<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation A98G
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 29
Isolates 30
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patBES01_BES703AJ577739AZT, DDI, 3TC, D4T, ABCEFVD67N, K70R, M184V, K219QA98G, K103NV35T, T39A, K46Q, V60I, T69N, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
  02_BES706AJ577740AZT, DDI, 3TC, D4T, ABCEFVD67N, K70R, T215I, K219QA98G, K103NK11T, V35P, K46Q, V60I, T69N, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
Non-B Workgroup (2005)UK4280UK4280AY901826AZT, 3TCNVPM184VA98G, K101E, G190AK11T, K20R, V35T, E42K, K122E, D123S, I135T, E138A, K173S, Q174K, D177G, V179I, I202V, Q207D, R211S, F214LA
Weber (2005)F51354F51354AY677539AZT, 3TC, DDC, D4T, DDINVP, EFVD67DN, K70KR, L74LV, T215FA98G, K103N, Y181CK11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312GA
 F87084F87084AY677580D4T, 3TC, AZTNVPM41L, M184V, T215YA98G, G190AP14A, V35T, T39A, E44ED, V90I, K122E, D123S, I135T, S162Y, K173L, Q174K, D177E, V179I, T200A, Q207E, R211S, V245E, D250E, A272G, I274IV, E291D, V292I, I293V, E312D, Y318X, Y319XA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Steegen (2009)BV141BV141-2EU8721433TC, D4TNVPM184VA98G, K103NV35T, T39A, K49R, V60I, K122E, D123G, S134R, I135T, K173A, Q174K, D177E, T200A, Q207E, R211KA
Moussa (2010)2511-CP001021HM117952D4T, 3TCNVPM184V, T215FA98G, K101E, Y181C, G190AE28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245KA
Ndembi (2010)DT3736_05_P13736GQ409623AZT, 3TCNVPD67N, M184VA98G, K103NV35T, V60I, D121H, K122E, I135T, I142V, K173A, Q174K, D177E, I178L, T200A, Q207EA
Towler (2010)9509635-DHM037900D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, G190AE6S, V35T, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, E203K, Q207E, R211RS, V245Q, D250E, A272T, T286A, E291D, V292I, I293V, E312D, S322A, A327VA
Charpentier (2011)6CP001071 D4T, 3TCNVPM184VA98G, K103KN, G190GA, K238KTK11AT, V35T, T39N, V60VI, D121H, K122E, I135T, I142IV, K173AS, Q174K, D177E, T200A, Q207A, R211NS, F214L, V245Q, E248DN, D250DE, S251SC, T286A, A288S, E291D, I293V, L295M, E297EGKR, E312DA
 121CP001724 D4T, 3TCNVPA62V, V75I, F116Y, Q151M, M184VA98G, Y181CI31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324EA
 219CP001004 D4T, 3TCNVPM41L, D67DN, L74LI, M184V, L210LW, T215FYA98G, K101E, G190AG45GR, L109I, V118VI, D121H, K122E, D123S, I142IT, S162D, E169EK, K173AT, Q174K, D177E, V179I, G196GS, I202IV, E203EK, Q207ADE, H208HY, R211RKNS, H221HYA
Rusine (2013)441H441HKC841692AZT, 3TCNVPD67DN, K70KR, M184V, K219KQA98G, G190AK11T, V35T, K64KR, K101KQ, K122E, D123N, I135IT, K173S, D177E, V179I, T200K, I202IV, Q207A, R211NS, V245Q, K281R, I293V, P294T, E312EDA
Sigaloff (2013)JCR061_0JCR061_0JX181990NRTINNRTID67G, K70R, M184V, K219QA98G, K103NK11T, K20R, V35T, T39A, E40D, K43R, V60I, S68G, P97PS, K122E, D123N, I135T, K173A, Q174K, D177E, G196E, Q197K, T200A, Q207A, R211S, F214L, D218E, V245E, I293V, P294TA
 JCR109_0JCR109_0JX182002NRTINNRTID67N, K70R, M184V, T215I, K219EA98G, Y181CE6S, V35T, V60I, D121Y, K122E, I135IT, K173T, Q174K, D177E, V179I, G190X, I202V, Q207A, R211S, F214L, L228H, V245E, E248D, D250E, I293V, P294TA
 JFP103_0JFP103_0JX182011NRTINNRTIM41L, D67N, K70R, L74I, M184V, L210W, T215F, K219QA98G, K101E, G190AK20R, E28K, K32Q, V35T, T39E, T69N, I94L, K103R, K122E, D123N, S162SN, K173S, Q174K, D177E, T200A, Q207A, R211N, D218E, V245Q, E248D, D250E, S251D, R284K, T286A, E291D, V292I, I293V, P294T, E312NA
 MBA046_0MBA046_0JX182017NRTINNRTIM184VA98G, K103N, Y181CE6D, V21I, E28EK, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207E, R211S, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, K311RA
Theys (2013)4069540695KC221207NRTI, TDFNNRTIM184VA98G, K103NE40D, V60I, D121H, K122E, I135T, T139K, I142V, K173S, Q174K, D177E, V179I, Q207D, R211KA
 4947949479KC221428NRTI, TDFNNRTID67N, T69D, K70R, L74IV, M184V, T215F, K219QA98G, V108I, Y181CK49R, V60I, K122E, D123N, I135V, K173S, Q174K, N175Y, D177E, V179I, Q197E, T200A, I202V, Q207A, R211S, L228HA
 4451944519KC221309NRTI, TDFNNRTIT215FA98G, K103NV60I, V118I, K122E, I135T, E169EA, K173S, Q174K, D177E, T200A, Q207A, R211S, F214LA
Wallis (2014)4151741517KM458599NRTINNRTIK65KR, M184MV, K219KRA98G, Y181CK11T, K20KR, V21VI, L34LI, V35T, T39TA, V60I, S68SN, T69X, V90I, K122E, D123DN, I135T, K166KR, R172RK, K173A, Q174K, D177E, I178LM, T200A, Q207D, R211K, F214L, D218EA
 4128241282KM458611NRTINNRTIM184V, L210W, T215YA98G, K103NK11T, K20R, V35T, T39R, K43E, S68G, K122E, D123N, I135T, K173S, D177E, V179I, Q197K, T200A, I202V, Q207A, R211KA
Meini (2015)111131111131KM438264AZT, 3TCNVPK70R, M184V, K219QA98G, G190AK20KR, V35T, T39S, V60I, T69TN, V118VI, K122E, D123N, I135T, K173S, Q174K, D177E, I178F, V179I, T200A, I202V, Q207A, F214L, L228RA
Boillot (2016)RUT04RUT04KT315984D4T, 3TCEFVM184V, T215TNSYA98G, G190AV35T, E40D, K49R, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200TA, Q207A, R211S, F214FLA
 VIR32VIR32KT315993D4T, 3TCEFVM41L, D67N, K70R, M184V, T215YA98G, Y188LK11T, V35T, T39A, V60I, V106I, D121Y, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, E224D, D237E, V245EA
Brooks (2016)2009A2009AKU900869TDF, 3TCNVP, EFVK65R, M184VA98G, V179F, Y181C, G190AK20R, V35T, K43KR, V60I, K103R, D121Y, K122E, I135T, K173A, Q174K, D177E, T200A, Q207RS, R211NSA
Ndahimana (2016)837837KU922867TDF, 3TCNVPM184V, K219KEA98G, Y181CT39R, V60I, D123N, K173A, D177E, V179I, T200E, I202V, Q207A, R211K, V245QA
Steegen (2016)GFKZB174GFKZB174KU128078TDF, 3TC, FTCNVP, EFVM184VA98G, Y188LP4H, K11T, V35T, K46Q, V106I, K122E, D123N, I135T, I142V, S162C, K173S, V179I, T200A, I202V, Q207A, R211S, F214L, L228H, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369TAA
 GFKZB243GFKZB243KU128154D4T, 3TC, TDF, FTCEFVM184V, K219EA98G, K103N, Y181YCK20KR, T27S, V35T, T39E, N54NI, W88C, K122E, D123N, I135T, I142V, K173S, T200A, I202V, Q207N, R211K, F214L, V245Q, E248N, K281R, T286A, E291D, I293V, P294T, Q334N, G335D, R356K, M357K, G359S, A371V, I375V, A376V, T386M, E399D, A400T, T403MA