, E291D, I293VA
 CR-11CR-11FJ688217AZT, 3TCNNRTID67DN, T69TADN, K70KR, V75VAIT, M184VA98G, Y188LK11T, V35T, T39N, E40ED, K49KR, V60I, S68SG, V106VI, K122E, D123S, I142V, F171Y, K173AITV, Q174K, D177E, I178M, G196E, T200A, K201KR, E203D, Q207E, R211K, F214FL, V245Q, K277R, T286A, E291D, V292I, I293V, P294T, E312NSA
Rusine (2013)441H441HKC841692AZT, 3TCNVPD67DN, K70KR, M184V, K219KQA98G, G190AK11T, V35T, K64KR, K101KQ, K122E, D123N, I135IT, K173S, D177E, V179I, T200K, I202IV, Q207A, R211NS, V245Q, K281R, I293V, P294T, E312EDA
Sigaloff (2013)JCR061_0JCR061_0JX181990NRTINNRTID67G, K70R, M184V, K219QA98G, K103NK11T, K20R, V35T, T39A, E40D, K43R, V60I, S68G, P97PS, K122E, D123N, I135T, K173A, Q174K, D177E, G196E, Q197K, T200A, Q207A, R211S, F214L, D218E, V245E, I293V, P294TA
 JCR109_0JCR109_0JX182002NRTINNRTID67N, K70R, M184V, T215I, K219EA98G, Y181CE6S, V35T, V60I, D121Y, K122E, I135IT, K173T, Q174K, D177E, V179I, G190X, I202V, Q207A, R211S, F214L, L228H, V245E, E248D, D250E, I293V, P294TA
 JFP103_0JFP103_0JX182011NRTINNRTIM41L, D67N, K70R, L74I, M184V, L210W, T215F, K219QA98G, K101E, G190AK20R, E28K, K32Q, V35T, T39E, T69N, I94L, K103R, K122E, D123N, S162SN, K173S, Q174K, D177E, T200A, Q207A, R211N, D218E, V245Q, E248D, D250E, S251D, R284K, T286A, E291D, V292I, I293V, P294T, E312NA
 MBA046_0MBA046_0JX182017NRTINNRTIM184VA98G, K103N, Y181CE6D, V21I, E28EK, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207E, R211S, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, K311RA
Theys (2013)4069540695KC221207NRTI, TDFNNRTIM184VA98G, K103NE40D, V60I, D121H, K122E, I135T, T139K, I142V, K173S, Q174K, D177E, V179I, Q207D, R211KA
 4947949479KC221428NRTI, TDFNNRTID67N, T69D, K70R, L74IV, M184V, T215F, K219QA98G, V108I, Y181CK49R, V60I, K122E, D123N, I135V, K173S, Q174K, N175Y, D177E, V179I, Q197E, T200A, I202V, Q207A, R211S, L228HA
 4451944519KC221309NRTI, TDFNNRTIT215FA98G, K103NV60I, V118I, K122E, I135T, E169EA, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
 4870248702KC218961NRTI, TDFNNRTIM41L, D67N, K70R, M184V, T215F, K219QA98GT39K, E40D, V60I, T69N, K122E, D123N, K173S, D177E, V179I, I202V, Q207A, R211K, F214L, V245QA
Acharya (2014)DGP075DGP075KJ185245AZT, 3TCNVPM184V, T215YA98G, Y181C, Y188LV35T, V60I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
 DGP053DGP053KJ185223TDF, 3TCNVPD67N, K70R, M184V, T215F, K219EA98GV35T, V60I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
Wallis (2014)4151741517KM458599NRTINNRTIK65KR, M184MV, K219KRA98G, Y181CK11T, K20KR, V21VI, L34LI, V35T, T39TA, V60I, S68SN, T69X, V90I, K122E, D123DN, I135T, K166KR, R172RK, K173A, Q174K, D177E, I178LM, T200A, Q207D, R211K, F214L, D218EA
 4128241282KM458611NRTINNRTIM184V, L210W, T215YA98G, K103NK11T, K20R, V35T, T39R, K43E, S68G, K122E, D123N, I135T, K173S, D177E, V179I, Q197K, T200A, I202V, Q207A, R211KA
Meini (2015)111131111131KM438264AZT, 3TCNVPK70R, M184V, K219QA98G, G190AK20KR, V35T, T39S, V60I, T69TN, V118VI, K122E, D123N, I135T, K173S, Q174K, D177E, I178F, V179I, T200A, I202V, Q207A, F214L, L228RA
 112220112220KM438265AZT, 3TC, DDINVPD67N, K70R, M184V, K219QA98G, K101E, G190AK11T, P25PS, V35T, V60I, T69N, F77FY, K122E, D123N, K173S, Q174K, D177E, V179I, G196E, Q207A, V245QA
Boillot (2016)RUT04RUT04KT315984D4T, 3TCEFVM184V, T215TNSYA98G, G190AV35T, E40D, K49R, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200TA, Q207A, R211S, F214FLA
 VIR32VIR32KT315993D4T, 3TCEFVM41L, D67N, K70R, M184V, T215YA98G, Y188LK11T, V35T, T39A, V60I, V106I, D121Y, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, E224D, D237E, V245EA
Brooks (2016)2009A2009AKU900869TDF, 3TCNVP, EFVK65R, M184VA98G, V179F, Y181C, G190AK20R, V35T, K43KR, V60I, K103R, D121Y, K122E, I135T, K173A, Q174K, D177E, T200A, Q207RS, R211NSA
Ndahimana Jd Riedel (2016)20292029KT982523NRTINNRTIV75M, L210W, T215YA98G, K103NK20R, V35K, T39E, K49KR, V60I, K122E, D123S, I135L, E138A, K173L, Q174K, T200A, Q207A, R211N, A272P, K275KNRS, T286A, A288AS, E291D, V292I, I293V, P294T, K311R, G335D, M357K, G359S, T369A, A371V, I375A, A376T, T377M, T386A, A400TA
Ndahimana (2016)837837KU922867TDF, 3TCNVPM184V, K219KEA98G, Y181CT39R, V60I, D123N, K173A, D177E, V179I, T200E, I202V, Q207A, R211K, V245QA
 12961296KU922892TDF, 3TCNVPK70E, M184VA98G, Y181CE40D, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, L228R, V245QA
Steegen (2016)GFKZB174GFKZB174KU128078TDF, 3TC, FTCNVP, EFVM184VA98G, Y188LP4H, K11T, V35T, K46Q, V106I, K122E, D123N, I135T, I142V, S162C, K173S, V179I, T200A, I202V, Q207A, R211S, F214L, L228H, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369TAA
 GFKZB243GFKZB243KU128154D4T, 3TC, TDF, FTCEFVM184V, K219EA98G, K103N, Y181YCK20KR, T27S, V35T, T39E, N54NI, W88C, K122E, D123N, I135T, I142V, K173S, T200A, I202V, Q207N, R211K, F214L, V245Q, E248N, K281R, T286A, E291D, I293V, P294T, Q334N, G335D, R356K, M357K, G359S, A371V, I375V, A376V, T386M, E399D, A400T, T403MA
Kekitiinwa (2017)65773_80065773_800KY237923NRTINNRTIL74V, M184V, K219KNA98G, Y181CK173A, Q174K, D177E, V179I, I202V, Q207A, R211K, H221YA
 79268_70279268_702KY237955NRTINNRTIM41L, M184V, T215FYA98GV118VI, K122E, D123N, I135V, T165I, K173S, D177E, V179I, T200A, I202IV, Q207A, R211K, F214FL, L228LRA
 28699_97728699_977KY237829NRTINNRTIM41L, D67H, K70R, M184V, T215F, K219EA98G, Y188LK20R, V35T, V60I, T69N, L109V, K122E, K173S, Q174K, D177E, V179I, G196E, I202V, Q207A, R211S, F214L, D218E, L228H, V245Q, E248D, D250E, A272P, T286A, A288T, E291D, V292I, I293VA
 65534_59665534_596KY237891NRTINNRTIL74V, Y115F, M184V, K219NA98G, L100I, K103NV90I, K122E, I135T, Q174K, D177E, I178L, T200A, Q207E, R211KA
 35367_94835367_948KY237840NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215YA98GV35T, E44D, V60I, K122E, D123N, I135T, I167V, K173A, Q174K, D177E, T200A, E203D, Q207A, H208Y, R211D, V245E, D250E, K281R, E291D, V292I, I293V, P294TA
 65586_102965586_1029KY237901NRTINNRTIM41L, M184V, L210W, T215FA98GK43E, K49KR, V60I, K122E, D123N, I135T, K173A, Q174K, I178V, V179I, I202V, Q207A, R211NS, F214LA
 65748_94565748_945KY237910NRTINNRTIM41L, M184V, L210W, T215YA98GE44D, V118VI, D123N, K173A, D177E, T200A, E203EQ, Q207D, R211RKA
 35365_77835365_778KY237839NRTINNRTID67N, K70R, M184V, T215F, K219EA98GK20R, V21I, V35T, T39R, V60VI, K64R, K122E, D123N, S162C, T165I, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211RK, F214L, V245Q, E248D, T286A, E291D, V292I, I293V, P294TA
Kityo (2017)8310683106KY061663NRTINNRTIM184VA98G, Y181CK49R, V60I, D121H, K122E, I135T, S162SC, K173S, Q174K, D177E, I178MV, V179VI, T200A, Q207A, R211S, H221HYA
 8348883488KY062042NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K103N, Y181C, G190AE44ED, V60I, K122E, D123N, I135T, T139R, I167IV, K173A, Q174K, D177E, G196GE, T200E, E203K, Q207E, R211RKA
 8310483104KY061661NRTINNRTIM41L, M184V, L210W, T215YA98G, G190AK43E, E44D, K173S, Q174K, D177E, V179I, T200A, I202V, E203EQ, Q207D, R211KA
 8318583185KY061741NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QA98G, K103NV60I, K122E, D123DN, I135L, E138G, S162C, K173A, Q174K, D177E, I178L, I202IV, Q207A, R211RK, L228HQRA
 8359583595KY062148NRTINNRTIM184VA98G, G190AK122E, D123G, P133PL, I135L, I142V, S162A, K173S, D177DE, V179I, Q207T, R211S, F214LA
 8353883538KY062092NRTINNRTID67N, K70R, M184V, K219QA98G, K103S, K238TV60I, K122E, D123NS, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, L228HA
 8291682916KY061480NRTINNRTIM184V, T215FA98G, G190AV60I, S68G, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207DGA
 8300683006KY061568NRTINNRTIM41L, D67N, K70KR, M184V, L210W, T215Y, K219KNA98G, K103N, K238TV60I, K101Q, K122E, D123N, I142V, K173LS, Q174K, D177E, V179I, T200A, I202V, Q207AA
 8346183461KY062015NRTINNRTIK70KR, M184V, T215TSA98G, G190AT69TS, K122E, D123NS, I135IT, S162SCNY, K173S, Q174K, D177E, V179T, T200A, Q207DA
 8354883548KY062102NRTINNRTIL74I, M184VA98G, G190E, P236PLV60I, K122E, D123S, I135T, E138A, K173S, Q174K, I178L, T200TA, Q207E, R211S, F214L, L228HA
 8292582925KY061489NRTINNRTIM41ML, M184V, T215FA98G, Y188L, P236PLK43E, V60I, S68SG, V106VI, K122E, D123N, I135T, I142V, K173S, D177E, V179I, T200A, I202V, Q207A, R211RKNS, D218EA
 8295282952KY061516NRTINNRTIM41LV, D67N, K70R, M184V, L210W, T215F, K219EA98G, Y181CK122KE, D123DEG, S163SN, K173A, D177E, V179I, T200A, I202V, Q207A, R211N, D218EA
 8345583455KY062009NRTINNRTIA62V, D67E, M184V, L210W, T215FA98G, K103N, P225HT69S, I94L, K122E, D123S, S162A, K173A, D177E, E194D, G196K, T200A, Q207AD, R211K, L228HA
 8325583255KY061810NRTINNRTIL74I, M184VA98G, K103N, V108I, P225HV60I, L109I, K122E, D123S, K173S, Q174K, D177E, V179I, I202V, Q207AA
 8342983429KY061983NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K103N, K238TE44D, I94L, K122KE, I135IT, K173S, D177E, V179I, T200A, I202V, Q207ADA
 2850428504KY061385NRTINNRTIK70R, M184VA98G, G190AV35T, V60I, T69CS, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214FL, V245Q, D250E, K281R, T286A, E291D, I293V, P294TA
 8300783007KY061569NRTINNRTIM41L, A62AV, V75L, M184V, T215FA98G, K103N, V108I, K238TL109LI, K122E, D123S, I142V, I167IV, K173L, Q174K, D177E, V179I, V189VI, I202V, Q207A, R211SA
 8324983249KY061804NRTINNRTIM41L, T69DN, M184V, L210W, T215YA98G, Y181C, G190AE44D, K49R, V111I, K122E, D123S, S162SN, I167IV, K173S, D177E, V179I, T200A, I202V, E203EK, Q207D, H208HYA
 8326483264KY061819NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, G190AE44D, V60I, V118I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, G196GE, T200A, E203D, Q207AD, R211S, F214LA
 8345883458KY062012NRTINNRTIM41ML, M184V, T215TFISA98G, Y181CK43E, K49R, I135T, I142V, K173S, D177E, V179I, T200K, I202V, Q207A, F214L, H221YA
 8289682896KY061461NRTINNRTIK65R, V75I, M184V, K219EA98G, Y181CV60I, S68G, K102Q, K103R, V118VI, K122E, D123S, I132L, S162C, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, F214LA
 8295582955KY061519NRTINNRTIM41ML, D67N, T69DN, K70R, L74LI, M184IV, T215F, K219QA98G, K103KN, V108VI, Y181C, G190GAK43R, V60I, V90I, D121H, K122E, D123S, I135T, S162Y, K173S, Q174K, D177E, V179I, T200A, Q207A, R211N, D218EA
 8352183521KY062075NRTINNRTID67N, K70R, M184V, T215F, K219EA98G, G190A, P236PLK49R, V60I, T69N, K122E, D123DN, I135T, K173A, Q174K, N175NY, D177E, V179I, T200A, I202IV, Q207EK, R211SA
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